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Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases

Year 2018, Volume: 13 Issue: 1, 92 - 97, 25.04.2018
https://doi.org/10.17094/ataunivbd.297133

Abstract

Drug-induced hypersensitivity and adverse symptoms related to the high mortality remain as a major problem for veterinary practitioners. Although application of Rifamycin SV without intradermal susceptibility tests have been commonly used in wound management in veterinary medicine, there is no literature about this subject. In cases presented here, neoplastic masses on the mammary glands of queens (n=3) and bitches (n=4) were removed by mastectomy. Subcutaneous Rifamycin SV was performed intra- and post-operatively. After the multiple subcutaneous usage of Rifamycin SV, acute symptoms including hypersensitivity reactions such as facial and sublingual swelling, hypersalivation, respiratory distress, tachycardia, acute vomiting, erythema and itchiness around the face, seizures and ataxia developed. In conclusion, although Rifamycin SV provides better healing effects on incision line, veterinary practitioners should consider the serious side effects of subcutaneous Rifamycin SV usage after gynaecological surgeries in companion animals.

References

  • 1. Falagas ME., Vergidis PI., 2005. Irrigation with antibiotic-containing solutions for the prevention and treatment of infections. Clin Microbio Infect, 11,862-867.
  • 2. Maurice-Williams RS., Pollock J., 1999. Topical antibiotics in neurosurgery: a re-evaluation of the Malis technique. Br J Neurosurg, 13,312-315.
  • 3. Cardot E., Tillie-Leblond I., Jeannin P., Facon A., Breuil K., Patte F., Tonnel AB., 1995. Anaphylactic reaction to local administration of rifamycin SV. J Allergy Clin Immunol, 95,1-7.
  • 4. Saydam IM., Yılmaz S., Seven E., 2005. The Influence of topically applied Nitrofurazone and Rifamycin on full-thickness wound healing. Cumhuriyet Medical J, 27,113-120.
  • 5. Kosus A., Kosus N., Guler A., Çapar M., 2010. Rifamycin SV application to subcutaneous tissue for prevention of post-cesarean surgical site infection. Eur J Gen Med, 7,269-276.
  • 6. Aygun F., Kuzgun A., Ulucan S., Keser A., Akpek M., Kaya MG., 2014. The protective effect of topical rifamycin treatment against sternal wound infection in diabetic patients undergoing on-pump coronary artery bypass graft surgery. Cardiovasc J Afr, 25,96-99.
  • 7. Benfer J., Struck H., 1976. The effect of rifamycin SV on the wound-healing process. Arzneimittelforschung, 26,1361-1364.
  • 8. Ebo DG., Verheecke G., Bridts CH., Mertens CH., Stevens WJ., 2006. Perioperative anaphylaxis from locally applied rifamycin SV and latex. Br J Anaesth, 9,738-741.
  • 9. Dyer F., Diesel G., Cooles S., Trait A., 2009. Suspected adverse reactions, 2009. Vet Rec, 67,118-121.
  • 10. Shmuel DL., Cortes Y., 2013. Anaphylaxis in dogs and cats. J Vet Emerg Crit Care, 23,377-394.

Evcil Hayvanlarda Operasyon Sonrası Rifamisin Nedenli Hayati Hipersensitivite Reaksiyonları: 7 Olgunun Değerlendirilmesi

Year 2018, Volume: 13 Issue: 1, 92 - 97, 25.04.2018
https://doi.org/10.17094/ataunivbd.297133

Abstract

İlaç nedenli hipersensitivite ve yüksek mortalite ile ilişkili yan etkiler veteriner hekimler için halen büyük bir sorun teşkil etmektedir. Her ne kadar veteriner pratikte intradermal duyarlılık testi olmaksızın yara sağaltımında Rifamisin SV uygulaması yaygın şekilde kullanılsa da konuyla ilgili literatür veri bulunmamaktadır. Sunulan olgularda, kedi (n=3) ve köpeklerin (n=4) meme bezlerinde bulunan neoplastik kitleler mastektomi operasyonu ile uzaklaştırıldı. Rifamisin SV’nin subkutanöz uygulaması intra ve post operatif olarak yapıldı. Rifamisin SV’nin multipl subkutanöz kullanımı sonrasında yüz ve dil altında ödem, hipersalivasyon, solunum güçlüğü, taşikardi, akut kusma, yüzde eritem ve kaşıntı, nöbet ve ataksi gibi hipersensitivite reaksiyonlarını içeren akut semptomlar gelişti. Sonuç olarak her ne kadar Rifamisin SV, insizyon hattında daha iyi iyileştirici etki sağlasa da veteriner hekimler özellikle jinekolojik operasyonlar sonrası topikal Rifamisin SV kullanımının şiddetli yan etkilerine karşı dikkatli olmalıdırlar.

