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Investigation of Antiviral Potential of Food Carotenoids and Apocarotenoids against RNA-dependent RNA Polymerase of Hepatitis C Virus

Year 2022, Volume: 11 Issue: 3, 931 - 942, 30.09.2022
https://doi.org/10.17798/bitlisfen.1161170

Abstract

Hepatitis C disease have been a global health threat and affects a significant portion of world population. Hepatitis C have also been a silent health threat for Turkiye, where there are around half million people infected with Hepatitis C Virus (HCV). Disease burden and mortality are expected to increase gradually in the next 20 years in Turkiye. Unavailability of enough data on the currently-available drugs in routine clinical practice, their side effects and interactions with other drugs, and their efficacies on the less common genotypes indicates the necessity of alternative treatment options. Natural products from herbal and medicinal plants can indeed provide an alternative as being drug-like dietary supplements. In particular, the carotenoids and apocarotenoids are underexplored in their antiviral potential, including anti-HCV activities. Therefore, we focused on the virtual screening of various carotenoids and apocarotenoids against the RNA-dependent RNA polymerase (RdRp) of HCV. Molecular docking experiments showed strong binding affinities of the ligands to both palm and thumb domains of RdRp of HCV. In fact, some of them such as neoxanthin, crocin, canthaxanthin and cryptoflavin bound quite strongly to both domains compared to native ligands and current antiviral drugs. MD simulation for neoxanthin-RdRp complex confirmed the stability of the ligand within the binding cavity of RdRp throughout 100 ns simulation. This clearly indicated the potential of carotenoids, specifically neoxanthin, as RdRp inhibitor in treating HCV. Thus, this study not only discovered anti-HCV drug candidates with the properties of easy-to-access and low cost, but also paved the way for the development of carotenoid or apocarotenoid based dietary supplement candidates for the prevention and treatment of HCV.

Supporting Institution

The Scientific and Technological Research Council of Turkiye

Project Number

221Z280

References

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Year 2022, Volume: 11 Issue: 3, 931 - 942, 30.09.2022
https://doi.org/10.17798/bitlisfen.1161170

