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The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study

Year 2023, Volume: 70 Issue: 4, 367 - 374, 29.09.2023

Haci Ahmet Deveci Gökhan Nur Abdulsamed Kükürt Mushap Kuru Ayla Deveci

https://doi.org/10.33988/auvfd.1068527
Cited By: 1

Abstract

In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. A total of 40 female Swiss albino mice were used, with 10 mice in each group. The mice were divided into four groups (Group I - Control group, Group II - CAPE group, Group III - Cadmium group, Group IV - Cadmium + CAPE group). Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels (P<0.001, P<0.01, and P<0.01, respectively) and increased their TSA, LDL, TOC, and OSI levels (P<0.05, P<0.01, P<0.01, and P<0.01, respectively). The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

Keywords

Cadmium Caffeic acid phenethyl ester Oxidant-antioxidant balance Paraoxonase activity Sialic acid

Ethical Statement

All procedures performed with experimental animals comply with ethical standards and were approved by the Kafkas University Animal Experiments Local Ethics Committee (2016-087).

Supporting Institution

This study was supported by Gaziantep University Scientific Research Projects (Project ID: IMYO.17.01).

Project Number

Project ID: IMYO.17.01

References

  • Afolabi OK, Oyewo EB, Adekunle AS, et al (2012): Impaired lipid levels and inflammatory response in rats exposed to cadmium. EXCLI J, 11, 677-687.
  • Aviram M, Rosenblat M, Bisgaier CL, et al (1998): Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions: A possible peroxidative role for paraoxonase. J Clin Invest, 101, 1581-1590.
  • Banskota AH, Tezuka Y, Kadota S (2001): Recent progress in pharmacological research of propolis. Phyther Res, 15, 561-571.
  • Bashir N, Manoharan V, Prabu SM (2014): Cadmium toxicity: oxidative stress and organ dysfunction. STM Journals, 4, 1-19.
  • Benzie IFF, Strain JJ (1996): The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem, 239, 70-76.
  • Borrelli F, Maffia P, Pinto L, et al (2002): Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73, 53-63.
  • Briffa J, Sinagra E, Blundell R (2020): Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon, 6, e04691.
  • Brzóska MM, Kamiński M, Supernak-Bobko D, et al (2003): Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies. Arch Toxicol, 77, 344-352.
  • Cao G, Prior RL (1998): Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem, 44, 1309-1315.
  • Castaldo S, Capasso F (2002): Propolis, an old remedy used in modern medicine. Fitoterapia, 73, 1-6.
  • Chen F, Gong P (2011): Caffeic acid phenethyl ester protect mice hepatic damage against Cadmium exposure. Proced Environ Sci, 8, 633-636.
  • Colacino JA, Arthur AE, Ferguson KK, et al (2014): Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress. Environ Res, 131, 6-12.
  • Costa LG, Cole TB, Jarvik GP, et al (2003): Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annu Rev Med, 54, 371-392.
  • Debord J, Bollinger JC, Merle L, et al (2003): Inhibition of human serum arylesterase by metal chlorides. J Inorg Biochem, 94, 1-4.
  • Deveci HA, Karapehlivan M (2018): Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry. Pestic Biochem Physiol, 144, 36-41.
  • Eckerson HW, Romson J, Wyte C, et al (1983): The human serum paraoxonase polymorphism: Identification of phenotypes by their response to salts. Am J Hum Genet, 35, 214-227.
  • Eguchi H, Ikeda Y, Ookawara T, et al (2005): Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion. Glycobiology, 15, 1094-1101.
