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HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS

Year 2003, Volume: 29 Issue: 2, 203 - 211, 13.05.2013

Utku Bakırel Tülay Bakırel Güven Kaşıkçı Erman Or

Abstract

Summary

This study was carried out in order to determine the possible effects of methimazole upon the invasive parameters of the cardiac functions of the dogs. Ten dogs was used in this study. In the begining of the study and 8 weeks after orally administration of methimazole (30 mg/kg), serum T4, T3 and TSH concentrations and contraction (LVCT) and relaxation times (LVRT), systolic (LVSP) and diastolic pressures (LVDP) of left ventricle were measured. After weeks, serum T4, T3 concentrations. LVSP and LVDP were significantly decreased, while TSH concentrations was significantly increased. However, increasing in the LVCT was no important. No difference was observed between the LVRT of healty and hypothroid dogs. The results of the present study suggested that methimazole caused significant changes in serum thyroid hormone concentrations as well as the left ventricle pressures of dogs.

Key words: Hemodynamic, Hypothyroidism, Dog, Methimazole.

 

KÖPEKLERE METHIMAZOI UYGULANMASIYLA OLUŞAN HİPOTİROİDİZMİN HEMODİNAMİK ETKİLERİ

Özet

Bu araştırma, methimazol'ün ötroid köpeklerin kardiak fonksiyonlarının invaziv parametreleri üzerine olası etkilerinin saptanması amacıyla yapıldı. Çalışmada on adet ötroid köpek kullanıldı. Methimazol (30 mg/kg) uygulanmasından önce ve sekiz balla sonra serum T4,T3 ve TSH konsantrasyonları ve sol ventrikülün sistolik (LVSP) ve diyastolik basınçları (LVDP), kasılma (LVCT) ve gevşeme zamanı (LVRT) ölçüldü. Sekiz haftanın sonunda TSH konsantrasyonu önemli oranda artarken, serum T4 ve Ta konsantrasyonları, LVSP ve LVDP önemli bir şekilde azaldı. Bununla birlikte LVCT deki artış önemli değildi. Kontrol ve hipotroid köpeklerin LVRT arasında farklılık gözlenmedi. Elde edilen veriler, methimazol'ün köpeklerde serum triod horman konsantrasyonlarının yanısıra sol ventrikül basınçlarında da önemli değişikliklere neden olduğunu gösterdi.

Anahtar kelimeler: Hemodinamik, Hipotiroidizm, Köpek, Methimazol.

Keywords

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Year 2003, Volume: 29 Issue: 2, 203 - 211, 13.05.2013

Utku Bakırel Tülay Bakırel Güven Kaşıkçı Erman Or

Abstract

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Details

Primary Language Turkish
Journal Section Research Article
Authors

Utku Bakırel

Tülay Bakırel

Güven Kaşıkçı

Erman Or

Publication Date May 13, 2013
Published in Issue Year 2003 Volume: 29 Issue: 2

Cite

APA Bakırel, U., Bakırel, T., Kaşıkçı, G., Or, E. (2013). HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 29(2), 203-211. https://doi.org/10.16988/iuvfd.66290
AMA Bakırel U, Bakırel T, Kaşıkçı G, Or E. HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS. iuvfd. May 2013;29(2):203-211. doi:10.16988/iuvfd.66290
Chicago Bakırel, Utku, Tülay Bakırel, Güven Kaşıkçı, and Erman Or. “HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 29, no. 2 (May 2013): 203-11. https://doi.org/10.16988/iuvfd.66290.
EndNote Bakırel U, Bakırel T, Kaşıkçı G, Or E (May 1, 2013) HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 29 2 203–211.
IEEE U. Bakırel, T. Bakırel, G. Kaşıkçı, and E. Or, “HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS”, iuvfd, vol. 29, no. 2, pp. 203–211, 2013, doi: 10.16988/iuvfd.66290.
ISNAD Bakırel, Utku et al. “HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 29/2 (May 2013), 203-211. https://doi.org/10.16988/iuvfd.66290.
JAMA Bakırel U, Bakırel T, Kaşıkçı G, Or E. HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS. iuvfd. 2013;29:203–211.
MLA Bakırel, Utku et al. “HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 29, no. 2, 2013, pp. 203-11, doi:10.16988/iuvfd.66290.
Vancouver Bakırel U, Bakırel T, Kaşıkçı G, Or E. HEMODYNAMIC EFFECTS OF HYPOTHYROIDISM INDUCED BY ADMINISTRATION OF METHIMAZOLE TO EUTHYROID DOGS. iuvfd. 2013;29(2):203-11.