Review
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An Overview of Experimental Models on Ischemic Heart Diseases

Year 2019, Volume: 9 Issue: 4, 358 - 365, 31.12.2019

Demet Sinem Guden Ahmet Ozer Sehırlı

https://doi.org/10.33808/clinexphealthsci.598928

Abstract

Objective: Heart failure is commonly defined as a heart dysfunction associated with pulmonary alveolar blood flow and consequent inability to ensure adequate blood supply to the tissues or to meet the body’s metabolic demand. Currently, there is a considerable lack of experimental uniformity for ischemic heart models as well as types of ischemia. Therefore, our objective is to summarize frequently applied methods that are designed to evaluate ischemic heart diseases. A systematic search was conducted to review experimental models according to keywords. In general, iatrogenic and transgenic cardiomyopathy models were used in the literature. These models were designed to generate global and regional ischemia.
Our review is conducted to evaluate experimental models with the intent of improving the modelling of ischemic heart diseases. Poor modelling can contribute to high mortality and morbidity rates in cardiology. Given the wide range of models available, the future animal models of ischemic heart failure will potentially provide more efficient and reliable preventative measures in the fight against complex cardiovascular diseases.

Keywords

ischemia/reperfusion heart failure cardiomyophaty

Supporting Institution

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Project Number

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Thanks

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References

  • Kadayıfcı A. UTS Dahiliye. 4th ed. Ankara:Atlas Kitapcılık Tic. Ltd. Sti; 2005.
  • Gross DR. Animal Models in Cardiovascular Research. 2nd Revised ed. Boston: Kluwer Academic; 1994.
  • Wolkart G, Kaber G, Kojda G, Brunner F. Role of endogenous hydrogen peroxide in cardiovascular ischaemia/reperfusion function. Studies in mouse hearts with catalase-overexpression in the vascular endothelium. Pharmacol Res 2006; 54:50-56.
  • Gonon AT, Bulhak A, Broijersen A, Pernow J. Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. Br J Pharmacol 2005; 144:860-866.
  • Ashton KJ, Willems L, Holmgren K, Ferreira L, Headrick JP. Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress. Exp Gerontol 2006; 41:189-204.
  • du Toit EF, Rossouw E, Salie R, Opie LH, Lochner A. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model. Cardiovasc Drugs Ther 2005; 19:23-31.
  • Lochner A, Genade S, Hattingh S, Marais E, Huisamen B, Moolman JA. Comparison between ischaemic and anisomycin-induced preconditioning: Role of p38 MAPK. Cardiovasc Drugs Ther 2003; 17:217-230.
  • Khudairi T, Khaw BA. Preservation of ischemic myocardial function and integrity with targeted cytoskeleton-specific immunoliposomes. J Am Coll Cardiol 2004; 43:1683-1689.
  • Ikizler M, Dernek S, Sevin B, Kural T. Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia. Anadolu Kardiyol Derg 2003; 3:303-308.
  • Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, et al. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia reperfusion injury. J Parenter Enteral Nutr 2003; 27(6):396-403.
  • Takahashi N, Ooie T, Saikawa T, Iwao T, Yoshimatsu H, Sakata T. Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusioninduced ventricular tachycardia. Exp Biol Med (Maywood) 2003; 228:1234-1238.
  • Ooie T, Takahashi N, Nawata T, Arikawa M, Yamanaka K, Kajimoto M, et al. Ischemia-induced translocation of protein kinaseC-epsilon mediates cardioprotection in the streptozotocin-induced diabetic rat. Circ J 2003; 67:955-961.
  • Dernek S, Ikizler M, Erkasap N, Ergun B, Koken T, Yilmaz K, et al. Cardioprotection with resveratrol pretreatment:Improved beneficial effects over standard treatment in rat hearts after global ischemia. Scand Cardiovasc J 2004; 38:245-254.
  • Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004; 94:78 -84.
  • Burgdorf C, Dendorfer A, Kurz T, Schömig E, Stölting I, Schütte F, et al. Role of neuronal KATP channels and extra neuronal monoamine transporter on norepinephrine overflow in a model of myocardial low flow ischemia. J Pharmacol Exp Ther 2004; 309:42-48.
