Research Article
BibTex RIS Cite

Year 2021, Volume: 49 Issue: 1, 1 - 10, 01.01.2021

İbrahim Bulduk Nurdoğan Topal

https://doi.org/10.15671/hjbc.773988
Cited By: 2

Abstract

References

  • S. Fahn, D. Oakes, I. Shoulson, K. Kieburtz, A. Rudolph, A Lang, C.W. Olanow, C. Tanner, K. Marek, L-DOPA and the progression of Parkinson's disease, New Engl. J. Med., 351(2004) 2498–2508.
  • C.E. Clarke, M. Guttman. Dopamine Agonist Monotherapy in Parkinson's Disease. Lancet, 360 (2002) 1767–1769.
  • M. Rezak, Current pharmacotherapeutic treatment options in Parkinson's disease, Dis. a Month, 53 (2007) 214–222.
  • D. Goncalves, G. Alves, P. Soares-da-Silva, A. Falcão, Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review, Anal. Chim. Acta, 710 (2012) 17–32.
  • F.J. David, M.R. Rafferty, J.A. Robichaud, J. Prodoehl, W.M. Kohrt, D.E. Vaillan-court, D.M. Corcos, Progressive resistance exercise and Parkinson's disease: a review of potential mechanisms, Parkinson’s Dis, (2011) 124527.
  • J.M. Cedarbaum, R. Williamson, H. Kutt, Simultaneous determination of L-DOPA, its metabolites and carbidopa in clinical samples, J. Chromatogr. B: Biomed. Sci. Appl., 415 (1987) 393–399.
  • Y. Michotte, M. Moors, D. Deleu, P. Herregodts, G. Ebinger, Simultaneous Determination of Levodopa, Carbidopa, 3-O-methyldopa and dopamine in plasma using high-performance liquid chromatography with electrochemical detection, J. Pharm. Biomed. Anal., 5 (1987) 659–664.
  • D.C. Titus, T.F. August, K.C. Yeh, R. Eisenhandler, W.F. Bayne, D.G. Musson, Simultaneous high-performance liquid chromatographic analysis of carbidopa, L-DOPA and 3-O-methyldopa in plasma and carbidopa, L-DOPA and dopamine in urine using electrochemical detection, J. Chromatogr. B: Biomed. Sci. Appl., 534 (1990) 87–100.
  • K.A. Sagar, M.R. Smyth, Simultaneous determination of L-DOPA, carbidopa and their metabolites in human plasma and urine samples using LC-EC, J. Pharm. Biomed. Anal., 22 (2000) 613–624.
  • V. Rizzo, M. Memmi, R. Moratti, G. Melzi d’Eril, E. Perucca, Concentrations of L-dopa in plasma and plasma ultrafiltrates. J. Pharm. Biomed. Anal., 14 (1996) 1043–1046.
  • T. Wikber, Simultaneous determination of L-DOPA, its main metabolites and carbidopa in plasma by liquid chromatography, J. Pharm. Biomed. Anal., 9 (1991) 167–176.
  • M. Karimi, J.L. Carl, S. Loftin. J.S. Perlmutter, Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of L-DOPA, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid. Journal of chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 836 (2006) 120-123.
  • F. Bugamelli, C. Marcheselli, E. Barba, M.A. Raggi, Determination of L‐dopa, carbidopa, 3‐O‐methyldopa and entacapone in human plasma by HPLC‐ED. Journal of Pharmaceutical and Biomedical Analysis, 54 (2011) 562–567.
  • H.F. Martins, D.P. Pinto, d.A.V. Nascimento, M.A.S. Marques, F.C. Amendoeira, Development of an HPLC/MS/MS methodology for determining 3-Omethyldopa in human plasma and its application in a bioequivalence study, Quím. Nova, 36 (2013) 171–176.
  • K. Igarashi, K. Hotta, F. Kasuya, K. Abe, S. Sakoda, Determination of cabergoline and L-dopa in human plasma using liquid chromatography-tandem mass spectrometry, J. Chromatogr. B, 792 (2003) 55–61.
  • R.R. Gonzalez, R.F. Fernandez, J.L. Vidal, A.G. Frenich, M.L. Perez, Development and validation of an ultra-high performance liquid chromatography-tandem mass-spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples, Neurosci. Methods, 198 (2011) 187–194.
  • P.O. Cinto, A.L.R.S. Souza, A.C. Lima, M.V. Chaud, M.P.D. Gremião, LC Evaluation of Intestinal Transport of Praziquantel. Chromatographia, 69 (2009) 213–217.
  • R. Hadjikinova, N. Petkova, D. Hadjikinov, P. Denev, D. Hrusavov, Development and Validation of HPLC-RID method for Determination of Sugars and Polyols. J. Pharm. Sci. & Res., 9 (2017)1263-1269.

Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials

Year 2021, Volume: 49 Issue: 1, 1 - 10, 01.01.2021

İbrahim Bulduk Nurdoğan Topal

https://doi.org/10.15671/hjbc.773988
Cited By: 2

Abstract

L-DOPA is an antiparkinsonian drug and is used per oral application. A reliable liquid chromatographic method for determination of L-DOPA in leaves, flowers and seeds of Vicia faba L. grown in Turkish habitats and pharmaceutical dosage forms has been developed. The analysis has been carried out using Ace C18 (5 µm, 4.6 x 250 mm,) column, and the separation was carried out using a mobile phase consisting of 50 mM potassium dihydrogen phosphate (pH 2.3) at a flow rate of 1.2 mL min-1 with UV detection at 280 nm. The method has been validated according to the acceptance criteria of the ICH guidelines. The method demonstrated good linearity (R2 > 0.999) over the assayed concentration range and showed good intra-day and inter-day precision. The detection limit (LOD) and the quantification limit (LOQ) values were determined as 1.70 and 5.13 μg mL-1 for L-DOPA. This method has been successfully used for the determination of L-DOPA in pharmaceutical formulations and plant materials.

Keywords

L-DOPA HPLC-UV METHOD DEVELOPMENT PLANT MATERIAL

References

  • S. Fahn, D. Oakes, I. Shoulson, K. Kieburtz, A. Rudolph, A Lang, C.W. Olanow, C. Tanner, K. Marek, L-DOPA and the progression of Parkinson's disease, New Engl. J. Med., 351(2004) 2498–2508.
  • C.E. Clarke, M. Guttman. Dopamine Agonist Monotherapy in Parkinson's Disease. Lancet, 360 (2002) 1767–1769.
  • M. Rezak, Current pharmacotherapeutic treatment options in Parkinson's disease, Dis. a Month, 53 (2007) 214–222.
  • D. Goncalves, G. Alves, P. Soares-da-Silva, A. Falcão, Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review, Anal. Chim. Acta, 710 (2012) 17–32.
  • F.J. David, M.R. Rafferty, J.A. Robichaud, J. Prodoehl, W.M. Kohrt, D.E. Vaillan-court, D.M. Corcos, Progressive resistance exercise and Parkinson's disease: a review of potential mechanisms, Parkinson’s Dis, (2011) 124527.
  • J.M. Cedarbaum, R. Williamson, H. Kutt, Simultaneous determination of L-DOPA, its metabolites and carbidopa in clinical samples, J. Chromatogr. B: Biomed. Sci. Appl., 415 (1987) 393–399.
  • Y. Michotte, M. Moors, D. Deleu, P. Herregodts, G. Ebinger, Simultaneous Determination of Levodopa, Carbidopa, 3-O-methyldopa and dopamine in plasma using high-performance liquid chromatography with electrochemical detection, J. Pharm. Biomed. Anal., 5 (1987) 659–664.
  • D.C. Titus, T.F. August, K.C. Yeh, R. Eisenhandler, W.F. Bayne, D.G. Musson, Simultaneous high-performance liquid chromatographic analysis of carbidopa, L-DOPA and 3-O-methyldopa in plasma and carbidopa, L-DOPA and dopamine in urine using electrochemical detection, J. Chromatogr. B: Biomed. Sci. Appl., 534 (1990) 87–100.
  • K.A. Sagar, M.R. Smyth, Simultaneous determination of L-DOPA, carbidopa and their metabolites in human plasma and urine samples using LC-EC, J. Pharm. Biomed. Anal., 22 (2000) 613–624.
  • V. Rizzo, M. Memmi, R. Moratti, G. Melzi d’Eril, E. Perucca, Concentrations of L-dopa in plasma and plasma ultrafiltrates. J. Pharm. Biomed. Anal., 14 (1996) 1043–1046.
  • T. Wikber, Simultaneous determination of L-DOPA, its main metabolites and carbidopa in plasma by liquid chromatography, J. Pharm. Biomed. Anal., 9 (1991) 167–176.
  • M. Karimi, J.L. Carl, S. Loftin. J.S. Perlmutter, Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of L-DOPA, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid. Journal of chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 836 (2006) 120-123.
  • F. Bugamelli, C. Marcheselli, E. Barba, M.A. Raggi, Determination of L‐dopa, carbidopa, 3‐O‐methyldopa and entacapone in human plasma by HPLC‐ED. Journal of Pharmaceutical and Biomedical Analysis, 54 (2011) 562–567.
  • H.F. Martins, D.P. Pinto, d.A.V. Nascimento, M.A.S. Marques, F.C. Amendoeira, Development of an HPLC/MS/MS methodology for determining 3-Omethyldopa in human plasma and its application in a bioequivalence study, Quím. Nova, 36 (2013) 171–176.
  • K. Igarashi, K. Hotta, F. Kasuya, K. Abe, S. Sakoda, Determination of cabergoline and L-dopa in human plasma using liquid chromatography-tandem mass spectrometry, J. Chromatogr. B, 792 (2003) 55–61.
  • R.R. Gonzalez, R.F. Fernandez, J.L. Vidal, A.G. Frenich, M.L. Perez, Development and validation of an ultra-high performance liquid chromatography-tandem mass-spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples, Neurosci. Methods, 198 (2011) 187–194.
  • P.O. Cinto, A.L.R.S. Souza, A.C. Lima, M.V. Chaud, M.P.D. Gremião, LC Evaluation of Intestinal Transport of Praziquantel. Chromatographia, 69 (2009) 213–217.
  • R. Hadjikinova, N. Petkova, D. Hadjikinov, P. Denev, D. Hrusavov, Development and Validation of HPLC-RID method for Determination of Sugars and Polyols. J. Pharm. Sci. & Res., 9 (2017)1263-1269.
There are 18 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