References

  • 1. Falagas ME., Vergidis PI., 2005. Irrigation with antibiotic-containing solutions for the prevention and treatment of infections. Clin Microbio Infect, 11,862-867.
  • 2. Maurice-Williams RS., Pollock J., 1999. Topical antibiotics in neurosurgery: a re-evaluation of the Malis technique. Br J Neurosurg, 13,312-315.
  • 3. Cardot E., Tillie-Leblond I., Jeannin P., Facon A., Breuil K., Patte F., Tonnel AB., 1995. Anaphylactic reaction to local administration of rifamycin SV. J Allergy Clin Immunol, 95,1-7.
  • 4. Saydam IM., Yılmaz S., Seven E., 2005. The Influence of topically applied Nitrofurazone and Rifamycin on full-thickness wound healing. Cumhuriyet Medical J, 27,113-120.
  • 5. Kosus A., Kosus N., Guler A., Çapar M., 2010. Rifamycin SV application to subcutaneous tissue for prevention of post-cesarean surgical site infection. Eur J Gen Med, 7,269-276.
  • 6. Aygun F., Kuzgun A., Ulucan S., Keser A., Akpek M., Kaya MG., 2014. The protective effect of topical rifamycin treatment against sternal wound infection in diabetic patients undergoing on-pump coronary artery bypass graft surgery. Cardiovasc J Afr, 25,96-99.
  • 7. Benfer J., Struck H., 1976. The effect of rifamycin SV on the wound-healing process. Arzneimittelforschung, 26,1361-1364.
  • 8. Ebo DG., Verheecke G., Bridts CH., Mertens CH., Stevens WJ., 2006. Perioperative anaphylaxis from locally applied rifamycin SV and latex. Br J Anaesth, 9,738-741.
  • 9. Dyer F., Diesel G., Cooles S., Trait A., 2009. Suspected adverse reactions, 2009. Vet Rec, 67,118-121.
  • 10. Shmuel DL., Cortes Y., 2013. Anaphylaxis in dogs and cats. J Vet Emerg Crit Care, 23,377-394.
There are 10 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Olgu Sunumu
Authors

Hatice Esra Çolakoğlu

İbrahim Mert Polat

Murat Onur Yazlık This is me

Ekrem Çağatay Çolakoğlu

Publication Date April 25, 2018
Published in Issue Year 2018 Volume: 13 Issue: 1

Cite

APA Çolakoğlu, H. E., Polat, İ. M., Yazlık, M. O., Çolakoğlu, E. Ç. (2018). Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 13(1), 92-97. https://doi.org/10.17094/ataunivbd.297133
AMA Çolakoğlu HE, Polat İM, Yazlık MO, Çolakoğlu EÇ. Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. April 2018;13(1):92-97. doi:10.17094/ataunivbd.297133
Chicago Çolakoğlu, Hatice Esra, İbrahim Mert Polat, Murat Onur Yazlık, and Ekrem Çağatay Çolakoğlu. “Postmastectomy Life-Threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13, no. 1 (April 2018): 92-97. https://doi.org/10.17094/ataunivbd.297133.
EndNote Çolakoğlu HE, Polat İM, Yazlık MO, Çolakoğlu EÇ (April 1, 2018) Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13 1 92–97.
IEEE H. E. Çolakoğlu, İ. M. Polat, M. O. Yazlık, and E. Ç. Çolakoğlu, “Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 13, no. 1, pp. 92–97, 2018, doi: 10.17094/ataunivbd.297133.
ISNAD Çolakoğlu, Hatice Esra et al. “Postmastectomy Life-Threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13/1 (April 2018), 92-97. https://doi.org/10.17094/ataunivbd.297133.
JAMA Çolakoğlu HE, Polat İM, Yazlık MO, Çolakoğlu EÇ. Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2018;13:92–97.
MLA Çolakoğlu, Hatice Esra et al. “Postmastectomy Life-Threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 13, no. 1, 2018, pp. 92-97, doi:10.17094/ataunivbd.297133.
Vancouver Çolakoğlu HE, Polat İM, Yazlık MO, Çolakoğlu EÇ. Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of Seven Cases. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2018;13(1):92-7.