  • Kawabata H, Ishikawa K. Cardioprotection with pioglitazone is abolished by nitric oxidesynthase inhibitor in ischemic rabbit hearts - comparison of the effects of pioglitazone and metformin. Diabetes Metab Res Rev 2003; 19:299-305.
  • Gonzalez GE, Mangas F, Chauvin AD, Monroy S, Donato M, Morales C, Gelpi RJ. Diastolic behavior during postischemic hypercontraction phase in rabbit stunned myocardium. Medicina (B. Aires) 2003; 63:403-409.
  • Castella M, Buckberg GD, Saleh S, Tan Z, Ignarro LJ. A new role for cardioplegic buffering: Should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts? J Thorac Cardiovasc Surg 2003; 126:1442 – 1448.
  • Gross DR, Dewanjee MK, Zhai P, Lanzo S, Wu SM. Successful prosthetic mitral valve implantation in pigs. ASAIO J 1997; 43:382-386.
  • Gross DR, Salley RK, Maley RH, Arden WA, Nammalwar P. Effects of internal mammary artery pedicle coronary artery bypass grafting on aortic valve leaflet positioning. J Heart Valve Dis 1995; 4:313-320.
  • Sparks DL, Gross DR, Hunsaker JC. Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs. Neurobiol Aging 2000; 21: 363-372.
  • Borke WB, Munkeby BH, Morkrid L, Thaulow E, Saugstad OD. Resuscitation with 100% O(2) does not protect the myocardium in hypoxic newborn piglets. Arch Dis Child Fetal Neonatal Ed 2004; 89:156-160.
  • Koka S, Das A, Salloum FN, Kukreja RC. Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice. Free Radic Biol Med 2013; 60: 80-88.
  • Qiang Y, Zhili G, Xiaofeng L, Qing O, Cheng He , Burnstock G, et al. Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampusafter transient global cerebral ischemia. Purinergic Signal 2013; 9(4):663-675.
  • Hearse DJ. Models and problems in the study of myocardial ischemia and tissue protection. Eur Heart J 1983; 4:43-48.
  • Verdouw PD, Wolffenbuttel BH, van der Giessen WJ. Domestic pigs in the study of myocardial ischemia. Eur Heart J 1983; 4: 61-67.
  • Eckstein RW. Coronary interarterial anastomoses in young pigs and mongrel dogs. Circ Res 1954; 2:460-465.
  • Brooks H, Al-Sadir J, Schwartz J, Rich B, Harper P, Resnekov L. Biventricular dynamics during quantitated anteroseptal infarction in the porcine heart. Am J Cardiol 1975; 36:765-775.
  • Opie LH, Bruyneel KJ, Lubbe WF. What has the baboon to offer as a model of experimental ischemia? Eur Heart J 1983; 4: 55-60.
  • Gross DR. Animal Models in Cardiovascular Research. 3nd Revised ed. USA: Springer; 2009.
  • Khouri EM, Gregg DE. An inflatable cuff for zero determination in blood flow studies. J Appl Physiol 1967; 23:395-397.
  • Elzinga WE, Skinner DB. Hemodynamic characteristics of critical stenosis in canine coronary arteries. J Thorac Cardiovasc Surg 1975; 69: 217-222.
  • Lekx KS, Prato FS, Sykes J, Wisenberg G. The partition coefficient of Gd-DTPA reflects maintained tissue viability in a canine model of chronic significant coronary stenosis. J Cardiovasc Magn Reson 2004; 6:33-42.
  • Morillas P, Hernandez A, Pallares V, Pallarés V, Bertomeu V, Roldán FJ, et al. Usefulness of trimetazidine in ischemia-reperfusion lesion. experimental study in myocardial stunning model. Arch Cardiol Mex 2004; 74:262 – 270.
  • Lubbers NL, Campbell TJ, Polakowski JS, Bulaj G, Layer RT, Moore J, et al. Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 2005; 46:141-146.
  • Nikolaidis LA, Doverspike A, Hentosz T, Zourelias L, Shen YT, Elahi D, Shannon RP. Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines. J Pharmacol Exp Ther 2005; 312:303-308.
  • Khalil PN, Neuhof C, Huss R, Pollhammer M, Khalil MN, Neuhof H, et al. Calpain inhibition reduces infarct size and improves dünya çapında hemodynamics and left ventricular contractility in a porcine myocardial ischemia/reperfusion model. Eur J Pharmacol 2005; 528:124-131.
  • Engbers HM, de Zeeuw S, Visser T, Cramer MJ, Grundeman PF. Myocardial blood supply by left ventricle-to-coronary artery channel: An old idea revisited. Int J Cardiol 2006; 106:145-151.
  • Apple KA, Yarbrough WM, Mukherjee R, Deschamps AM, Escobar PG, Mingoia JT, et al. Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling. J Cardiovasc Pharmacol 2006; 47:228-235.
