Case Report
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Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?

Year 2018, Volume: 11 Issue: 4, 501 - 507, 15.12.2018

Hadi Alihosseini Ekrem Çağatay Çolakoğlu Ali Evren Haydardedeoğlu Arif Kurtdede

https://doi.org/10.30607/kvj.453321

Abstract

Idiopathic hepatic
fibrosis (İHF) is an inevitable result of chronic liver disease progressing to
cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or
juvenile form in German Shepherd Dogs. However, few data have been published on
the incidence and prevalence of IHF in canine species. The case report presented
here describes idiopathic hepatic fibrosis in four neutered German Shephered
dogs with a
familial relationship. The main clinical complaints were
refractory ascites, variable appetite and progressive weight loss. Hepatic
fibrosis was confirmed with diagnostic applications and liver biopsy.
Nevertheless, all dogs died in spite of supportive and aggressive treatment.
Necropsy was performed in the dogs according to written owner consent. In
conclusion, the cases presented here reflect the congenital condition of
idiopathic hepatic fibrosis in young German Shepherd Dogs with
histopathological evidence. However, there was evidence of familial
relationship in the cases presented here. 

Keywords

Dog fibrosis liver idiopathic genetic

References

  • Brown DL, Winkle TV, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 Dogs. Vet Pathol. 2010; 47: 102-107.
  • Desmet V. What is congenital hepatic fibrosis? Histopathol. 1998; 20: 465–477.
  • Center SA. Chronic liver disease: Current concepts of disease mechanisms. JSAP. 1999; 40: 106‐114.
  • Eulenberg VM, Lidbury JA. Hepatic fibrosis in dogs. J Vet Intern Med. 2018: 32; 26-41.
  • Favier RP. Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am: Smal An Pract. 2009: 39; 481-488.
  • Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 2000: 275(4); 2247-2250.
  • James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. AVJ, 2008; 86: 180-186.
  • Owczarczak S. Chronic Hepatic Fibrosis in an 8 year old French Bulldog. Seminar Paper, Cornell University College of Veterinary Medicine, USA, 2010.
  • Rutger HC, Haywood S, Kelly DF. Idiopathic hepatic fibrosis in 15 dogs. Vet Record. 1993; 133; 115-118.
  • Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagnostic Invest. 2000; 12: 101–110.

Dört Alman Çoban Köpeğinde Hepatik Fibroz İdiyopatik, Genetik Yatkınlık ya da Ailesel İlişki mi?

Year 2018, Volume: 11 Issue: 4, 501 - 507, 15.12.2018

Hadi Alihosseini Ekrem Çağatay Çolakoğlu Ali Evren Haydardedeoğlu Arif Kurtdede

https://doi.org/10.30607/kvj.453321

Abstract

İdiyopatik hepatik
fibroz (İHF) siroza kadar gidebilen kronik karaciğer hastalığının kaçınılmaz
bir sonucudur. İdiyopatik hepatik fibroz, Alman Çoban Köpeklerinde jüvenil ya
da doğmasal olarak şekillenebilmektedir. Bununla birlikte, köpeklerde İHF’nin
prevalans veya insidansı hakkında az sayıda veri bulunmaktadır. Sunulan olgu
serisi, ailesel ilişkisi bulunan dört Alman Çoban Köpeğindeki idiyopatik
hepatik fibrozu tanımlamaktadır. Olgulardaki esas klinik şikayetler;
tekrarlayan asites, değişken iştah durumu ve ilerleyici kilo kaybıydı. Hepatik
fibroz tanısı diyagnostik uygulamalar ve karaciğer biyopsisi ile doğrulandı.
Destekleyici agresif tedaviye ragmen tüm köpekler kaybedildi. Hasta sahibinin
izni ile köpeklerde nekropsi gerçekleştirildi. Sonuç olarak, sunulan olgular
Alman Çoban Köpeklerinde histopatolojik kanıtı olan konjenital idiyopatik
hepatik fibrozu yansıtmaktadır. Bununla birlikte, sunulan olgularda ailesel
ilişki kanıtı da söz konusudur. 

Keywords

Fibroz idiyopatik karaciğer köpek genetic

References

  • Brown DL, Winkle TV, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 Dogs. Vet Pathol. 2010; 47: 102-107.
  • Desmet V. What is congenital hepatic fibrosis? Histopathol. 1998; 20: 465–477.
  • Center SA. Chronic liver disease: Current concepts of disease mechanisms. JSAP. 1999; 40: 106‐114.
  • Eulenberg VM, Lidbury JA. Hepatic fibrosis in dogs. J Vet Intern Med. 2018: 32; 26-41.
  • Favier RP. Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am: Smal An Pract. 2009: 39; 481-488.
  • Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 2000: 275(4); 2247-2250.
  • James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. AVJ, 2008; 86: 180-186.
  • Owczarczak S. Chronic Hepatic Fibrosis in an 8 year old French Bulldog. Seminar Paper, Cornell University College of Veterinary Medicine, USA, 2010.
  • Rutger HC, Haywood S, Kelly DF. Idiopathic hepatic fibrosis in 15 dogs. Vet Record. 1993; 133; 115-118.
  • Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagnostic Invest. 2000; 12: 101–110.
There are 10 citations in total.

Details

Primary Language English
Journal Section CASE REPORT
Authors

Hadi Alihosseini

Ekrem Çağatay Çolakoğlu

Ali Evren Haydardedeoğlu This is me

Arif Kurtdede This is me

Publication Date December 15, 2018
Acceptance Date September 28, 2018
Published in Issue Year 2018 Volume: 11 Issue: 4

Cite

APA Alihosseini, H., Çolakoğlu, E. Ç., Haydardedeoğlu, A. E., Kurtdede, A. (2018). Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. Kocatepe Veterinary Journal, 11(4), 501-507. https://doi.org/10.30607/kvj.453321
AMA Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. December 2018;11(4):501-507. doi:10.30607/kvj.453321
Chicago Alihosseini, Hadi, Ekrem Çağatay Çolakoğlu, Ali Evren Haydardedeoğlu, and Arif Kurtdede. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal 11, no. 4 (December 2018): 501-7. https://doi.org/10.30607/kvj.453321.
EndNote Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A (December 1, 2018) Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. Kocatepe Veterinary Journal 11 4 501–507.
IEEE H. Alihosseini, E. Ç. Çolakoğlu, A. E. Haydardedeoğlu, and A. Kurtdede, “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”, kvj, vol. 11, no. 4, pp. 501–507, 2018, doi: 10.30607/kvj.453321.
ISNAD Alihosseini, Hadi et al. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal 11/4 (December 2018), 501-507. https://doi.org/10.30607/kvj.453321.
JAMA Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. 2018;11:501–507.
MLA Alihosseini, Hadi et al. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal, vol. 11, no. 4, 2018, pp. 501-7, doi:10.30607/kvj.453321.
Vancouver Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. 2018;11(4):501-7.
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