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Sığır İdrar Keselerindeki Non-neoplastik Lezyonların Patomorfolojik Özellikleri

Year 2018, Volume: 7 Issue: 2, 222 - 228, 27.12.2018
https://doi.org/10.31196/huvfd.508994

Abstract

Non-neoplastik epitelyal ve stromal değişiklikler,
idrar kesesinin premalign neoplastik gelişimlerinin erken evresinde prognostik
olabilir. Bu lezyonların tanısı ve histolojik sınıflandırması, hem insan hem de
veteriner hekimlikte önleme ve tedavi için değerli bilgiler vermektedir.
Türkiye’de, diğer hayvanlarda az sayıda olgu görülmesine rağmen sığır idrar
kesesi lezyonlarına yüksek oranlarda rastlanmaktadır. Yıllara dayalı yeterli
deneyimlerimiz ve saha çalışmalarımıza göre, uzun vadede eğrelti otu tüketen
büyükbaş hayvanların idrar keselerinde yangısal ve neoplastik patolojiler
kolaylıkla gelişebilir. Bu çalışmada, başlıca epitelyal, stromal, damarsal ve
yangısal karakterli lezyonları içeren non-neoplastik olgular tanımlanmış ve
ayrı ayrı açıklanmıştır. İdrar kesesi epitelinde dejeneratif, deskuamatif,
kistik, hiperplastik ve metaplastik lezyonlar belirgin olarak bulundu. Ardışık
lezyonlar stromal değişiklikler ve dolaşım problemleri ile karakterize damarsal
lezyonları da içeriyordu. Bunlara eşlik eden, dikkate değer mononükleer hücre
infiltrasyonları çok sayıda vakada bulundu. Sonuç olarak, bu tür non-neoplastik
lezyonların en azından neoplastik lezyonlar kadar önemli olduğu düşünülmelidir,
çünkü lezyonlar premalign neoplastik transformasyon sırasında bir risk
oluşturabilir.