  • Duncker DJ, Haitsma DB, Liem DA, Verdouw PD, Merkus D. Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction. Cardiovasc Res 2005; 65:889-896.
  • Radke PW, Heinl-Green A, Frass OM, Post MJ, Sato K, Geddes DM, et al. Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies. Endothelium 2006; 13:25-33.
  • Yip G, Khandheria B, Belohlavek M, Pislaru C, Seward J, Bailey K, et al. Strain echocardiography tracks dobutamineinduced decrease in regional myocardial perfusion in nonocclusive coronary stenosis. J AmColl Cardiol 2004; 44:1664-1671.
  • Saitoh S, Muto M, Osugi T, Aikawa K, Matsumoto K, Onogi F, et al. Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm. Coron Artery Dis 2004; 15:137-145.
  • Thompson CA, Reddy VK, Srinivasan A, Houser S, Hayase M, Davila A, et al. Left ventricular functional recovery with percutaneous, transvascular direct myocardial delivery of bone marrow-derived cells. J HeartLung Transplant 2005; 24:1385-1392.
  • Segers P, Tchana-Sato V, Leather HA, Lambermont B,Ghuysen A, Dogne JM, et al. Determinants of left ventricular preload-adjusted maximal power. Am J Physiol Heart Circ Physiol 2003; 284:2295-2301.
  • Zhang QY, Ge JB, Chen JZ, Zhu JH, Zhang LH, Lau CP, et al. Mast cell contributes to cardiomyocyte apoptosis after coronary microembolization. J Histochem Cytochem 2006; 54:515- 523.
  • Ryan LP, Jackson BM, Parish LM, Plappert TJ, St John-Sutton MG, Gorman JH 3rd, Gorman RC. Regional and global patterns of annular remodeling in ischemic mitral regurgitation. Ann Thorac Surg 2007; 84:553-559.
  • Pilla JJ, Blom AS, Brockman DJ, Ferrari VA, Yuan Q, Acker MA. Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction. J Thorac Cardiovasc Surg 2003; 126:1467-1476.
  • Blom AS, Pilla JJ, Gorman RC III, Gorman JH, Mukherjee R, Spinale FG, et al. Infarct size reduction and attenuation of global çapında left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep. Heart Fail Rev 2005; 10 (2):125-139.
  • Tracey WR, Magee WP, Oleynek JJ, Hill RJ, Smith AH, Flynn DM, et al. Novel N6-substituted adenosine 5 ¢ -N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. Am J Physiol Heart Circ Physiol 2003; 285:2780-2787.
  • Flynn DM, Smith AH, Treadway JL, Magee WP, Sutt JC, McPherson RK, et al. The sulfonylurea glipizide does not inhibit ischemic preconditioning in anesthetized rabbits. Cardiovasc Drugs Ther 2005; 19:337-346.
  • Thompson RB, van den Bos EJ, Davis BH, Morimoto Y, Craig D, Sutton BS, et al. Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J Heart Lung Transplant 2005;24:205-214.
  • Woo YJ, Grand TJ, Berry MF, Atluri P, Moise MA, Hsu VM, et al. Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2005; 130:321-329.
  • Sehirli AO, Koyun D, Tetik Ş, Özsavcı D, Yiğiner Ö, Çetinel Ş, Tok OE. Melatonin protects against ischemic heart failure in rats. J Pineal Res 2013; 148-158.
  • Dai Z, Jiang DJ, Hu GY, Du YH, Yu J, Hu CP, et al. 3,4,5,6-tetrahydroxyxanthone protects against myocardialischemia-reperfusion injury in rats. Cardiovasc Drugs Ther 2004; 18:279-288.
  • Fang X, Tang W, Sun S, Huang L, Chang YT, Huang Z, Weil MH. Cardiopulmonary resuscitation in a rat model of chronic myocardial ischemia. J Appl Physiol 2006; 101:1091-1096.
  • Miki T, Miura T, Yano T, Takahashi A, Sakamoto J, Tanno Met al. Alteration in erythropoietin-induced cardioprotective signaling by post infarct ventricular remodeling. J Pharmacol Exp Ther 2006; 317:68-75.
  • Moolman JA, Hartley S, Van Wyk J, Marais E, Lochner A. Inhibition of myocardial apoptosis by ischaemic and beta-adrenergic preconditioning is dependent on p38 MAPK. Cardiovasc Drugs Ther 2006; 20:13-25.
  • Shiomi T, Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, et al. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 106:3126-3132.
  • Matsusaka H, Kinugawa S, Ide T, Matsushima S, Shiomi T, Kubota T, et al. Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction. J Cardiovasc Pharmacol 2006; 48:95-102.
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Year 2019, Volume: 9 Issue: 4, 358 - 365, 31.12.2019

