2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery

Fatih Mehmet Emen; Ruken Esra Demirdöğen; Göktürk Avşar; Derya Kılıç

doi:10.18596/jotcsa.467177

Research Article

Year 2019, Volume: 6 Issue: 1, 29 - 34, 15.05.2019

Fatih Mehmet Emen Ruken Esra Demirdöğen Göktürk Avşar Derya Kılıç

https://doi.org/10.18596/jotcsa.467177

Cited By: 1

Abstract

References

1. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem.Mater. 2001; 13(2):308-11.
2. Wang, S. Ordered mesoporous materials for drug delivery. Micropor. Mesopor. Mat. 2009; 117(1-2): 1-9.
3. Zeng W. Qian XF. Yin J. Zhu ZK. The drug delivery system of MCM-41 materials via co-condensation synthesis. Mater. Chem. Phys. 2006; 97(2-3): 437-41.
4. Sousa A. Souza KC. Sousa EMB. Mesoporous silica/apatite nanocomposite: special synthesis route to control local drug delivery. Acta. Biomater. 2008; 4(3): 671-9.
5. Qu F. Zhu G. Huang S. Li S. Sun J. Zhang D. Qiu S.Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica. Micropor. Mesopor. Mat. 2006; 92(1-3): 1-9.
6. Mal NK. Fujiwara M. Tanaka Y. Taguchi T. Matsukata M. Photo-switched storage and release of guest molecules in the pore void of coumarin-modified MCM-41. Chem. Mater. 2003; 15(17): 3385-34.
7. Aiello R. Cavallaro G. Giammona G. Pasqua L. Pierro P. Testa F. Mesoporous silicate as matrix for drug delivery systems of non-steroidal antinflammatory drugs. In Studies in Surface Science and Catalysis Elsevier. 2002; 142:1165-72.
8. Cavallaro G. Pierro P. Palumbo FS. Testa F. Pasqua L. Aiello R. Drug delivery devices based on mesoporous silicate. Drug. Deliv. 2004; 11(1):41-6.
9. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit 2007; 46(40):7548-58.
10. Xu W. Xu Y. Wu D. Sun Y. Ibuprofen delivery systems based on monodispersed spherical MCM-41 materials. In Studies in Surface Science and Catalysis Elsevier. 2007; 170:861-5.
11. Manzano M. Aina V. Arean CO. Balas F. Cauda V. Colilla M. Vallet-Regi M. Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chem. Eng. J. 2008; 137(1):30-7. 12. Carino IS. Pasqua L. Testa F. Aiello R. Puoci F. Iemma F. Picci N. Silica-based mesoporous materials as drug delivery system for methotrexate release. Drug. Deliv. 2007; 14(8):491-5.
13. Nunes CD. Vaz PD. Fernandes AC. Ferreira P. Romao CC. Calhorda MJ. Loading and delivery of sertraline using inorganic micro and mesoporous materials. Eur. J. Pharm. Biopharm. 2007; 66(3):357-65.
14. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem. Mater. 2001; 13(2):308-11.
15. Popova M. Szegedi A. Mavrodinova V. Tušar NN. Mihály J. Klébert S. Yoncheva K. Preparation of resveratrol-loaded nanoporous silica materials with different structures. J. Solid State Chem. 2014; 219:37-42.
16. Horcajada P. Ramila A. Perez-Pariente J. Vallet-Regı M. Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor. Mesopor. Mat. 2004; 68(1-3):105-9.
17. Rámila A. Munoz B. Pérez-Pariente J. Vallet-Regí M. Mesoporous MCM-41 as drug host system. J. Sol-Gel Sci. Tech. 2003; 26(1-3):1199-202.
18. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit. 2007; 46(40):7548-58.
19. Antochshuk V. Jaroniec M. Adsorption, thermogravimetric, and NMR studies of FSM-16 material functionalized with alkylmonochlorosilanes. J. Phys. Chem. B. 1999; 103(30):6252-61.
20. Dash S. Murthy PN. Nath L. Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta. Pol. Pharm. 2010;67(3):217-23.

2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery

Year 2019, Volume: 6 Issue: 1, 29 - 34, 15.05.2019

Fatih Mehmet Emen Ruken Esra Demirdöğen Göktürk Avşar Derya Kılıç

https://doi.org/10.18596/jotcsa.467177

Cited By: 1

Abstract

Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41
was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO₂)
environment. 2-chloro-benzoythiourea modified MCM-41 was prepared
and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections
observed at low angle XRD show the mesoporous SiO₂ structure. The
paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET
surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m²/g
2-chloro-benzoythiourea
modified MCM-4, respectively. The absorption and
releasing studies of ibuprofen were caried out in simulated body fluid. The
result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea
modified MCM-41 and slower drug release rate was achieved.

