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Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus

Year 2011, Volume: 37 Issue: 2, 97 - 106, 01.11.2011

Abstract

The aim of this study was to determine the titers of neutralising antibodies against rabies virus in five hundred vaccinated owned and stray dogs within the Istanbul province. The levels of the neutralising antibody titration in the blood serum were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA) method. Sixty five (13%) of the dogs examined had adequate level (0.5 IU/ml and over) of antibody titration. Also, the effects on the formation of the neutralising antibody levels following the vaccination of some factors, such as being owned or stray, the number of repetition of vaccination, the age, living area, sex, interval between the last vaccination and sampling, have been evaluated statistically. As a result of the statistical evaluations, it has been determined that interval between the last vaccination and sampling had an important effect on formation of the neutralising antibody titration (P<0.001). Also, it was determined that the effect of the age of the dog was also significant for the neutralising antibody levels (P<0.05). On contrary, being owned or stray, sex, living area and the number of repetition of the vaccination had no effects on the neutralising antibody levels.

Key Words: Dogs, rabies, vaccines, immunogenity of rabies vaccine

References

  • ATAG, 2003. Australian Technical Advisory Group on Immunisation of the Australian Government Department of Health and Ageing. The Australian Immunisation Handbook. 8th edition. Commonwealth of Australia Department of Health and Ageing, Australia, pp. 1-10
  • Bozkaya, Ç., 2000. Ankara'da soğuk zincir donanımında sahip ecza depolarında aşı ve diğer biyolojik maddelerin soğuk zincir ko şullarına uygun olarak saklama durumlarının değerlendirilmesi. Master of Science Thesis, University of Hacettepe. Institute of Medical Science, Ankara.
  • Cliquet, F., Verifier, Y., Sagne, L., Aubert, M., Schereffer, J.L., Selve, M., Wasniewski, M., Servat, A., 2003. Neutralising antibody titration in 25,000 sera of dogs and cats vaccinated against rabies in France, in the framework of the new regulations that offer an alternative to quarantine. Revue Scientifique et Technique Office International des Epizooties 22, 857-866.
  • Delgado, S., Carmenes, P., 1997. Immune response following a vaccination campaign against rabies in dogs from northwestern Spain. Preventive Veterinary Medicine 31, 257-261.
  • Doymaz, M.Z.,2000. Medikal Viroloji. Nobel Tıp Press, Istanbul.
  • E C , 2003. Regulation of the European Parliament and of the Council on the animal health requirements applicable to the non-commercial movement of pet animals and amending Council Directive 92/65/EEC (EC) No 998/2003. (Accessed 10/12/2010). http ://ec.europa.eu/food/animal/liveanimals/pets/annex2c reg998 03 en.pdf Fooks, A.R., Mcelhinney, L.M., Brookes, S.M., Johnson, N., Keene, V., Parsons, G., Soldan, A., 2002. Rabies antibody testing and the UK Pet Travel Scheme. Veterinary Record 150, 428-430.
  • Hogenesch, H., Thompson, S., Dunham, A., Cedilia, M., Hayek, M., 2003. Effect of age on immune parameters and the immune response of dogs to vaccines: a cross-sectional study. Veterinary Immunology and Immunopathology 94, 113-121.
  • Johnson, H.N., 1965. Rabies Virus. In Horsfall FL and Tamm I. Viral and Rickettsial Infections of Man. 4th edition. J. B. Lippincott Company, Philadelphia, pp.814-835.