Demet Sinem Guden Ahmet Ozer Sehırlı

https://doi.org/10.33808/clinexphealthsci.598928

Abstract

Project Number

---

References

  • Kadayıfcı A. UTS Dahiliye. 4th ed. Ankara:Atlas Kitapcılık Tic. Ltd. Sti; 2005.
  • Gross DR. Animal Models in Cardiovascular Research. 2nd Revised ed. Boston: Kluwer Academic; 1994.
  • Wolkart G, Kaber G, Kojda G, Brunner F. Role of endogenous hydrogen peroxide in cardiovascular ischaemia/reperfusion function. Studies in mouse hearts with catalase-overexpression in the vascular endothelium. Pharmacol Res 2006; 54:50-56.
  • Gonon AT, Bulhak A, Broijersen A, Pernow J. Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. Br J Pharmacol 2005; 144:860-866.
  • Ashton KJ, Willems L, Holmgren K, Ferreira L, Headrick JP. Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress. Exp Gerontol 2006; 41:189-204.
  • du Toit EF, Rossouw E, Salie R, Opie LH, Lochner A. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model. Cardiovasc Drugs Ther 2005; 19:23-31.
  • Lochner A, Genade S, Hattingh S, Marais E, Huisamen B, Moolman JA. Comparison between ischaemic and anisomycin-induced preconditioning: Role of p38 MAPK. Cardiovasc Drugs Ther 2003; 17:217-230.
  • Khudairi T, Khaw BA. Preservation of ischemic myocardial function and integrity with targeted cytoskeleton-specific immunoliposomes. J Am Coll Cardiol 2004; 43:1683-1689.
  • Ikizler M, Dernek S, Sevin B, Kural T. Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia. Anadolu Kardiyol Derg 2003; 3:303-308.
  • Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, et al. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia reperfusion injury. J Parenter Enteral Nutr 2003; 27(6):396-403.
  • Takahashi N, Ooie T, Saikawa T, Iwao T, Yoshimatsu H, Sakata T. Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusioninduced ventricular tachycardia. Exp Biol Med (Maywood) 2003; 228:1234-1238.
  • Ooie T, Takahashi N, Nawata T, Arikawa M, Yamanaka K, Kajimoto M, et al. Ischemia-induced translocation of protein kinaseC-epsilon mediates cardioprotection in the streptozotocin-induced diabetic rat. Circ J 2003; 67:955-961.
  • Dernek S, Ikizler M, Erkasap N, Ergun B, Koken T, Yilmaz K, et al. Cardioprotection with resveratrol pretreatment:Improved beneficial effects over standard treatment in rat hearts after global ischemia. Scand Cardiovasc J 2004; 38:245-254.
  • Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004; 94:78 -84.
  • Burgdorf C, Dendorfer A, Kurz T, Schömig E, Stölting I, Schütte F, et al. Role of neuronal KATP channels and extra neuronal monoamine transporter on norepinephrine overflow in a model of myocardial low flow ischemia. J Pharmacol Exp Ther 2004; 309:42-48.
  • Kawabata H, Ishikawa K. Cardioprotection with pioglitazone is abolished by nitric oxidesynthase inhibitor in ischemic rabbit hearts - comparison of the effects of pioglitazone and metformin. Diabetes Metab Res Rev 2003; 19:299-305.
  • Gonzalez GE, Mangas F, Chauvin AD, Monroy S, Donato M, Morales C, Gelpi RJ. Diastolic behavior during postischemic hypercontraction phase in rabbit stunned myocardium. Medicina (B. Aires) 2003; 63:403-409.
  • Castella M, Buckberg GD, Saleh S, Tan Z, Ignarro LJ. A new role for cardioplegic buffering: Should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts? J Thorac Cardiovasc Surg 2003; 126:1442 – 1448.
  • Gross DR, Dewanjee MK, Zhai P, Lanzo S, Wu SM. Successful prosthetic mitral valve implantation in pigs. ASAIO J 1997; 43:382-386.
