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ZEYTİNDE BULUNAN POLİFENOLLER VE FARMAKOLOJİK ETKİLERİ

Year 2023, Volume: 1 Issue: 1, 19 - 25, 02.01.2024

Abstract

Akdeniz tarzı beslenmenin vazgeçilmezi olan zeytinin sunmuş olduğu faydaların başında antioksidan etkisi vardır. İçerdiği zengin fenolik bileşikler sayesinde oksidatif stresin azaltılmasında önemli bir rol oynamaktadır. Bu sayede diğer rahatsızlıkların ve hastalıkların önlenmesinde ya da tedavisinde ayrıca fayda sağladığı söylenebilir. Zeytin ve yaprağından elde edilen ektstraktının yanın da içerdiği önemli fenolik bileşikler arasında olan Oleuropein ve Hidroksitirozol pek çok çalışmaya konu olmuştur. Bunlar arasında en çok antioksidan, antidiyabetik, antimikrobiyal, anti-inflamatuar, antihipertansif ve antikanser etkiler araştırılmıştır. Zeytin zengin biyoaktif bileşikleri ile hem bireysel hem de sinerjistik olarak çeşitli farmakolojik etkiler göstermektedir. Zeytinde en bol bulunan ve en aktif madde olan Oleuropeinin enzimlerin inhibe, modüle ve/veya regüle edilmesinde baş rolü oynadığı söylenebilir.