  • Kasempimolporn, S., Sichanasai, B., Saengseesom, W., Puempumpanich, S., Chartraporn, S., Sitprija, V., 2007. Prevalence of rabies virus infection and rabies antibody in stray dogs: A survey in Bangkok, Thailand. Preventive Veterinary Medicine 78, 325-332.
  • Kıyan, A., 2001. Istanbul İli Küçükçekmece İlçesi Sağlık Grup Başkanlığı Bölgesinde Soğuk Zincir. Thesis for Expertise, Istanbul University Faculty of Medicine İstanbul.
  • Lala, M.K., Lala, K.R., 2003. Thermostability of vacinnes. Indian Pediatrics 40, 311-319.
  • Lloyd, J. , 2000. Technologies for vaccine delivery in the 21st century. Switzerland Technologies Team of the Department of Vaccines and Biologicals, Geneva.
  • Mansfield, K.L., Burr, P.D., Snodgrass, D.R., Sayers, R., Fooks, A.R., 2004. Factors affecting the serological response of dogs and cats to rabies vaccination. Veterinary Record 154, 423-426.
  • MARA, 2010. Ministry of Agriculture and Rural Affairs. Contestation Program with Animal Diseases and Injurious 2010/02. Ministry of Agriculture and Rural Affairs General Directorate of Protection and Control, http ://www.kkgm. gov.tr/ mev/genelge .html (Erişim 10/12/2010)
  • Ozdamar, K., 1999. Statisitcs Data Analysis with Package Program SPSS, I. Kaan Press, Eskişehir, pp.62.
  • Rupprecht, C.E.; Hanlon, C.A., Hemachudha, T., 2002. Rabies re-examined. The Lancet Infection Disease 2, 327-343.
  • Sage, G, Khawplod, P., Wilde, H., Lobaugh, C., Hemachudha, T., Tepsumethanon, W., Lumlertdaecha B., 1993. Immune response to rabies vaccine in Alaskan dogs: failure to achieve a consistently protective antibody response. Transactions of the Royal Society of Tropical Medicine And Hygiene 87(5), 593-5.
  • Shimazaki, Y., Inoue, S., Takahashi, C., Gamoh, K., Etol, M., Kamiyama, T., Makie, H., 2003. Immune response to Japanese Rabies Vaccine in Domestic Dogs. Journal of Veterinary Medicine B 50, 95-98.
  • Sugiyama, M., Yos hiki, R., Tatsuno, Y., Hiraga, S., Boh, O., Gamoh, K., Minamoto, N., 1997. A new Competitive Enzyme-Linked Immunosorbent Assay demonstrates adequate immune levels to rabies virus in compulsorily vaccinated Japanese domestic dogs. Clinical and Diagnostic Laboratory Immunology 4, 727-730.
  • WHO, 1992. Expert Committee on Rabies 8th Report.
  • WHO Technical Report Series No:824. http:// www. who. int/rab ies /en/WHO_Exp ert_Committee 8th report.pdf (Accessed 10/12/2010).
  • WHO, 1998. Oral Immunization of dogs against rabies. Report of the sixth WHO consultation. Zoonotic Diseases Division of Emerging and other Communicable Disease Surveillance and Control (EMC), Geneva, Switzerland.
  • WHO, 2004. Expert Consultation on Rabies First Report. WHO Technical Report Series No:931. http://whqlibdoc.who.rnt/trs/WHO_TRS_931_eng.pdf (Accessed 10/12/2010).
  • WHO, 2006. Temperature sensivity of vaccines. Quality, Safety and Standarts (QSS) team of the Department of Immunization, Vaccines and Biologicals, Geneva, Switzerland.
  • WHO, 2008. Rabies Bulletin Europe. Volume 32. Distribution of Rabies in Europe. Summary of rabies cases in Europe 3rd quarter. http://www.who-rabies-bulletin.org/Journal/Archive/Bulletin_2008_4.pdf (Accessed 10/12/2010).
  • WHO, 2009. Rabies Bulletin Europe. Volume 33. Comparison of the reporting quarter (I/2009) with the same quarter of the previous year (I/2008). http ://www.who-rabiesbulletin.org/Joumal/Archive/Bulletin_2009_1pdf (Accessed 10/12/2010).
  • WHO, 2010. Rabies. http ://www.who.int/mediacentre/factsheets/fs___99/ en/ (Accessed 10/12/2010).
  • Verthelyi, D., Klinman, D.M., 2000. Sex hormones correlate with the activity of cytokine-secreting cells in vitro. Immunology 100, 384-390.
Year 2011, Volume: 37 Issue: 2, 97 - 106, 01.11.2011