  • Gross DR, Salley RK, Maley RH, Arden WA, Nammalwar P. Effects of internal mammary artery pedicle coronary artery bypass grafting on aortic valve leaflet positioning. J Heart Valve Dis 1995; 4:313-320.
  • Sparks DL, Gross DR, Hunsaker JC. Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs. Neurobiol Aging 2000; 21: 363-372.
  • Borke WB, Munkeby BH, Morkrid L, Thaulow E, Saugstad OD. Resuscitation with 100% O(2) does not protect the myocardium in hypoxic newborn piglets. Arch Dis Child Fetal Neonatal Ed 2004; 89:156-160.
  • Koka S, Das A, Salloum FN, Kukreja RC. Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice. Free Radic Biol Med 2013; 60: 80-88.
  • Qiang Y, Zhili G, Xiaofeng L, Qing O, Cheng He , Burnstock G, et al. Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampusafter transient global cerebral ischemia. Purinergic Signal 2013; 9(4):663-675.
  • Hearse DJ. Models and problems in the study of myocardial ischemia and tissue protection. Eur Heart J 1983; 4:43-48.
  • Verdouw PD, Wolffenbuttel BH, van der Giessen WJ. Domestic pigs in the study of myocardial ischemia. Eur Heart J 1983; 4: 61-67.
  • Eckstein RW. Coronary interarterial anastomoses in young pigs and mongrel dogs. Circ Res 1954; 2:460-465.
  • Brooks H, Al-Sadir J, Schwartz J, Rich B, Harper P, Resnekov L. Biventricular dynamics during quantitated anteroseptal infarction in the porcine heart. Am J Cardiol 1975; 36:765-775.
  • Opie LH, Bruyneel KJ, Lubbe WF. What has the baboon to offer as a model of experimental ischemia? Eur Heart J 1983; 4: 55-60.
  • Gross DR. Animal Models in Cardiovascular Research. 3nd Revised ed. USA: Springer; 2009.
  • Khouri EM, Gregg DE. An inflatable cuff for zero determination in blood flow studies. J Appl Physiol 1967; 23:395-397.
  • Elzinga WE, Skinner DB. Hemodynamic characteristics of critical stenosis in canine coronary arteries. J Thorac Cardiovasc Surg 1975; 69: 217-222.
  • Lekx KS, Prato FS, Sykes J, Wisenberg G. The partition coefficient of Gd-DTPA reflects maintained tissue viability in a canine model of chronic significant coronary stenosis. J Cardiovasc Magn Reson 2004; 6:33-42.
  • Morillas P, Hernandez A, Pallares V, Pallarés V, Bertomeu V, Roldán FJ, et al. Usefulness of trimetazidine in ischemia-reperfusion lesion. experimental study in myocardial stunning model. Arch Cardiol Mex 2004; 74:262 – 270.
  • Lubbers NL, Campbell TJ, Polakowski JS, Bulaj G, Layer RT, Moore J, et al. Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 2005; 46:141-146.
  • Nikolaidis LA, Doverspike A, Hentosz T, Zourelias L, Shen YT, Elahi D, Shannon RP. Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines. J Pharmacol Exp Ther 2005; 312:303-308.
  • Khalil PN, Neuhof C, Huss R, Pollhammer M, Khalil MN, Neuhof H, et al. Calpain inhibition reduces infarct size and improves dünya çapında hemodynamics and left ventricular contractility in a porcine myocardial ischemia/reperfusion model. Eur J Pharmacol 2005; 528:124-131.
  • Engbers HM, de Zeeuw S, Visser T, Cramer MJ, Grundeman PF. Myocardial blood supply by left ventricle-to-coronary artery channel: An old idea revisited. Int J Cardiol 2006; 106:145-151.
  • Apple KA, Yarbrough WM, Mukherjee R, Deschamps AM, Escobar PG, Mingoia JT, et al. Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling. J Cardiovasc Pharmacol 2006; 47:228-235.
  • Duncker DJ, Haitsma DB, Liem DA, Verdouw PD, Merkus D. Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction. Cardiovasc Res 2005; 65:889-896.
  • Radke PW, Heinl-Green A, Frass OM, Post MJ, Sato K, Geddes DM, et al. Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies. Endothelium 2006; 13:25-33.
