Research Article
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Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats

Year 2021, Volume: 10 Issue: 1, 66 - 72, 22.06.2021

Ali Osman İnan Zafer Durgun Oğuzcan Koca Durmuş Hatipoğlu

https://doi.org/10.31196/huvfd.884704
Cited By: 1

Abstract

This research was conducted to determine the effect of Coenzyme Q10 (CoQ10) on blood glucose, total protein, triglyceride, and total cholesterol levels in rats for that experimental hypothyroidism was induced. A total of 32 healthy adult male Wistar Albino rats were used as a material in the research. After the adaptation period of animals for ten days, the main research period was conducted for a total of three weeks. The rats housed as four rats in each cage during the research were divided into four experimental groups as control (K), CoQ10 (C), Hypothyroid (H), and CoQ10+Hypothyroid (CH). CoQ10 was administered intraperitoneally every day to the group C animals. In addition, propylthiouracil (PTU) was added daily to the water of rats in group H to induce experimental hypothyroidism. Both CoQ10 and PTU administration was performed on the animals in the group HC. At the end of the trial period, blood was drawn from the hearts of rats in all groups. Glucose, total protein, triglyceride, and total cholesterol levels were determined in plasma samples obtained from blood samples. It was observed in the research that hypothyroidism administration (group H) decreased plasma glucose and triglyceride values (p<0.05) and increased total protein and total cholesterol levels (p<0.05) compared to group K. In the study, it was observed that while CoQ10 administration (group HC) did not have a statistically significant effect on plasma glucose, total protein and triglyceride values in hypothyroidism-induced rats (group H), it increased the total cholesterol level (p<0,05). In the research, it was observed that the CoQ10 administration (group C) decreased plasma triglyceride values compared to that of group K (p<0.05). As a result, since CoQ10 administration increases total cholesterol level in hypothyroidism, the effect of CoQ10 supplementation on blood lipid profile in metabolic diseases should be considered.