References

  • Aydin Y, Ozkul IA, 1995: Nonneoplastic findings of the urinary bladder in cattle and water buffalo in the black sea region of Turkey. Ankara Üniv Vet Fak Derg, 42, 189-192.
  • Carvalho T, Pinto C, Peleteiro MC, 2006: Urinary bladder lesions in bovine enzootic haematuria. J Comp Pathol, 134, 336–346.
  • Harik LR, Merino, C, Coindre JM, Amin, MB, Pedeutour F, Weiss SW, 2006: Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases. Am J Surg Pathol, 30, 787–794.
  • Keles H, Bozkurt MF, Ulucan A, Demirel HH, Yuksel H, Karadas E, Ozkul IA, 2018: The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Üniv Vet Fak Derg, 65, 341–348.
  • Koren J, Mensikova J, Mukensnabl P, Zamecnik M, 2006: Mullerianosis of the urinary bladder: report of a case with suggested metaplastic origin. Virchows Arch Int J Pathol, 449, 268–271.
  • Lopez-Beltran A, Cheng L, Andersson L, Brausi M, de Matteis A, Montironi R, Sesterhenn I, van det Kwast KT, Mazerolles C, 2002: Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation. Virchows Arch, 440, 3–11.
  • Montironi R, Lopez-Beltran A, Mazzucchelli R, Bostwick DG, 2003: Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies. J Clin Pathol, 56, 91–95.
  • Nochomovitz LE, Orenstein JM, 1985: Inflammatory pseudotumor of the urinary bladder--possible relationship to nodular fasciitis. Two case reports, cytologic observations, and ultrastructural observations. Am J Surg Pathol, 9, 366–373.
  • Ozkul IA, Dincel AS, Keles H, Vural SA, 2008: Immunohistochemistry of bovine urinary bladder mucosal hyperplasia and neoplasia. Bull Vet Inst Puławy, 52, 643-647.
  • Pamukcu AM, 1974: Tumors of the Urinary Bladder. Bull Wld Hlth Org, 50, 43–52.
  • Pamukcu AM, Göksoy SK, Price JM, 1967: Urinary bladder neoplasms induced by feeding bracken fern (Pteris aquilina) to cows. Cancer Res, 27, 917–924.
  • Peixoto PV, França TN, Barros CS, Tokarnia CH, 2003: Histopathological aspects of bovine enzootic hematuria in Brazil. Pesqui Veterinária Bras, 23, 65–81.
  • Proppe KH, Scully RE, Rosai J, 1984: Postoperative spindle cell nodules of genitourinary tract resembling sarcomas. A report of eight cases. Am J Surg Pathol, 8, 101–108.
  • Readal N, Epstein JI, 2010: Papillary urothelial hyperplasia: relationship to urothelial neoplasms. Pathology (Phila), 42, 360–363.
  • Reuter VE, 1999: Bladder. Risk and prognostic factors--a pathologist’s perspective. Urol Clin North Am, 26, 481–492.
  • Roperto S, Borzacchiello G, Brun R, Leonardi L, Maiolino P, Martano M, Paciello O, Papparella S, Restucci B, Russo V, Salvatore G, Urraro C, Roperto F, 2010: A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. J Comp Pathol, 142, 95–108.
  • Roth JA, 1980: Reactive pseudosarcomatous response in urinary bladder. Urology, 16, 635–637.
  • Sampson N, Untergasser G, Plas E, Berger P, 2007: The ageing male reproductive tract. J Pathol, 211, 206–218.
  • Volmar KE, Chan TY, De Marzo AM, Epstein JI, 2003: Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol, 27, 1243–1252.
  • Wick MR, Brown BA, Young RH, Mills SE, 1988: Spindle-cell proliferations of the urinary tract. An immunohistochemical study. Am J Surg Pathol, 12, 379–389.
  • Wiener DP, Koss LG, Sablay B, Freed SZ, 1979: The prevalence and significance of Brunn’s nests, cystitis cystica and squamous metaplasia in normal bladders. J Urol, 122, 317–321.
  • Wong-You-Cheong JJ, Woodward PJ, Manning MA, Davis CJ, 2006: From the archives of the AFIP: Inflammatory and nonneoplastic bladder masses: radiologic-pathologic correlation. Radiogr Rev Publ Radiol Soc N Am Inc, 26, 1847–1868.
  • Young RH, 2008: Non-neoplastic disorders of the urinary bladder. In: “Urologic Surgical Pathology’’, 2nd ed., Ed; Bostwick DG and Cheng L, Mosby Elsevier, pp. 215–256.
  • Young RH, 2009: Tumor-like lesions of the urinary bladder. Mod Pathol, Suppl 2, S37-52.
  • Yucel-Tenekeci G, Oztekin M, Bozkurt MF, Dincel AS, Ozkul IA, 2017: Pathomorphological and immunohistochemical studies of tumours in the urinary bladders of water buffalo in Marmara, the Central and Western Black Sea Region of Turkey. Kafkas Univ Vet Fak Derg, 23, 269–273.

Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders

Year 2018, Volume: 7 Issue: 2, 222 - 228, 27.12.2018
https://doi.org/10.31196/huvfd.508994

Abstract

Non-neoplastic epithelial and
stromal changes might be prognostic in early phase of premalignant neoplastic
developments of urinary bladder. In this regard, diagnosis and histological classification
of these lesions give valuable knowledge for prevention and treatment in both
human and veterinary medicine. In Turkey, bovine urinary bladder lesions have
been encountered in great ratio even though the small numbers of cases have been
observed in other animals. According to our great experiences and field-studies
for years concentrating on the topic, inflammatory and neoplastic of
pathologies in urinary bladders might be easily developed after long term Bracken
fern-consuming cattle. In current study, non-neoplastic cases including mainly
epithelial, stromal, vascular, and inflammatory characteristic lesions were
identified and described separately. Degenerative, desquamative, cystic,
hyperplastic, and metaplastic lesions were found prominently in urinary bladder
epithelium. Consecutive lesions comprised stromal changes and vascular lesions
characterized with circulatory problems. Accompanying those, remarkable mononuclear
cell infiltrations were found in a lot of cases. In conclusion, such kind of non-neoplastic
lesions at least should be considered as important as neoplastic lesions
because the lesions can have a risk in course of premalignant neoplastic
transformation.

