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Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi

Year 2017, Volume: 14 Issue: 1, 61 - 72, 04.04.2017

İrem Ergin Mürşide Ayşe Demirel

Abstract

İntra-abdominal
adezyon, başta jinekolojik operasyonlar olmak üzere pek çok abdominal cerrahi
girişim sonrası ortaya çıkan; ağrı, intestinal veya üretral tıkanma gibi klinik
semptomlarla kendini gösteren önemli bir komplikasyondur. Abdominal boşlukta
fibrin oluşumu adezyon patofizyolojisinin temelini oluşturmaktadır. İntra-abdominal
adezyonların önlenmesi ile ilgili pek çok pre-klinik ve klinik çalışmalar
yapılmıştır. Bu çalışmalarda hedef, adezyon mekanizmasını iyi anlamak, bu
mekanizmanın bir noktasından girerek zincirin kırılmasını sağlamak ve böylece
adezyon oluşumunu engellemektir. Bu amaçla, farklı etki mekanizmasına sahip pek
çok madde kullanılmaktadır. Bu derlemede, adezyonun oluşum mekanizmasının
ayrıntılı olarak ortaya konması, intra-abdominal adezyon oluşumunu önlemek için
güncel tedavi yöntemlerinin kedi ve köpeklerde abdominal cerrahi ve jinekolojik
operasyonlar sonrası uygulanabilirliğinin araştırmacı ve klinisyenlerle
paylaşılması amaçlanmıştır.

