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Pharmacokinetic of Florfenicol After Administration in Sheep

Year 2015, Volume: 8 Issue: 1, 19 - 24, 01.06.2015

Abstract

Florfenicol a monofluorinated analogue of tiamphenicol, has antibacterial activity against a broad spectrum of bacterial strains, including enteric bacteria that are resistant to chloramphenicol and tiamphenicol. Pharmacokinetic parameters of florfenikol were determined in sheep after administration a sing intravenous (İV) doses 30 mg/kg body weight. Florfenicol concentrations in plasma were determined by a validated high-performance liquid chromatography (HPLC) methods with UV dedection at a wavelength of 223 nm. Blood samples were obtained at 5., 10., 15., 20., 30., 45. minutes ile 1., 1.5, 2., 3., 4., 6., 8., 10., 12., 14., 18., 24., 30. hours after injection. Plasma concentration–time data after iv administration were best described by a two –compartment open model. Concentrations of the drug in plasma were determined by HPLC. The pharmacokinetic parameters were as follows: elimination half life (t½) was 3.34±0.25 hours, mean residence time (MRT) was 3.68 ±0.07 hours, mean volume of distribition at steady-state (Vdss) was. 0.97±0.07 kg/l, total body cleance (CL) 0.26 ±0.008 l/h/kg, area under curve (AUC) 113.13±3.45 μg.saat/ml after iv injections of 30 mg/kg doses weight.

References

  • Adams PE, Varma KJ, Powers TE. Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses. Am.J.Vet.Res. 1987; 48(12): 1725-1732.
  • Afifi NA, Abo el-Sooud KA. Tissue concentrations and pharmacokinetics of florfenicol in broiler chickens. Br. Poult Sci. 1997; 38(4): 425-428.
  • Ali BH, Al-qarawi, Hashaad M. Comparative plasma pharmacokinetics and tolerance of florfenicol following intramusculer and intravenous administration to camel, sheep and goats.Veterinary research communications. 2003; 27(6): 475-483.
  • Atef M, El- Gendi AY, Amer AM, el-aty AM. Disposition kinetics of florfenicol in goats by using two analytical methods. J.Vet. Med. A Physiol Pathol Clin Med. 2001; 48(3):129-136.
  • Balton LF, Kelley LC, Lee MD, Fedorka-Cray PJ. Detection of multidrug- resistant salmonella enterica serotype typhimurium DT104 based on a gene Which confers cross-resistance to florfenicol and chloramfenicol. J. of Clin. Microb. 1999; 37(5): 1348-1351.
  • Bretzlaff KM, Neff-DavisCA, Ot RS. Florfenicol in nonlactatating dairy cows: pharmacokinetics, binding to plasma proteins and effects on phagocytosis by blood neutrophilis. J.Vet.Pharmaco.Ther. 1987; 10: 233-240.
  • Craene BA, Deprez P, Dhaese E, Nelis HJ, Leenheer AP. Pharmacokinetics of florfenicol in cerebrospinal fluid and plasma of calves, Antimicrobial Agents And Chemotherapy. 1997; 41(9): 1991-1995.
  • Ho SP, HSU TY, Chen MH, Wang WS. Antibacterial effect of chloramfenicol, tiamfenicol and florfenicol against aquatic animal bacteria. J.Vet. Med. Sci. 2000; 62(5): 479-485.
  • Jıanzhong S, Xıubo L, Haıyang J, Walter HH. Bioavailability and pharmacokineticsof florfenicolin healthy sheep. J. Vet. Pharmacol. Therap. 2004; 27(3): 163-168.
  • Keyes K, Hudson C, Maurer JJ, Thayer S, White DG, Lee MD. Detection of florfenicol resitance genes in Escherichia coli isolated from sick chickens. Antimicrobial Agents And Chemotherapy. 2000; 44(2):421-424.
  • Lane VM, Wetzlıch S, Clifford A, Taylor I, Craıgmıll AL. İntravenous and subcutaneous pharmacokinetics of florfenicol in sheep. 2004; 27(4): 191-196.
  • Lavy E, ZivG, Soback S Clinical pharmacology of florfenicol in lactating goats. Acta. Vet. Scand. 1991; 87: 133-136.
  • Lobell Rd, Varma KJ, Johnson JC. Pharmacokinetics of florfenicol folloving intravenous and intramuscular doses to cattle. J.Vet. Pharmacol. Ther. 1994; 17: 253-258.
  • Sams RA. Florfenicol: Chemisty and metabolism of a novel broad-spectrum antibiotic.ın:Proceedings of the XVIII World Buiatrics Congress Bologna Italy 13-17. 1994.
  • Shen J, Wu X, Hu D, Jıang H. Pharmacokinetics of florfenicol in healthy and Escherichia coli infected broiler chickens. Research in Veterinary Science. 2002; 73: 137-140.
  • Shumaker RC. PKCALC: A Basic interactive computer program for statistical and pharmacokinetic analysis of data, Drug Metabol Rev. 1986; 17: 331-48.
  • Soback S, Paape MJ, Filep R, Varma KJ. Florfenicol pharmacokinetics in lactating cows after intravenous intramuscular and intramammary administration. J.Vet. Pharmacol. 1995; 18(6): 413-417.
  • Varma KJ, Sams RA, Lobell RD. Pharmacokinetics and efficacy of a new broad spectrum antibiotic florfenicol in cattle. Acta. Vet Scand. 1991; 87: 102-104.
  • Vogel GJ, Parrott JC. Mortality survey in feedyars The incidence of death from digestive, respiratory and other causes in feedyards on the great plains Compend. Contin. Educ. Pract Vet. 1994; 16 (2): 227-234.
  • Vue C, Schmidt LJ, Stehly GR, Gingerich WH Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish. Journal of Chromatography B. 2002; 780: 111-117.
  • Wagner JG. Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Pub Inc, Illinois, USA. 1975.
  • White DG, Hudson C, Maurer JJ, Ayers S, Zhao S, Lee MD, Bolton L, Foley T, Sherwood J. Characterization of cloromphenicol and florfenicol resistance in E.coli Associated with bovine diarrhea. J. of Clin. Microb. 2000; 38(12): 4593-4598.