İbrahim Bulduk 0000-0001-6172-7738

Nurdoğan Topal 0000-0002-3466-1005

Publication Date January 1, 2021
Acceptance Date September 29, 2020
Published in Issue Year 2021 Volume: 49 Issue: 1

Cite

APA Bulduk, İ., & Topal, N. (2021). Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials. Hacettepe Journal of Biology and Chemistry, 49(1), 1-10. https://doi.org/10.15671/hjbc.773988
AMA Bulduk İ, Topal N. Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials. HJBC. January 2021;49(1):1-10. doi:10.15671/hjbc.773988
Chicago Bulduk, İbrahim, and Nurdoğan Topal. “Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials”. Hacettepe Journal of Biology and Chemistry 49, no. 1 (January 2021): 1-10. https://doi.org/10.15671/hjbc.773988.
EndNote Bulduk İ, Topal N (January 1, 2021) Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials. Hacettepe Journal of Biology and Chemistry 49 1 1–10.
IEEE İ. Bulduk and N. Topal, “Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials”, HJBC, vol. 49, no. 1, pp. 1–10, 2021, doi: 10.15671/hjbc.773988.
ISNAD Bulduk, İbrahim - Topal, Nurdoğan. “Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials”. Hacettepe Journal of Biology and Chemistry 49/1 (January 2021), 1-10. https://doi.org/10.15671/hjbc.773988.
JAMA Bulduk İ, Topal N. Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials. HJBC. 2021;49:1–10.
MLA Bulduk, İbrahim and Nurdoğan Topal. “Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials”. Hacettepe Journal of Biology and Chemistry, vol. 49, no. 1, 2021, pp. 1-10, doi:10.15671/hjbc.773988.
Vancouver Bulduk İ, Topal N. Development and Validation of a Quantification Method for L-DOPA in Plants and Pharmaceutical Materials. HJBC. 2021;49(1):1-10.

Cited By

Characterization and HPLC Method Validation for Determination of Dopamine Hydrochloride in Prepared Nano Particles and Pharmacokinetic Application
Analytical Chemistry Letters
https://doi.org/10.1080/22297928.2022.2121662
An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices
Separations
https://doi.org/10.3390/separations9080224
 Download Cover Image

HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY

Copyright © Hacettepe University Faculty of Science

http://www.hjbc.hacettepe.edu.tr/

https://dergipark.org.tr/tr/pub/hjbc