References

  • Aydin Y, Ozkul IA, 1995: Nonneoplastic findings of the urinary bladder in cattle and water buffalo in the black sea region of Turkey. Ankara Üniv Vet Fak Derg, 42, 189-192.
  • Carvalho T, Pinto C, Peleteiro MC, 2006: Urinary bladder lesions in bovine enzootic haematuria. J Comp Pathol, 134, 336–346.
  • Harik LR, Merino, C, Coindre JM, Amin, MB, Pedeutour F, Weiss SW, 2006: Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases. Am J Surg Pathol, 30, 787–794.
  • Keles H, Bozkurt MF, Ulucan A, Demirel HH, Yuksel H, Karadas E, Ozkul IA, 2018: The role of inducible nitric oxide synthase in urinary bladders of cattle with enzootic hematuria and its struggle with uroplakin III. Ankara Üniv Vet Fak Derg, 65, 341–348.
  • Koren J, Mensikova J, Mukensnabl P, Zamecnik M, 2006: Mullerianosis of the urinary bladder: report of a case with suggested metaplastic origin. Virchows Arch Int J Pathol, 449, 268–271.
  • Lopez-Beltran A, Cheng L, Andersson L, Brausi M, de Matteis A, Montironi R, Sesterhenn I, van det Kwast KT, Mazerolles C, 2002: Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation. Virchows Arch, 440, 3–11.
  • Montironi R, Lopez-Beltran A, Mazzucchelli R, Bostwick DG, 2003: Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies. J Clin Pathol, 56, 91–95.
  • Nochomovitz LE, Orenstein JM, 1985: Inflammatory pseudotumor of the urinary bladder--possible relationship to nodular fasciitis. Two case reports, cytologic observations, and ultrastructural observations. Am J Surg Pathol, 9, 366–373.
  • Ozkul IA, Dincel AS, Keles H, Vural SA, 2008: Immunohistochemistry of bovine urinary bladder mucosal hyperplasia and neoplasia. Bull Vet Inst Puławy, 52, 643-647.
  • Pamukcu AM, 1974: Tumors of the Urinary Bladder. Bull Wld Hlth Org, 50, 43–52.
  • Pamukcu AM, Göksoy SK, Price JM, 1967: Urinary bladder neoplasms induced by feeding bracken fern (Pteris aquilina) to cows. Cancer Res, 27, 917–924.
  • Peixoto PV, França TN, Barros CS, Tokarnia CH, 2003: Histopathological aspects of bovine enzootic hematuria in Brazil. Pesqui Veterinária Bras, 23, 65–81.
  • Proppe KH, Scully RE, Rosai J, 1984: Postoperative spindle cell nodules of genitourinary tract resembling sarcomas. A report of eight cases. Am J Surg Pathol, 8, 101–108.
  • Readal N, Epstein JI, 2010: Papillary urothelial hyperplasia: relationship to urothelial neoplasms. Pathology (Phila), 42, 360–363.
  • Reuter VE, 1999: Bladder. Risk and prognostic factors--a pathologist’s perspective. Urol Clin North Am, 26, 481–492.
  • Roperto S, Borzacchiello G, Brun R, Leonardi L, Maiolino P, Martano M, Paciello O, Papparella S, Restucci B, Russo V, Salvatore G, Urraro C, Roperto F, 2010: A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. J Comp Pathol, 142, 95–108.
  • Roth JA, 1980: Reactive pseudosarcomatous response in urinary bladder. Urology, 16, 635–637.
  • Sampson N, Untergasser G, Plas E, Berger P, 2007: The ageing male reproductive tract. J Pathol, 211, 206–218.
  • Volmar KE, Chan TY, De Marzo AM, Epstein JI, 2003: Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol, 27, 1243–1252.
  • Wick MR, Brown BA, Young RH, Mills SE, 1988: Spindle-cell proliferations of the urinary tract. An immunohistochemical study. Am J Surg Pathol, 12, 379–389.
  • Wiener DP, Koss LG, Sablay B, Freed SZ, 1979: The prevalence and significance of Brunn’s nests, cystitis cystica and squamous metaplasia in normal bladders. J Urol, 122, 317–321.
  • Wong-You-Cheong JJ, Woodward PJ, Manning MA, Davis CJ, 2006: From the archives of the AFIP: Inflammatory and nonneoplastic bladder masses: radiologic-pathologic correlation. Radiogr Rev Publ Radiol Soc N Am Inc, 26, 1847–1868.
  • Young RH, 2008: Non-neoplastic disorders of the urinary bladder. In: “Urologic Surgical Pathology’’, 2nd ed., Ed; Bostwick DG and Cheng L, Mosby Elsevier, pp. 215–256.
  • Young RH, 2009: Tumor-like lesions of the urinary bladder. Mod Pathol, Suppl 2, S37-52.
  • Yucel-Tenekeci G, Oztekin M, Bozkurt MF, Dincel AS, Ozkul IA, 2017: Pathomorphological and immunohistochemical studies of tumours in the urinary bladders of water buffalo in Marmara, the Central and Western Black Sea Region of Turkey. Kafkas Univ Vet Fak Derg, 23, 269–273.
There are 25 citations in total.