Koyunlara Uygulanan Florfenikolün Farmakokinetiği

Year 2015, Volume: 8 Issue: 1, 19 - 24, 01.06.2015

Abstract

Florfenikol; tiamfenikol ve kloramfenikole dirençli enterik bakterileri de içine alan geniş spektrumlu ve tiamfenikolün tek florlu yapısal analoğudur. Bu araştırmada 30 mg/kg tek doz İV yol ile uygulanan florfenikolün koyunlardaki farmakokinetik parametreleri belirlendi. Florfenikolün plazmadaki konsantrasyonları, UV detektörü bulunan, dalga boyu 223 nm olan yüksek performanslı likit kromatografi (HPLC) de belirlendi. İlaç uygulamasını takiben 5., 10., 15., 20., 30., 45. dakikalar ile 1., 1.5, 2., 3., 4., 6., 8., 10., 12., 14., 18., 24., 30. saatlerde kan örnekleri alındı. İV uygulamadan sonra HPLC tarafından belirlenen plazmadaki ilaç konsantrasyonlarından elde edilen plazma-zaman konsantrasyon verileri iki kompartmanlı modele göre değerlendirildi. İV uygulama yolu ile 30 mg/kg uygulanan florfenikolün farmakokinetik parametreleri ise eliminasyon yarılama ömrü (t½) 3.34±0.25 saat, ortalama kanda kalış zamanı (MRT) 3.68±0.07 saat, denge halindeki dağılım hacmi (Vdss) 0.97±0.07 kg/l, vücut klirensi (Cl) 0.26 ±0.008 l/h/kg, eğrinin altında kalan (AUC 0-∞) ise 113.13±3.45 μg.h/ml olarak bulunmuştur.

