Abstract
Project Number
Project No. VTF-150037
References
- 1.Agarwal, A., Makker, K., & Sharma, R. (2008). Clinical relevance of oxidative stress in male factor infertility: an update. American Journal of Reproductive Immunology, 59(1), 2-11. https://doi.org/10.1111/j.1600-0897.2007.00559.x
- 2.Amraoui, W., Adjabi, N., Bououza, F., Boumendjel, M., Taibi, F., Boumendjel, A., Abdennour, C., & Messarah, M. (2018). Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-induced Oxidative Stress in Wistar Albinos Rats. Toxicological Research, 34(3), 231-239. https://doi.org/10.5487/TR.2018.34.3.231.
- 3.Bağış, M. (2013). Kronik alkolik sıçanlarda oluşan testis hasarı üzerine chrysin’nin koruyucu etkisinin histolojik olarak incelenmesi. PhD, University of Osman Gazi, Eskişehir, Türkiye,
- 4.Conover, W.J. (1980). Practical nonparametric statistics (2nd ed.), Wiley and Sons, Newyork,. p. 229-239.
- 5.Eladak, S., Moison, D., Guerquin, M.J., Matilionyte, G., Kilcoyne, K., N'Tumba-Byn, T., Messiaen, S., Deceuninck, Y., Pozzi-Gaudin, S., Benachi, A., Livera, G., Antignac, JP., Mitchell, R., Rouiller-Fabre, V., & Habert, R. (2018). Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis. PLoS One, 13(1):e01911934. https://doi.org/10.1371/journal.pone.0191934.
The Effect of Vitamin E on Testicular Histology and Antioxidant Level in Rats Exposed to Bisphenol A
Abstract
This study, it was aimed to investigate the effect of Vitamin E on testicular tissue and antioxidant levels in rats exposed to Bisphenol A. It was determined that the general histological appearances were similar in the control and sham groups, there was a decrease in tubule diameter in the BPA-treated group, but the seminiferous tubular epithelial layer increased. Epithelial shedding and subbasal vacuoles were detected in some tubules in the vitamin E group. Undifferentiated Embryonic Cell Transcription Factor 1 (UTF-1) positive tubule and cell counts were found to be quite high in the BPA group. The antioxidant parameter SOD value was found to be low in the BPA group and higher in the Vitamin E group. It was noted that the MDA value was higher in the BPA-applied group compared to the other groups. At the end of the study, it was determined that vitamin E applied against BPA exposure had positive effects on testicular histology and antioxidant levels in testicular tissue.
Supporting Institution
The current work was financially supported by the Scientific Research Projects of Aydin Adnan Menderes University, .
Project Number
Project No. VTF-150037
Thanks
The authors would like to acknowledge Prof. Dr. Murat Boyacioglu, Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Aydin Adnan Menderes University, for the evaluation of the oxidant-antioxidant parameters.
References
- 1.Agarwal, A., Makker, K., & Sharma, R. (2008). Clinical relevance of oxidative stress in male factor infertility: an update. American Journal of Reproductive Immunology, 59(1), 2-11. https://doi.org/10.1111/j.1600-0897.2007.00559.x
- 2.Amraoui, W., Adjabi, N., Bououza, F., Boumendjel, M., Taibi, F., Boumendjel, A., Abdennour, C., & Messarah, M. (2018). Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-induced Oxidative Stress in Wistar Albinos Rats. Toxicological Research, 34(3), 231-239. https://doi.org/10.5487/TR.2018.34.3.231.
- 3.Bağış, M. (2013). Kronik alkolik sıçanlarda oluşan testis hasarı üzerine chrysin’nin koruyucu etkisinin histolojik olarak incelenmesi. PhD, University of Osman Gazi, Eskişehir, Türkiye,
- 4.Conover, W.J. (1980). Practical nonparametric statistics (2nd ed.), Wiley and Sons, Newyork,. p. 229-239.
- 5.Eladak, S., Moison, D., Guerquin, M.J., Matilionyte, G., Kilcoyne, K., N'Tumba-Byn, T., Messiaen, S., Deceuninck, Y., Pozzi-Gaudin, S., Benachi, A., Livera, G., Antignac, JP., Mitchell, R., Rouiller-Fabre, V., & Habert, R. (2018). Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis. PLoS One, 13(1):e01911934. https://doi.org/10.1371/journal.pone.0191934.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Sciences |
| Journal Section | Research Article |
| Authors | |
| Project Number | Project No. VTF-150037 |
| Publication Date | December 28, 2022 |
| Submission Date | October 3, 2022 |
| Published in Issue | Year 2022 Volume: 11 Issue: 2 |