Keywords

CoQ10 hypothyroidism plasma parameters thyroid hormones rat

Supporting Institution

BAP

Project Number

19202013

References

  • Abdi S, Montazeri V, Garjani A, Shayanfar A, Pirouzpanah S, 2020: Coenzyme Q10 in association with metabolism-related AMPK/PFKFB3 and angiogenic VEGF/VEGFR2 genes in breast cancer patients. Mol Biol Rep; 47(4): 2459-2473.
  • Acosta MJ, Fonseca LV, Desbats MA, Cerqua C, Zordan R, Trevisson E, Salviati L, 2016: Coenzyme Q biosynthesis in health and disease. BBA-Bioenergetics; 1857(8): 1079-1085.
  • Alahmar AT, Sengupta P, 2020: Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility. Biol Trace Elem Res; 1-7.
  • Alcázar-Fabra M, Navas P, Brea-Calvo G, 2016: Coenzyme Q biosynthesis and its role in the respiratory chain structure. BBA-Bioenergetics; 1857(8): 1073-1078.
  • Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, 2019: Lipoprotein lipase is active as a monomer. PNAS-USA; 116(13): 6319-6328.
  • Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru GP, 2006: Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J; 27(22): 2675-2681.
  • Bhagavan HN, Chopra RK, 2006: Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res. ; 40(5): 445-453.
  • Castelo-Branco C, Steinvarcel F, Osorio A, Ros C, Balasch J, 2010: Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol; 26(10): 736-742.
  • Comte B, Vidal H, Laville M, Riou J-P, 1990: Influence of thyroid hormones on gluconeogenesis from glycerol in rat hepatocytes: a dose-response study. Metab. Clin. Exp; 39(3): 259-263.
  • Cooper D, Greenspan F, Ladenson P, 2007: Hyperthyroidism and Thyrotoxicosis. Greenspan’s basic and clinical endocrinology; 8th edition : 248-252.
  • Diekman T, Demacker PN, Kastelein JJ, Stalenhoef AF, Wiersinga WM, 1998: Increased oxidizability of low-density lipoproteins in hypothyroidism. J. Clin. Endocrinol. Metab.; 83(5): 1752-1755.
  • Dludla PV, Nyambuya TM, Orlando P, Silvestri S, Mxinwa V, Mokgalaboni K, Nkambule BB, Louw J, Muller CJ, Tiano L, 2020: The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials. Endocrinol Diabetes Metab; 3(2): e00118.
  • Duntas LH, Orgiazzi J, Brabant G, 2011: The interface between thyroid and diabetes mellitus. Clinical Endocrinology; 75(1): 1-9.
  • Hayase K, Yonekawa G, Yokogoshi H, Yoshida A, 1991: Triiodothyronine administration affects urea synthesis in rats. The Journal of nutrition; 121(7): 970-978.
  • Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P, 2018: Coenzyme Q10 supplementation in aging and disease. Front Physiol; 9: 44.
  • Kandir S, Keskin E, 2016: Effects of hypothyroidism and hyperthyroidism on hematological parameters in rats. Ankara Univ Vet Fak Derg;63(4): 371-376.
  • Kismali G, 2009: Effects of Coenzyme Q10 on blood biochemistry in rats. Kafkas Univ Vet Fak Derg; 15(2): 191-194.
  • Kozacz A, Grunt P, Steczkowska M, Mikulski T, Dąbrowski J, Górecka M, Sanocka U, Ziemba AW, 2014: Thermogenic effect of glucose in hypothyroid subjects. Int. J. Endocrinol.; 308017-308017.
  • Lam KS, Chan MK, Yeung RT, 1986: High-density lipoprotein cholesterol, hepatic lipase and lipoprotein lipase activities in thyroid dysfunction effects of treatment. QJM-INT J MED.; 59(2): 513-521.
  • Lee SK, Lee JO, Kim JH, Kim N, You GY, Moon JW, Sha J, Kim SJ, Lee YW, Kang HJ, 2012: Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes. Cell Signal; 24(12): 2329-2336.
  • Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC, 2007: Activation of the hepatic LDL receptor promoter by thyroid hormone. BBA; 1771(9): 1216-1225.
  • Mantle D, Hargreaves I, 2019: Coenzyme Q10 and degenerative disorders affecting longevity: an overview. Antioxidants; 8(2): 44.
  • Marchesini G, Fabbri A, Bianchi G, Motta E, Bugianesi E, Urbini D, Pascoli A, Lodi A, 1993: Hepatic conversion of amino nitrogen to urea nitrogen in hypothyroid patients and upon L-thyroxine therapy. Metab. Clin. Exp; 42(10): 1263-1269.
  • Marcin G, Maria S, Marcin RT, Krzysztof L, Magdalena G, Łukasz K, Marcin S, Piotr W, 2016: Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats. J. Vet. Res.; 60(4): 489-493.
  • McCall MR, Tang JY, Bielicki JK, Forte TM, 1995: Inhibition of lecithin-cholesterol acyltransferase and modification of HDL apolipoproteins by aldehydes. Arterioscler Thromb Vasc Biol; 15(10): 1599-1606.
  • McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, 2017: A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. AAN; 88(2): 152-159.
  • Meisinger C, Ittermann T, Tiller D, Agger C, Nauck M, Schipf S, Wallaschofski H, Jørgensen T, Linneberg A, Thiery J, 2014: Sex-specific associations between thyrotropin and serum lipid profiles. Thyroid; 24(3): 424-432.
  • Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, 2015: Williams Textbook of Endocrinology E-Book. Elsevier Health Sciences.
  • Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad M, 2018: Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry Res; 265: 62-69.
  • Mullur R, Liu Y-Y, Brent GA, 2014: Thyroid hormone regulation of metabolism. Physiological reviews; 94(2): 355-382.
  • Ness GC, Lopez D, Chambers CM, Newsome WP, Cornelius P, Long CA, Harwood Jr HJ, 1998: Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo AI gene expression. Biochem Pharmacol; 56(1): 121-129 . Nishi M, 2018: Diabetes mellitus and thyroid diseases. Diabetology International; 9(2): 108-112.
  • Noyan A, 2011: Yaşamda ve Hekimlikte Fizyoloji.(1. Baskı). İstanbul: Palme Yayıncılık : 483-488.
  • Ogura F, Morii H, Ohno M, Ueno T, Kitabatake S, Hamada N, Ito K, 1980: Serum coenzyme Q10 levels in thyroid disorders. Horm Metab Res; 12(10): 537-540.
  • Pandolfi C, Ferrari D, Stanic I, Pellegrini L, 1994: Circulating levels of CoQ10 in hypo-and hyperthyroidism. Minerva Endocrinol; 19(3): 139-142.
  • Polat M, Polat Y, Akbulut T, Cinar V, Marangoz I, 2017: The effects of trainings applied with CoQ10 and zinc supplementation on the thyroid hormone metabolism in Soccer players.
  • Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR, 2014: Thyroid hormones and skeletal muscle—new insights and potential implications. Nature Reviews Endocrinology; 10(4): 206-214.
  • Samimi F, Baazm M, Eftekhar E, Rajabi S, Goodarzi MT, Mashayekhi FJ, 2019: Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways. Res Pharm Sci; 14(6): 524.
  • Shin D-J, Osborne TF, 2003: Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2). Journal of Biological Chemistry; 278(36): 34114-34118.
  • Singh U, Devaraj S, Jialal I, 2007: Coenzyme Q10 supplementation and heart failure. Nutr Rev; 65(6): 286-293.
  • Souza LL, Cordeiro A, Oliveira LS, de Paula GS, Faustino LC, Ortiga-Carvalho TM, Oliveira KJ, Pazos-Moura CC, 2011: Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms. J Endocrinol; 211(1): 65-72.
  • Tafazoli A, 2017: Coenzyme Q10 in breast cancer care. Future Oncology; 13(11): 1035-1041.
  • Tekin M, 2003: Örneklerle bilgisayarda istatistik. SÜ Veteriner Fakültesi Yayın Ünitesi, Konya
  • Trajkovic-Arsic M, Müller J, Darras VM, Groba C, Lee S, Weih D, Bauer K, Visser TJ, Heuer H, 2010: Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. Endocrinology; 151(10): 5053-5062.
  • Vinales KL, Begaye B, Bogardus C, Walter M, Krakoff J, Piaggi P, 2019: FGF21 is a hormonal mediator of the human “thrifty” metabolic phenotype. Diabetes; 68(2): 318-323.
  • Wolmarans DW, 2017: Maintaining euthyroidism: fundamentals of thyroid hormone physiology, iodine metabolism and hypothyroidism. South African Family Practice; 59(4): 11-21.
  • Yang X, Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC-C, 2016: Neuroprotection of coenzyme Q10 in neurodegenerative diseases. Curr Top Med Chem; 16(8): 858-866.
  • Zhu Z-G, Sun M-X, Zhang W-L, Wang W-W, Jin Y-M, Xie C-L, 2017: The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials. Neurol Sci; 38(2): 215-224.

