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Medikal Ozonun Deri Lezyonlarının İyileşmesi Üzerine Etkileri

Year 2022, Volume: 3 Issue: 2, 57 - 61, 30.12.2022

Abstract

Fiziksel, kimyasal ve bakteriyel ajanlara karşı bariyer görevi gören deri yaralanmasına bağlı olarak; kaybolan fonksiyonlarını eski haline getirmek ve dokularını onarabilme yeteneğinin yanı sıra yara iyileşmesinde de belirli basamaklardan oluşan bir mekanizmayı içermektedir. Deride yara oluşumunun hemen ardından başlayan hemostazis evresini takiben 2-5 gün boyunca devam eden inflamasyon evresi ve daha sonra proliferasyon evresi başlamaktadır. Bu süreçte anjiyogenezis, granülasyon doku oluşumu, kollajen birikimi ve epitelizasyon birlikte görülmektedir. Yara iyileşmesinin son evresi ise maturasyon ve remodelling evresidir. Ozon mikroorganizmaların yok olmasına ve iyileşme sürecinin uyarılmasını sağlayan güçlü bir oksitleyicidir. Bakteri, mantar ve virüs enfeksiyonlarına karşı immun sistemi aktive etmektedir. Antipatojenik etki gösteren, arteriyollerin vazodilatasyonunu sağlayarak oksijenlenmeyi artıran ozon; basınç altındaki oksijenin dokulara yayılarak anaerobik bakteri üremesi engeller. Epitelizasyon sürecinde matriks birikimi ve hücre çoğalmasını artıran ozon, yara iyileşmesinde daha az inflamatuar hücre ve daha çok miyofibroblast içeren granülasyon dokusu oluşturmaktadır. Ayrıca toksinleri uzaklaştırarak, besin ve immünolojik faktörler açısından iyileşme sürecine destek sağlamaktadır.

References

  • 1. Beldon P. Basic science of wound healing. Surgery 2010; 28(9); 409-412. doi: 10.1016/j.mpsur.2010.05.007.
  • 2. Borges GA, Elias ST, Silva SMM, Magalhaes PO, Macedo SB et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy. J Craniomaxillofac Surg 2017; 45(3); 364-370. doi: 10.1016/j.jcms.2017.01.005.
  • 3. Broughton G, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006; 117(7); 12-34. doi: 10.1097/01.prs.0000225430.42531.c2.
  • 4. Canedo-Dorantes L, Canedo-Ayala M. Skin acute wound healing: A compherensive review. J Inflamm Res 2019; 19(1); 1-15. doi: 10.1155/2019/3706315.
  • 5. Coelho CS, Bernadi WA, Ginelli AM, Spagnol T, Gardel SL et al. Use of ozone therapy in chronic laminitis in a horse. J Ozone Ther 2015; 1(1); 1-6. 6. Fitzpatrick E, Holland OJ, Vanderlelie JJ. Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J 2018; 15(4); 633-644. doi: 10.1111/iwj.12907.
  • 7. Gantwerker EA, Hom DB. Skin: Histology and physiology of wound healing. Clin Plast 2012; 39(1); 85-97. doi: 10.1016/j.cps.2011.09.005.
  • 8. Gulmen S, Kurtoglu T, Meteoglu I, Kaya S, Okutan H. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant staphylococcus aureus mediastinitis. J Surg Res 2013; 185(1); 64-69. doi: 10.1016/j.jss.2013.05.085.
  • 9. Kozat S, Okman EN. Has ozone therapy a future in veterinary medicine? J Anim Sci 2019; 3(1); 25-34.
  • 10. Lai-Cheong JE, McGrath JA. Structure and function of skin, hair and nails. Medicine (UK) 2013; 41(6); 317-320. doi: 10.1016/j.mpmed.2013.04.017.