References

  • [1] Stefani, M.; Rigacci, S. Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation. BioFactors 2014, 40, 482–493.
  • [2] Temiz, MA., Temur, A. Olive (Olea europaea L.) leaf extract boosts antioxıdant status and attenuates hepatic and pancreatic changes in diabetic rats. Applied Biological Research 21(1): 10-19; (2019) 2019.
  • [3] Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., Stefani, M. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 2021, 10, 1044-1067.
  • [4] Temiz, MA., Temur, A. The effect of olive leaf extract on digestive enzyme inhibition and insulin production in streptozotocin-induced diabetic rats. Ankara Üniv Vet Fak Derg, 66, 163-169, 2019.
  • [5] Temiz, MA., Temur, A. Effect of solvent variation on polyphenolic profile and total phenolic content of olive leaf extract. YYU J AGR SCI, 2017, 27(1): 43-50.
  • [6] AlShaal, S., Karabet, F., Daghestani, M. Determination of the Antioxidant Properties of the Syrian Olive Leaves Extracts and Isolation Oleuropein by HPLC Techniques. Anal. Bioanal. Chem. Res., 2019, 6,(1), 97-110.
  • [7] Hao, J.; Shen, W.; Yu, G.; Jia, H.; Li, X.; Feng, Z.; Wang, Y.; Weber, P.; Wertz, K.; Sharman, E. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. J. Nutr. Biochem. 2010, 21, 634–644.
  • [8] Cumaoğlu, A.; Ari, N.; Kartal, M.; Karasu, Ç. Polyphenolic extracts from Olea europea L. protect against cytokine-induced β-cell damage through maintenance of redox homeostasis. Rejuv. Res. 2011, 14, 325–334.
  • [9] World Health Organization. WHO Estimates of the Global Burden of Foodborne Diseases, 1st ed.; WHO Library Cataloguing-in-Publication Data, Ed.; World Health Organization: Geneva, Switzerland, 2015; ISBN 978-92-4-156516-5.
  • [10] da Silva Farias, A.; Akutsu, R.; Botelho, R.; Zandonadi, R. Good Practices in Home Kitchens: Construction and Validation of an Instrument for Household Food-Borne Disease Assessment and Prevention. Int. J. Environ. Res. Public Health 2019, 16, 1005.
  • [11] Liu, Y.; McKeever, L.C.; Malik, N.S.A. Assessment of the antimicrobial activity of olive leaf extract against foodborne bacterial pathogens. Front. Microbiol. 2017, 8, 113.
  • [12] Erdohan, Ö., Turhan, K.N. Olive leaf extract and usage for development of antimicrobial food packaging. A. Méndez-Vilas (Ed.). Science against microbial pathogens: communicating current research and technological advances, Formatex: Norristown, PA, USA, 2012; pp. 1094–1101.
  • [13] Fayez, N., Khalil, W. Abdel‑Sattar, E., Abdel‑Fattah, A.M. In vitro and in vivo assessment of the anti‑inflammatory activity of olive leaf extract in rats. Inflammopharmacology, 2023, 31:1529–1538.
  • [14] Fernández-Prior, Á., Bermúdez-Oria, A., Millán-Linares, M., Fernández-Bolaños, J., Espejo-Calvo, J.A., Rodríguez-Gutiérrez, G. Anti-Inflammatory and Antioxidant Activity of Hydroxytyrosol and 3,4-Dihydroxyphenyglycol Purified from Table Olive Effluents. Foods, 2021, 10, 227-241.
  • [15] Qabaha, K., AL-Rimawi, F., Qasem, A., Naser, S.A. Oleuropein is responsible for the major anti-ınflammatory effects of olive leaf extract. Journal of medicinal food, 2018, 21(3): 302-305.
  • [16] El, S.N., Karakaya, S., Olive tree (Olea europaea) leaves: potential beneficial effects on human health. Nutr Rev 2009: 67(11); 632-8.
  • [17] Hoffman, R.; Gerber, M. Food processing and Mediterranean diet. Nutrients 2015, 7, 7925–7964.
  • [18] Guash-Ferré, M.; Merino, J.; Sun, Q.; Fito, M.; Salas-Salvado, J. Dietary polyphenols, Mediterranean diet, prediabetes and type 2 diabetes: A narrative review of the evidence. Oxidative Med. Cell. Long. 2017.
  • [19] Susalit, E.; Agus, N.; Effendi, I.; Tjandrawinata, R.R.; Nofiarny, D.; Perrinjaquet-Moccetti, T.; Verbruggen, M. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Compar ison with Captopril. Phytomedicine: Int. J. Phytother. Phytopharm. 2011, 18, 251–258.
  • [20] Lockyer, S.; Rowland, I.; Spencer, J.P.; Yaqoob, P.; Stonehouse, W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomised controlled trial. Eur. J. Nutr. 2017, 56, 1421–1432.
  • [21] Hermans, M.P., Lempereur, P., Salembier, J.P., Maes, N., Albert, A., Jansen, O., Pincemail, J. Supplementation effect of a combination of olive (Olea europea L.) leaf and fruit extracts in the clinical management of hypertension and metabolic syndrome. Antioxidants 2020, 9, 872-887.
  • [22] Hanahan, D., Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646–674.
  • [23] Whibley, C., Pharoah, P. D. P., and Hollstein, M. (2009) p53 polymorphisms: cancer implications. Nat. Rev. Cancer 9, 95–107.
  • [24] Ferraiuolo, M., Di Agostino, S., Blandino, G., and Strano, S. (2016) Oncogenic intra-p53 family member interactions in human cancers. Front. Oncol. 6, 77.
  • [25] Liu, P., Cheng, H., Roberts, T. M., and Zhao, J. J. (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8, 627–644.
  • [26] Chimento, A., Casaburi, I., Rosano, C., Avena, P., Luca, A. d., et al. (2014) Oleuropein and hydroxytyrosol activate GPER/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. Mol. Nutr. Food Res. 58, 478–489.
  • [27] Shamshoum, H., Vlavcheski, F., Tsiani, E. Anticancer effects of oleuropein. International Union of Biochemistry and Molecular Biology, Biofactors, 2017, 8;43(4): 517-528.
  • [28] Goldsmith, C. D., Vuong, Q. V., Sadeqzadeh, E., Stathopoulos, C. E., and Roach, P. D. (2015) Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells. Mol. Basel Switz. 20, 12992–13004.
  • [29] Mijatovic, S.A.; Timotijevic, G.S.; Miljkovic, D.M.; Radovic, J.M.; Maksimovic-Ivanic, D.D.; Dekanski, D.P.; Stosic-Grujicic, S.D. Multiple antimelanoma potential of dry olive leaf extract. Int. J. Cancer 2011, 128, 1955–1965.
  • [30] Luo, C., Li, Y., Wang, H., Cui, Y., Feng, Z., et al. (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to antiproliferation and apoptosis on human prostate cancer cells. Curr. Cancer Drug Targets 13, 625–639.
  • [31] Goulas, V., Exarchou, V., Troganis, A. N., Psomiadou, E., Fotsis, T., et al. (2009) Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol. Nutr. Food Res. 53, 600–608.
  • [32] Corona, G., Deiana, M., Incani, A., Vauzour, D., and Dessi, M. A. (2009) Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Mol. Nutr. Food Res. 53, 897–903.

