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Periodontal hastalık ve D vitamini ilişkisi

Year 2022, Volume: 3 Issue: 4, 381 - 385, 26.12.2022

Tolga Aydoğan Meltem Hendek Ebru Olgun

https://doi.org/10.47582/jompac.1208868

Abstract

D vitamini, insan deri hücreleri tarafından sentezlenen veya diyet yoluyla tüketilen immünomodülatör, antienflamatuar, antiproliferatif etkilere sahip bir hormondur. D vitamini eksikliği kemik mineral yoğunluğunun azalmasına, osteoporoza, periodontal hastalıkların ilerlemesine ve çene kemiğinde rezorpsiyon oluşmasına neden olarak, periodontal hastalık riskini artırabilir. Ayrıca D vitamini kemik metabolizması, alveolar kemik rezorpsiyonu ve diş kayıplarının önlenmesi için de önemlidir. Diş eti epitel hücrelerinin antibakteriyel savunmasını arttırır ve dişeti enflamasyonunu azaltır, periodontal cerrahi sonrası postoperatif yara iyileşmesini hızlandırır ve periodontolojide profilaksi olarak kullanılan önemli bir takviyedir. Bu derlemenin amacı, periodontal hastalıkta D vitamininin rolünü vurgulamaktır.

Keywords

periodontitis D vitamini 25(OH)D3 Periodontal tedavi 1.25(OH)2D3

References

  • Tatakis D, Kumar N, Purnima S. Etiology and pathogenesis of periodontal diseases. Dental Clinics 2005; 49: 491-516.
  • Taubman Martin A, Kawai T, Han X. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol 2007; 34: 367-9.
  • Löe H, Theilade E, Jensen SB. Experımental gingivitis in man. J Periodontol 1965; 36: 177-87.
  • Lindhe J, Hamp Se, Loe H. Experimental periodontitis in the beagle dog. Int Dent J 1973; 23: 432-7.
  • Johnson RJ, Matthews JL, Stone MJ, Hurt WC, Newman JT. Immunopathology of periodontal disease: immunologic profiles in periodontitis and juvenile periodontitis. J Periodontol 1980; 51: 705-12.
  • Nisengard RJ, Newman MN, Myers D, Horikoshi A. Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). J Periodontol 1980; 51: 30-3.
  • Kornman Kenneth S. Mapping the pathogenesis of periodontitis: a new look. J Periodontol 2008; 79: 1560-8.
  • Kaseda R, Hosojima M, Sato H, Saito A. Role of megalin and cubilin in the metabolism of vitamin D3. Therapeutic Apheresis and Dialysis 2011; 15: 14-7.
  • Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Rheumatic Dis Clin 2012; 38: 1-11.
  • Holick MF. Vitamin D deficiency. N Engl JMed 2007; 357: 266- 81.
  • Hossein-Nezhad A, Holick MF. Vitamin D for health: a global perspective. In: Mayo Clinic Proceedings. Elsevier, 2013. p. 720-755.
  • Ribeiro LSF, Araujo NS, Zilli Vieira CL, Dos Santos JN, Cury PR. Impact of serum vitamin D levels on periodontal healing outcomes: a preliminary cohort study. Int J Dent Hygiene 2022. https://doi.org/10.1111/idh.12619
  • James WPT. 22nd Marabou Symposium: the changing faces of vitamin D. Nutr Rev 2008; 66(suppl_2): S286-S290.
  • Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003; 77: 204-10.
  • TEMD. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu, TEMD 2022.
  • Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Reports 2008; 10: 110-7.
  • Nakashyan V, Tipton DA, Karydis A, Livada R, Stein SH. Effect of 1, 25 (OH) 2D3 and 20(OH)D3 on interleukin-1β-stimulated interleukin-6 and-8 production by human gingival fibroblasts. J Periodontal Res 2017; 52: 832-41.
  • Wang Q, Zhou X, Jiang J, et al. Relationship between serum 25-hydroxyvitamin D3 levels and severity of chronic periodontitis in type 2 diabetic patients: a cross-sectional study. J Periodontal Res 2019; 54: 671-80.
  • Hossein-Nezhad A, Spira A and Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PloS One 2013; 8: e58725.
  • Liu K, Meng H, Hou J. Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. PLoS One 2012; 7: e52053.
  • Andrukhova Olena, Slavic S, Smorodchenko A, et al. FGF 23 regulates renal sodium handling and blood pressure. EMBO molecular medicine, 2014, 6.6: 744-59.
  • Prattichizzo F, De Nigris V, La Sala L, Procopio AD, Olivieri F, Ceriello A. “Inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes. Oxidative Medicine and Cellular Longevity 2016, 2016.
  • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Review of Pathology 2010; 5: 99.
  • Elenkova M, Tipton DA, Karydis A, Stein SH. Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE. J Periodont Res 2019; 54: 154-63.
