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Breast cancer and the molecular mechanism of estrogen signaling

Year 2023, Volume: 14 Issue: 48, 57 - 68, 30.04.2023
https://doi.org/10.17944/interdiscip.1285662

Abstract

Cancer is a complex pathology that occurs due to the uncontrolled proliferation and growth of cells in any organ or tissue of the body. Breast cancer is the most frequently diagnosed cancer among women worldwide and is the second leading cause of cancer-related deaths. Breast cancer is a pathology that exhibits heterogeneity in which genetic and environmental risk factors play a role. Although many treatment approaches have been developed for breast cancer today, the frequency of the number of patients diagnosed with breast cancer and lost their lives due to this reason is increasing in the world. The most significant limitation to the success of the treatment approaches developing drug resistance in breast cancer cells, and the disease relapses after a certain period and exhibits a more aggressive profile. Therefore, understanding the molecular biology of breast cancer is essential for developing potent therapeutic approaches. It is known that the development of breast cancer is related to changes in direct and indirect signaling mechanisms mediated by estrogen and estrogen receptor. These signaling mechanisms exhibit highly complex interaction patterns. This review summarizes the pathology of breast cancer, estrogenic compounds, estrogen receptors, genomic and non-genomic molecular signaling mechanisms mediated by estrogen and estrogen receptor.

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Year 2023, Volume: 14 Issue: 48, 57 - 68, 30.04.2023
https://doi.org/10.17944/interdiscip.1285662

Abstract

References

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  • Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics. CA Cancer J Clin. 2023;73(1):17-48. DOI: https://doi.org/10.3322/caac.21763
  • Gültekin M, Boztaş G, Utku EŞ, Ergün AK, Sevinç A, Tütüncü S ve ark. Türkiye kanser istatistikleri. Sağlık Bakanlığı, Türkiye Halk Sağlığı Kurumu, 2014 Ocak;43:12-32.
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer Statistics 2018: GLOBOCAN estimates of ıncidence and mortality worldwide for 36 cancers in 185 countries. CA:Cancer J Clın. 2018;394–424. DOI: https://doi.org/10.3322/caac.21492
  • Assi HA, Khoury KE, Dbouk H, Khalil LE, Mouhieddine TH, El Saghir NS. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis. 2013 Jun;5(1):2–8. DOI: https://doi.org/10.3978/j.issn.2072-1439.2013.05.24
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  • Koçak S, Çelik L, Özbaş S, Saka DS, Tükün A, Yalçın B. Meme kanserinde risk faktörleri, riskin değerlendirilmesi ve prevansiyon: İstanbul 2010 konsensus raporu. J Breast Health. 2011;7(2):47-67.
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  • Oliveira AM, Ross JS, Fletcher JA. Tumor suppressor genes in breast cancer: the gatekeepers and the caretakers. J Clin Pathol. 2005 Dec;124(1):16-28.DOI: https://doi.org/10.1309/5XW3L8LU445QWGQR Curran JE, Vaughan T, Lea RA, Weinstein SR, Morrison NA, Griffiths LR. Association of A vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer. 1999 Nov 19;83(6):723-6. DOI: https://doi.org/10.1002/(sici)1097-0215(19991210)83:6<723::aid-ijc4>3.0.co;2-3
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  • Newman B, Austin MA, Lee M, King MC. Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families. PNAS USA. 1988 May;85(9):3044-8. DOI: https://doi.org/10.1073/pnas.85.9.3044
  • Ohlsson RI, Pfeifer-Ohlsson SB. Cancer genes, proto-oncogenes, and development. Exp Cell Res. 1987 Nov;173(1):1-16. DOI: https://doi.org/10.1016/0014-4827(87)90327-2
  • Guerin M, Barrois M, Terrier MJ, Spielmann M, Riou G. Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene. 1988;3(1):21-31.
  • Børresen AL, Ottestad L, Gaustad A, Andersen TI, Heikkilä R, Jahnsen T et al. Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis. Br J Cancer. 1990 Oct;62(4):585-90.DOI: https://doi.org/10.1038/bjc.1990.334
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There are 79 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Reviews
Authors

Yalçın Erzurumlu 0000-0001-6835-4436

Hatice Kübra Doğan This is me 0000-0002-6061-1300

Early Pub Date April 30, 2023
Publication Date April 30, 2023
Submission Date January 31, 2022
Published in Issue Year 2023 Volume: 14 Issue: 48

Cite

Vancouver Erzurumlu Y, Doğan HK. Breast cancer and the molecular mechanism of estrogen signaling. Interdiscip Med J. 2023;14(48):57-68.