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Borun ratlarda embriyo morfolojisi üzerine etkisi / The effect of boron on embryo morphology in rats

Year 2016, Volume: 1 Issue: 2, 60 - 65, 09.09.2016

Abstract

Doğada birçok bileşiği bulunan, sanayi alanındaki kullanımının yanı sıra bitkiler için esansiyel bir element olan borun, canlıların metabolik ve fizyolojik olaylarında etkin bir rol oynadığı bilinmektedir. Bu çalışmada, ilk kez borun embriyo gelişimine etkisinin in vivo olarak belirlenmesi amaçlandı.  İn vivo değerlendirmede dişi ratlar her grupta 3 hayvan olacak şekilde,  kontrol-pozitif (normal yem), kontrol-negatif (bor içermeyen), düşük (0.04 µg bor/ml), marjinal (0.3 µg bor/ml) ve normal (2 µg bor/ml) miktarda bor içeren diyetlerle beslenenler olarak 5 gruba ayrıldı. Dişi ratlar 14 gün boyunca beslendi ve çiftleşmeden sonra 10-13 günlük embriyolar gebelik süresince gruplardan toplandı. Embriyo gelişimleri morfolojik incelendi. Buna göre embriyoların morfolojik gelişim parametrelerinin bordan eksik diyetle beslenen grupta bor verilen gruplara kıyasla istatistiksel olarak azaldığı belirlendi. Sonuç olarak borun ratlarda embriyonel gelişimin şekillenmesinde önemli rol oynadığı sonucuna varıldı.

References

  • Hunt C.D., Biochemical effects of physiological amounts of dietary boron. Journal of Trace Element and Experimental Medicine, 9,185–213, 1996.
  • Nielsen F.H., Hunt C.D., Mullen L.M., Hunt J.R., Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. Faseb Journal, 1, 394–7, 1987.
  • Turkez H., Geyikoglu F., Tatar A., Keles S., Özkanc A., Effects of some boron compounds on peripheral human blood. Zeitschrift für Naturforschung,62, 889–96, 2007.
  • Ince S., Kucukkurt I., Cigerci I.H., Fidan A.F., Eryavuz, A., The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. Journal of Trace Element and Experimental Medicine, 24,161–4, 2010.
  • Ince S., Arslan-Acaröz D., An update on health effects of metalloid trace element: Boron. Aperito Journal of Drug Designing and Pharmacology, 2, 1, 2015.
  • Mccoy H., Kenney M.A., Montgomery C., Irwin A., Williams L., Orrell R., Relation of boron to the composition and mechanical properties of bone. Environmental Health Perspective, 102, 49-53, 1994.
  • Samman S., Naghii M.R., Lyons Wall P.M., Verus A.P., The nutritional and metabolic effects of boron in humans and animals. Biological Trace Element Research, 66, 227-235, 1998.
  • Küçükkurt I., Akbel E., Karabag F., Ince S., The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health, 31, 255-260, 2015.
  • Karabag-Çoban F., Ince S., Kucukkurt I., Demirel H.H., Hazman O., Boron attenuates malathion-induced oxidative stress andacetylcholinesterase inhibition in rats. Drug and Chemical Toxicology, 38, 391-99, 2015.
  • Bourgeois A.C., Scott M.E., Sabally K., Koski K.G., Low dietary boron reduces parasite (nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. Journal of Nutrition, 137, 2080-86, 2007.
  • Van Maele-Fabry G., Picard J.J., Attenon P., Berthet Paul., Delhaise F., Govers M.J.A.P., Peters P.W.J., Piersma A.H., Schmid B.P., Stadler J., Verhoef A., Verseil C., Interlaboratory evaluation of three culture media for postimplantation rodent embryos. Reproductive Toxicology, 5, 417-26, 1991.
  • Nakagawa M., Price R.L., Chintanawonges C., Simpson D.G., Horacek M.J., Borg T.K., Terracio L., Analysis of heart development in cultured rat embryos. Journal of Molecular and Cellular Cardiology, 29, 369-79, 1997.
  • Liu J.N., Chan H.M., Kubow S., Oxidative stress status and development of late organogenesis stage rat whole embryos cultured from gestational days 13.5 to 14.5. Toxicolology In Vitro, 21, 53-62, 2007.
  • Kwong W.Y., Wild A.E., Roberts P., Willis A.C., Fleming T.P., Maternal undernutrition during the preimplantation period of rat development causes blastocystabnormalities and programming of postnatal hypertension. Development, 127, 4195-4202, 2000.
  • Fazlıoğulları S., Antiemetiklerin rat embryoları gelişimi üzerine toksik ve teratojen etkilerinin in vitro kültür ortamında araştırılması, Doktora tezi, Selçuk Üniversitesi, Anatomi (Tıp) Anatomi Anabilim Dalı, Konya, 2010.
  • Uysal İ.İ., Karabulut A.K., Şeker M., Gürbilek M., Klorakinin rat embroyosu gelişimi ve morfolojik yapısı üzerine etkileri ve serbest radikalllerin bu etkideki rolü, Genel Tıp Dergisi, 14(3), 83-89, 2004.
  • Lanoue L., Taubeneck M.W., Muniz J., Hanna L.A., Strong P.L., Murray F.J., Nielsen F.H., Hunt C.D., Keen C.L., Assessing the effects of low boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems. Biological Trace Element Research, 66, 271-98, 1998.
  • Eckhert, C.D., Boron stimulates embryonic trout growth. Journal of Nutrition, 128, 2488-93, 1998.
  • Fort D.J., Stover E.L., Strong P.L., Murray F.J., Keen C.L., Chronic feeding of a low boron diet adversely affects reproduction and development in Xenopus laevis. Journal of Nutrition, 129, 2055-60, 1999.
Year 2016, Volume: 1 Issue: 2, 60 - 65, 09.09.2016