  • Hu X, Niu L, Ma C, et al. Calcitriol decreases live Porphyromonas gingivalis internalized into epithelial cells and monocytes by promoting autophagy. J Periodontol 2020; 91: 956-66.
  • Han J, Cheng C, Zhu Z, et al. Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. J Oral Sci 2019; 61: 53-60.
  • Oh C, Kim HJ, Kim HM. Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α. J Periodont Implant Sci 2019; 49: 270-86.
  • Chen LL, Li H, Zhang PP, Wang SM. Association between vitamin D receptor polymorphisms and periodontitis: A meta- analysis. J Periodontol 2012; 83: 1095-103.
  • Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Calcium and the risk for periodontal disease. J Periodontol 2000; 71: 1057-66.
  • Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr 2004; 80: 108-13.
  • Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr 2005; 82: 575-80.
  • Millen AE, Hovey KM, LaMonte MJ, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J Periodontol 2013; 84: 1243-56.
  • Garcia MN, Hildebolt CF, Miley DD, et al. One-year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol 2011, 82: 25-32.
  • Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD. Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. J Periodontol 2012; 83: 1183-91.
  • Gao W, Tang H, Wang D, Zhou X, Song Y, Wang Z. Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial. J Periodontal Res 2020; 55: 354-62.
  • Liu H, Guo J, Wang L, et al. Distinctive anabolic roles of 1, 25-dihydroxyvitamin D3 and parathyroid hormone in teeth and mandible versus long bones. J Endocrinol 2009; 203: 203-13.
  • Gong A, Chen J, Wu J, et al. 1, 25-dihydroxyvitamin D deficiency accelerates alveolar bone loss independent of aging and extracellular calcium and phosphorus. J Periodontol 2018; 89: 983-94.
  • Abu-Amer, Y. NF-κB signaling and bone resorption. Osteoporosis Int 2013; 24: 2377-86.
  • Lin, Zongtao; Li, Wei. The roles of vitamin D and its analogs in inflammatory diseases. Current Topics in Medicinal Chemistry 2016; 16: 1242-61.
  • Zanetti M, Harris SS, Dawson-Hughes B. Ability of vitamin D to reduce inflammation in adults without acute illness. Nutr Rev 2014; 72: 95-8.
  • Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001; 111: 452-6.
  • Jimenez M, Giovannucci E, Kaye EK, Joshipura KJ, Dietrich T. Predicted vitamin D status and incidence of tooth loss and periodontitis. Public Health Nutr 2014; 17: 844-52.
  • Millen AE, Andrews CA, LaMonte MJ, et al. Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study. J Periodontol 2014; 85: 1321-32.
  • Pavlesen S, Mai X, Wactawski‐Wende J, et al. Vitamin D status and tooth loss in postmenopausal females: the Buffalo osteoporosis and periodontal disease (OsteoPerio) study. J Periodontol 2016; 87: 852-63.
  • Schulze‐Späte U, Dietrich T, Wu C, Wang K, Hasturk H, Dibart S. Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation–a randomized, double-blind, placebo-controlled clinical investigation. Clin Oral Implants Res 2016; 27: 701-6.
  • Hiremath VP, Rao CB, Naik V, Prasad KV. Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health Prev Dent 2013; 11: 61-9.
  • Bashutski JD, Eber RM, Kinney JS, et al. The impact of vitamin D status on periodontal surgery outcomes. J Dent Res 2011; 90: 1007-12.
  • Zhou X, Zhang P, Wang Q, et al. 25-hydroxyvitamin D3 alleviates experimental periodontitis via promoting expression of cathelicidin in mice with type 2 diabetic mellitus. J Nutritional Sci Vitaminol 2018; 64: 307-15.
  • Machado V, Lobo S, Proença L, Mendes JJ, Botelho J. Vitamin D and periodontitis: A systematic review and meta- analysis. Nutrients 2020; 12: 2177.
  • Joergensen C, Gall MA, Schmedes A, Tarnow L, Parving HH, Rossing P. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care 2010; 33: 2238-43.
  • Joergensen C, Hovind P, Schmedes A, Parving HH, Rossing P. Vitamin D levels, microvascular complications, and mortality in type 1 diabetes. Diabetes Care 2011; 34: 1081-5.
  • Antonoglou G, Knuuttila M, Niemelä O, et al. Serum 1, 25 (OH) D level increases after elimination of periodontal inflammation in T1DM subjects. J Clin Endocrinol Metabol 2013; 98: 3999-4005.
  • Antonoglou GN, Knuuttila M, Niemelä O, et al. Serum parathyroid hormone and active vitamin D in chronic periodontitis. J Clin Periodontol 2015 42: 726-32.

