Research Article
Year 2020,
Volume: 7 Issue: 2, 123 - 129, 31.12.2020
Abstract
References
- Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group, (1994). The effect of vitamin E and Beta carotene on the incidence of lung cancer and other cancers in male smokers. The New England Journal of Medicine, 330, 1029–1035.
- Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C., (2015). Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Sao Paulo Medical Journal, 133(2), 164-165.
- Biemond P., van Eijk H.G., Swaak A.J., Koster J.F., (1984). Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. The Journal of Clinical Investigation, 73, 1576-1579.
- Childs A., Jacobs C., Kaminski T., Halliwell B., Leeuwenburg C., (2001). Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radical Biology and Medicine, 15;31(6), 745-753.
- d’Uscio L.V., Milstien S., Richardson D., Smith L., Katusic Z.S., (2003). Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circulation Research, 92, 88-95.
- Erden F., Tanyeri P., (2004). Ülkemizde vitamin ve mineral eklentilerin akılcı kullanımı. Sürekli Tıp Eğitim Dergisi, 13(11), 411-414.
- Ergen A., Bozkurt Bekoğlu F., (2016). Türkiye’de besin destek ürünlerine yönelik görüşler ve tüketici profilini tanımlamaya yönelik bir araştırma. Journal of Business Research-Turk, 8(1), 323-341.
- Fletcher R.H., Fairfield K.M., (2002). Vitamins for chronic disease prevention in adults. The Journal of the American Medical Association, 287(23), 3127-3129.
- Heller R., Hecker M., Stahmann N., Thiele J.J., Werner-Felmayer G., Werner E.R., (2004). Alfa-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivate trolox stabilizes tetrahydrobiopterin. Free Radical Biology and Medicine, 37(5), 620-631.
- Henning S.M., Ingles S., Mahmoud M., W Go V.L., Carlton E., Caulfield M., Nelson J.C., Heber D., (2000). Multivitamin and mineral supplement did not alter the antioxidant capacity in plasma of healthy young men and women. Nutrition Research, 20(2), 167-176.
- Ignarro L.J., (2010). Nitric oxide, biology and pathobiology. 2nd Ed. Academic Press Publications, USA.
- Mercan U., (2004). Toksikolojide serbest radikallerin önemi. Van Veterinary Journal, 15 (1-2), 91-96.
- Miranda K.M., Espey M.G., Wink D.A., (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide- Biology and Chemistry, 5, 62-71.
- Oplander C., Cortese M.M., Korth H-G., Kirsch M., Mahotka C., Wetzel W., Pallua N., Suschek C.V., (2007). The impact of nitrite and antioxidants on ultraviolet-A-induced cell death of human skin fibroblasts. Free Radical Biology and Medicine, 43, 818-829.
- Ozcan A., Ogun M., (2015). Biochemistry of reactive oxygen and nitrogen species, basic principles and clinical significance of oxidative stres. (Gowder SJT Ed.), 37-58. Packer L., (1993). Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins. Annals of the New York Academy of Science, 31(691), 48-60.
- Palozza P., Krinsky N.I., (1992). Beta-carotene and alpha-tocopherol are synergistic antioxidants. Archives of Biochemistry and Biophysics, 297(1), 184-187.
- Patel K.B., Stratford M.R., Wardman P., Everett S.A., (2002). Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate. Free Radical Biology and Medicine, 32, 203-211.
- Phaniendra A., Jestadi D.B., Periyasamy L., (2015). Free radicals: properties, sources. Targets, and their implications in various diseases. Indian Journal of Clinical Biochemistry, 30(1), 11-26.
- Pipingas A., Sinclair A., Croft K.D., Januszewski A.S., Jenkins A.J., Mori T.A., Cockerell R., Grima N.A., Stough C., Scholey A., Myers S.P., Sali A., Pase M.P., (2015). Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial. Journal of Functional Foods, 19, 949-957.
- Ribeiro M.L., Arçari D.P., Squassoni A.C., Pedrazzoli J., (2007). Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers. Mechanisms of Ageing and Development, 128, 577-580.
- Rubbo H., Radi R., Anselmi D., Kirk M., Barnes S., Butler J., Eiserich J.P., Freeman B.A., (2000). Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation. The Journal of Biological Chemistry, 275(15), 10812-10818.
- Safa S., Moghaddam G., Jozani R.J., Daghigh K.H., Janmohammadi H., (2016). Effect of vitamin E and selenium nanoparticles on post-thaw variables and oxidative status of rooster semen. Animal Reproduction Science, 74, 100-106.