  • Yip G, Khandheria B, Belohlavek M, Pislaru C, Seward J, Bailey K, et al. Strain echocardiography tracks dobutamineinduced decrease in regional myocardial perfusion in nonocclusive coronary stenosis. J AmColl Cardiol 2004; 44:1664-1671.
  • Saitoh S, Muto M, Osugi T, Aikawa K, Matsumoto K, Onogi F, et al. Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm. Coron Artery Dis 2004; 15:137-145.
  • Thompson CA, Reddy VK, Srinivasan A, Houser S, Hayase M, Davila A, et al. Left ventricular functional recovery with percutaneous, transvascular direct myocardial delivery of bone marrow-derived cells. J HeartLung Transplant 2005; 24:1385-1392.
  • Segers P, Tchana-Sato V, Leather HA, Lambermont B,Ghuysen A, Dogne JM, et al. Determinants of left ventricular preload-adjusted maximal power. Am J Physiol Heart Circ Physiol 2003; 284:2295-2301.
  • Zhang QY, Ge JB, Chen JZ, Zhu JH, Zhang LH, Lau CP, et al. Mast cell contributes to cardiomyocyte apoptosis after coronary microembolization. J Histochem Cytochem 2006; 54:515- 523.
  • Ryan LP, Jackson BM, Parish LM, Plappert TJ, St John-Sutton MG, Gorman JH 3rd, Gorman RC. Regional and global patterns of annular remodeling in ischemic mitral regurgitation. Ann Thorac Surg 2007; 84:553-559.
  • Pilla JJ, Blom AS, Brockman DJ, Ferrari VA, Yuan Q, Acker MA. Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction. J Thorac Cardiovasc Surg 2003; 126:1467-1476.
  • Blom AS, Pilla JJ, Gorman RC III, Gorman JH, Mukherjee R, Spinale FG, et al. Infarct size reduction and attenuation of global çapında left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep. Heart Fail Rev 2005; 10 (2):125-139.
  • Tracey WR, Magee WP, Oleynek JJ, Hill RJ, Smith AH, Flynn DM, et al. Novel N6-substituted adenosine 5 ¢ -N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. Am J Physiol Heart Circ Physiol 2003; 285:2780-2787.
  • Flynn DM, Smith AH, Treadway JL, Magee WP, Sutt JC, McPherson RK, et al. The sulfonylurea glipizide does not inhibit ischemic preconditioning in anesthetized rabbits. Cardiovasc Drugs Ther 2005; 19:337-346.
  • Thompson RB, van den Bos EJ, Davis BH, Morimoto Y, Craig D, Sutton BS, et al. Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J Heart Lung Transplant 2005;24:205-214.
  • Woo YJ, Grand TJ, Berry MF, Atluri P, Moise MA, Hsu VM, et al. Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2005; 130:321-329.
  • Sehirli AO, Koyun D, Tetik Ş, Özsavcı D, Yiğiner Ö, Çetinel Ş, Tok OE. Melatonin protects against ischemic heart failure in rats. J Pineal Res 2013; 148-158.
  • Dai Z, Jiang DJ, Hu GY, Du YH, Yu J, Hu CP, et al. 3,4,5,6-tetrahydroxyxanthone protects against myocardialischemia-reperfusion injury in rats. Cardiovasc Drugs Ther 2004; 18:279-288.
  • Fang X, Tang W, Sun S, Huang L, Chang YT, Huang Z, Weil MH. Cardiopulmonary resuscitation in a rat model of chronic myocardial ischemia. J Appl Physiol 2006; 101:1091-1096.
  • Miki T, Miura T, Yano T, Takahashi A, Sakamoto J, Tanno Met al. Alteration in erythropoietin-induced cardioprotective signaling by post infarct ventricular remodeling. J Pharmacol Exp Ther 2006; 317:68-75.
  • Moolman JA, Hartley S, Van Wyk J, Marais E, Lochner A. Inhibition of myocardial apoptosis by ischaemic and beta-adrenergic preconditioning is dependent on p38 MAPK. Cardiovasc Drugs Ther 2006; 20:13-25.
  • Shiomi T, Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, et al. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 106:3126-3132.
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There are 67 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review
Authors