Abstract

References

  • ATAG, 2003. Australian Technical Advisory Group on Immunisation of the Australian Government Department of Health and Ageing. The Australian Immunisation Handbook. 8th edition. Commonwealth of Australia Department of Health and Ageing, Australia, pp. 1-10
  • Bozkaya, Ç., 2000. Ankara'da soğuk zincir donanımında sahip ecza depolarında aşı ve diğer biyolojik maddelerin soğuk zincir ko şullarına uygun olarak saklama durumlarının değerlendirilmesi. Master of Science Thesis, University of Hacettepe. Institute of Medical Science, Ankara.
  • Cliquet, F., Verifier, Y., Sagne, L., Aubert, M., Schereffer, J.L., Selve, M., Wasniewski, M., Servat, A., 2003. Neutralising antibody titration in 25,000 sera of dogs and cats vaccinated against rabies in France, in the framework of the new regulations that offer an alternative to quarantine. Revue Scientifique et Technique Office International des Epizooties 22, 857-866.
  • Delgado, S., Carmenes, P., 1997. Immune response following a vaccination campaign against rabies in dogs from northwestern Spain. Preventive Veterinary Medicine 31, 257-261.
  • Doymaz, M.Z.,2000. Medikal Viroloji. Nobel Tıp Press, Istanbul.
  • E C , 2003. Regulation of the European Parliament and of the Council on the animal health requirements applicable to the non-commercial movement of pet animals and amending Council Directive 92/65/EEC (EC) No 998/2003. (Accessed 10/12/2010). http ://ec.europa.eu/food/animal/liveanimals/pets/annex2c reg998 03 en.pdf Fooks, A.R., Mcelhinney, L.M., Brookes, S.M., Johnson, N., Keene, V., Parsons, G., Soldan, A., 2002. Rabies antibody testing and the UK Pet Travel Scheme. Veterinary Record 150, 428-430.
  • Hogenesch, H., Thompson, S., Dunham, A., Cedilia, M., Hayek, M., 2003. Effect of age on immune parameters and the immune response of dogs to vaccines: a cross-sectional study. Veterinary Immunology and Immunopathology 94, 113-121.
  • Johnson, H.N., 1965. Rabies Virus. In Horsfall FL and Tamm I. Viral and Rickettsial Infections of Man. 4th edition. J. B. Lippincott Company, Philadelphia, pp.814-835.
  • Kasempimolporn, S., Sichanasai, B., Saengseesom, W., Puempumpanich, S., Chartraporn, S., Sitprija, V., 2007. Prevalence of rabies virus infection and rabies antibody in stray dogs: A survey in Bangkok, Thailand. Preventive Veterinary Medicine 78, 325-332.
  • Kıyan, A., 2001. Istanbul İli Küçükçekmece İlçesi Sağlık Grup Başkanlığı Bölgesinde Soğuk Zincir. Thesis for Expertise, Istanbul University Faculty of Medicine İstanbul.
  • Lala, M.K., Lala, K.R., 2003. Thermostability of vacinnes. Indian Pediatrics 40, 311-319.
  • Lloyd, J. , 2000. Technologies for vaccine delivery in the 21st century. Switzerland Technologies Team of the Department of Vaccines and Biologicals, Geneva.
  • Mansfield, K.L., Burr, P.D., Snodgrass, D.R., Sayers, R., Fooks, A.R., 2004. Factors affecting the serological response of dogs and cats to rabies vaccination. Veterinary Record 154, 423-426.
  • MARA, 2010. Ministry of Agriculture and Rural Affairs. Contestation Program with Animal Diseases and Injurious 2010/02. Ministry of Agriculture and Rural Affairs General Directorate of Protection and Control, http ://www.kkgm. gov.tr/ mev/genelge .html (Erişim 10/12/2010)
  • Ozdamar, K., 1999. Statisitcs Data Analysis with Package Program SPSS, I. Kaan Press, Eskişehir, pp.62.
  • Rupprecht, C.E.; Hanlon, C.A., Hemachudha, T., 2002. Rabies re-examined. The Lancet Infection Disease 2, 327-343.
  • Sage, G, Khawplod, P., Wilde, H., Lobaugh, C., Hemachudha, T., Tepsumethanon, W., Lumlertdaecha B., 1993. Immune response to rabies vaccine in Alaskan dogs: failure to achieve a consistently protective antibody response. Transactions of the Royal Society of Tropical Medicine And Hygiene 87(5), 593-5.
  • Shimazaki, Y., Inoue, S., Takahashi, C., Gamoh, K., Etol, M., Kamiyama, T., Makie, H., 2003. Immune response to Japanese Rabies Vaccine in Domestic Dogs. Journal of Veterinary Medicine B 50, 95-98.
  • Sugiyama, M., Yos hiki, R., Tatsuno, Y., Hiraga, S., Boh, O., Gamoh, K., Minamoto, N., 1997. A new Competitive Enzyme-Linked Immunosorbent Assay demonstrates adequate immune levels to rabies virus in compulsorily vaccinated Japanese domestic dogs. Clinical and Diagnostic Laboratory Immunology 4, 727-730.
  • WHO, 1992. Expert Committee on Rabies 8th Report.
  • WHO Technical Report Series No:824. http:// www. who. int/rab ies /en/WHO_Exp ert_Committee 8th report.pdf (Accessed 10/12/2010).
  • WHO, 1998. Oral Immunization of dogs against rabies. Report of the sixth WHO consultation. Zoonotic Diseases Division of Emerging and other Communicable Disease Surveillance and Control (EMC), Geneva, Switzerland.
  • WHO, 2004. Expert Consultation on Rabies First Report. WHO Technical Report Series No:931. http://whqlibdoc.who.rnt/trs/WHO_TRS_931_eng.pdf (Accessed 10/12/2010).
  • WHO, 2006. Temperature sensivity of vaccines. Quality, Safety and Standarts (QSS) team of the Department of Immunization, Vaccines and Biologicals, Geneva, Switzerland.
  • WHO, 2008. Rabies Bulletin Europe. Volume 32. Distribution of Rabies in Europe. Summary of rabies cases in Europe 3rd quarter. http://www.who-rabies-bulletin.org/Journal/Archive/Bulletin_2008_4.pdf (Accessed 10/12/2010).
  • WHO, 2009. Rabies Bulletin Europe. Volume 33. Comparison of the reporting quarter (I/2009) with the same quarter of the previous year (I/2008). http ://www.who-rabiesbulletin.org/Joumal/Archive/Bulletin_2009_1pdf (Accessed 10/12/2010).
  • WHO, 2010. Rabies. http ://www.who.int/mediacentre/factsheets/fs___99/ en/ (Accessed 10/12/2010).
  • Verthelyi, D., Klinman, D.M., 2000. Sex hormones correlate with the activity of cytokine-secreting cells in vitro. Immunology 100, 384-390.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Aliye Gazi This is me