Relationship between periodontal disease and vitamin D

Year 2022, Volume: 3 Issue: 4, 381 - 385, 26.12.2022

Tolga Aydoğan Meltem Hendek Ebru Olgun

https://doi.org/10.47582/jompac.1208868

Abstract

Vitamin D is a hormone synthesized by human skin cells or consumed through diet with immunomodulatory, anti-inflammatory, and antiproliferative effects. Vitamin D deficiency may increase the risk of periodontal disease by causing decreased bone mineral density, osteoporosis, progression of periodontal diseases, and resorption of the jawbone. In addition, vitamin D is important for bone metabolism, alveolar bone resorption, and the prevention of tooth loss. It increases the antibacterial defense of gingival epithelial cells, reduces gingival inflammation, accelerates postoperative wound healing after periodontal surgery, and is a key supplement functioning as a prophylaxis in periodontology. The present review study aims to highlight the role of vitamin D in periodontal disease.

Keywords

Periodontititis vitamin D 25(OH)D3 periodontal treatment 1.25(OH)2D3

References

  • Tatakis D, Kumar N, Purnima S. Etiology and pathogenesis of periodontal diseases. Dental Clinics 2005; 49: 491-516.
  • Taubman Martin A, Kawai T, Han X. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol 2007; 34: 367-9.
  • Löe H, Theilade E, Jensen SB. Experımental gingivitis in man. J Periodontol 1965; 36: 177-87.
  • Lindhe J, Hamp Se, Loe H. Experimental periodontitis in the beagle dog. Int Dent J 1973; 23: 432-7.
  • Johnson RJ, Matthews JL, Stone MJ, Hurt WC, Newman JT. Immunopathology of periodontal disease: immunologic profiles in periodontitis and juvenile periodontitis. J Periodontol 1980; 51: 705-12.
  • Nisengard RJ, Newman MN, Myers D, Horikoshi A. Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). J Periodontol 1980; 51: 30-3.
  • Kornman Kenneth S. Mapping the pathogenesis of periodontitis: a new look. J Periodontol 2008; 79: 1560-8.
  • Kaseda R, Hosojima M, Sato H, Saito A. Role of megalin and cubilin in the metabolism of vitamin D3. Therapeutic Apheresis and Dialysis 2011; 15: 14-7.
  • Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Rheumatic Dis Clin 2012; 38: 1-11.
  • Holick MF. Vitamin D deficiency. N Engl JMed 2007; 357: 266- 81.
  • Hossein-Nezhad A, Holick MF. Vitamin D for health: a global perspective. In: Mayo Clinic Proceedings. Elsevier, 2013. p. 720-755.
  • Ribeiro LSF, Araujo NS, Zilli Vieira CL, Dos Santos JN, Cury PR. Impact of serum vitamin D levels on periodontal healing outcomes: a preliminary cohort study. Int J Dent Hygiene 2022. https://doi.org/10.1111/idh.12619
  • James WPT. 22nd Marabou Symposium: the changing faces of vitamin D. Nutr Rev 2008; 66(suppl_2): S286-S290.
  • Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003; 77: 204-10.
  • TEMD. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu, TEMD 2022.
  • Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Reports 2008; 10: 110-7.
  • Nakashyan V, Tipton DA, Karydis A, Livada R, Stein SH. Effect of 1, 25 (OH) 2D3 and 20(OH)D3 on interleukin-1β-stimulated interleukin-6 and-8 production by human gingival fibroblasts. J Periodontal Res 2017; 52: 832-41.
  • Wang Q, Zhou X, Jiang J, et al. Relationship between serum 25-hydroxyvitamin D3 levels and severity of chronic periodontitis in type 2 diabetic patients: a cross-sectional study. J Periodontal Res 2019; 54: 671-80.
  • Hossein-Nezhad A, Spira A and Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PloS One 2013; 8: e58725.
  • Liu K, Meng H, Hou J. Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. PLoS One 2012; 7: e52053.
  • Andrukhova Olena, Slavic S, Smorodchenko A, et al. FGF 23 regulates renal sodium handling and blood pressure. EMBO molecular medicine, 2014, 6.6: 744-59.
  • Prattichizzo F, De Nigris V, La Sala L, Procopio AD, Olivieri F, Ceriello A. “Inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes. Oxidative Medicine and Cellular Longevity 2016, 2016.
  • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Review of Pathology 2010; 5: 99.
  • Elenkova M, Tipton DA, Karydis A, Stein SH. Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE. J Periodont Res 2019; 54: 154-63.
  • Hu X, Niu L, Ma C, et al. Calcitriol decreases live Porphyromonas gingivalis internalized into epithelial cells and monocytes by promoting autophagy. J Periodontol 2020; 91: 956-66.
  • Han J, Cheng C, Zhu Z, et al. Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. J Oral Sci 2019; 61: 53-60.
