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Identification of Allele Frequency of Factor XI Deficiency (FXID) in Holstein Cows Reared in Thrace District of Turkey

Year 2016, Volume: 42 Issue: 2, 190 - 193, 04.07.2016

Kozet Avanus Ahmet Altınel

https://doi.org/10.16988/iuvfd.2016.53309

Abstract

Factor XI (FXI) is a protein that plays a key role in plasma coagulation. Factor XI Deficiency (FXID) is an autosomal recessive disease caused by an insertion into exon 12 of FXI gene. The aim of this study is to determine the allele frequency of Factor XI Deficiency (FXID) in Holstein cows reared in Thrace region of Turkey. Blood samples of 287 Holstein cows were used for DNA isolation. Amplification of FXI gene was followed by the evaluation of PCR products with visualization on 2% agarose gel electrophoresis. FXID mutant allele was not observed in any of the samples used in this study. In conclusion, none of the Holstein cows were neither affected nor carriers for FXID among all analysed Holstein cows reared in Thrace region of Turkey.

References

  • Akyüz, B., Sarıözkan, S., Bayram, D., 2012. Factor XI mutation in normally fertile and repeat breeding Holstein cows in the Middle Anatolian region of Turkey: A financial approach. Animal Production Science 52, 1042-1045.
  • Akyüz, B., 2013. Türkiye’deki iki farklı işletmede yetiştirilen Holştayn boğalarda Faktör XI Yetmezliği (FXID) allel frekansının belirlenmesi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 19, 127-131.
  • Brush, P.J., Anderson, P.H., Gunning, R.F., 1987. Identification of factor XI deficiency in Holstein-Friesian cattle in Britain. Veterinary Record 121, 14-17.
  • Čítek, J., Řehout, V., Hanusová, L., Vrabcová, P., 2008. Sporadic incidence of factor XI deficiency in Holstein cattle. Journal of the Science of Food and Agriculture 88, 2069-2072.
  • Gentile, A., Testoni, S., 2006. Inherited disorders of cattle: a selected review. Slovenian Veterinary Research 43, 17- 29.
  • Gentry, P.A., Black, W.D., 1980. Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle. Journal of Dairy Science 63, 616- 620.
  • Gentry, P.A., Ross, M.L., 1993. Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Canadian Veterinary Journal 57, 242-247.
  • Ghanem, M.E., Nishibori, M., Nakao, T., Nakatani, K., Akita, M., 2005. Factor XI mutation in a Holstein cow with repeat breeding in Japan. Journal of Veterinary Medical Science 67, 713-715.
  • Ghanem, M.E., Nishibori, M., 2009. Genetic description of factor XI deficiency in Holstein semen in Western Japan. Reproduction in Domestic Animals 44, 792-796.
  • Gurgul, A., Rubis, D., Slota, E., 2009. Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle. Journal of Applied Genetics 50, 149-152.
  • Karslı, T., Şahin, E., Karslı, B.A., Alkan, S., Balcıoğlu, M.S., 2011. Identification of alleles for factor XI (FXID) and uridine monophosphate synthase (DUMPS) deficiencies in Holstein cows reared in Antalya. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 17, 503-505.
  • Kociba, G.D., Ratnoff, O.D., Loeb, W.F., Wall, R.L., Heider, L.E., 1969. Bovine thromboplastin antecedent (factor XI) deficiency. Journal of Laboratory and Clinical Medicine 74, 37-41.
  • Korkmaz Ağaoğlu, Ö., Ağaoğlu, A.R., Saatci, M., 2015. Estimating allele frequencies of some hereditary diseases in Holstein cattle reared in Burdur Province, Turkey. Turkish Journal of Veterinary and Animal Sciences 39, 338-342.
  • Liptrap, R.M., Gentry, P.A., Ross, M.L., Cummings, E., 1995. Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency. Veterinary Research Communications 19, 463-671.
  • Marron, B.M., Robinson, J.L., Gentry, P.A., Beever, J.E., 2004. Identification of a mutation associated with factor XI deficiency in Holstein cattle. Animal Genetics 35, 454- 456.
  • Meydan, H., Yildiz, M.A., Özdil, F., Gedik, Y., Özbeyaz, C., 2009. Identification of factor XI deficiency in Holstein cattle in Turkey. Acta Veterinaria Scandinavica 51, 5.
  • Mukhopadhyaya, P.N., Jha, M., Muraleedharan, P., Gupta, R.R., Rathod, R.N., Mehta, H.H., Khoda, V.K., 2006. Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency. Genetics & Molecular Research 5, 323-332.
  • Oner, Y., Keskin, A., Elmaci, C., 2010. Identification of BLAD, DUMPS, Citrullinaemia and Factor XI deficiency in Holstein cattle in Turkey. Asian Journal of Animal and Veterinary Advances 5, 60-65.
  • Patel, R.K., Soni, K.J., Chauhan, J.B., Singh, K.M., Rao, K.R.S.S., 2007. Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis. Genetics and Molecular Biology 30, 580-583.
  • Windsor, P.A., Agerholm, J.S., 2009. Inherited diseases of Australian Holstein-Friesian cattle. Australian Veterinary Journal 87, 193-199.
  • Yaşar, G., Akyüz, B., 2012. Kayseri civarında yetiştirilen Holştayn ineklerde kalıtsal faktör XI yetmezliği geninin allel frekansının belirlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 9, 7-12.
  • Zhang, K., Wang, Z., Wang, Q., 2010. Detecting FXI Deficiency in Holstein cattle using PCR analysis. Journal of Agricultural Science and Technology 11, 109-111.

Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi

Year 2016, Volume: 42 Issue: 2, 190 - 193, 04.07.2016

Kozet Avanus Ahmet Altınel

https://doi.org/10.16988/iuvfd.2016.53309

Abstract

Faktör XI (FXI) plazma pıhtılaşmasında görev alan önemli bir proteindir. FXI eksikliği (FXID) FXI geninin 12. ekzonunda meydana gelen bir insersiyon sonucu oluşan otozomal resesif bir hastalıktır. Bu çalışmanın amacı Türkiye’nin Trakya bölgesinde yetiştirilen Holştayn ineklerde FXID allel frekansının belirlenmesidir. DNA izolasyonu 287 Holştayn ineğine ait kan örneklerinden yapılmıştır. FXI geninin polimeraz zincir reaksiyonu (PZR) ile çoğaltılmasını takiben oluşan ürünler %2’lik agaroz jel elektroforezi ile görüntülenerek değerlendirilmiştir. Örneklerin hiçbirinde FXID mutant alleli gözlenmemiştir. Sonuç olarak Trakya bölgesinde taranan tüm Holştayn ineklerde FXID’den etkilenen veya taşıyıcısı olan inek tespit edilmemiştir.

Keywords

Holştayn Trakya FXID genetik hastalık

References

  • Akyüz, B., Sarıözkan, S., Bayram, D., 2012. Factor XI mutation in normally fertile and repeat breeding Holstein cows in the Middle Anatolian region of Turkey: A financial approach. Animal Production Science 52, 1042-1045.
  • Akyüz, B., 2013. Türkiye’deki iki farklı işletmede yetiştirilen Holştayn boğalarda Faktör XI Yetmezliği (FXID) allel frekansının belirlenmesi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 19, 127-131.
  • Brush, P.J., Anderson, P.H., Gunning, R.F., 1987. Identification of factor XI deficiency in Holstein-Friesian cattle in Britain. Veterinary Record 121, 14-17.
  • Čítek, J., Řehout, V., Hanusová, L., Vrabcová, P., 2008. Sporadic incidence of factor XI deficiency in Holstein cattle. Journal of the Science of Food and Agriculture 88, 2069-2072.
  • Gentile, A., Testoni, S., 2006. Inherited disorders of cattle: a selected review. Slovenian Veterinary Research 43, 17- 29.
  • Gentry, P.A., Black, W.D., 1980. Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle. Journal of Dairy Science 63, 616- 620.
  • Gentry, P.A., Ross, M.L., 1993. Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Canadian Veterinary Journal 57, 242-247.
  • Ghanem, M.E., Nishibori, M., Nakao, T., Nakatani, K., Akita, M., 2005. Factor XI mutation in a Holstein cow with repeat breeding in Japan. Journal of Veterinary Medical Science 67, 713-715.
  • Ghanem, M.E., Nishibori, M., 2009. Genetic description of factor XI deficiency in Holstein semen in Western Japan. Reproduction in Domestic Animals 44, 792-796.
  • Gurgul, A., Rubis, D., Slota, E., 2009. Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle. Journal of Applied Genetics 50, 149-152.
  • Karslı, T., Şahin, E., Karslı, B.A., Alkan, S., Balcıoğlu, M.S., 2011. Identification of alleles for factor XI (FXID) and uridine monophosphate synthase (DUMPS) deficiencies in Holstein cows reared in Antalya. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 17, 503-505.
  • Kociba, G.D., Ratnoff, O.D., Loeb, W.F., Wall, R.L., Heider, L.E., 1969. Bovine thromboplastin antecedent (factor XI) deficiency. Journal of Laboratory and Clinical Medicine 74, 37-41.
  • Korkmaz Ağaoğlu, Ö., Ağaoğlu, A.R., Saatci, M., 2015. Estimating allele frequencies of some hereditary diseases in Holstein cattle reared in Burdur Province, Turkey. Turkish Journal of Veterinary and Animal Sciences 39, 338-342.