  • El-Sokkary GH, Nafady AA, Shabash EH (2010): Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat. Ecotoxicol Environ Saf, 73, 456-463.
  • Erel O (2004): A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem, 37, 277-285.
  • Erel O (2005): A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103-1111.
  • Fadillioglu E, Erdogan H, Iraz M, et al (2003): Effects of caffeic acid phenethyl ester against doxorubicin-induced neuronal oxidant injury. Neurosci Res Commun, 33, 132-138.
  • Gavett SH, Oberdörster G (1994): Cadmium chloride and cadmium metallothionein-induced pulmonary injury and recruitment of polymorphonuclear leukocytes. Exp Lung Res, 20, 517-537.
  • Gelen V, Kükürt A, Şengül E, et al (2021): Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation? 341-361. In: FA Badria (Ed), Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. IntechOpen, London.
  • Gong P, Chen FX, Ma GF, et al (2008): Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice. Toxicology, 251, 35-44.
  • Gülcü F, Gürsu MF (2003): The Standardization of paraoxonase and arylesterase activity measurements. Turkish J Biochem, 28, 45-49.
  • Güven A, Güven A, Kaya I (2009): Farelerde kadmiyum ve karbon tetraklorür ile oluşturulan oksidatif hasara kefirin etkisinin belirlenmesi. Kafkas Üniv Fen Bil Enst Derg, 2, 25-30.
  • Güven A, Nur G, Deveci HA (2021): Biochemical and histopathological profile of the liver in chemical poisoning. 123-149. In: A Güven (Ed), Oxidative Stress and Antioxidant Defense System. Livre de Lyon, Lyon.
  • Hussein O, Zidan J, Abu Jabal K, et al (2012): Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic fatty liver disease. Int J Hepatol, 2012, 265305.
  • Işık Bircan C, Merhan O (2020): Kadmiyum uygulanan farelerde oluşturulan oksidatif strese karşı resveratrolün koruyucu etkisinin araştırılması. Erciyes Üniv Vet Fak Derg, 17, 215-220.
  • Järup L, Berglund M, Elinder CG, et al (1998): Health effects of cadmium exposure - A review of the literature and a risk estimate. Scand J Work Environ Heal, 24, 1-51.
  • Jurczuk M, Brzóska MM, Moniuszko-Jakoniuk J, et al (2004): Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem Toxicol, 42, 429-438.
  • Kara H, Karataş F, Canatan H (2005): Effect of single dose cadmium chloride administration on oxidative stress in male and female rats. Turkish J Vet Anim Sci, 29, 37-42.
  • Karapehlivan M, Ogun M, Kaya I, et al (2014): Protective effect of omega-3 fatty acid against mercury chloride intoxication in mice. J Trace Elem Med Biol, 28, 94-99.
  • Karoui-Kharrat D, Kaddour H, Hamdi Y, et al (2017): Response of antioxidant enzymes to cadmium-induced cytotoxicity in rat cerebellar granule neurons. Open Life Sci, 12, 113-119.
  • Kobroob A, Chattipakorn N, Wongmekiat O (2012): Caffeic acid phenethyl ester ameliorates cadmium-induced kidney mitochondrial injury. Chem Biol Interact, 200, 21-27.
  • Kocamaz D, Merhan O (2019): Kadmiyum uygulanan farelerde gelişen akciğer hasarına karşı resveratrolün etkisi. 122-127. In: Proceedings book of International Conference on Mathematics – Engineering - Natural and Medical Sciences, Adana, Turkey.
  • Kükürt A (2020): Doğal bir antioksidan olarak propolis tedavisinin koruyucu etkileri. 501-515. In: C Evereklioğlu (Ed), Sağlık Bilimlerinde Teori ve Araştırmalar II. Gece Kitaplığı, Ankara.
  • Kükürt A, Gelen V, Başer ÖF, et al (2021): Thiols: Role in oxidative stress-related disorders. 27-47. In: P Atukeren (Ed), Accenting Lipid Peroxidation. IntechOpen, London.