Keywords

İntra-abdominal adezyon kedi köpek operasyon

References

  • 1. Ahrenholz DH, Simmons RL. Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis. Surgery 1980; 88(1): 41-7.
  • 2. Akinrinmade JF, Lawal AO. Gross and histologic evaluation of abdominal adhesions associated with chromic catgut and polypropylene sutured enteropexies in dog. Int J Morphol 2010; 28(4): 1221-5.
  • 3. Alonso JM, Alves ALG, Watanabe MJ, Rodrigues CA, Hussni CA. Peritoneal response to abdominal surgery: The role of equine abdominal adhesions and current prophylactic strategies. Vet Med Int Volume 2014; Article ID 279730.
  • 4. Alponat A, Lakshminarasappa SR, Teh M, Rajnakova A, Moochhala S, Goh PMY, Chan S. Effects of physical barriers in prevention of adhesions: An incisional hernia model in rats. J Surg Res 1997; 68(2): 126-32.
  • 5. Alponat A, Lakshminarasappa SR, Yavuz N, Goh PM. Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: An incisional hernia model in rats. Am Surg 1997; 63(9): 818-9.
  • 6. Arakawa T, Timasheff SN. Mechanism of poly(ethylene glycol) interaction with proteins. Biochemistry 1985; 24(24): 6756-62.
  • 7. Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol 2011; 17(41): 4545-53.
  • 8. Aysan E, Demir M, Kinaci E, Basak F. Complications of intestinal milking: Experimental model. ANZ J Surg 2005; 75(5): 322-5.
  • 9. Bakkum EA, Emeis JJ, Dalmeijer RA, van Blitterswijk CA, Trimbos JB, Kemper TC. Longterm analysis of peritoneal plasminogen activator activity and adhesion formation after surgical trauma in the rat model. Fertil Steril 1996; 66(6): 1018-22.
  • 10. Baxter, G. M. Intraabdominal adhesion in horses. Compend Contin Educ Pract Vet 1991; 13:1587-98.
  • 21. Dönmez M. Kolşisin’in ratlarda deneysel olarak oluşturulan intraabdominal adezyonların gelişimi üzerine etkisi. Uzmanlık Tezi, T.C. Sağlık Bakanlığı Taksim Eğitim ve Araştırma Hastanesi, İkinci Genel Cerrahi Kliniği, İstanbul-Türkiye, 2008; s.1-42.
  • 22. Elkins TE, Stovall TG, Warren J, Ling FW, Meyer NL. A histologic evaluation of peritoneal injury and repair: Implications for adhesion formation. Obstet Gynecol 1987; 70(2): 225- 8.
  • 23. Ellis H. The cause and prevention of post-operative intraperitoneal adhesions. Surg Gynecol Obstet 1971; 133(3): 497-511.
  • 24. Eroglu A, Demirci S, Kurtman C, Akbay A, Eroglu N. Prevention of intra-abdominal adhesions by using Seprafilm in rats undergoing bowel resection and radiation therapy. Colorectal Dis 2001; 3(1): 33-7.
  • 25. Fabri PJ, Ellison EC, Anderson ED, Kudsk KA. High molecular weight dextran effect on adhesion formation and peritonitis in rats. Surgery 1983; 94(2): 336-41.
  • 26. Falk K, Holmdahl L, Halvarsson M, Larsson K, Lidman B, Bengmark S. Polymers that reduce intraperitoneal adhesion formation. Br J Surg 1998; 85(8): 1153-6.
  • 27. Falk K, Björquist P, Strömqvist M, Holmdahl L. Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1. Br J Surg 2001; 88(2): 286-9.
  • 28. Gervin AS, Puckett CL, Silver D. Serosal hypofibrinolysis. A cause of postoperative adhesions. Am J Surg 1973; 125(1): 80-8.
  • 29. Ghoul W. The effects of combined liquid and membrane barriers in prevention of post-operative intra-abdominal adhesions after experimental jejunal anastomosis in dogs. Dtsch Tierarztl Wochenschr 2005; 112(1):3-10.
  • 30. Granat M, Tur-Kaspa I, Zylber-Katz E, Schenker JG. Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat. Fertil Steril 1983; 40(3): 369-72.
  • 41. Jagelman DG, Ellis H. Starch and intraperitoneal adhesion formation. Br J Surg 1973; 60(2): 111-4.
  • 42. Jalali FSS, Farshid AA, Saifzadeh S, Javanmardi, S. Evaluation of topical application of honey in prevention of post-operative peritoneal adhesion formation in dogs. Iran J Vet Res 2006; 7(4): 59-62.
  • 43. Jiang S, Wang W, Yan H, Fan C. Prevention of intra-abdominal adhesion by bi-layer electrospun membrane. Int J Mol Sci 2013; 14(6): 11861-70.
  • 44. Kayaoğlu HA, Özkan N, Yenidoğan E, Köseoğlu RD. Effect of antibiotic lavage in adhesion prevention in bacterial peritonitis. Ulus Travma Acil Cerrahi Derg 2013; 19(3):189-94.
  • 45. Kim Y. Comparative study for preventive effects of intra-abdominal adhesion using cyclo-oxygenase-2 enzyme (COX-2) inhibitor, low molecular weight heparin (LMWH), and synthetic barrier. Yonsei Med J 2013; 54(6):1491-7.
  • 46. Kirby BM. Peritoneum and abdominal cavity. Slatter DJ. eds. In: Small Animal Surgery. Philadelphia: WB Saunders, 2003; pp. 414-45.
  • 47. Koç O, Dağ A, Öcal AK, Dirlik MM, Çömelekoğlu Ü, Gümüş LT, Serinsöz E, Kanık EA, Akça H. Karın içi adezyon önleyici %4'lük ikodekstrin solüsyonunun gastrointestinal sistem anastomozları üzerine etkisi. Ulus Travma Acil Cerrahi Derg 2013;19(4):305-12.
  • 48. Lai HS, Chen Y. Effect of octreotide on postoperative intraperitoneal adhesions in rats. Scand J Gastroenterol 1996; 31(7): 678-81.
  • 49. Maciver AH, McCall M, Shapiro AMJ. Intra-abdominal adhesions: Cellular mechanisms and strategies for prevention. Int J Surg 2011; 9(8): 589-94.
  • 50. Mayer M, Yedgar S, Hurwitz A, Palti Z, Finzi Z. Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation. Am J Obstet Gynecol 1988; 159(4): 957-63.
  • 61. Rougier JP, Guia S, Hagège J, Nguyen G, Ronco PM. PAI- secretion andmatrix deposition in human peritoneal mesothelial cell cultures: transcriptional regulation by TGF-beta 1. Kidney Int 1998; 54(1): 87-98.
  • 62. Ryan GB, Grobéty J, Majno G. Postoperative peritoneal adhesions. A study of the mechanisms. Am J Pathol 1971; 65(1): 117-48.
  • 63. Scott-Coombes D, Whawell S, Vipond MN, Thompson J. Human intraperitoneal fibrinolytic response to elective surgery. Br J Surg 1995; 82(3): 414-7.
  • 64. Silva M, da Silva OC, da Silva LAF, Ribeiro RC, Jorge PMB, Helou JB, Teixeira PPM, Brun MV. Methylene blue 1% solution on the prevention of intraperitoneal adhesion formation in a dog model. Ciênc Rural 2013; 43(9): 1668-74.
  • 65. Steinleitner A, Lambert H, Suarez M, Serpa N, Robin B. Reduction of primary posttraumatic adhesion formation with the prostacyclin analog iloprost in a rodent model. Am J Obstet Gynecol 1991; 165(6): 1817-20.
  • 66. Wagaman R, Ingram JM, Rao PS, Saba HI. Intravenous versus intraperitoneal administration of dextran in the rabbit: Effects on fibrinolysis. Am J Obstet Gynecol 1986; 155(3): 464-70.
  • 67. van Goor H, de Graaf JS, Grond J, Sluiter WJ, Bom VJ, Bleichrodt R. Fibrinolytic activity in the abdominal cavity of rats with faecal peritonitis. Br J Surg 1994; 81(7): 1046-9.
  • 68. Vipond MN, Whawell SA, Thompson JN, Dudley HA. Peritoneal fibrinolytic activity and intra-abdominal adhesions. Lancet 1990; 335(8698):1120-2.
  • 69. Wang XC, Gui CQ, Zheng QS. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis. World J Gastroenterol 2003; 9(3): 568-71.
  • 70. Whawell SA, Vipond MN, Scott-Coombes DM, Thompson JN. Plasminogen activator inhibitor 2 reduces peritoneal fibrinolytic activity in inflammation. Br J Surg 1993; 80(1): 107-9.