References

  • Adams PE, Varma KJ, Powers TE. Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses. Am.J.Vet.Res. 1987; 48(12): 1725-1732.
  • Afifi NA, Abo el-Sooud KA. Tissue concentrations and pharmacokinetics of florfenicol in broiler chickens. Br. Poult Sci. 1997; 38(4): 425-428.
  • Ali BH, Al-qarawi, Hashaad M. Comparative plasma pharmacokinetics and tolerance of florfenicol following intramusculer and intravenous administration to camel, sheep and goats.Veterinary research communications. 2003; 27(6): 475-483.
  • Atef M, El- Gendi AY, Amer AM, el-aty AM. Disposition kinetics of florfenicol in goats by using two analytical methods. J.Vet. Med. A Physiol Pathol Clin Med. 2001; 48(3):129-136.
  • Balton LF, Kelley LC, Lee MD, Fedorka-Cray PJ. Detection of multidrug- resistant salmonella enterica serotype typhimurium DT104 based on a gene Which confers cross-resistance to florfenicol and chloramfenicol. J. of Clin. Microb. 1999; 37(5): 1348-1351.
  • Bretzlaff KM, Neff-DavisCA, Ot RS. Florfenicol in nonlactatating dairy cows: pharmacokinetics, binding to plasma proteins and effects on phagocytosis by blood neutrophilis. J.Vet.Pharmaco.Ther. 1987; 10: 233-240.
  • Craene BA, Deprez P, Dhaese E, Nelis HJ, Leenheer AP. Pharmacokinetics of florfenicol in cerebrospinal fluid and plasma of calves, Antimicrobial Agents And Chemotherapy. 1997; 41(9): 1991-1995.
  • Ho SP, HSU TY, Chen MH, Wang WS. Antibacterial effect of chloramfenicol, tiamfenicol and florfenicol against aquatic animal bacteria. J.Vet. Med. Sci. 2000; 62(5): 479-485.
  • Jıanzhong S, Xıubo L, Haıyang J, Walter HH. Bioavailability and pharmacokineticsof florfenicolin healthy sheep. J. Vet. Pharmacol. Therap. 2004; 27(3): 163-168.
  • Keyes K, Hudson C, Maurer JJ, Thayer S, White DG, Lee MD. Detection of florfenicol resitance genes in Escherichia coli isolated from sick chickens. Antimicrobial Agents And Chemotherapy. 2000; 44(2):421-424.
  • Lane VM, Wetzlıch S, Clifford A, Taylor I, Craıgmıll AL. İntravenous and subcutaneous pharmacokinetics of florfenicol in sheep. 2004; 27(4): 191-196.
  • Lavy E, ZivG, Soback S Clinical pharmacology of florfenicol in lactating goats. Acta. Vet. Scand. 1991; 87: 133-136.
  • Lobell Rd, Varma KJ, Johnson JC. Pharmacokinetics of florfenicol folloving intravenous and intramuscular doses to cattle. J.Vet. Pharmacol. Ther. 1994; 17: 253-258.
  • Sams RA. Florfenicol: Chemisty and metabolism of a novel broad-spectrum antibiotic.ın:Proceedings of the XVIII World Buiatrics Congress Bologna Italy 13-17. 1994.
  • Shen J, Wu X, Hu D, Jıang H. Pharmacokinetics of florfenicol in healthy and Escherichia coli infected broiler chickens. Research in Veterinary Science. 2002; 73: 137-140.
  • Shumaker RC. PKCALC: A Basic interactive computer program for statistical and pharmacokinetic analysis of data, Drug Metabol Rev. 1986; 17: 331-48.
  • Soback S, Paape MJ, Filep R, Varma KJ. Florfenicol pharmacokinetics in lactating cows after intravenous intramuscular and intramammary administration. J.Vet. Pharmacol. 1995; 18(6): 413-417.
  • Varma KJ, Sams RA, Lobell RD. Pharmacokinetics and efficacy of a new broad spectrum antibiotic florfenicol in cattle. Acta. Vet Scand. 1991; 87: 102-104.
  • Vogel GJ, Parrott JC. Mortality survey in feedyars The incidence of death from digestive, respiratory and other causes in feedyards on the great plains Compend. Contin. Educ. Pract Vet. 1994; 16 (2): 227-234.
  • Vue C, Schmidt LJ, Stehly GR, Gingerich WH Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish. Journal of Chromatography B. 2002; 780: 111-117.
  • Wagner JG. Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Pub Inc, Illinois, USA. 1975.
  • White DG, Hudson C, Maurer JJ, Ayers S, Zhao S, Lee MD, Bolton L, Foley T, Sherwood J. Characterization of cloromphenicol and florfenicol resistance in E.coli Associated with bovine diarrhea. J. of Clin. Microb. 2000; 38(12): 4593-4598.
There are 22 citations in total.

Details

Journal Section RESEARCH ARTICLE
Authors

Yavuz Osman Birdane

Fatih Mehmet Birdane This is me

Mehmet Özdemir This is me

Mustafa Kabu This is me

Hidayet Yavuz This is me

Publication Date June 1, 2015
Acceptance Date December 11, 2014
Published in Issue Year 2015 Volume: 8 Issue: 1

Cite

APA Birdane, Y. O., Birdane, F. M., Özdemir, M., Kabu, M., et al. (2015). Pharmacokinetic of Florfenicol After Administration in Sheep. Kocatepe Veterinary Journal, 8(1), 19-24.
AMA Birdane YO, Birdane FM, Özdemir M, Kabu M, Yavuz H. Pharmacokinetic of Florfenicol After Administration in Sheep. kvj. January 2015;8(1):19-24.
Chicago Birdane, Yavuz Osman, Fatih Mehmet Birdane, Mehmet Özdemir, Mustafa Kabu, and Hidayet Yavuz. “Pharmacokinetic of Florfenicol After Administration in Sheep”. Kocatepe Veterinary Journal 8, no. 1 (January 2015): 19-24.
EndNote Birdane YO, Birdane FM, Özdemir M, Kabu M, Yavuz H (January 1, 2015) Pharmacokinetic of Florfenicol After Administration in Sheep. Kocatepe Veterinary Journal 8 1 19–24.
IEEE Y. O. Birdane, F. M. Birdane, M. Özdemir, M. Kabu, and H. Yavuz, “Pharmacokinetic of Florfenicol After Administration in Sheep”, kvj, vol. 8, no. 1, pp. 19–24, 2015.
ISNAD Birdane, Yavuz Osman et al. “Pharmacokinetic of Florfenicol After Administration in Sheep”. Kocatepe Veterinary Journal 8/1 (January 2015), 19-24.
JAMA Birdane YO, Birdane FM, Özdemir M, Kabu M, Yavuz H. Pharmacokinetic of Florfenicol After Administration in Sheep. kvj. 2015;8:19–24.
MLA Birdane, Yavuz Osman et al. “Pharmacokinetic of Florfenicol After Administration in Sheep”. Kocatepe Veterinary Journal, vol. 8, no. 1, 2015, pp. 19-24.
Vancouver Birdane YO, Birdane FM, Özdemir M, Kabu M, Yavuz H. Pharmacokinetic of Florfenicol After Administration in Sheep. kvj. 2015;8(1):19-24.

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