Abstract

Project Number

221Z280

References

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  • A. J. Millman, N. P. Nelson, and C. Vellozzi, “Hepatitis C: Review of the Epidemiology, Clinical Care, and Continued Challenges in the Direct Acting Antiviral Era,” Curr Epidemiol reports, vol. 4, pp. 174–185, 2017. https://doi.org/10.1007/S40471-017-0108-X
  • A. M. Hauri, G. L. Armstrong, and Y. J. F. Hutin, “The global burden of disease attributable to contaminated injections given in health care settings,” Int J STD AIDS, vol. 15, pp. 7–16, 2004. https://doi.org/10.1258/095646204322637182
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  • A. A. Rabaan, S. H. Al-Ahmed, A. M. Bazzi, W. A. Alfouzan, S. A, Alsuliman, F. A. Aldrazi, and S. Haque, “Overview of hepatitis C infection, molecular biology, and new treatment,” J Infect Public Health, vol. 13, pp. 773–783, 2020. https://doi.org/10.1016/J.JIPH.2019.11.015
  • N. Tozun, O. Ozdogan, Y. Cakaloglu, R. Idilman, Z. Karasu, U. Akarca, S. Kaymakoglu, and O. Ergonul, “Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study,” Clin Microbiol Infect, vol. 21, pp. 1020–1026, 2015. https://doi.org/10.1016/J.CMI.2015.06.028
  • “Türkiye Viral Hepatit Önleme ve Kontrol Programi”, Accessed: Aug. 01, 2022. [Online]. Available: https://hsgm.saglik.gov.tr/tr/bulasicihastaliklar-haberler/turkiye-viral-hepatit-onleme-ve-kontrol-programi.html
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  • B. Henry, “Drug pricing and challenges to hepatitis c treatment access,” J Heal Biomed law, vol. 14, pp. 265–283, 2018.
  • J. H. Hoofnagle and L. B. Seeff, “Peginterferon and Ribavirin for Chronic Hepatitis C,” N Engl J Med, vol. 355, pp. 2444–2451, 2006. https://doi.org/10.1056/NEJMCT061675
  • M. Zając, I. Muszalska, A. Sobczak, A. Dadej, S. Tomczak, and A. Jelińska, “Hepatitis C – New drugs and treatment prospects,” Eur J Med Chem, vol. 165, pp. 225–249, 2019. https://doi.org/10.1016/J.EJMECH.2019.01.025
  • R. González-Grande, M. Jiménez-Pérez, C. G. Arjona, and J. M. Torres, “New approaches in the treatment of hepatitis C,” World J Gastroenterol, vol. 22, pp. 1421–1432, 2016. https://doi.org/10.3748/WJG.V22.I4.1421
  • J. Yabuzaki, “Carotenoids Database: structures, chemical fingerprints and distribution among organisms,” Database, vol. 2017, pp. 1–11, 2017 https://doi.org/10.1093/DATABASE/BAX004
  • O. Fidan and J. Zhan, “Discovery and engineering of an endophytic Pseudomonas strain from Taxus chinensis for efficient production of zeaxanthin diglucoside,” J Biol Eng, vol. 13, pp. 1–18, 2019. https://doi.org/10.1186/S13036-019-0196-X
  • J. Dzib-Cauich, R. Us-Camas, and R. Rivera-Madrid, “Natural Sources of Apocarotenoids and Their Applications,” in Biol Chem Appl Apocarotenoids, S. Ramamoorthy, R. R. Madrid, C, G. P. Doss, Eds. Boca Raton: CRC Press, pp. 11–39, 2020. https://doi.org/10.1201/9780429344206-2
  • C. Zhang, “Biosynthesis of Carotenoids and Apocarotenoids by Microorganisms and Their Industrial Potential,” in Prog Carotenoid Res, L. Q. Zepka, E. Jacob-Lopes and V. V. De Rosso, Eds. London: IntechOpen, pp. 85–105, 2018. https://doi.org/10.5772/INTECHOPEN.79061
  • R. W. Tuveson, R. A. Larson, and J. Kagan, “Role of cloned carotenoid genes expressed in Escherichia coli in protecting against inactivation by near-UV light and specific phototoxic molecules,” J Bacteriol, vol. 170, pp. 4675–4680, 1988. https://doi.org/10.1128/jb.170.10.4675-4680.1988
  • A. J. Simkin, “Carotenoids and Apocarotenoids in Planta: Their Role in Plant Development, Contribution to the Flavour and Aroma of Fruits and Flowers, and Their Nutraceutical Benefits,” Plants (Basel), vol. 10, pp. 2321, 2021. https://doi.org/10.3390/PLANTS10112321
  • Y. Sharoni et al., “Carotenoids and apocarotenoids in cellular signaling related to cancer: A review,” Mol Nutr Food Res, vol. 56, pp. 259–269, 2012. https://doi.org/10.1002/MNFR.201100311
  • S. Mujwar, L. Sun, and O. Fidan, “In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19,” J Food Biochem, vol. 2022 May 11, pp. e14219, 2022. https://doi.org/10.1111/JFBC.14219
  • G. E. Hegazy, M. M. Abu-Serie, G. M. Agu-Elela, H. Ghozlan, S. A. Sabry, N. A. Soliman, and Y. R. Abdel-Fattah, “In vitro dual (anticancer and antiviral) activity of the carotenoids produced by haloalkaliphilic archaeon Natrialba sp. M6,” Sci Rep, vol. 10, pp. 5986, 2020. https://doi.org/10.1038/s41598-020-62663-y
  • S. Santoyo, L. Jaime, M. Plaza, M. Herrero, I.Rodriguez-Meizoso, E. Ibañez, and G. Reglero, “Antiviral compounds obtained from microalgae commonly used as carotenoid sources,” J Appl Phycol, vol. 24, pp. 731–741, 2011. https://doi.org/10.1007/s10811-011-9692-1
  • S. Fakhri, Z. Nouri, S. Z. Moradi, and M. H. Farzaei, “Astaxanthin, COVID‐19 and immune response: Focus on oxidative stress, apoptosis and autophagy,” Phyther Res, vol. 34, pp. 2790–2792, 2020. https://doi.org/10.1002/PTR.6797
  • D. J. Kaio, P. H. Rondo, J. M. Souza, A. V Firmino, L. A. Luzia, and A. A. Segurado, “Vitamin A and beta-carotene concentrations in adults with HIV/AIDS on highly active antiretroviral therapy,” J Nutr Sci Vitaminol, vol. 59, pp. 496–502, 2013. https://doi.org/10.3177/jnsv.59.496
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There are 57 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Araştırma Makalesi
Authors

Özkan Fidan 0000-0001-5312-4742

Project Number 221Z280
Publication Date September 30, 2022
Submission Date August 12, 2022
Acceptance Date September 23, 2022
Published in Issue Year 2022 Volume: 11 Issue: 3

Cite

IEEE Ö. Fidan, “Investigation of Antiviral Potential of Food Carotenoids and Apocarotenoids against RNA-dependent RNA Polymerase of Hepatitis C Virus”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol. 11, no. 3, pp. 931–942, 2022, doi: 10.17798/bitlisfen.1161170.

Bitlis Eren University
Journal of Science Editor
Bitlis Eren University Graduate Institute
Bes Minare Mah. Ahmet Eren Bulvari, Merkez Kampus, 13000 BITLIS