POLYPHENOLS IN OLIVES AND THEIR PHARMACOLOGICAL EFFECTS

Year 2023, Volume: 1 Issue: 1, 19 - 25, 02.01.2024

Abstract

One of the benefits of olives, which are indispensable for the Mediterranean style diet, is their antioxidant effect. It plays an important role in reducing oxidative stress thanks to the rich phenolic compounds it contains. In this way, it can be said that it is also beneficial in the prevention or treatment of other disorders and diseases. Oleuropein and Hydroxytyrosol, which are among the important phenolic compounds contained in the extract obtained from olives and leaves, have been the subject of many studies. Among these, antioxidant, antidiabetic, antimicrobial, anti-inflammatory, antihypertensive and anticancer effects have been most investigated. Olives show various pharmacological effects, both individually and synergistically, with their rich bioactive compounds. It can be said that Oleuropein, the most abundant and active substance in olives, plays a leading role in inhibiting, modulating and/or regulating enzymes.

References

  • [1] Stefani, M.; Rigacci, S. Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation. BioFactors 2014, 40, 482–493.
  • [2] Temiz, MA., Temur, A. Olive (Olea europaea L.) leaf extract boosts antioxıdant status and attenuates hepatic and pancreatic changes in diabetic rats. Applied Biological Research 21(1): 10-19; (2019) 2019.
  • [3] Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., Stefani, M. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 2021, 10, 1044-1067.
  • [4] Temiz, MA., Temur, A. The effect of olive leaf extract on digestive enzyme inhibition and insulin production in streptozotocin-induced diabetic rats. Ankara Üniv Vet Fak Derg, 66, 163-169, 2019.
  • [5] Temiz, MA., Temur, A. Effect of solvent variation on polyphenolic profile and total phenolic content of olive leaf extract. YYU J AGR SCI, 2017, 27(1): 43-50.
  • [6] AlShaal, S., Karabet, F., Daghestani, M. Determination of the Antioxidant Properties of the Syrian Olive Leaves Extracts and Isolation Oleuropein by HPLC Techniques. Anal. Bioanal. Chem. Res., 2019, 6,(1), 97-110.
  • [7] Hao, J.; Shen, W.; Yu, G.; Jia, H.; Li, X.; Feng, Z.; Wang, Y.; Weber, P.; Wertz, K.; Sharman, E. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. J. Nutr. Biochem. 2010, 21, 634–644.
  • [8] Cumaoğlu, A.; Ari, N.; Kartal, M.; Karasu, Ç. Polyphenolic extracts from Olea europea L. protect against cytokine-induced β-cell damage through maintenance of redox homeostasis. Rejuv. Res. 2011, 14, 325–334.
  • [9] World Health Organization. WHO Estimates of the Global Burden of Foodborne Diseases, 1st ed.; WHO Library Cataloguing-in-Publication Data, Ed.; World Health Organization: Geneva, Switzerland, 2015; ISBN 978-92-4-156516-5.
  • [10] da Silva Farias, A.; Akutsu, R.; Botelho, R.; Zandonadi, R. Good Practices in Home Kitchens: Construction and Validation of an Instrument for Household Food-Borne Disease Assessment and Prevention. Int. J. Environ. Res. Public Health 2019, 16, 1005.
  • [11] Liu, Y.; McKeever, L.C.; Malik, N.S.A. Assessment of the antimicrobial activity of olive leaf extract against foodborne bacterial pathogens. Front. Microbiol. 2017, 8, 113.
  • [12] Erdohan, Ö., Turhan, K.N. Olive leaf extract and usage for development of antimicrobial food packaging. A. Méndez-Vilas (Ed.). Science against microbial pathogens: communicating current research and technological advances, Formatex: Norristown, PA, USA, 2012; pp. 1094–1101.
  • [13] Fayez, N., Khalil, W. Abdel‑Sattar, E., Abdel‑Fattah, A.M. In vitro and in vivo assessment of the anti‑inflammatory activity of olive leaf extract in rats. Inflammopharmacology, 2023, 31:1529–1538.