  • Kükürt A, Karapehlivan M (2022): Protective effect of astaxanthin on experimental ovarian damage in rats. J Biochem Mol Toxicol, 36, e22966.
  • Kükürt A, Kuru M, Karapehlivan M (2020): Nitrik oksit, nitrik oksit sentaz ve dişi üreme distemindeki rolleri. 113-123. In: C Evereklioğlu (Ed), Sağlık Bilimleri Alanında Akademik Çalışmalar II. Gece Kitaplığı, Ankara.
  • Lee DH, Lim JS, Song K, et al (2006). Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress–related markers in the US population: Results from the Third National Health and Nutrition Examination Survey. Environ Health Perspect, 114, 350-354.
  • Liju VB, Jeena K, Kuttan R (2013): Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L). Food Chem Toxicol, 53, 52-61.
  • López E, Arce C, Oset-Gasque MJ, et al (2006): Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radic Biol Med, 40, 940-951.
  • McDowell LR (2003): Minerals in Animal and Human Nutrition. Second Edition, Elsevier.
  • Merhan O, Kocamaz D (2018): Farelerde kadmiyumla indüklenen oksidatif testis hasarına karşı resveratrolün koruyucu etkisi. 26-36. In: Proceedings book of 2nd International Congress on Multidisciplinary Studies. Adana, Turkey.
  • Nur G, Deveci H, Ersan Y, et al (2016): Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice. Medicine Science, 5, 972-978.
  • Nur G, Güven A, Kılıçle PA (2018): The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos. J Cell Neurosci and Oxid Stress, 10, 647-655.
  • Oktem F, Ozguner F, Sulak O, et al (2005): Lithium-induced renal toxicity in rats: Protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem, 277, 109-115.
  • Renugadevi J, Prabu SM (2010): Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol, 62, 171-181.
  • Santos FW, Zeni G, Rocha JBT, et al (2005): Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues. Chem Biol Interact, 151, 159-165.
  • Schauer R (1982): Chemistry, metabolism, and biological functions of sialic acids. Adv Carbohydr Chem Biochem, 40, 131-234.
  • Sorenson RC, Bisgaier CL, Aviram M, et al (1999): Human serum paraoxonase/arylesterase’s retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: Apolipoprotein A-I stabilizes activity. Arterioscler Thromb Vasc Biol, 19, 2214-2225.
  • Sydow G (1985): A simplified quick method for determination of sialic acid in serum. Biomed Biochim Acta, 44, 1721-1723.
  • Tchounwou PB, Yedjou CG, Patlolla AK, et al (2012). Heavy metal toxicity and the environment. Exp Suppl, 101, 133-164.
  • Van Lenten BJ, Hama SY, De Beer FC, et al (1995): Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest, 96, 2758-2767.
  • Varki NM, Varki A (2007): Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Investig, 87, 851-857.
  • Vlachos GD, Bartzeliotou A, Schulpis KH, et al (2006): Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem, 39, 923-928.
  • Waalkes MP (2000): Cadmium carcinogenesis in review. J Inorg Biochem, 79, 241-244.
  • Watson AD, Berliner JA, Hama SY, et al (1995): Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest, 96, 2882-2891.
  • Wijnberger LD, Krediet TG, Visser GH, et al (2003): Early neonatal antioxidant capacity after preexisting impaired placental function. Early Hum Dev, 71, 111-116.
  • Yamano T, DeCicco LA, Rikans LE (2000): Attenuation of cadmium-induced liver injury in senescent male Fischer 344 rats: Role of kupffer cells and inflammatory cytokines. Toxicol Appl Pharmacol, 162, 68-75.
  • Yang H, Shu Y (2015): Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. Int J Mol Sci, 16, 1484-1494.