Intra-Abdominal Adhesion Physiology and Prevention with medical treatment after Gynecologic Operations in Cats and Dogs

Year 2017, Volume: 14 Issue: 1, 61 - 72, 04.04.2017

İrem Ergin Mürşide Ayşe Demirel

Abstract

Intra-abdominal adhesions may occur after
abdominal surgical approach, especially gynecological operations, represent
important clinical symptoms such as pain and intestinal or urethral
obstruction. The formation of fibrin in the abdominal cavity is essential for
adhesion pathophysiology. Several clinical studies were done about prevention
of intra-abdominal adhesions. Aim of these studies was to understand adhesion
mechanism and to prevent adhesion formations. For this purpose, many agents are
used with different mechanisms. In this review, it aimed to reveal in detail
the mechanism of adhesion formation, to share prevention of intra-abdominal
adhesions with current treatment methods especially after abdominal surgery and
gynecological operations in cats and dogs with colleagues and clinicians.

Keywords

Cat dog intra-abdominal adhesion operation

References

  • 1. Ahrenholz DH, Simmons RL. Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis. Surgery 1980; 88(1): 41-7.
  • 2. Akinrinmade JF, Lawal AO. Gross and histologic evaluation of abdominal adhesions associated with chromic catgut and polypropylene sutured enteropexies in dog. Int J Morphol 2010; 28(4): 1221-5.
  • 3. Alonso JM, Alves ALG, Watanabe MJ, Rodrigues CA, Hussni CA. Peritoneal response to abdominal surgery: The role of equine abdominal adhesions and current prophylactic strategies. Vet Med Int Volume 2014; Article ID 279730.
  • 4. Alponat A, Lakshminarasappa SR, Teh M, Rajnakova A, Moochhala S, Goh PMY, Chan S. Effects of physical barriers in prevention of adhesions: An incisional hernia model in rats. J Surg Res 1997; 68(2): 126-32.
  • 5. Alponat A, Lakshminarasappa SR, Yavuz N, Goh PM. Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: An incisional hernia model in rats. Am Surg 1997; 63(9): 818-9.
  • 6. Arakawa T, Timasheff SN. Mechanism of poly(ethylene glycol) interaction with proteins. Biochemistry 1985; 24(24): 6756-62.
  • 7. Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol 2011; 17(41): 4545-53.
  • 8. Aysan E, Demir M, Kinaci E, Basak F. Complications of intestinal milking: Experimental model. ANZ J Surg 2005; 75(5): 322-5.
  • 9. Bakkum EA, Emeis JJ, Dalmeijer RA, van Blitterswijk CA, Trimbos JB, Kemper TC. Longterm analysis of peritoneal plasminogen activator activity and adhesion formation after surgical trauma in the rat model. Fertil Steril 1996; 66(6): 1018-22.
  • 10. Baxter, G. M. Intraabdominal adhesion in horses. Compend Contin Educ Pract Vet 1991; 13:1587-98.
  • 21. Dönmez M. Kolşisin’in ratlarda deneysel olarak oluşturulan intraabdominal adezyonların gelişimi üzerine etkisi. Uzmanlık Tezi, T.C. Sağlık Bakanlığı Taksim Eğitim ve Araştırma Hastanesi, İkinci Genel Cerrahi Kliniği, İstanbul-Türkiye, 2008; s.1-42.
  • 22. Elkins TE, Stovall TG, Warren J, Ling FW, Meyer NL. A histologic evaluation of peritoneal injury and repair: Implications for adhesion formation. Obstet Gynecol 1987; 70(2): 225- 8.
  • 23. Ellis H. The cause and prevention of post-operative intraperitoneal adhesions. Surg Gynecol Obstet 1971; 133(3): 497-511.
  • 24. Eroglu A, Demirci S, Kurtman C, Akbay A, Eroglu N. Prevention of intra-abdominal adhesions by using Seprafilm in rats undergoing bowel resection and radiation therapy. Colorectal Dis 2001; 3(1): 33-7.
  • 25. Fabri PJ, Ellison EC, Anderson ED, Kudsk KA. High molecular weight dextran effect on adhesion formation and peritonitis in rats. Surgery 1983; 94(2): 336-41.
  • 26. Falk K, Holmdahl L, Halvarsson M, Larsson K, Lidman B, Bengmark S. Polymers that reduce intraperitoneal adhesion formation. Br J Surg 1998; 85(8): 1153-6.
  • 27. Falk K, Björquist P, Strömqvist M, Holmdahl L. Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1. Br J Surg 2001; 88(2): 286-9.