Hipotiroidili Ratlarda Koenzim Q10'un Plazma Parametreleri Üzerine Etkisi

Year 2021, Volume: 10 Issue: 1, 66 - 72, 22.06.2021

Ali Osman İnan Zafer Durgun Oğuzcan Koca Durmuş Hatipoğlu

https://doi.org/10.31196/huvfd.884704
Cited By: 1

Abstract

Deneysel olarak hipotiroidizm oluşturulmuş ratlarda Koenzim Q10 (KoQ10)’un kan glikoz, total protein, trigliserit ve total kolesterol düzeyleri üzerindeki etkisinin belirlenmesi amaçlandı. Araştırmada materyal olarak sağlıklı toplam 32 adet yetişkin erkek Wistar Albino ırkı rattan yararlanıldı. Hayvanların10 günlük adaptasyon süresini takiben esas araştırma dönemi toplam 3 hafta sürdürüldü. Çalışma süresince her kafeste 4 rat olacak şekilde barındırılan ratlar kontrol (K), KoQ10 (C), Hipotiroid (H) ve KoQ10+ Hipotiroid (CH) olmak üzere 4 deneme grubuna ayrıldı. C grubu hayvanlara her gün intraperitoneal olarak KoQ10 uygulandı. Deneysel hipotiroidizm oluşturmak amacıyla, H grubundaki ratların sularına günlük propiltiyourasil (PTU) ilave edildi. HC grubundaki hayvanlara ise hem KoQ10, hem de PTU uygulaması yapıldı. Deneme sonunda gruplardaki deneklerden genel anestezi altında kardiak punksiyon ile yeterli oranda kan alındı ve plazmaları elde edildi. Elde edilen plazma örneklerinden glikoz, total protein, trigliserit ve total kolesterol düzeyleri belirlendi. Araştırmada, hipotiroidizm oluşturulmasının, kontrol grubu ile kıyaslandığında plazma glikoz ve trigliserit değerlerini düşürdüğü (p<0,05), total protein ve total kolesterol düzeylerini arttırdığı (p<0,05) gözlendi. Çalışmada, KoQ10 tedavisinin (HC grubu), hipotiroidizm oluşturulan ratlar ile kıyaslandığında (H grubu) plazma glikoz, total protein ve trigliserit değerleri üzerinde istatistiksel öneme sahip bir etkisi belirlenemezken, total kolesterol düzeyini artırdığı görüldü(p<0,05). Araştırmada KoQ10 (C grubu) uygulamasının, K grubuna göre plazma trigliserit değerlerini azalttığı (p<0,05) görüldü. Sonuç olarak hipotiroidide, CoQ10 uygulaması toplam kolesterol düzeyini arttırdığından, metabolik hastalıklarda CoQ10 takviyesinin kan lipit profili üzerindeki etkisi göz önünde bulundurulmalıdır.

