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Year 2023, Volume: 11 Issue: 3, 837 - 849, 27.09.2023

Evrim Sever Mehlika Pulat

https://doi.org/10.29109/gujsc.1342653

Abstract

Project Number

FDK-6920

References

  • [1] Ahmed E. M., Hydrogel: Preparation, characterization, and applications: A review, Journal of Advanced Research, 6 (2015) 105–121.
  • [2] Varaprasad K., Raghavendra G. M., Jayaramudu T., Yallapu M. M., Sadiku R., A mini review on hydrogels classification and recent developments in miscellaneous applications, Material Science and Engineering C, 79 (2017) 958–971.
  • [3] Lin C.C., Metters A.T., Hydrogels in controlled release formulations: network design and mathematical modeling, Advanced Drug Delivery Reviews, 58(12-13) (2006) 1379-1408.
  • [4] Aljohani W. J., Wenchao L., Ullah M. W., Zhang X., Yang G., Application of sodium alginate hydrogel, IOSR Journal of Biotechnology and Biochemistry, 3 (2017) 19-31.
  • [5] Ye J., Yang G., Zhang J., Xiao Z., He L., Zhang H., Liu Q., Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering, Peer J., (2021) 11022.
  • [6] Kevadiya B. D., Patel H. A., Joshi G. V., Abdi S. H. R., Bajaj H. C., Montmorillonite-Alginate Composites as a Drug Delivery System: Intercalation and In vitro Release of Diclofenac sodium, Indian Journal of Pharmaceutical Sciences, 72 (6) (2010) 732-737.
  • [7] Akin K., Ugraskan V., Isık B., Cakar F., Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads, International Journal of Biological Macromolecules, 223 (2022) 543–554.
  • [8] Pulat M., Asıl D., Fluconazole release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylic acid, and citraconic acid, Journal of Applied Polymer Science, 113 (2009) 2613–2619.
  • [9] Song S.Z., Cardinal J.R., Kim S.H., Kim S.W., Progestin Permeation Through Polymer Membranes V: Progesterone Release from Monolithic Hydrogel Devices, Journal of Pharmaceutical Sciences, 70 (2) (1981) 216-219.
  • [10] Xu S. W., Zheng J. P., Tong L., Yao K. D., Interaction of Functional Groups of Gelatin and Montmorillonite in Nanocomposite, Journal of Applied Polymer Science, 101 (2006) 1556–1561.
  • [11] Kim S., Kang Y., Krueger C. A., Sen M., Holcomb J. B., Chen D., Wenke J. C., Yang Y., Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation, Acta Biomaterialia, 8 (2012) 1768-1777.
  • [12] Dai Y. N., Li P., Zhang J. P., Wang A. Q., Wei Q., A Novel pH Sensitive N-Succinyl Chitosan/Alginate Hydrogel Bead for Nifedipine Delivery, Biopharmaceutics and Drug Disposition, 29 (2008) 173-184.
  • [13] Zheng J. P., Li P., Ma Y. L., Yao K. D., Gelatin/Montmorillonite Hybrid Nanocomposite. I. Preparation and Properties, Journal of Applied Polymer Science, 86 (2002) 1189–1194.
  • [14] Johlin J.M., The Isoelectric Point of Gelatin and Its Relation to the Minimum Physical Properties of Gelatin, Journal of Biological Chemistry, 86 (1) (1930) 231-243.
  • [15] Kenawy E.R., Azaam M. M., El-nshar EM., Sodium alginate-g-poly (acrylic acid-co-2-hydroxyethyl methacrylate)/ montmorillonite superabsorbent composite: Preparation, swelling investigation and its application as a slow-release fertilizer, Arabian Journal of Chemistry, 12(6) (2019) 847-856.
  • [16] Paulus H.E., Furst D.E., Dromgoole S.H., Drugs for Rheumatic Disease, Churchill Livingstone (1987).
  • [17] Razzaq A., Qureshi İ. Z., Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice, Toxicology and Applied Pharmacology, 452 (2022) 116192.
  • [18] Shabanpour S., Shariati F. P., Khatibani A. B., Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite, Brazillian Journal of Pharmaceutical Science, 58 (2022) e20243.

The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels

Year 2023, Volume: 11 Issue: 3, 837 - 849, 27.09.2023

Evrim Sever Mehlika Pulat

https://doi.org/10.29109/gujsc.1342653

Abstract

The purpose of our study is to develop a controlled Naproxen releasing system for anti-inflammatory, analgesic treatments. Interpenetrating polymer network (IPN) type of hydrogels were obtained by using natural polymers alginate and gelatin. The hydrogels were prepared by combining Alginate and Gelatin in the presence of Glutaraldehyde as crosslinker of gelatin. Montmorillonite (MMT) clay was used as a nano-dimensioned and layered dopant. The prepared hydrogels were characterized via hydrogel formation, swelling/degradation measurements, Fourier Transform Infrared Spectroscopy (FT-IR), and Scanning Electron Microscopy (SEM) analysis. Swelling tests presented that the presence of MMT in the polymer network decreases the swelling. From the SEM micrographs, it can be seen that MMT added hydrogel has smaller and more pore than the other. The release studies of Naproxen were maintained in Britton-Robinson Buffer (BRB) solution (pH=7.4) and at 37°C. It is observed that the swelling profiles of the hydrogels were compatible with the releasing behaviors. The release kinetics of Naproxen are match the Fickian diffusion.