  • 28. Gervin AS, Puckett CL, Silver D. Serosal hypofibrinolysis. A cause of postoperative adhesions. Am J Surg 1973; 125(1): 80-8.
  • 29. Ghoul W. The effects of combined liquid and membrane barriers in prevention of post-operative intra-abdominal adhesions after experimental jejunal anastomosis in dogs. Dtsch Tierarztl Wochenschr 2005; 112(1):3-10.
  • 30. Granat M, Tur-Kaspa I, Zylber-Katz E, Schenker JG. Reduction of peritoneal adhesion formation by colchicine: A comparative study in the rat. Fertil Steril 1983; 40(3): 369-72.
  • 41. Jagelman DG, Ellis H. Starch and intraperitoneal adhesion formation. Br J Surg 1973; 60(2): 111-4.
  • 42. Jalali FSS, Farshid AA, Saifzadeh S, Javanmardi, S. Evaluation of topical application of honey in prevention of post-operative peritoneal adhesion formation in dogs. Iran J Vet Res 2006; 7(4): 59-62.
  • 43. Jiang S, Wang W, Yan H, Fan C. Prevention of intra-abdominal adhesion by bi-layer electrospun membrane. Int J Mol Sci 2013; 14(6): 11861-70.
  • 44. Kayaoğlu HA, Özkan N, Yenidoğan E, Köseoğlu RD. Effect of antibiotic lavage in adhesion prevention in bacterial peritonitis. Ulus Travma Acil Cerrahi Derg 2013; 19(3):189-94.
  • 45. Kim Y. Comparative study for preventive effects of intra-abdominal adhesion using cyclo-oxygenase-2 enzyme (COX-2) inhibitor, low molecular weight heparin (LMWH), and synthetic barrier. Yonsei Med J 2013; 54(6):1491-7.
  • 46. Kirby BM. Peritoneum and abdominal cavity. Slatter DJ. eds. In: Small Animal Surgery. Philadelphia: WB Saunders, 2003; pp. 414-45.
  • 47. Koç O, Dağ A, Öcal AK, Dirlik MM, Çömelekoğlu Ü, Gümüş LT, Serinsöz E, Kanık EA, Akça H. Karın içi adezyon önleyici %4'lük ikodekstrin solüsyonunun gastrointestinal sistem anastomozları üzerine etkisi. Ulus Travma Acil Cerrahi Derg 2013;19(4):305-12.
  • 48. Lai HS, Chen Y. Effect of octreotide on postoperative intraperitoneal adhesions in rats. Scand J Gastroenterol 1996; 31(7): 678-81.
  • 49. Maciver AH, McCall M, Shapiro AMJ. Intra-abdominal adhesions: Cellular mechanisms and strategies for prevention. Int J Surg 2011; 9(8): 589-94.
  • 50. Mayer M, Yedgar S, Hurwitz A, Palti Z, Finzi Z. Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation. Am J Obstet Gynecol 1988; 159(4): 957-63.
  • 61. Rougier JP, Guia S, Hagège J, Nguyen G, Ronco PM. PAI- secretion andmatrix deposition in human peritoneal mesothelial cell cultures: transcriptional regulation by TGF-beta 1. Kidney Int 1998; 54(1): 87-98.
  • 62. Ryan GB, Grobéty J, Majno G. Postoperative peritoneal adhesions. A study of the mechanisms. Am J Pathol 1971; 65(1): 117-48.
  • 63. Scott-Coombes D, Whawell S, Vipond MN, Thompson J. Human intraperitoneal fibrinolytic response to elective surgery. Br J Surg 1995; 82(3): 414-7.
  • 64. Silva M, da Silva OC, da Silva LAF, Ribeiro RC, Jorge PMB, Helou JB, Teixeira PPM, Brun MV. Methylene blue 1% solution on the prevention of intraperitoneal adhesion formation in a dog model. Ciênc Rural 2013; 43(9): 1668-74.
  • 65. Steinleitner A, Lambert H, Suarez M, Serpa N, Robin B. Reduction of primary posttraumatic adhesion formation with the prostacyclin analog iloprost in a rodent model. Am J Obstet Gynecol 1991; 165(6): 1817-20.
  • 66. Wagaman R, Ingram JM, Rao PS, Saba HI. Intravenous versus intraperitoneal administration of dextran in the rabbit: Effects on fibrinolysis. Am J Obstet Gynecol 1986; 155(3): 464-70.
  • 67. van Goor H, de Graaf JS, Grond J, Sluiter WJ, Bom VJ, Bleichrodt R. Fibrinolytic activity in the abdominal cavity of rats with faecal peritonitis. Br J Surg 1994; 81(7): 1046-9.
  • 68. Vipond MN, Whawell SA, Thompson JN, Dudley HA. Peritoneal fibrinolytic activity and intra-abdominal adhesions. Lancet 1990; 335(8698):1120-2.
  • 69. Wang XC, Gui CQ, Zheng QS. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis. World J Gastroenterol 2003; 9(3): 568-71.
  • 70. Whawell SA, Vipond MN, Scott-Coombes DM, Thompson JN. Plasminogen activator inhibitor 2 reduces peritoneal fibrinolytic activity in inflammation. Br J Surg 1993; 80(1): 107-9.
There are 40 citations in total.