Keywords

Drug delivery system(DDS), mesoporous MCM-41

References

1. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem.Mater. 2001; 13(2):308-11.
2. Wang, S. Ordered mesoporous materials for drug delivery. Micropor. Mesopor. Mat. 2009; 117(1-2): 1-9.
3. Zeng W. Qian XF. Yin J. Zhu ZK. The drug delivery system of MCM-41 materials via co-condensation synthesis. Mater. Chem. Phys. 2006; 97(2-3): 437-41.
4. Sousa A. Souza KC. Sousa EMB. Mesoporous silica/apatite nanocomposite: special synthesis route to control local drug delivery. Acta. Biomater. 2008; 4(3): 671-9.
5. Qu F. Zhu G. Huang S. Li S. Sun J. Zhang D. Qiu S.Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica. Micropor. Mesopor. Mat. 2006; 92(1-3): 1-9.
6. Mal NK. Fujiwara M. Tanaka Y. Taguchi T. Matsukata M. Photo-switched storage and release of guest molecules in the pore void of coumarin-modified MCM-41. Chem. Mater. 2003; 15(17): 3385-34.
7. Aiello R. Cavallaro G. Giammona G. Pasqua L. Pierro P. Testa F. Mesoporous silicate as matrix for drug delivery systems of non-steroidal antinflammatory drugs. In Studies in Surface Science and Catalysis Elsevier. 2002; 142:1165-72.
8. Cavallaro G. Pierro P. Palumbo FS. Testa F. Pasqua L. Aiello R. Drug delivery devices based on mesoporous silicate. Drug. Deliv. 2004; 11(1):41-6.
9. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit 2007; 46(40):7548-58.
10. Xu W. Xu Y. Wu D. Sun Y. Ibuprofen delivery systems based on monodispersed spherical MCM-41 materials. In Studies in Surface Science and Catalysis Elsevier. 2007; 170:861-5.
11. Manzano M. Aina V. Arean CO. Balas F. Cauda V. Colilla M. Vallet-Regi M. Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chem. Eng. J. 2008; 137(1):30-7. 12. Carino IS. Pasqua L. Testa F. Aiello R. Puoci F. Iemma F. Picci N. Silica-based mesoporous materials as drug delivery system for methotrexate release. Drug. Deliv. 2007; 14(8):491-5.
13. Nunes CD. Vaz PD. Fernandes AC. Ferreira P. Romao CC. Calhorda MJ. Loading and delivery of sertraline using inorganic micro and mesoporous materials. Eur. J. Pharm. Biopharm. 2007; 66(3):357-65.
14. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem. Mater. 2001; 13(2):308-11.
15. Popova M. Szegedi A. Mavrodinova V. Tušar NN. Mihály J. Klébert S. Yoncheva K. Preparation of resveratrol-loaded nanoporous silica materials with different structures. J. Solid State Chem. 2014; 219:37-42.
16. Horcajada P. Ramila A. Perez-Pariente J. Vallet-Regı M. Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor. Mesopor. Mat. 2004; 68(1-3):105-9.
17. Rámila A. Munoz B. Pérez-Pariente J. Vallet-Regí M. Mesoporous MCM-41 as drug host system. J. Sol-Gel Sci. Tech. 2003; 26(1-3):1199-202.
18. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit. 2007; 46(40):7548-58.
19. Antochshuk V. Jaroniec M. Adsorption, thermogravimetric, and NMR studies of FSM-16 material functionalized with alkylmonochlorosilanes. J. Phys. Chem. B. 1999; 103(30):6252-61.
20. Dash S. Murthy PN. Nath L. Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta. Pol. Pharm. 2010;67(3):217-23.

There are 19 citations in total.

Details

Primary Language	English
Subjects	Chemical Engineering
Journal Section	Articles
Authors	Fatih Mehmet Emen Ruken Esra Demirdöğen Göktürk Avşar Derya Kılıç
Publication Date	May 15, 2019
Submission Date	October 4, 2018
Acceptance Date	January 18, 2019
Published in Issue	Year 2019 Volume: 6 Issue: 1

Cite

Vancouver	Emen FM, Demirdöğen RE, Avşar G, Kılıç D. 2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery. JOTCSA. 2019;6(1):29-34.

Journal of the Turkish Chemical Society Section A: Chemistry

Abstract

References

2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery

Abstract

Keywords

References

Details

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Regioselective Synthesis of Some Rhamnopyranoside Esters for PASS Predication, and ADMET Studies

Journal of the Turkish Chemical Society Section A: Chemistry

Mohammed Mahbubul MATİN

https://doi.org/10.18596/jotcsa.829658