  • 11. Mohammed Al-Dalain S, Martinez G, Candelario-Jalil E, Menendez S, Re L et al. Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats. Pharmacol Res 2001; 44(5); 391-396. doi: 10.1006/phrs.2001.0867.
  • 12. Maslennikov OV, Kontorshcikova CN, Gribkova IA. Ozone therapy in practice Health Manual, Ministry Health Service of the Russian Federation The State Medical Academy of Nizhny Novgorod. Russia, 2008.
  • 13. Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques J. Ozone therapy in medicine and dentistry. J Contemp Dent 2008; 9(4); 1-9. doi: 10.5005/jcdp-9-4-75.
  • 14. Pchepiorka R, Moreira MS, Lascane NA, Catalani LH, Allegrini S et al. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Arch Oral Biol 2020; 119(1); 1-7. doi: 10.1016/j.archoralbio.2020.104889.
  • 15. Peteoca A, Istrate A, Goanta AM, Ionuşcu I, Tarase A. The use of ozone therapy in veterinary medicine: a systematic review. AgroLife Sci J 2020; 9(2); 226-239.
  • 16. Pivotto AP, Banhuk FW, Staffen IV, Daga MA, Ayala TS et al. Clinical uses and molecular aspects of ozone therapy: A review. Online J Biol Sci 2020; 20(1); 37-49. doi: 10.3844/ojbsci.2020.37.49.
  • 17. Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012; 49(1); 35-43. doi: 10.1159/000339613.
  • 18. Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a celluler perspective. Physiol Rev 2019; 99(1); 665-706. doi: 10.1152/physrev.00067.2017.
  • 19. Rosul MV, Patskan MB. Ozone therapy effectiviness in patients with ulcerous lesions due to diabetes mellitus. Wiadomosci Lekarskie 2016; 69(1); 7-9.
  • 20. Sciorsci RL, Lillo E, Occhiogrosso L, Rizzo A. Ozone therapy in veterinary medicine: A review. Res Vet Sci 2020; 130; 240-246. doi: 10.1016/j.rvsc.2020.03.026.
  • 21. Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery 2017; 35(9); 473-477. doi: 10.1016/j.mpsur.2017.06.004.
  • 22. Soares CD, Morais TM, Araujo RM, Meyer PF, Oliviera EA et al. Effects of subcutaneous injection of ozone during wound healing in rats. Growth Factors 2019; 37(1-2); 95-103. Doi: 10.1080/08977194.2019.1643339.
  • 23. Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 2017; 58(1-2); 81-94. doi: 10.1159/000454919.
  • 24. Sunnen GV. Ozone in medicine: overview and future directions. J Adv Med 1988; 1(3); 159-174.
  • 25. Sunnen GV. Ozone, nitric oxide and avian influenza; preliminary theoretical considerations and possible directions. Ozonics International 2005.
  • 26. Svystonyuk DA, Ngu J, Mewhart HE, Lipon BD, Teng G et al. Fibroblast growth factor-2 regulates human cardiac myofibroblast mediated extracellular matrix remodeling. J Transl Med 2015; 13(1); 1-11. doi: 10.1186/s12967-015-0510-4.
  • 27. Wen Q, Liu D, Wang X, Zhang Y, Fang S et al. A systematic review of ozone therapy for treating chronically refractory wounds and ulcers. Int Wound J 2022; 19; 853-870. doi: 10.1111/iwj.13687.
  • 28. Viebahn-Haensler R. Milestones of medical ozone. Rev Soc Esp Dolor 2005; 12(2); 3-9.
  • 29. Zeng J, Lu J. Mechanisms of action involved in ozone-therapy in skin diseases. Int Immunopharmacol 2018; 56(138); 235-241. doi: 10.1016/j.intimp.2018.01.040