Year 2023, Volume: 70 Issue: 4, 367 - 374, 29.09.2023

Haci Ahmet Deveci Gökhan Nur Abdulsamed Kükürt Mushap Kuru Ayla Deveci

https://doi.org/10.33988/auvfd.1068527
Cited By: 1

Abstract

Project Number

Project ID: IMYO.17.01

References

  • Afolabi OK, Oyewo EB, Adekunle AS, et al (2012): Impaired lipid levels and inflammatory response in rats exposed to cadmium. EXCLI J, 11, 677-687.
  • Aviram M, Rosenblat M, Bisgaier CL, et al (1998): Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions: A possible peroxidative role for paraoxonase. J Clin Invest, 101, 1581-1590.
  • Banskota AH, Tezuka Y, Kadota S (2001): Recent progress in pharmacological research of propolis. Phyther Res, 15, 561-571.
  • Bashir N, Manoharan V, Prabu SM (2014): Cadmium toxicity: oxidative stress and organ dysfunction. STM Journals, 4, 1-19.
  • Benzie IFF, Strain JJ (1996): The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem, 239, 70-76.
  • Borrelli F, Maffia P, Pinto L, et al (2002): Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73, 53-63.
  • Briffa J, Sinagra E, Blundell R (2020): Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon, 6, e04691.
  • Brzóska MM, Kamiński M, Supernak-Bobko D, et al (2003): Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies. Arch Toxicol, 77, 344-352.
  • Cao G, Prior RL (1998): Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem, 44, 1309-1315.
  • Castaldo S, Capasso F (2002): Propolis, an old remedy used in modern medicine. Fitoterapia, 73, 1-6.
  • Chen F, Gong P (2011): Caffeic acid phenethyl ester protect mice hepatic damage against Cadmium exposure. Proced Environ Sci, 8, 633-636.
  • Colacino JA, Arthur AE, Ferguson KK, et al (2014): Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress. Environ Res, 131, 6-12.
  • Costa LG, Cole TB, Jarvik GP, et al (2003): Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annu Rev Med, 54, 371-392.
  • Debord J, Bollinger JC, Merle L, et al (2003): Inhibition of human serum arylesterase by metal chlorides. J Inorg Biochem, 94, 1-4.
  • Deveci HA, Karapehlivan M (2018): Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry. Pestic Biochem Physiol, 144, 36-41.
  • Eckerson HW, Romson J, Wyte C, et al (1983): The human serum paraoxonase polymorphism: Identification of phenotypes by their response to salts. Am J Hum Genet, 35, 214-227.
  • Eguchi H, Ikeda Y, Ookawara T, et al (2005): Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion. Glycobiology, 15, 1094-1101.
  • El-Sokkary GH, Nafady AA, Shabash EH (2010): Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat. Ecotoxicol Environ Saf, 73, 456-463.
  • Erel O (2004): A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem, 37, 277-285.
  • Erel O (2005): A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103-1111.
  • Fadillioglu E, Erdogan H, Iraz M, et al (2003): Effects of caffeic acid phenethyl ester against doxorubicin-induced neuronal oxidant injury. Neurosci Res Commun, 33, 132-138.
  • Gavett SH, Oberdörster G (1994): Cadmium chloride and cadmium metallothionein-induced pulmonary injury and recruitment of polymorphonuclear leukocytes. Exp Lung Res, 20, 517-537.
  • Gelen V, Kükürt A, Şengül E, et al (2021): Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation? 341-361. In: FA Badria (Ed), Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. IntechOpen, London.
  • Gong P, Chen FX, Ma GF, et al (2008): Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice. Toxicology, 251, 35-44.
  • Gülcü F, Gürsu MF (2003): The Standardization of paraoxonase and arylesterase activity measurements. Turkish J Biochem, 28, 45-49.
  • Güven A, Güven A, Kaya I (2009): Farelerde kadmiyum ve karbon tetraklorür ile oluşturulan oksidatif hasara kefirin etkisinin belirlenmesi. Kafkas Üniv Fen Bil Enst Derg, 2, 25-30.
  • Güven A, Nur G, Deveci HA (2021): Biochemical and histopathological profile of the liver in chemical poisoning. 123-149. In: A Güven (Ed), Oxidative Stress and Antioxidant Defense System. Livre de Lyon, Lyon.
  • Hussein O, Zidan J, Abu Jabal K, et al (2012): Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic fatty liver disease. Int J Hepatol, 2012, 265305.
  • Işık Bircan C, Merhan O (2020): Kadmiyum uygulanan farelerde oluşturulan oksidatif strese karşı resveratrolün koruyucu etkisinin araştırılması. Erciyes Üniv Vet Fak Derg, 17, 215-220.
  • Järup L, Berglund M, Elinder CG, et al (1998): Health effects of cadmium exposure - A review of the literature and a risk estimate. Scand J Work Environ Heal, 24, 1-51.
  • Jurczuk M, Brzóska MM, Moniuszko-Jakoniuk J, et al (2004): Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem Toxicol, 42, 429-438.
  • Kara H, Karataş F, Canatan H (2005): Effect of single dose cadmium chloride administration on oxidative stress in male and female rats. Turkish J Vet Anim Sci, 29, 37-42.