Details

Journal Section Articles
Authors

İrem Ergin This is me

Mürşide Ayşe Demirel

Publication Date April 4, 2017
Submission Date April 4, 2017
Acceptance Date April 19, 2016
Published in Issue Year 2017 Volume: 14 Issue: 1

Cite

APA Ergin, İ., & Demirel, M. A. (2017). Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 14(1), 61-72.
AMA Ergin İ, Demirel MA. Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi. Erciyes Üniv Vet Fak Derg. April 2017;14(1):61-72.
Chicago Ergin, İrem, and Mürşide Ayşe Demirel. “Kedi Ve Köpeklerde Abdominal Cerrahi Ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu Ve Medikal Olarak Önlenmesi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14, no. 1 (April 2017): 61-72.
EndNote Ergin İ, Demirel MA (April 1, 2017) Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14 1 61–72.
IEEE İ. Ergin and M. A. Demirel, “Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi”, Erciyes Üniv Vet Fak Derg, vol. 14, no. 1, pp. 61–72, 2017.
ISNAD Ergin, İrem - Demirel, Mürşide Ayşe. “Kedi Ve Köpeklerde Abdominal Cerrahi Ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu Ve Medikal Olarak Önlenmesi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14/1 (April 2017), 61-72.
JAMA Ergin İ, Demirel MA. Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi. Erciyes Üniv Vet Fak Derg. 2017;14:61–72.
MLA Ergin, İrem and Mürşide Ayşe Demirel. “Kedi Ve Köpeklerde Abdominal Cerrahi Ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu Ve Medikal Olarak Önlenmesi”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, vol. 14, no. 1, 2017, pp. 61-72.
Vancouver Ergin İ, Demirel MA. Kedi ve Köpeklerde Abdominal Cerrahi ve Jinekolojik Operasyonlar Sonrası İntra-Abdominal Adezyon Oluşumu ve Medikal Olarak Önlenmesi. Erciyes Üniv Vet Fak Derg. 2017;14(1):61-72.
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