- Sivonová M., Zitnanová I., Horáková L., Strosová M., Muchová J., Balgavý P., Dobrota D., Duracková Z., (2006). The combined effect of pycnogenol with ascorbic acid and trolox on the oxidation of lipids and proteins. General Physiology and Biophysics, 25, 379-396.
- SPSS, SPSS for windows release 16.0.2., 2008. SPSS Inc., Chicago.
- Tabart J., Kevers C., Pincemail J., Defraigne J-O., Dommes J., (2009). Comperative antioxidant capacities of phenolic compounds measured by various tests. Food Chemistry, 113, 1226-1233.
- Urso M.L., Clarkson P.M., (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology, 189, 41-54.
- Wei Q.Y., Zhou B., Cai Y.J., Cai Y-J., Yang L., Liu Z-L., (2006). Synergistic effect of green tea polyphenols with trolox on free radical-induced oxidative DNA damage, Food Chemistry, 96 (1), 90-95.
- Report of a joint FAO/WHO expert consultation, (1998). Vitamin and mineral requirements in human nutrition. Bangkok, Thailand.
- Zhang P., Omaye S.T., (2001). Antioxidant and prooxidant roles for β-carotene, α-tocopherol and ascorbic acid in human lung cells. Toxicology in Vitro, 15, 13-24.
Effect of ACE Plus Selenium on Total Antioxidant/Oxidant Capacity and Nitric Oxide Levels in Rabbits
Abstract
Pills including vitamins and minerals have been used as part of sedentary lifestyle, malnutrition, aging, and of age-related ilnesses in developed countries. This study specefically focuses on the effect of ACE Plus Selenium given rabbits through intraperitoneal (i.p) injection on their total oxidant, antioxidant capacity (TOC, TAC), and nitric oxide (NO) levels.In this study, 0,5 ml/kg of normal saline was injected to rabbits in control group and 0,5 ml/kg of ACE Plus Selenium was conducted to the treatment group for twice (every other day) via i.p route. Following the injection, plasmas of blood samples obtained in the second and fourth days, were seperated, and stored at -20ºC till the analysis. Plasma TAC, TOC and NO levels were determined spectrophotometrically. The TOC, TAC and NO levels of the rabbits were compared to the control group statistically. While TOC levels were observed to decrease (p<0,05) on the fourth day, the NO levels increased (p<0,01) on the second day and became normal on the fourth day. Further no statistical alteration was observed in the TAC levels.
As a result, it can be concluded that ACE Plus Selenium had no effect on TAC level, it may decrease TOC levels in parallel to the decline in oxidative stress; further it can increase NO levels acutely as a result of α-tocopherol and ascorbat ingredients.
References
- Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group, (1994). The effect of vitamin E and Beta carotene on the incidence of lung cancer and other cancers in male smokers. The New England Journal of Medicine, 330, 1029–1035.
- Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C., (2015). Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Sao Paulo Medical Journal, 133(2), 164-165.
- Biemond P., van Eijk H.G., Swaak A.J., Koster J.F., (1984). Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. The Journal of Clinical Investigation, 73, 1576-1579.
- Childs A., Jacobs C., Kaminski T., Halliwell B., Leeuwenburg C., (2001). Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radical Biology and Medicine, 15;31(6), 745-753.
- d’Uscio L.V., Milstien S., Richardson D., Smith L., Katusic Z.S., (2003). Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circulation Research, 92, 88-95.
- Erden F., Tanyeri P., (2004). Ülkemizde vitamin ve mineral eklentilerin akılcı kullanımı. Sürekli Tıp Eğitim Dergisi, 13(11), 411-414.
- Ergen A., Bozkurt Bekoğlu F., (2016). Türkiye’de besin destek ürünlerine yönelik görüşler ve tüketici profilini tanımlamaya yönelik bir araştırma. Journal of Business Research-Turk, 8(1), 323-341.
- Fletcher R.H., Fairfield K.M., (2002). Vitamins for chronic disease prevention in adults. The Journal of the American Medical Association, 287(23), 3127-3129.
- Heller R., Hecker M., Stahmann N., Thiele J.J., Werner-Felmayer G., Werner E.R., (2004). Alfa-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivate trolox stabilizes tetrahydrobiopterin. Free Radical Biology and Medicine, 37(5), 620-631.