Keywords

KoQ10 hipotiroidizm plazma parametreleri tiroid hormonları rat

Project Number

19202013

References

  • Abdi S, Montazeri V, Garjani A, Shayanfar A, Pirouzpanah S, 2020: Coenzyme Q10 in association with metabolism-related AMPK/PFKFB3 and angiogenic VEGF/VEGFR2 genes in breast cancer patients. Mol Biol Rep; 47(4): 2459-2473.
  • Acosta MJ, Fonseca LV, Desbats MA, Cerqua C, Zordan R, Trevisson E, Salviati L, 2016: Coenzyme Q biosynthesis in health and disease. BBA-Bioenergetics; 1857(8): 1079-1085.
  • Alahmar AT, Sengupta P, 2020: Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility. Biol Trace Elem Res; 1-7.
  • Alcázar-Fabra M, Navas P, Brea-Calvo G, 2016: Coenzyme Q biosynthesis and its role in the respiratory chain structure. BBA-Bioenergetics; 1857(8): 1073-1078.
  • Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, 2019: Lipoprotein lipase is active as a monomer. PNAS-USA; 116(13): 6319-6328.
  • Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru GP, 2006: Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J; 27(22): 2675-2681.
  • Bhagavan HN, Chopra RK, 2006: Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res. ; 40(5): 445-453.
  • Castelo-Branco C, Steinvarcel F, Osorio A, Ros C, Balasch J, 2010: Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol; 26(10): 736-742.
  • Comte B, Vidal H, Laville M, Riou J-P, 1990: Influence of thyroid hormones on gluconeogenesis from glycerol in rat hepatocytes: a dose-response study. Metab. Clin. Exp; 39(3): 259-263.
  • Cooper D, Greenspan F, Ladenson P, 2007: Hyperthyroidism and Thyrotoxicosis. Greenspan’s basic and clinical endocrinology; 8th edition : 248-252.
  • Diekman T, Demacker PN, Kastelein JJ, Stalenhoef AF, Wiersinga WM, 1998: Increased oxidizability of low-density lipoproteins in hypothyroidism. J. Clin. Endocrinol. Metab.; 83(5): 1752-1755.
  • Dludla PV, Nyambuya TM, Orlando P, Silvestri S, Mxinwa V, Mokgalaboni K, Nkambule BB, Louw J, Muller CJ, Tiano L, 2020: The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials. Endocrinol Diabetes Metab; 3(2): e00118.
  • Duntas LH, Orgiazzi J, Brabant G, 2011: The interface between thyroid and diabetes mellitus. Clinical Endocrinology; 75(1): 1-9.
  • Hayase K, Yonekawa G, Yokogoshi H, Yoshida A, 1991: Triiodothyronine administration affects urea synthesis in rats. The Journal of nutrition; 121(7): 970-978.
  • Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P, 2018: Coenzyme Q10 supplementation in aging and disease. Front Physiol; 9: 44.
  • Kandir S, Keskin E, 2016: Effects of hypothyroidism and hyperthyroidism on hematological parameters in rats. Ankara Univ Vet Fak Derg;63(4): 371-376.
  • Kismali G, 2009: Effects of Coenzyme Q10 on blood biochemistry in rats. Kafkas Univ Vet Fak Derg; 15(2): 191-194.
  • Kozacz A, Grunt P, Steczkowska M, Mikulski T, Dąbrowski J, Górecka M, Sanocka U, Ziemba AW, 2014: Thermogenic effect of glucose in hypothyroid subjects. Int. J. Endocrinol.; 308017-308017.
  • Lam KS, Chan MK, Yeung RT, 1986: High-density lipoprotein cholesterol, hepatic lipase and lipoprotein lipase activities in thyroid dysfunction effects of treatment. QJM-INT J MED.; 59(2): 513-521.
  • Lee SK, Lee JO, Kim JH, Kim N, You GY, Moon JW, Sha J, Kim SJ, Lee YW, Kang HJ, 2012: Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes. Cell Signal; 24(12): 2329-2336.
  • Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC, 2007: Activation of the hepatic LDL receptor promoter by thyroid hormone. BBA; 1771(9): 1216-1225.
  • Mantle D, Hargreaves I, 2019: Coenzyme Q10 and degenerative disorders affecting longevity: an overview. Antioxidants; 8(2): 44.
  • Marchesini G, Fabbri A, Bianchi G, Motta E, Bugianesi E, Urbini D, Pascoli A, Lodi A, 1993: Hepatic conversion of amino nitrogen to urea nitrogen in hypothyroid patients and upon L-thyroxine therapy. Metab. Clin. Exp; 42(10): 1263-1269.