  • [14] Fernández-Prior, Á., Bermúdez-Oria, A., Millán-Linares, M., Fernández-Bolaños, J., Espejo-Calvo, J.A., Rodríguez-Gutiérrez, G. Anti-Inflammatory and Antioxidant Activity of Hydroxytyrosol and 3,4-Dihydroxyphenyglycol Purified from Table Olive Effluents. Foods, 2021, 10, 227-241.
  • [15] Qabaha, K., AL-Rimawi, F., Qasem, A., Naser, S.A. Oleuropein is responsible for the major anti-ınflammatory effects of olive leaf extract. Journal of medicinal food, 2018, 21(3): 302-305.
  • [16] El, S.N., Karakaya, S., Olive tree (Olea europaea) leaves: potential beneficial effects on human health. Nutr Rev 2009: 67(11); 632-8.
  • [17] Hoffman, R.; Gerber, M. Food processing and Mediterranean diet. Nutrients 2015, 7, 7925–7964.
  • [18] Guash-Ferré, M.; Merino, J.; Sun, Q.; Fito, M.; Salas-Salvado, J. Dietary polyphenols, Mediterranean diet, prediabetes and type 2 diabetes: A narrative review of the evidence. Oxidative Med. Cell. Long. 2017.
  • [19] Susalit, E.; Agus, N.; Effendi, I.; Tjandrawinata, R.R.; Nofiarny, D.; Perrinjaquet-Moccetti, T.; Verbruggen, M. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Compar ison with Captopril. Phytomedicine: Int. J. Phytother. Phytopharm. 2011, 18, 251–258.
  • [20] Lockyer, S.; Rowland, I.; Spencer, J.P.; Yaqoob, P.; Stonehouse, W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomised controlled trial. Eur. J. Nutr. 2017, 56, 1421–1432.
  • [21] Hermans, M.P., Lempereur, P., Salembier, J.P., Maes, N., Albert, A., Jansen, O., Pincemail, J. Supplementation effect of a combination of olive (Olea europea L.) leaf and fruit extracts in the clinical management of hypertension and metabolic syndrome. Antioxidants 2020, 9, 872-887.
  • [22] Hanahan, D., Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646–674.
  • [23] Whibley, C., Pharoah, P. D. P., and Hollstein, M. (2009) p53 polymorphisms: cancer implications. Nat. Rev. Cancer 9, 95–107.
  • [24] Ferraiuolo, M., Di Agostino, S., Blandino, G., and Strano, S. (2016) Oncogenic intra-p53 family member interactions in human cancers. Front. Oncol. 6, 77.
  • [25] Liu, P., Cheng, H., Roberts, T. M., and Zhao, J. J. (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8, 627–644.
  • [26] Chimento, A., Casaburi, I., Rosano, C., Avena, P., Luca, A. d., et al. (2014) Oleuropein and hydroxytyrosol activate GPER/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. Mol. Nutr. Food Res. 58, 478–489.
  • [27] Shamshoum, H., Vlavcheski, F., Tsiani, E. Anticancer effects of oleuropein. International Union of Biochemistry and Molecular Biology, Biofactors, 2017, 8;43(4): 517-528.
  • [28] Goldsmith, C. D., Vuong, Q. V., Sadeqzadeh, E., Stathopoulos, C. E., and Roach, P. D. (2015) Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells. Mol. Basel Switz. 20, 12992–13004.
  • [29] Mijatovic, S.A.; Timotijevic, G.S.; Miljkovic, D.M.; Radovic, J.M.; Maksimovic-Ivanic, D.D.; Dekanski, D.P.; Stosic-Grujicic, S.D. Multiple antimelanoma potential of dry olive leaf extract. Int. J. Cancer 2011, 128, 1955–1965.
  • [30] Luo, C., Li, Y., Wang, H., Cui, Y., Feng, Z., et al. (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to antiproliferation and apoptosis on human prostate cancer cells. Curr. Cancer Drug Targets 13, 625–639.
  • [31] Goulas, V., Exarchou, V., Troganis, A. N., Psomiadou, E., Fotsis, T., et al. (2009) Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol. Nutr. Food Res. 53, 600–608.
  • [32] Corona, G., Deiana, M., Incani, A., Vauzour, D., and Dessi, M. A. (2009) Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Mol. Nutr. Food Res. 53, 897–903.
There are 32 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Research Article
Authors

Mehmet Ali Temiz 0000-0002-4680-3023

Publication Date January 2, 2024
Submission Date December 30, 2023
Acceptance Date January 2, 2024
Published in Issue Year 2023 Volume: 1 Issue: 1

Cite

Vancouver Temiz MA. ZEYTİNDE BULUNAN POLİFENOLLER VE FARMAKOLOJİK ETKİLERİ. JAFE. 2024;1(1):19-25.