Details

Primary Language English
Journal Section Research
Authors

Hikmet Keles

Mehmet Fatih Bozkurt This is me

Zafer Ozyıldız This is me

Mehmet Eray Alcıgır This is me

Publication Date December 27, 2018
Submission Date October 18, 2018
Acceptance Date December 3, 2018
Published in Issue Year 2018 Volume: 7 Issue: 2

Cite

APA Keles, H., Bozkurt, M. F., Ozyıldız, Z., Alcıgır, M. E. (2018). Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders. Harran Üniversitesi Veteriner Fakültesi Dergisi, 7(2), 222-228. https://doi.org/10.31196/huvfd.508994
AMA Keles H, Bozkurt MF, Ozyıldız Z, Alcıgır ME. Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders. Harran Univ Vet Fak Derg. December 2018;7(2):222-228. doi:10.31196/huvfd.508994
Chicago Keles, Hikmet, Mehmet Fatih Bozkurt, Zafer Ozyıldız, and Mehmet Eray Alcıgır. “Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders”. Harran Üniversitesi Veteriner Fakültesi Dergisi 7, no. 2 (December 2018): 222-28. https://doi.org/10.31196/huvfd.508994.
EndNote Keles H, Bozkurt MF, Ozyıldız Z, Alcıgır ME (December 1, 2018) Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders. Harran Üniversitesi Veteriner Fakültesi Dergisi 7 2 222–228.
IEEE H. Keles, M. F. Bozkurt, Z. Ozyıldız, and M. E. Alcıgır, “Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders”, Harran Univ Vet Fak Derg, vol. 7, no. 2, pp. 222–228, 2018, doi: 10.31196/huvfd.508994.
ISNAD Keles, Hikmet et al. “Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders”. Harran Üniversitesi Veteriner Fakültesi Dergisi 7/2 (December 2018), 222-228. https://doi.org/10.31196/huvfd.508994.
JAMA Keles H, Bozkurt MF, Ozyıldız Z, Alcıgır ME. Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders. Harran Univ Vet Fak Derg. 2018;7:222–228.
MLA Keles, Hikmet et al. “Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders”. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol. 7, no. 2, 2018, pp. 222-8, doi:10.31196/huvfd.508994.
Vancouver Keles H, Bozkurt MF, Ozyıldız Z, Alcıgır ME. Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders. Harran Univ Vet Fak Derg. 2018;7(2):222-8.