Keywords

Hydrogel gelatin Montmorillonite controlled drug release Naproxen

Supporting Institution

Gazi Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

FDK-6920

Thanks

This study was supported with the project number FDK-6920 under the program of Gazi University Scientific Research Project Unit. We would like to thank Gazi University Scientific Research Projects Unit for their contribution to this study.

References

  • [1] Ahmed E. M., Hydrogel: Preparation, characterization, and applications: A review, Journal of Advanced Research, 6 (2015) 105–121.
  • [2] Varaprasad K., Raghavendra G. M., Jayaramudu T., Yallapu M. M., Sadiku R., A mini review on hydrogels classification and recent developments in miscellaneous applications, Material Science and Engineering C, 79 (2017) 958–971.
  • [3] Lin C.C., Metters A.T., Hydrogels in controlled release formulations: network design and mathematical modeling, Advanced Drug Delivery Reviews, 58(12-13) (2006) 1379-1408.
  • [4] Aljohani W. J., Wenchao L., Ullah M. W., Zhang X., Yang G., Application of sodium alginate hydrogel, IOSR Journal of Biotechnology and Biochemistry, 3 (2017) 19-31.
  • [5] Ye J., Yang G., Zhang J., Xiao Z., He L., Zhang H., Liu Q., Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering, Peer J., (2021) 11022.
  • [6] Kevadiya B. D., Patel H. A., Joshi G. V., Abdi S. H. R., Bajaj H. C., Montmorillonite-Alginate Composites as a Drug Delivery System: Intercalation and In vitro Release of Diclofenac sodium, Indian Journal of Pharmaceutical Sciences, 72 (6) (2010) 732-737.
  • [7] Akin K., Ugraskan V., Isık B., Cakar F., Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads, International Journal of Biological Macromolecules, 223 (2022) 543–554.
  • [8] Pulat M., Asıl D., Fluconazole release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylic acid, and citraconic acid, Journal of Applied Polymer Science, 113 (2009) 2613–2619.
  • [9] Song S.Z., Cardinal J.R., Kim S.H., Kim S.W., Progestin Permeation Through Polymer Membranes V: Progesterone Release from Monolithic Hydrogel Devices, Journal of Pharmaceutical Sciences, 70 (2) (1981) 216-219.
  • [10] Xu S. W., Zheng J. P., Tong L., Yao K. D., Interaction of Functional Groups of Gelatin and Montmorillonite in Nanocomposite, Journal of Applied Polymer Science, 101 (2006) 1556–1561.
  • [11] Kim S., Kang Y., Krueger C. A., Sen M., Holcomb J. B., Chen D., Wenke J. C., Yang Y., Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation, Acta Biomaterialia, 8 (2012) 1768-1777.
  • [12] Dai Y. N., Li P., Zhang J. P., Wang A. Q., Wei Q., A Novel pH Sensitive N-Succinyl Chitosan/Alginate Hydrogel Bead for Nifedipine Delivery, Biopharmaceutics and Drug Disposition, 29 (2008) 173-184.
  • [13] Zheng J. P., Li P., Ma Y. L., Yao K. D., Gelatin/Montmorillonite Hybrid Nanocomposite. I. Preparation and Properties, Journal of Applied Polymer Science, 86 (2002) 1189–1194.
  • [14] Johlin J.M., The Isoelectric Point of Gelatin and Its Relation to the Minimum Physical Properties of Gelatin, Journal of Biological Chemistry, 86 (1) (1930) 231-243.
  • [15] Kenawy E.R., Azaam M. M., El-nshar EM., Sodium alginate-g-poly (acrylic acid-co-2-hydroxyethyl methacrylate)/ montmorillonite superabsorbent composite: Preparation, swelling investigation and its application as a slow-release fertilizer, Arabian Journal of Chemistry, 12(6) (2019) 847-856.
  • [16] Paulus H.E., Furst D.E., Dromgoole S.H., Drugs for Rheumatic Disease, Churchill Livingstone (1987).
  • [17] Razzaq A., Qureshi İ. Z., Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice, Toxicology and Applied Pharmacology, 452 (2022) 116192.
  • [18] Shabanpour S., Shariati F. P., Khatibani A. B., Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite, Brazillian Journal of Pharmaceutical Science, 58 (2022) e20243.
There are 18 citations in total.

Details

Primary Language English
Subjects Physical Properties of Materials, Biomaterial , Polymer Science and Technologies
Journal Section Tasarım ve Teknoloji
Authors

Evrim Sever 0000-0001-5015-3468

Mehlika Pulat 0000-0001-5724-5250

Project Number FDK-6920
Early Pub Date September 14, 2023
Publication Date September 27, 2023
Submission Date August 14, 2023
Published in Issue Year 2023 Volume: 11 Issue: 3

Cite

APA Sever, E., & Pulat, M. (2023). The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi University Journal of Science Part C: Design and Technology, 11(3), 837-849. https://doi.org/10.29109/gujsc.1342653
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