Effects of Medical Ozone on Healing of Skin Lesions

Year 2022, Volume: 3 Issue: 2, 57 - 61, 30.12.2022

Abstract

Depending on the skin injury, which acts as a barrier against physical, chemical and bacterial agents; It includes a mechanism consisting of certain steps in wound healing, as well as the ability to restore last functions and repair tissues. Following the hemostasis phase, which starts right after the wound formation on the skin, the inflammation phase continues for 2-5 days and then the proliferation phase begins. In this process, angiogenesis, granulation tissue formation, collagen deposition and epithelialization are seen together. The final phase of wound healing is the maturation and remodelling phase. Ozone is a powerful oxidizer that destroys microorganisms and stimulates the healing process. It activates the immun system against bacterial, fungal and viral infections. Ozone, which has an antipathogenic effect and increases oxygenation by providing vasodilation of arterioles; Oxygen under pressure spreads to the tissues and prevents anaerobic bacteria growth. Ozone, which increases matrix accumulation and cell proliferation in the epithelialization process, creates granulation tissue containing less inflammatory cells and more miyofibroblasts in wound healing. It also supports the healing process in terms of nutrients and immunological factors by removing toxins.

References

  • 1. Beldon P. Basic science of wound healing. Surgery 2010; 28(9); 409-412. doi: 10.1016/j.mpsur.2010.05.007.
  • 2. Borges GA, Elias ST, Silva SMM, Magalhaes PO, Macedo SB et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy. J Craniomaxillofac Surg 2017; 45(3); 364-370. doi: 10.1016/j.jcms.2017.01.005.
  • 3. Broughton G, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006; 117(7); 12-34. doi: 10.1097/01.prs.0000225430.42531.c2.
  • 4. Canedo-Dorantes L, Canedo-Ayala M. Skin acute wound healing: A compherensive review. J Inflamm Res 2019; 19(1); 1-15. doi: 10.1155/2019/3706315.
  • 5. Coelho CS, Bernadi WA, Ginelli AM, Spagnol T, Gardel SL et al. Use of ozone therapy in chronic laminitis in a horse. J Ozone Ther 2015; 1(1); 1-6. 6. Fitzpatrick E, Holland OJ, Vanderlelie JJ. Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J 2018; 15(4); 633-644. doi: 10.1111/iwj.12907.
  • 7. Gantwerker EA, Hom DB. Skin: Histology and physiology of wound healing. Clin Plast 2012; 39(1); 85-97. doi: 10.1016/j.cps.2011.09.005.
  • 8. Gulmen S, Kurtoglu T, Meteoglu I, Kaya S, Okutan H. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant staphylococcus aureus mediastinitis. J Surg Res 2013; 185(1); 64-69. doi: 10.1016/j.jss.2013.05.085.
  • 9. Kozat S, Okman EN. Has ozone therapy a future in veterinary medicine? J Anim Sci 2019; 3(1); 25-34.
  • 10. Lai-Cheong JE, McGrath JA. Structure and function of skin, hair and nails. Medicine (UK) 2013; 41(6); 317-320. doi: 10.1016/j.mpmed.2013.04.017.
  • 11. Mohammed Al-Dalain S, Martinez G, Candelario-Jalil E, Menendez S, Re L et al. Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats. Pharmacol Res 2001; 44(5); 391-396. doi: 10.1006/phrs.2001.0867.
  • 12. Maslennikov OV, Kontorshcikova CN, Gribkova IA. Ozone therapy in practice Health Manual, Ministry Health Service of the Russian Federation The State Medical Academy of Nizhny Novgorod. Russia, 2008.
  • 13. Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques J. Ozone therapy in medicine and dentistry. J Contemp Dent 2008; 9(4); 1-9. doi: 10.5005/jcdp-9-4-75.
  • 14. Pchepiorka R, Moreira MS, Lascane NA, Catalani LH, Allegrini S et al. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Arch Oral Biol 2020; 119(1); 1-7. doi: 10.1016/j.archoralbio.2020.104889.
  • 15. Peteoca A, Istrate A, Goanta AM, Ionuşcu I, Tarase A. The use of ozone therapy in veterinary medicine: a systematic review. AgroLife Sci J 2020; 9(2); 226-239.
  • 16. Pivotto AP, Banhuk FW, Staffen IV, Daga MA, Ayala TS et al. Clinical uses and molecular aspects of ozone therapy: A review. Online J Biol Sci 2020; 20(1); 37-49. doi: 10.3844/ojbsci.2020.37.49.
  • 17. Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012; 49(1); 35-43. doi: 10.1159/000339613.
  • 18. Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a celluler perspective. Physiol Rev 2019; 99(1); 665-706. doi: 10.1152/physrev.00067.2017.
  • 19. Rosul MV, Patskan MB. Ozone therapy effectiviness in patients with ulcerous lesions due to diabetes mellitus. Wiadomosci Lekarskie 2016; 69(1); 7-9.
  • 20. Sciorsci RL, Lillo E, Occhiogrosso L, Rizzo A. Ozone therapy in veterinary medicine: A review. Res Vet Sci 2020; 130; 240-246. doi: 10.1016/j.rvsc.2020.03.026.
  • 21. Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery 2017; 35(9); 473-477. doi: 10.1016/j.mpsur.2017.06.004.
  • 22. Soares CD, Morais TM, Araujo RM, Meyer PF, Oliviera EA et al. Effects of subcutaneous injection of ozone during wound healing in rats. Growth Factors 2019; 37(1-2); 95-103. Doi: 10.1080/08977194.2019.1643339.
  • 23. Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 2017; 58(1-2); 81-94. doi: 10.1159/000454919.
  • 24. Sunnen GV. Ozone in medicine: overview and future directions. J Adv Med 1988; 1(3); 159-174.
  • 25. Sunnen GV. Ozone, nitric oxide and avian influenza; preliminary theoretical considerations and possible directions. Ozonics International 2005.
  • 26. Svystonyuk DA, Ngu J, Mewhart HE, Lipon BD, Teng G et al. Fibroblast growth factor-2 regulates human cardiac myofibroblast mediated extracellular matrix remodeling. J Transl Med 2015; 13(1); 1-11. doi: 10.1186/s12967-015-0510-4.
  • 27. Wen Q, Liu D, Wang X, Zhang Y, Fang S et al. A systematic review of ozone therapy for treating chronically refractory wounds and ulcers. Int Wound J 2022; 19; 853-870. doi: 10.1111/iwj.13687.
  • 28. Viebahn-Haensler R. Milestones of medical ozone. Rev Soc Esp Dolor 2005; 12(2); 3-9.
  • 29. Zeng J, Lu J. Mechanisms of action involved in ozone-therapy in skin diseases. Int Immunopharmacol 2018; 56(138); 235-241. doi: 10.1016/j.intimp.2018.01.040
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Reviews
Authors

Nevzat Emre Aslan 0000-0001-8970-7763

Hanifi Erol 0000-0001-8140-3108

Publication Date December 30, 2022
Submission Date November 4, 2022
Published in Issue Year 2022 Volume: 3 Issue: 2

Cite

Vancouver Aslan NE, Erol H. Medikal Ozonun Deri Lezyonlarının İyileşmesi Üzerine Etkileri. Bozok Vet Sci. 2022;3(2):57-61.