Demet Sinem Guden 0000-0001-5423-3641

Ahmet Ozer Sehırlı 0000-0002-5175-9290

Project Number ---
Publication Date December 31, 2019
Submission Date July 30, 2019
Published in Issue Year 2019 Volume: 9 Issue: 4

Cite

APA Guden, D. S., & Sehırlı, A. O. (2019). An Overview of Experimental Models on Ischemic Heart Diseases. Clinical and Experimental Health Sciences, 9(4), 358-365. https://doi.org/10.33808/clinexphealthsci.598928
AMA Guden DS, Sehırlı AO. An Overview of Experimental Models on Ischemic Heart Diseases. Clinical and Experimental Health Sciences. December 2019;9(4):358-365. doi:10.33808/clinexphealthsci.598928
Chicago Guden, Demet Sinem, and Ahmet Ozer Sehırlı. “An Overview of Experimental Models on Ischemic Heart Diseases”. Clinical and Experimental Health Sciences 9, no. 4 (December 2019): 358-65. https://doi.org/10.33808/clinexphealthsci.598928.
EndNote Guden DS, Sehırlı AO (December 1, 2019) An Overview of Experimental Models on Ischemic Heart Diseases. Clinical and Experimental Health Sciences 9 4 358–365.
IEEE D. S. Guden and A. O. Sehırlı, “An Overview of Experimental Models on Ischemic Heart Diseases”, Clinical and Experimental Health Sciences, vol. 9, no. 4, pp. 358–365, 2019, doi: 10.33808/clinexphealthsci.598928.
ISNAD Guden, Demet Sinem - Sehırlı, Ahmet Ozer. “An Overview of Experimental Models on Ischemic Heart Diseases”. Clinical and Experimental Health Sciences 9/4 (December 2019), 358-365. https://doi.org/10.33808/clinexphealthsci.598928.
JAMA Guden DS, Sehırlı AO. An Overview of Experimental Models on Ischemic Heart Diseases. Clinical and Experimental Health Sciences. 2019;9:358–365.
MLA Guden, Demet Sinem and Ahmet Ozer Sehırlı. “An Overview of Experimental Models on Ischemic Heart Diseases”. Clinical and Experimental Health Sciences, vol. 9, no. 4, 2019, pp. 358-65, doi:10.33808/clinexphealthsci.598928.
Vancouver Guden DS, Sehırlı AO. An Overview of Experimental Models on Ischemic Heart Diseases. Clinical and Experimental Health Sciences. 2019;9(4):358-65.
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