Seyyal Ak

Publication Date November 1, 2011
Published in Issue Year 2011 Volume: 37 Issue: 2

Cite

APA Gazi, A., & Ak, S. (2011). Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 37(2), 97-106. https://doi.org/10.16988/iuvfd.07530
AMA Gazi A, Ak S. Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus. iuvfd. November 2011;37(2):97-106. doi:10.16988/iuvfd.07530
Chicago Gazi, Aliye, and Seyyal Ak. “Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs Against Rabies Virus”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 37, no. 2 (November 2011): 97-106. https://doi.org/10.16988/iuvfd.07530.
EndNote Gazi A, Ak S (November 1, 2011) Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 37 2 97–106.
IEEE A. Gazi and S. Ak, “Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus”, iuvfd, vol. 37, no. 2, pp. 97–106, 2011, doi: 10.16988/iuvfd.07530.
ISNAD Gazi, Aliye - Ak, Seyyal. “Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs Against Rabies Virus”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 37/2 (November 2011), 97-106. https://doi.org/10.16988/iuvfd.07530.
JAMA Gazi A, Ak S. Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus. iuvfd. 2011;37:97–106.
MLA Gazi, Aliye and Seyyal Ak. “Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs Against Rabies Virus”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 37, no. 2, 2011, pp. 97-106, doi:10.16988/iuvfd.07530.
Vancouver Gazi A, Ak S. Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus. iuvfd. 2011;37(2):97-106.