- Henning S.M., Ingles S., Mahmoud M., W Go V.L., Carlton E., Caulfield M., Nelson J.C., Heber D., (2000). Multivitamin and mineral supplement did not alter the antioxidant capacity in plasma of healthy young men and women. Nutrition Research, 20(2), 167-176.
- Ignarro L.J., (2010). Nitric oxide, biology and pathobiology. 2nd Ed. Academic Press Publications, USA.
- Mercan U., (2004). Toksikolojide serbest radikallerin önemi. Van Veterinary Journal, 15 (1-2), 91-96.
- Miranda K.M., Espey M.G., Wink D.A., (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide- Biology and Chemistry, 5, 62-71.
- Oplander C., Cortese M.M., Korth H-G., Kirsch M., Mahotka C., Wetzel W., Pallua N., Suschek C.V., (2007). The impact of nitrite and antioxidants on ultraviolet-A-induced cell death of human skin fibroblasts. Free Radical Biology and Medicine, 43, 818-829.
- Ozcan A., Ogun M., (2015). Biochemistry of reactive oxygen and nitrogen species, basic principles and clinical significance of oxidative stres. (Gowder SJT Ed.), 37-58. Packer L., (1993). Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins. Annals of the New York Academy of Science, 31(691), 48-60.
- Palozza P., Krinsky N.I., (1992). Beta-carotene and alpha-tocopherol are synergistic antioxidants. Archives of Biochemistry and Biophysics, 297(1), 184-187.
- Patel K.B., Stratford M.R., Wardman P., Everett S.A., (2002). Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate. Free Radical Biology and Medicine, 32, 203-211.
- Phaniendra A., Jestadi D.B., Periyasamy L., (2015). Free radicals: properties, sources. Targets, and their implications in various diseases. Indian Journal of Clinical Biochemistry, 30(1), 11-26.
- Pipingas A., Sinclair A., Croft K.D., Januszewski A.S., Jenkins A.J., Mori T.A., Cockerell R., Grima N.A., Stough C., Scholey A., Myers S.P., Sali A., Pase M.P., (2015). Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial. Journal of Functional Foods, 19, 949-957.
- Ribeiro M.L., Arçari D.P., Squassoni A.C., Pedrazzoli J., (2007). Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers. Mechanisms of Ageing and Development, 128, 577-580.
- Rubbo H., Radi R., Anselmi D., Kirk M., Barnes S., Butler J., Eiserich J.P., Freeman B.A., (2000). Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation. The Journal of Biological Chemistry, 275(15), 10812-10818.
- Safa S., Moghaddam G., Jozani R.J., Daghigh K.H., Janmohammadi H., (2016). Effect of vitamin E and selenium nanoparticles on post-thaw variables and oxidative status of rooster semen. Animal Reproduction Science, 74, 100-106.
- Sivonová M., Zitnanová I., Horáková L., Strosová M., Muchová J., Balgavý P., Dobrota D., Duracková Z., (2006). The combined effect of pycnogenol with ascorbic acid and trolox on the oxidation of lipids and proteins. General Physiology and Biophysics, 25, 379-396.
- SPSS, SPSS for windows release 16.0.2., 2008. SPSS Inc., Chicago.
- Tabart J., Kevers C., Pincemail J., Defraigne J-O., Dommes J., (2009). Comperative antioxidant capacities of phenolic compounds measured by various tests. Food Chemistry, 113, 1226-1233.
- Urso M.L., Clarkson P.M., (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology, 189, 41-54.
- Wei Q.Y., Zhou B., Cai Y.J., Cai Y-J., Yang L., Liu Z-L., (2006). Synergistic effect of green tea polyphenols with trolox on free radical-induced oxidative DNA damage, Food Chemistry, 96 (1), 90-95.
- Report of a joint FAO/WHO expert consultation, (1998). Vitamin and mineral requirements in human nutrition. Bangkok, Thailand.
- Zhang P., Omaye S.T., (2001). Antioxidant and prooxidant roles for β-carotene, α-tocopherol and ascorbic acid in human lung cells. Toxicology in Vitro, 15, 13-24.
There are 29 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Environmental Sciences |
| Journal Section | Caucasian Journal of Science |
| Authors | |
| Publication Date | December 31, 2020 |
| Submission Date | November 23, 2020 |
| Acceptance Date | December 23, 2020 |
| Published in Issue | Year 2020 Volume: 7 Issue: 2 |