Abstract

References

  • Hunt C.D., Biochemical effects of physiological amounts of dietary boron. Journal of Trace Element and Experimental Medicine, 9,185–213, 1996.
  • Nielsen F.H., Hunt C.D., Mullen L.M., Hunt J.R., Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. Faseb Journal, 1, 394–7, 1987.
  • Turkez H., Geyikoglu F., Tatar A., Keles S., Özkanc A., Effects of some boron compounds on peripheral human blood. Zeitschrift für Naturforschung,62, 889–96, 2007.
  • Ince S., Kucukkurt I., Cigerci I.H., Fidan A.F., Eryavuz, A., The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. Journal of Trace Element and Experimental Medicine, 24,161–4, 2010.
  • Ince S., Arslan-Acaröz D., An update on health effects of metalloid trace element: Boron. Aperito Journal of Drug Designing and Pharmacology, 2, 1, 2015.
  • Mccoy H., Kenney M.A., Montgomery C., Irwin A., Williams L., Orrell R., Relation of boron to the composition and mechanical properties of bone. Environmental Health Perspective, 102, 49-53, 1994.
  • Samman S., Naghii M.R., Lyons Wall P.M., Verus A.P., The nutritional and metabolic effects of boron in humans and animals. Biological Trace Element Research, 66, 227-235, 1998.
  • Küçükkurt I., Akbel E., Karabag F., Ince S., The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health, 31, 255-260, 2015.
  • Karabag-Çoban F., Ince S., Kucukkurt I., Demirel H.H., Hazman O., Boron attenuates malathion-induced oxidative stress andacetylcholinesterase inhibition in rats. Drug and Chemical Toxicology, 38, 391-99, 2015.
  • Bourgeois A.C., Scott M.E., Sabally K., Koski K.G., Low dietary boron reduces parasite (nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. Journal of Nutrition, 137, 2080-86, 2007.
  • Van Maele-Fabry G., Picard J.J., Attenon P., Berthet Paul., Delhaise F., Govers M.J.A.P., Peters P.W.J., Piersma A.H., Schmid B.P., Stadler J., Verhoef A., Verseil C., Interlaboratory evaluation of three culture media for postimplantation rodent embryos. Reproductive Toxicology, 5, 417-26, 1991.
  • Nakagawa M., Price R.L., Chintanawonges C., Simpson D.G., Horacek M.J., Borg T.K., Terracio L., Analysis of heart development in cultured rat embryos. Journal of Molecular and Cellular Cardiology, 29, 369-79, 1997.
  • Liu J.N., Chan H.M., Kubow S., Oxidative stress status and development of late organogenesis stage rat whole embryos cultured from gestational days 13.5 to 14.5. Toxicolology In Vitro, 21, 53-62, 2007.
  • Kwong W.Y., Wild A.E., Roberts P., Willis A.C., Fleming T.P., Maternal undernutrition during the preimplantation period of rat development causes blastocystabnormalities and programming of postnatal hypertension. Development, 127, 4195-4202, 2000.
  • Fazlıoğulları S., Antiemetiklerin rat embryoları gelişimi üzerine toksik ve teratojen etkilerinin in vitro kültür ortamında araştırılması, Doktora tezi, Selçuk Üniversitesi, Anatomi (Tıp) Anatomi Anabilim Dalı, Konya, 2010.
  • Uysal İ.İ., Karabulut A.K., Şeker M., Gürbilek M., Klorakinin rat embroyosu gelişimi ve morfolojik yapısı üzerine etkileri ve serbest radikalllerin bu etkideki rolü, Genel Tıp Dergisi, 14(3), 83-89, 2004.
  • Lanoue L., Taubeneck M.W., Muniz J., Hanna L.A., Strong P.L., Murray F.J., Nielsen F.H., Hunt C.D., Keen C.L., Assessing the effects of low boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems. Biological Trace Element Research, 66, 271-98, 1998.
  • Eckhert, C.D., Boron stimulates embryonic trout growth. Journal of Nutrition, 128, 2488-93, 1998.
  • Fort D.J., Stover E.L., Strong P.L., Murray F.J., Keen C.L., Chronic feeding of a low boron diet adversely affects reproduction and development in Xenopus laevis. Journal of Nutrition, 129, 2055-60, 1999.
There are 19 citations in total.

Details

Journal Section Research Article
Authors

Sinan İnce

Hasan Hüseyin Demirel This is me

Metin Erdoğan

Cevdet Uğuz

Yuksel Agca This is me

Gamze Dal This is me

Publication Date September 9, 2016
Published in Issue Year 2016 Volume: 1 Issue: 2

Cite

APA İnce, S., Demirel, H. H., Erdoğan, M., Uğuz, C., et al. (2016). Borun ratlarda embriyo morfolojisi üzerine etkisi / The effect of boron on embryo morphology in rats. Journal of Boron, 1(2), 60-65.

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TENMAK Boron Research Institute