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Ovarian Granulosa Cell Tumor and Complex Mammary Adenocarcinoma in a Bitch

Year 2016, Volume: 42 Issue: 2, 194 - 197, 04.07.2016
https://doi.org/10.16988/iuvfd.2016.65695

Abstract

An 11-year old boxer bitch was presented to the Department of Obstetrics and Gynaecology clinic for routine ovariohysterectomy and coincidentally an ovarial mass was detected which was diagnosed as granulosa cell tumor (GCT) in pathologic examinations. Blood sample was collected for hormonal analysis during this surgery in which estrogen concentration was under the reference range, progesterone concentration was normal. Mammary gland enlargements were also detected on the dog during initial examination with no other sign regarding to vulvar discharge/swelling. One month later following ovariohysterectomy, the dog was presented again for bilateral total mastectomy. Tumoral tissues were diagnosed as complex adenocarcinoma grade II, histopathologically. The possible interaction and promotional effect of GCT on the development of mammary tumors (MTs) is not yet fully understood. Regarding to serum estrogen and progesterone concentrations were not above the reference ranges suggest us GCT did not secrete hormones yet. In conclusion, this case is important as it reports the possible effect of GCT on the development of MTs and suggests not to ignore this disease in a dog with mammary tumours.

References

  • Ball, R.L., Birchard, S.J., May, L.R., Threlfall, W.R., Young, G.S., 2010. Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007). Journal of American Veterinary Medical Association 236, 548-553.
  • de las Mulas, J.M., Millan, Y., Dios, R., 2005. A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog. Veterinary Pathology 42, 200-212.
  • Diez-Bru, N., Garcia-Real, I., Martinez, E.M., Rollan, E., Mayenco, A., Llorens, P., 1998. Ultrasonographic appearance of ovarian tumors in 10 dogs. Veterinary Radiology & Ultrasound 39, 226-233.
  • Feldman, E.C., Nelson, R.W., 1987. Canine female reproduction. In: Feldman, E.C., Nelson, R.W. (Eds.), Canine and Feline Endocrinology and Reproduction. WB Saunders, pp. 399-480.
  • Genuth, S.M., 1998. The reproductive glands. In, Berne, R.M., Levy, M.N. (Eds.), Physiology. Mosby, Inc, St. Louis, pp. 965-1013.
  • Geraldes, M., Gartner, F., Schmitt, F., 2000. Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mamamry glands and spontaneous mammary tumours. Veterinary Record 146, 403-406.
  • Johnston, S.D., Root Kustritz, M.V., Olson, P.N.S. 2001. Disorders of the canine ovary. Ovarian remnant syndrome. In: Canine and Feline Theriogenology, W.B. Saunders, Philadelphia, pp. 199-200.
  • Kennedy, P.C., Cullen, M., Ewards, J.F., Goldschmidt, M.H., Larsen, S., Munson, L., Nielsen, S., 1998. Histological classification of tumors of the genital system of domestic animals. In: Kennedy P.C. (Ed.), World Helath Organization, International histological classification of tumors of domestic animals. American Registry of Pathology, Washington D.C., pp. 24-27.
  • Kennedy, P.C., Miller, R.B., 1993. The female genital system. In: Jubb, K.V.F., Kennedy, P.C., Palmer, N. (Eds.): Pathology of Domestic Animals. Academic Press, San Diego, pp. 349-470.
  • Klein, M.K., 2001. Tumours of the female reproductive system: In: Withrow, S.J., MacEwen, E.G., (Eds.), Small Animal Clinical Oncology. W.B. Saunders, pp. 445-454.
  • Lavalle, G.E., Bertagnolli, A.C., Tavares, W.L., Cassali, G.D., 2009. Cox-2 expression in canine mammary carcinomas: correlation with angiogenesis and overall survival. Veterinary Pathology 46, 1275-1280.
  • Pluhar, G.E., Memon, M.A., Wheaton, L.G., 1995. Granulosa cell tumour in an ovariohysterectomized dog. Journal of American Veterinary Medical Association 207, 10631065.
  • Rivera, P., Melin, M., Biagi, T., Fall, T., Haggstrom, J., LindbladToh, K., von Euler, H., 2009. Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Research 69, 8770-8774.
  • Rutteman, G.R., 1990. Hormones and mamamry tumour disease in the female dog: an update. In vivo, 4, 33-40.
  • Schaefers-Okkens, A.C., Ettinger, S.N., Feldman, E.C., 2005. Estrous cycle and breeding management of the healthy bitch. In, Fathman, L. (Eds.), Textbook of Veterinary Internal Medicine. Elsevier-Saunders, St-Louis, pp. 1640-1649.
  • Sleeckx, N., de Rooster, H., Veldhuis Koreze, E.J.B., Van Ginneken, C., Van Brantegen, L., 2011. Canine Mammary tumours, an overview. Reproduction in Domestic Animals 46, 1121-1131.
  • Sorenmo, K.U., Shofer, F.S., Goldschmidt, M.H., 2000. Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma. Journal of Veterinary Internal Medicine 14, 266-270.
  • Spoor, M.S., Flesner, B.K., Trzil, J.E., Whitney, M.S., Shaw, D.P., Selting, K.A., 2014. What is your diagnosis? Intraabdominal mass in a female spayed dog. Veterinary Clinical Pathology 43, 109-110.
  • Tavasoli, A., Solati, A., 2011. Granulosa cell tumor of the ovary in dog: case report from Tehran. Journal of Cell and Animal Biology 5, 66-68.
  • Tunca, R., Serin, G., Epikmen, E.T., Aydoğan, A., Avcı, H., 2011. İki Köpekte Granüloza Hücre Tümörü. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 17, 675-678.
  • Zanghi, A., Catone, G., Marino, G., Quartuccio, M., Nicotina, P.A., 2007. Endometrial polypoid adenomyomatosis in a bitch with ovarian granulosa cell tumour and pyometra. Journal of Comparative Pathology 136, 8386.

Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu

Year 2016, Volume: 42 Issue: 2, 194 - 197, 04.07.2016
https://doi.org/10.16988/iuvfd.2016.65695

Abstract

On bir yaşlı boxer köpek rutin kısırlaştırma için Doğum ve Jinekoloji Anabilim Dalı kliniğine getirildi ve histopatolojik olarak granüloza hücre tümörü (GHT) olarak teşhis edilen bir kitle tesadüfen saptandı. Ameliyat esnasında hormonal analiz için kan örneği toplandı ve bu kan örneğinde östrojen konsantrasyonu referans değerlerin altında, progesteron konsantrasyonu ise normal olarak tespit edildi. Köpeğin ilk muayenesi esnasında meme bezlerinde genişlemeler tespit edildi ve herhangi bir vulvar akıntı/şişlik tespit edilmedi. Kısırlaştırmayı takiben bir ay sonra köpek total bilateral mastektomi için kliniğimize tekrar getirildi. Histopatolojik olarak tümörel kitleler kompleks adenokarsinom tip II olarak tespit edildi. Köpekte hem GHT hem de meme tümörü aynı anda bulunduğu halde, GHT’nün köpek meme tümörü gelişimi üzerine etkisi tam anlamıyla anlaşılamadı. Serum östrojen ve progesteron konsantrasyonlarının referans değerlerden yüksek olmamasına bağlı olarak, GHT’nün henüz hormon salgılamadığı düşünüldü. Sonuç olarak, bu olgu GHT’nün köpek meme tümörünün gelişimi üzerine olası etkisinden bahsetmesinden ve köpekte meme tümörü varlığında bu hastalığın göz ardı edilmemesi gerekliliğini önermesinden dolayı önemlidir.

 

