Abstract
Amaç: Çin’in Wuhan kentinde ortaya çıkan COVID-19 pandemisi, dünyada 670 milyondan fazla insanı etkilemiştir. Her yaş grubunda görülen hastalığın mortalite ve morbiditesi özellikle yaşlı nüfus, kronik hastalığı olanlar ve gebelerde daha fazla gözlemlenmiştir. Bu çalışmanın amacı, pandemi sürecinde hastanemizde takip edilen ve doğum yapan, gebeliğinde COVID-19 enfeksiyonu geçirmiş gebelerin maternal ve neonatal sonuçlarını-morbiditelerini incelemek ve COVID-19 geçirmemiş gebelerin sonuçları ile karşılaştırmaktır.
Gereç ve Yöntemler: Hastanemizde Nisan 2020-Haziran 2021 tarihleri arasında izlenen ve çalışma şartlarını sağlayan gebelerin ve bebeklerin maternal-neonatal verileri dosya kayıtlarından alınarak, gebelikte COVID-19 enfeksiyonu geçiren ve geçirmeyen gebeler ve bebeklerinden oluşan ikili gruplar karşılaştırıldı.
Bulgular: Çalışmaya 2164 anne ve bebek çifti dahil edildi. Gebeliğinde COVID-19 geçirmiş (n=66) ve geçirmemiş olan anneler (n=2098) ve bebekleri arasında anne yaşı, doğum şekli, doğum ağırlığı, doğum haftası, cinsiyet, APGAR skorları, yenidoğan yoğun bakım ünitesinde yatma süreleri bakımından anlamlı fark saptanmadı.
Sonuç: Çalışma sonuçlarımız henüz etiyopatogenezi yeterince aydınlatılamamış olan COVID-19 enfeksiyonunun, maternal-neonatal risk ve hastalıkların üzerine etkisinin halen tam olarak bilinmediği görüşünü desteklemektedir.
Supporting Institution
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Project Number
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Thanks
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References
- World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-mediabriefing-on-2019-ncov-on-11-february-2020 (12- 03-2020)
- Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;26;69(25) :769-75.
- Wang S, Guo L, Chen L, Liu W, Cao Y, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020;71(15):853-7.
- Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020;18(7): 164852.
- Metz TD., Clifton RG. Hughes BL. Sandoval G, Saade GR, Grobman WA et al; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-80.
- Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr. 2021;175(8):817-26
- Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306.
- Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99(7):823-29.
- Shu L, Niu C, Li R, Huang T, Wang Y, Huang M, et al. Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11(1):361.
- Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572
- Akin IM, Kanburoglu MK, Tayman C, Oncel MY, Imdadoglu T, Dilek M et al. Neo-Covid Study Group. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society. Eur J Pediatr. 2022;181(5):1933-42.
- Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R et al. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021;4(4):e217523.
- Galang RR, Newton SM, Woodworth KR, Griffin I, Oduyebo T, Sancken CL et al. Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection—Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments. Clin Infect Dis. 2021;73(Suppl 1): S17–23.
- Melekoglu NA, Ozdemir H, Yasar S. Neonatal Outcomes of Pregnant Women With Confirmed Coronavirus Disease 2019: One-Year Experience of a Tertiary Care Center. Clin Pediatr (Phila). 2022;61(2):177-83.
- Sunder A, Varghese B, Darwish B, Shaikho N, Rashid M. Impacts and effects of COVID-19 infection in pregnancy. Saudi Med J. 2022;43(1):67-74.
- Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021;225(5):522.e1-522.e11.
Abstract
Objective: The COVID-19 pandemic, which emerged in Wuhan, China has affected more than 670 million people in the world. The mortality and morbidity of Coronavirus which is seen in all age groups, has been observed more especially in the elderly population, those with chronic diseases and pregnant women. The aim of this study is to examine the morbidity and the maternal-neonatal outcomes of COVID-19 infection during pregnancy.
Material and Methods: The maternal-neonatal data of the pregnant women and babies who met the study critera and were followed up in our hospital between April 2020 and June 2021, were obtained from file records. The dual groups of pregnant women who had and did not have COVID-19 infection during pregnancy and their babies were compared.
Results: A total of 2164 mother and infant couples were included in the study. No significant difference was found between mothers who had COVID-19 during pregnancy (n=66) and mothers who did not (n=2098) and their babies in terms of maternal age, delivery type, birth weight, birth week, gender, APGAR scores, and length of stay in the neonatal intensive care unit.
Conclusion: The results of our study is consistent with the idea that the effect of maternal COVID-19 infection on maternal-neonatal risk and diseases, is still unknown.
Project Number
yok
References
- World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-mediabriefing-on-2019-ncov-on-11-february-2020 (12- 03-2020)
- Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;26;69(25) :769-75.
- Wang S, Guo L, Chen L, Liu W, Cao Y, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020;71(15):853-7.
- Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020;18(7): 164852.
- Metz TD., Clifton RG. Hughes BL. Sandoval G, Saade GR, Grobman WA et al; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-80.
- Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr. 2021;175(8):817-26
- Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306.
- Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99(7):823-29.
- Shu L, Niu C, Li R, Huang T, Wang Y, Huang M, et al. Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11(1):361.
- Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572
- Akin IM, Kanburoglu MK, Tayman C, Oncel MY, Imdadoglu T, Dilek M et al. Neo-Covid Study Group. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society. Eur J Pediatr. 2022;181(5):1933-42.
- Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R et al. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021;4(4):e217523.
- Galang RR, Newton SM, Woodworth KR, Griffin I, Oduyebo T, Sancken CL et al. Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection—Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments. Clin Infect Dis. 2021;73(Suppl 1): S17–23.
- Melekoglu NA, Ozdemir H, Yasar S. Neonatal Outcomes of Pregnant Women With Confirmed Coronavirus Disease 2019: One-Year Experience of a Tertiary Care Center. Clin Pediatr (Phila). 2022;61(2):177-83.
- Sunder A, Varghese B, Darwish B, Shaikho N, Rashid M. Impacts and effects of COVID-19 infection in pregnancy. Saudi Med J. 2022;43(1):67-74.
- Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021;225(5):522.e1-522.e11.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Özgün Araştırma |
| Authors | |
| Project Number | yok |
| Early Pub Date | April 30, 2023 |
| Publication Date | April 30, 2023 |
| Submission Date | December 27, 2022 |
| Published in Issue | Year 2023 Volume: 25 Issue: 1 |
Cite
Bu Dergi, Kırıkkale Üniversitesi Tıp Fakültesi Yayınıdır.