  • Liptrap, R.M., Gentry, P.A., Ross, M.L., Cummings, E., 1995. Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency. Veterinary Research Communications 19, 463-671.
  • Marron, B.M., Robinson, J.L., Gentry, P.A., Beever, J.E., 2004. Identification of a mutation associated with factor XI deficiency in Holstein cattle. Animal Genetics 35, 454- 456.
  • Meydan, H., Yildiz, M.A., Özdil, F., Gedik, Y., Özbeyaz, C., 2009. Identification of factor XI deficiency in Holstein cattle in Turkey. Acta Veterinaria Scandinavica 51, 5.
  • Mukhopadhyaya, P.N., Jha, M., Muraleedharan, P., Gupta, R.R., Rathod, R.N., Mehta, H.H., Khoda, V.K., 2006. Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency. Genetics & Molecular Research 5, 323-332.
  • Oner, Y., Keskin, A., Elmaci, C., 2010. Identification of BLAD, DUMPS, Citrullinaemia and Factor XI deficiency in Holstein cattle in Turkey. Asian Journal of Animal and Veterinary Advances 5, 60-65.
  • Patel, R.K., Soni, K.J., Chauhan, J.B., Singh, K.M., Rao, K.R.S.S., 2007. Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis. Genetics and Molecular Biology 30, 580-583.
  • Windsor, P.A., Agerholm, J.S., 2009. Inherited diseases of Australian Holstein-Friesian cattle. Australian Veterinary Journal 87, 193-199.
  • Yaşar, G., Akyüz, B., 2012. Kayseri civarında yetiştirilen Holştayn ineklerde kalıtsal faktör XI yetmezliği geninin allel frekansının belirlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 9, 7-12.
  • Zhang, K., Wang, Z., Wang, Q., 2010. Detecting FXI Deficiency in Holstein cattle using PCR analysis. Journal of Agricultural Science and Technology 11, 109-111.
There are 22 citations in total.

Details

Subjects Health Care Administration
Journal Section Short Communication
Authors

Kozet Avanus

Ahmet Altınel This is me

Publication Date July 4, 2016
Published in Issue Year 2016 Volume: 42 Issue: 2

Cite

APA Avanus, K., & Altınel, A. (2016). Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 42(2), 190-193. https://doi.org/10.16988/iuvfd.2016.53309
AMA Avanus K, Altınel A. Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi. iuvfd. June 2016;42(2):190-193. doi:10.16988/iuvfd.2016.53309
Chicago Avanus, Kozet, and Ahmet Altınel. “Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42, no. 2 (June 2016): 190-93. https://doi.org/10.16988/iuvfd.2016.53309.
EndNote Avanus K, Altınel A (June 1, 2016) Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42 2 190–193.
IEEE K. Avanus and A. Altınel, “Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi”, iuvfd, vol. 42, no. 2, pp. 190–193, 2016, doi: 10.16988/iuvfd.2016.53309.
ISNAD Avanus, Kozet - Altınel, Ahmet. “Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42/2 (June 2016), 190-193. https://doi.org/10.16988/iuvfd.2016.53309.
JAMA Avanus K, Altınel A. Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi. iuvfd. 2016;42:190–193.
MLA Avanus, Kozet and Ahmet Altınel. “Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 42, no. 2, 2016, pp. 190-3, doi:10.16988/iuvfd.2016.53309.
Vancouver Avanus K, Altınel A. Türkiye’de Trakya Yöresinde Yetiştirilen Holştayn İneklerde Faktör XI Yetmezliği (FXID) Allel Frekansının Belirlenmesi. iuvfd. 2016;42(2):190-3.