References

  • Ball, R.L., Birchard, S.J., May, L.R., Threlfall, W.R., Young, G.S., 2010. Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007). Journal of American Veterinary Medical Association 236, 548-553.
  • de las Mulas, J.M., Millan, Y., Dios, R., 2005. A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog. Veterinary Pathology 42, 200-212.
  • Diez-Bru, N., Garcia-Real, I., Martinez, E.M., Rollan, E., Mayenco, A., Llorens, P., 1998. Ultrasonographic appearance of ovarian tumors in 10 dogs. Veterinary Radiology & Ultrasound 39, 226-233.
  • Feldman, E.C., Nelson, R.W., 1987. Canine female reproduction. In: Feldman, E.C., Nelson, R.W. (Eds.), Canine and Feline Endocrinology and Reproduction. WB Saunders, pp. 399-480.
  • Genuth, S.M., 1998. The reproductive glands. In, Berne, R.M., Levy, M.N. (Eds.), Physiology. Mosby, Inc, St. Louis, pp. 965-1013.
  • Geraldes, M., Gartner, F., Schmitt, F., 2000. Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mamamry glands and spontaneous mammary tumours. Veterinary Record 146, 403-406.
  • Johnston, S.D., Root Kustritz, M.V., Olson, P.N.S. 2001. Disorders of the canine ovary. Ovarian remnant syndrome. In: Canine and Feline Theriogenology, W.B. Saunders, Philadelphia, pp. 199-200.
  • Kennedy, P.C., Cullen, M., Ewards, J.F., Goldschmidt, M.H., Larsen, S., Munson, L., Nielsen, S., 1998. Histological classification of tumors of the genital system of domestic animals. In: Kennedy P.C. (Ed.), World Helath Organization, International histological classification of tumors of domestic animals. American Registry of Pathology, Washington D.C., pp. 24-27.
  • Kennedy, P.C., Miller, R.B., 1993. The female genital system. In: Jubb, K.V.F., Kennedy, P.C., Palmer, N. (Eds.): Pathology of Domestic Animals. Academic Press, San Diego, pp. 349-470.
  • Klein, M.K., 2001. Tumours of the female reproductive system: In: Withrow, S.J., MacEwen, E.G., (Eds.), Small Animal Clinical Oncology. W.B. Saunders, pp. 445-454.
  • Lavalle, G.E., Bertagnolli, A.C., Tavares, W.L., Cassali, G.D., 2009. Cox-2 expression in canine mammary carcinomas: correlation with angiogenesis and overall survival. Veterinary Pathology 46, 1275-1280.
  • Pluhar, G.E., Memon, M.A., Wheaton, L.G., 1995. Granulosa cell tumour in an ovariohysterectomized dog. Journal of American Veterinary Medical Association 207, 10631065.
  • Rivera, P., Melin, M., Biagi, T., Fall, T., Haggstrom, J., LindbladToh, K., von Euler, H., 2009. Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Research 69, 8770-8774.
  • Rutteman, G.R., 1990. Hormones and mamamry tumour disease in the female dog: an update. In vivo, 4, 33-40.
  • Schaefers-Okkens, A.C., Ettinger, S.N., Feldman, E.C., 2005. Estrous cycle and breeding management of the healthy bitch. In, Fathman, L. (Eds.), Textbook of Veterinary Internal Medicine. Elsevier-Saunders, St-Louis, pp. 1640-1649.
  • Sleeckx, N., de Rooster, H., Veldhuis Koreze, E.J.B., Van Ginneken, C., Van Brantegen, L., 2011. Canine Mammary tumours, an overview. Reproduction in Domestic Animals 46, 1121-1131.
  • Sorenmo, K.U., Shofer, F.S., Goldschmidt, M.H., 2000. Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma. Journal of Veterinary Internal Medicine 14, 266-270.
  • Spoor, M.S., Flesner, B.K., Trzil, J.E., Whitney, M.S., Shaw, D.P., Selting, K.A., 2014. What is your diagnosis? Intraabdominal mass in a female spayed dog. Veterinary Clinical Pathology 43, 109-110.
  • Tavasoli, A., Solati, A., 2011. Granulosa cell tumor of the ovary in dog: case report from Tehran. Journal of Cell and Animal Biology 5, 66-68.
  • Tunca, R., Serin, G., Epikmen, E.T., Aydoğan, A., Avcı, H., 2011. İki Köpekte Granüloza Hücre Tümörü. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 17, 675-678.
  • Zanghi, A., Catone, G., Marino, G., Quartuccio, M., Nicotina, P.A., 2007. Endometrial polypoid adenomyomatosis in a bitch with ovarian granulosa cell tumour and pyometra. Journal of Comparative Pathology 136, 8386.
There are 21 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Report
Authors

Ahmet Sabuncu This is me

Sinem Özlem Enginler

Kıvılcım Sönmez

Seçkin Serdar Arun This is me

Publication Date July 4, 2016
Published in Issue Year 2016 Volume: 42 Issue: 2

Cite

APA Sabuncu, A., Enginler, S. Ö., Sönmez, K., Arun, S. S. (2016). Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 42(2), 194-197. https://doi.org/10.16988/iuvfd.2016.65695
AMA Sabuncu A, Enginler SÖ, Sönmez K, Arun SS. Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu. iuvfd. June 2016;42(2):194-197. doi:10.16988/iuvfd.2016.65695
Chicago Sabuncu, Ahmet, Sinem Özlem Enginler, Kıvılcım Sönmez, and Seçkin Serdar Arun. “Bir Köpekte Ovarian Granüloza Hücre Tümörü Ve Kompleks Meme Adenokarsinomu”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42, no. 2 (June 2016): 194-97. https://doi.org/10.16988/iuvfd.2016.65695.
EndNote Sabuncu A, Enginler SÖ, Sönmez K, Arun SS (June 1, 2016) Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42 2 194–197.
IEEE A. Sabuncu, S. Ö. Enginler, K. Sönmez, and S. S. Arun, “Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu”, iuvfd, vol. 42, no. 2, pp. 194–197, 2016, doi: 10.16988/iuvfd.2016.65695.
ISNAD Sabuncu, Ahmet et al. “Bir Köpekte Ovarian Granüloza Hücre Tümörü Ve Kompleks Meme Adenokarsinomu”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 42/2 (June 2016), 194-197. https://doi.org/10.16988/iuvfd.2016.65695.
JAMA Sabuncu A, Enginler SÖ, Sönmez K, Arun SS. Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu. iuvfd. 2016;42:194–197.
MLA Sabuncu, Ahmet et al. “Bir Köpekte Ovarian Granüloza Hücre Tümörü Ve Kompleks Meme Adenokarsinomu”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 42, no. 2, 2016, pp. 194-7, doi:10.16988/iuvfd.2016.65695.
Vancouver Sabuncu A, Enginler SÖ, Sönmez K, Arun SS. Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme Adenokarsinomu. iuvfd. 2016;42(2):194-7.