  • Karapehlivan M, Ogun M, Kaya I, et al (2014): Protective effect of omega-3 fatty acid against mercury chloride intoxication in mice. J Trace Elem Med Biol, 28, 94-99.
  • Karoui-Kharrat D, Kaddour H, Hamdi Y, et al (2017): Response of antioxidant enzymes to cadmium-induced cytotoxicity in rat cerebellar granule neurons. Open Life Sci, 12, 113-119.
  • Kobroob A, Chattipakorn N, Wongmekiat O (2012): Caffeic acid phenethyl ester ameliorates cadmium-induced kidney mitochondrial injury. Chem Biol Interact, 200, 21-27.
  • Kocamaz D, Merhan O (2019): Kadmiyum uygulanan farelerde gelişen akciğer hasarına karşı resveratrolün etkisi. 122-127. In: Proceedings book of International Conference on Mathematics – Engineering - Natural and Medical Sciences, Adana, Turkey.
  • Kükürt A (2020): Doğal bir antioksidan olarak propolis tedavisinin koruyucu etkileri. 501-515. In: C Evereklioğlu (Ed), Sağlık Bilimlerinde Teori ve Araştırmalar II. Gece Kitaplığı, Ankara.
  • Kükürt A, Gelen V, Başer ÖF, et al (2021): Thiols: Role in oxidative stress-related disorders. 27-47. In: P Atukeren (Ed), Accenting Lipid Peroxidation. IntechOpen, London.
  • Kükürt A, Karapehlivan M (2022): Protective effect of astaxanthin on experimental ovarian damage in rats. J Biochem Mol Toxicol, 36, e22966.
  • Kükürt A, Kuru M, Karapehlivan M (2020): Nitrik oksit, nitrik oksit sentaz ve dişi üreme distemindeki rolleri. 113-123. In: C Evereklioğlu (Ed), Sağlık Bilimleri Alanında Akademik Çalışmalar II. Gece Kitaplığı, Ankara.
  • Lee DH, Lim JS, Song K, et al (2006). Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress–related markers in the US population: Results from the Third National Health and Nutrition Examination Survey. Environ Health Perspect, 114, 350-354.
  • Liju VB, Jeena K, Kuttan R (2013): Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L). Food Chem Toxicol, 53, 52-61.
  • López E, Arce C, Oset-Gasque MJ, et al (2006): Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radic Biol Med, 40, 940-951.
  • McDowell LR (2003): Minerals in Animal and Human Nutrition. Second Edition, Elsevier.
  • Merhan O, Kocamaz D (2018): Farelerde kadmiyumla indüklenen oksidatif testis hasarına karşı resveratrolün koruyucu etkisi. 26-36. In: Proceedings book of 2nd International Congress on Multidisciplinary Studies. Adana, Turkey.
  • Nur G, Deveci H, Ersan Y, et al (2016): Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice. Medicine Science, 5, 972-978.
  • Nur G, Güven A, Kılıçle PA (2018): The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos. J Cell Neurosci and Oxid Stress, 10, 647-655.
  • Oktem F, Ozguner F, Sulak O, et al (2005): Lithium-induced renal toxicity in rats: Protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem, 277, 109-115.
  • Renugadevi J, Prabu SM (2010): Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol, 62, 171-181.
  • Santos FW, Zeni G, Rocha JBT, et al (2005): Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues. Chem Biol Interact, 151, 159-165.
  • Schauer R (1982): Chemistry, metabolism, and biological functions of sialic acids. Adv Carbohydr Chem Biochem, 40, 131-234.
  • Sorenson RC, Bisgaier CL, Aviram M, et al (1999): Human serum paraoxonase/arylesterase’s retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: Apolipoprotein A-I stabilizes activity. Arterioscler Thromb Vasc Biol, 19, 2214-2225.
  • Sydow G (1985): A simplified quick method for determination of sialic acid in serum. Biomed Biochim Acta, 44, 1721-1723.
  • Tchounwou PB, Yedjou CG, Patlolla AK, et al (2012). Heavy metal toxicity and the environment. Exp Suppl, 101, 133-164.
  • Van Lenten BJ, Hama SY, De Beer FC, et al (1995): Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest, 96, 2758-2767.
  • Varki NM, Varki A (2007): Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Investig, 87, 851-857.
  • Vlachos GD, Bartzeliotou A, Schulpis KH, et al (2006): Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem, 39, 923-928.
  • Waalkes MP (2000): Cadmium carcinogenesis in review. J Inorg Biochem, 79, 241-244.
  • Watson AD, Berliner JA, Hama SY, et al (1995): Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest, 96, 2882-2891.
  • Wijnberger LD, Krediet TG, Visser GH, et al (2003): Early neonatal antioxidant capacity after preexisting impaired placental function. Early Hum Dev, 71, 111-116.
  • Yamano T, DeCicco LA, Rikans LE (2000): Attenuation of cadmium-induced liver injury in senescent male Fischer 344 rats: Role of kupffer cells and inflammatory cytokines. Toxicol Appl Pharmacol, 162, 68-75.
  • Yang H, Shu Y (2015): Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. Int J Mol Sci, 16, 1484-1494.
There are 62 citations in total.