  • Marcin G, Maria S, Marcin RT, Krzysztof L, Magdalena G, Łukasz K, Marcin S, Piotr W, 2016: Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats. J. Vet. Res.; 60(4): 489-493.
  • McCall MR, Tang JY, Bielicki JK, Forte TM, 1995: Inhibition of lecithin-cholesterol acyltransferase and modification of HDL apolipoproteins by aldehydes. Arterioscler Thromb Vasc Biol; 15(10): 1599-1606.
  • McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, 2017: A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. AAN; 88(2): 152-159.
  • Meisinger C, Ittermann T, Tiller D, Agger C, Nauck M, Schipf S, Wallaschofski H, Jørgensen T, Linneberg A, Thiery J, 2014: Sex-specific associations between thyrotropin and serum lipid profiles. Thyroid; 24(3): 424-432.
  • Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, 2015: Williams Textbook of Endocrinology E-Book. Elsevier Health Sciences.
  • Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad M, 2018: Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry Res; 265: 62-69.
  • Mullur R, Liu Y-Y, Brent GA, 2014: Thyroid hormone regulation of metabolism. Physiological reviews; 94(2): 355-382.
  • Ness GC, Lopez D, Chambers CM, Newsome WP, Cornelius P, Long CA, Harwood Jr HJ, 1998: Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo AI gene expression. Biochem Pharmacol; 56(1): 121-129 . Nishi M, 2018: Diabetes mellitus and thyroid diseases. Diabetology International; 9(2): 108-112.
  • Noyan A, 2011: Yaşamda ve Hekimlikte Fizyoloji.(1. Baskı). İstanbul: Palme Yayıncılık : 483-488.
  • Ogura F, Morii H, Ohno M, Ueno T, Kitabatake S, Hamada N, Ito K, 1980: Serum coenzyme Q10 levels in thyroid disorders. Horm Metab Res; 12(10): 537-540.
  • Pandolfi C, Ferrari D, Stanic I, Pellegrini L, 1994: Circulating levels of CoQ10 in hypo-and hyperthyroidism. Minerva Endocrinol; 19(3): 139-142.
  • Polat M, Polat Y, Akbulut T, Cinar V, Marangoz I, 2017: The effects of trainings applied with CoQ10 and zinc supplementation on the thyroid hormone metabolism in Soccer players.
  • Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR, 2014: Thyroid hormones and skeletal muscle—new insights and potential implications. Nature Reviews Endocrinology; 10(4): 206-214.
  • Samimi F, Baazm M, Eftekhar E, Rajabi S, Goodarzi MT, Mashayekhi FJ, 2019: Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways. Res Pharm Sci; 14(6): 524.
  • Shin D-J, Osborne TF, 2003: Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2). Journal of Biological Chemistry; 278(36): 34114-34118.
  • Singh U, Devaraj S, Jialal I, 2007: Coenzyme Q10 supplementation and heart failure. Nutr Rev; 65(6): 286-293.
  • Souza LL, Cordeiro A, Oliveira LS, de Paula GS, Faustino LC, Ortiga-Carvalho TM, Oliveira KJ, Pazos-Moura CC, 2011: Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms. J Endocrinol; 211(1): 65-72.
  • Tafazoli A, 2017: Coenzyme Q10 in breast cancer care. Future Oncology; 13(11): 1035-1041.
  • Tekin M, 2003: Örneklerle bilgisayarda istatistik. SÜ Veteriner Fakültesi Yayın Ünitesi, Konya
  • Trajkovic-Arsic M, Müller J, Darras VM, Groba C, Lee S, Weih D, Bauer K, Visser TJ, Heuer H, 2010: Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. Endocrinology; 151(10): 5053-5062.
  • Vinales KL, Begaye B, Bogardus C, Walter M, Krakoff J, Piaggi P, 2019: FGF21 is a hormonal mediator of the human “thrifty” metabolic phenotype. Diabetes; 68(2): 318-323.
  • Wolmarans DW, 2017: Maintaining euthyroidism: fundamentals of thyroid hormone physiology, iodine metabolism and hypothyroidism. South African Family Practice; 59(4): 11-21.
  • Yang X, Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC-C, 2016: Neuroprotection of coenzyme Q10 in neurodegenerative diseases. Curr Top Med Chem; 16(8): 858-866.
  • Zhu Z-G, Sun M-X, Zhang W-L, Wang W-W, Jin Y-M, Xie C-L, 2017: The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials. Neurol Sci; 38(2): 215-224.
There are 47 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research
Authors