  • Oh C, Kim HJ, Kim HM. Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α. J Periodont Implant Sci 2019; 49: 270-86.
  • Chen LL, Li H, Zhang PP, Wang SM. Association between vitamin D receptor polymorphisms and periodontitis: A meta- analysis. J Periodontol 2012; 83: 1095-103.
  • Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Calcium and the risk for periodontal disease. J Periodontol 2000; 71: 1057-66.
  • Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr 2004; 80: 108-13.
  • Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr 2005; 82: 575-80.
  • Millen AE, Hovey KM, LaMonte MJ, et al. Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J Periodontol 2013; 84: 1243-56.
  • Garcia MN, Hildebolt CF, Miley DD, et al. One-year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol 2011, 82: 25-32.
  • Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD. Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. J Periodontol 2012; 83: 1183-91.
  • Gao W, Tang H, Wang D, Zhou X, Song Y, Wang Z. Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial. J Periodontal Res 2020; 55: 354-62.
  • Liu H, Guo J, Wang L, et al. Distinctive anabolic roles of 1, 25-dihydroxyvitamin D3 and parathyroid hormone in teeth and mandible versus long bones. J Endocrinol 2009; 203: 203-13.
  • Gong A, Chen J, Wu J, et al. 1, 25-dihydroxyvitamin D deficiency accelerates alveolar bone loss independent of aging and extracellular calcium and phosphorus. J Periodontol 2018; 89: 983-94.
  • Abu-Amer, Y. NF-κB signaling and bone resorption. Osteoporosis Int 2013; 24: 2377-86.
  • Lin, Zongtao; Li, Wei. The roles of vitamin D and its analogs in inflammatory diseases. Current Topics in Medicinal Chemistry 2016; 16: 1242-61.
  • Zanetti M, Harris SS, Dawson-Hughes B. Ability of vitamin D to reduce inflammation in adults without acute illness. Nutr Rev 2014; 72: 95-8.
  • Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001; 111: 452-6.
  • Jimenez M, Giovannucci E, Kaye EK, Joshipura KJ, Dietrich T. Predicted vitamin D status and incidence of tooth loss and periodontitis. Public Health Nutr 2014; 17: 844-52.
  • Millen AE, Andrews CA, LaMonte MJ, et al. Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study. J Periodontol 2014; 85: 1321-32.
  • Pavlesen S, Mai X, Wactawski‐Wende J, et al. Vitamin D status and tooth loss in postmenopausal females: the Buffalo osteoporosis and periodontal disease (OsteoPerio) study. J Periodontol 2016; 87: 852-63.
  • Schulze‐Späte U, Dietrich T, Wu C, Wang K, Hasturk H, Dibart S. Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation–a randomized, double-blind, placebo-controlled clinical investigation. Clin Oral Implants Res 2016; 27: 701-6.
  • Hiremath VP, Rao CB, Naik V, Prasad KV. Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health Prev Dent 2013; 11: 61-9.
  • Bashutski JD, Eber RM, Kinney JS, et al. The impact of vitamin D status on periodontal surgery outcomes. J Dent Res 2011; 90: 1007-12.
  • Zhou X, Zhang P, Wang Q, et al. 25-hydroxyvitamin D3 alleviates experimental periodontitis via promoting expression of cathelicidin in mice with type 2 diabetic mellitus. J Nutritional Sci Vitaminol 2018; 64: 307-15.
  • Machado V, Lobo S, Proença L, Mendes JJ, Botelho J. Vitamin D and periodontitis: A systematic review and meta- analysis. Nutrients 2020; 12: 2177.
  • Joergensen C, Gall MA, Schmedes A, Tarnow L, Parving HH, Rossing P. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care 2010; 33: 2238-43.
  • Joergensen C, Hovind P, Schmedes A, Parving HH, Rossing P. Vitamin D levels, microvascular complications, and mortality in type 1 diabetes. Diabetes Care 2011; 34: 1081-5.
  • Antonoglou G, Knuuttila M, Niemelä O, et al. Serum 1, 25 (OH) D level increases after elimination of periodontal inflammation in T1DM subjects. J Clin Endocrinol Metabol 2013; 98: 3999-4005.
  • Antonoglou GN, Knuuttila M, Niemelä O, et al. Serum parathyroid hormone and active vitamin D in chronic periodontitis. J Clin Periodontol 2015 42: 726-32.
There are 53 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review [en] Derleme [tr]
Authors

Tolga Aydoğan 0000-0001-7876-5503

Meltem Hendek 0000-0003-1518-4159

Ebru Olgun 0000-0001-7298-8589

Publication Date December 26, 2022
Published in Issue Year 2022 Volume: 3 Issue: 4

Cite

AMA Aydoğan T, Hendek M, Olgun E. Relationship between periodontal disease and vitamin D. J Med Palliat Care / JOMPAC / jompac. December 2022;3(4):381-385. doi:10.47582/jompac.1208868
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