Details

Primary Language English
Subjects Veterinary Biochemistry, Veterinary Obstetrics and Gynecology
Journal Section Research Article
Authors

Haci Ahmet Deveci 0000-0002-3862-1991

Gökhan Nur 0000-0002-5861-8538

Abdulsamed Kükürt 0000-0002-3603-0506

Mushap Kuru 0000-0003-4409-251X

Ayla Deveci 0000-0003-2574-0251

Project Number Project ID: IMYO.17.01
Publication Date September 29, 2023
Published in Issue Year 2023Volume: 70 Issue: 4

Cite

APA Deveci, H. A., Nur, G., Kükürt, A., Kuru, M., et al. (2023). The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(4), 367-374. https://doi.org/10.33988/auvfd.1068527
AMA Deveci HA, Nur G, Kükürt A, Kuru M, Deveci A. The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Univ Vet Fak Derg. September 2023;70(4):367-374. doi:10.33988/auvfd.1068527
Chicago Deveci, Haci Ahmet, Gökhan Nur, Abdulsamed Kükürt, Mushap Kuru, and Ayla Deveci. “The Protective Effect of Caffeic Acid Phenethyl Ester on Cadmium-Induced Liver Toxicity: A Histopathological and Biochemical Study”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 70, no. 4 (September 2023): 367-74. https://doi.org/10.33988/auvfd.1068527.
EndNote Deveci HA, Nur G, Kükürt A, Kuru M, Deveci A (September 1, 2023) The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Üniversitesi Veteriner Fakültesi Dergisi 70 4 367–374.
IEEE H. A. Deveci, G. Nur, A. Kükürt, M. Kuru, and A. Deveci, “The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study”, Ankara Univ Vet Fak Derg, vol. 70, no. 4, pp. 367–374, 2023, doi: 10.33988/auvfd.1068527.
ISNAD Deveci, Haci Ahmet et al. “The Protective Effect of Caffeic Acid Phenethyl Ester on Cadmium-Induced Liver Toxicity: A Histopathological and Biochemical Study”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 70/4 (September 2023), 367-374. https://doi.org/10.33988/auvfd.1068527.
JAMA Deveci HA, Nur G, Kükürt A, Kuru M, Deveci A. The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Univ Vet Fak Derg. 2023;70:367–374.
MLA Deveci, Haci Ahmet et al. “The Protective Effect of Caffeic Acid Phenethyl Ester on Cadmium-Induced Liver Toxicity: A Histopathological and Biochemical Study”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 70, no. 4, 2023, pp. 367-74, doi:10.33988/auvfd.1068527.
Vancouver Deveci HA, Nur G, Kükürt A, Kuru M, Deveci A. The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Univ Vet Fak Derg. 2023;70(4):367-74.

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