Ali Osman İnan 0000-0001-7464-4405

Zafer Durgun 0000-0002-9385-638X

Oğuzcan Koca 0000-0001-5311-3111

Durmuş Hatipoğlu 0000-0003-3790-7821

Project Number 19202013
Publication Date June 22, 2021
Submission Date February 22, 2021
Acceptance Date May 31, 2021
Published in Issue Year 2021 Volume: 10 Issue: 1

Cite

APA İnan, A. O., Durgun, Z., Koca, O., Hatipoğlu, D. (2021). Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Üniversitesi Veteriner Fakültesi Dergisi, 10(1), 66-72. https://doi.org/10.31196/huvfd.884704
AMA İnan AO, Durgun Z, Koca O, Hatipoğlu D. Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Univ Vet Fak Derg. June 2021;10(1):66-72. doi:10.31196/huvfd.884704
Chicago İnan, Ali Osman, Zafer Durgun, Oğuzcan Koca, and Durmuş Hatipoğlu. “Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi 10, no. 1 (June 2021): 66-72. https://doi.org/10.31196/huvfd.884704.
EndNote İnan AO, Durgun Z, Koca O, Hatipoğlu D (June 1, 2021) Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Üniversitesi Veteriner Fakültesi Dergisi 10 1 66–72.
IEEE A. O. İnan, Z. Durgun, O. Koca, and D. Hatipoğlu, “Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats”, Harran Univ Vet Fak Derg, vol. 10, no. 1, pp. 66–72, 2021, doi: 10.31196/huvfd.884704.
ISNAD İnan, Ali Osman et al. “Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi 10/1 (June 2021), 66-72. https://doi.org/10.31196/huvfd.884704.
JAMA İnan AO, Durgun Z, Koca O, Hatipoğlu D. Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Univ Vet Fak Derg. 2021;10:66–72.
MLA İnan, Ali Osman et al. “Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol. 10, no. 1, 2021, pp. 66-72, doi:10.31196/huvfd.884704.
Vancouver İnan AO, Durgun Z, Koca O, Hatipoğlu D. Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Univ Vet Fak Derg. 2021;10(1):66-72.

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