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Effects of Oxytocin Administration on Doppler Indices of Mammary Artery in Postpartum Ewes

Year 2020, Volume: 13 Issue: 3, 313 - 318, 30.09.2020
https://doi.org/10.30607/kvj.748613

Abstract

Oxytocin hormone, which is frequently used in order to hasten uterine involution process and to ensure milk ejection, is also effective in regulation of vascular tone. Doppler ultrasonography is a highly practical technique that allows the evaluation of blood flow characteristics of tissues and organs. In this study, it was aimed to investigate the hemodynamic changes of mammary artery caused by oxytocin administration in postpartum ewes. The study was conducted with 20 primiparous Kivircik ewes which lambed singleton. The ewes were randomly divided into oxytocin and control groups (n=10 for each group). A dose of 10 IU/sheep oxytocin and 1 ml/sheep saline solution were administered intramuscularly bid on the first 3 days postpartum to oxytocin and control groups, respectively. The pulsed Doppler ultrasonography is used to measure pulsatility and resistance indices (PI and RI, respectively) of external pudendal artery. Although oxytocin group tended to have relatively higher PI and RI values, significant differences were detected only in PI values of the first and second days postpartum (p<0.001 and p<0.05, respectively) between groups. It has been concluded that oxytocin administration increased the resistance of mammary artery in early postpartum ewes.

References

  • Adam ZA, Ragab GA, Awaad AS, Tawfiek MG, Abdel Maksoud MKM. Anatomical and radiographical studies on the arterial supply of the udder in goat and their surgical importance. BJBAS. 2016; 5(3): 291-298.
  • Barbagianni MS, Gouletsou PG, Valasi I, Petridis IG, Giannenas I, Fthenakis GC. Ultrasonographic findings in the ovine udder during lactogenesis in healthy ewes or ewes with pregnancy toxaemia. J Dairy Res. 2015; 82(3): 293-303.
  • Cumbers MR, Chung ST, Wakerley JB. A neuromodulatory role for oxytocin within the supramammillary nucleus. Neuropeptides. 2007; 41(4): 217-226.
  • Dantas A, Siqueira ER, Fernandes S, Oba E, Machado VMV, Castilho AM, Sartori MMP, Santos RV. Mammary artery Doppler ultrasonography of Brazilian Bergamasca dairy ewe lambs under the influence of two different feding plans. Pesq Vet Bras. 2017; 37(2): 179-182.
  • Erdogan G. Veteriner jinekolojide Doppler ultrasonografi kullanım alanları. Turkiye Klinikleri J Vet Sci Obstet Gynecol-Special Topics. 2018; 4(1): 43-49.
  • Ginther OJ. Producing Spectral Graphs, In: Ultrasonic Imaging and Animal Reproduction: Color-Doppler Ultrasonography Book 4, Ed; Ginther OJ, Equiservices Publishing, Wisconsin, USA. 2007; pp. 61-86.
  • Gorewit RC, Aromando MC, Bristol DG. Measuring bovine mammary gland blood flow using a transit time ultrasonic flow probe. J Dairy Sci. 1989; 72(7): 1918-1928.
  • Gutkowska J, Jankowski M, Mukaddam-Daher S, McCann SM. Oxytocin is a cardiovascular hormone. Braz J Med Biol Res. 2000; 33(6): 625-633.
  • Haanwickel MA, Elias LK, Favaretto ALV, Gutkowska J, McCann SM. Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat. Proc Natl Acad Sci USA. 1995; 92(17): 7902-7906.
  • Kensinger MH, Collier RJ, Wilcox CJ, Caton D. Variability of resting mammary blood flow in nonlactating Holstein cows. J Dairy Sci. 1983; 66(8): 1742-1746.
  • Kuru M, Mülazımoglu SB, Kaya D. Koyun ve keçilerde güç doğum. Turkiye Klinikleri J Vet Sci Obstet Gynecol-Special Topics. 2016; 2(1): 74-77.
  • Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrin. 2004; 25(3-4): 150-176.
  • Macuhova J, Tancin V, Bruckmaler RM. Effects of oxytocin administration on oxytocin release and milk ejection. J Dairy Sci. 2004; 87(5): 1236-1244.
  • Meinecke-Tillmann S. Basics of ultrasonographic examination in sheep. Small Rumin Res. 2017; 152: 10-21.
  • Nakano J, Fisher RD. Studies on the cardiovascular effects of synthetic oxytocin. J Pharmacol Exp Ther. 1963; 142(2): 206-214.
  • Petersson M. Cardiovascular effects of oxytocin. Prog Brain Res. 2002; 139: 281-288.
  • Petersson M, Alster P, Lundeberg T, Uvnas-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiol Behav. 1996; 60(5): 1311-1315.
  • Petridis IG, Barbagianni MS, Ioannidi KS, Samaras E, Fthenakis GC, Vloumidi EI. Doppler ultraonographic examination in sheep. Small Rumin Res. 2017; 152: 22-32.
  • Petridis IG, Gouletsou PG, Barbagianni MS, Amiridis GS, Brozos C, Valasi I, Fthenakis GC. Ultrasonographic findings in the ovine udder during involution. J Dairy Res. 2014; 81(3): 288-296.
  • Piccione G, Arcigli A, Assenza A, Percipalle M, Coala G. Pulsed wave-Doppler ultrasonographic evaluation of the mammary blood flow in the ewe. Acta Vet Brno. 2004; 73(1): 23-27.
  • Prosser CG, Davis SR, Farr VC, Lacasse P. Regulation of blood flow in the mammary microvasculature. J Dairy Sci. 1996; 79(7): 1184-1197.
  • Reynolds M, Linzell JL, Rasmussen F. Comparison of four methods for measuring mammary blood flow in conscious goats. Am J Physiol. 1968; 214(6): 1415-1424.
  • Risvanli A, Dogan H, Saat N, Seker I. Relationship between pulsed wave Doppler ultrasonographic features of milk veins and CMT scores in Simmental cows. Ankara Üniv Vet Fak Derg. 2018; 65(1): 69-72.
  • Rizzo A, Mutinati M, Minoia G, Spedicato M, Pantaleo M, Sciorsci RL. The impact of oxytocin on the hemodynamic features of the milk vein in dairy cows: a color Doppler investigation. Res Vet Sci. 2012; 93(2): 983-988.
  • Russel AJ, Doney FJM, Gunn RG. Subjective assessment of fat in live sheep. J Agric Sci. 1969; 72(3): 451-454.
  • Santos VJC, Simplicio K, Sanchez D, Coutinho I, Teixeira P, Barros F, Almeida V, Rodrigues I, Bartlewski P, Oliveira M, Feliciano M, Vicente W. B-mode and Doppler sonography of the mammary glands in dairy goats for mastitis diagnosis. Reprod Dom Anim. 2015; 50(2): 251-255.
  • Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC. Human vascular endothelial cells Express oxytocin receptors. Endocrinology. 1999; 140(3): 1301-1309.
  • Vedernikov YP, Betancourt A, Wentz MJ, Saade GR, Garfield RE. Adaption to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin. Am J Obstet Gynecol. 2006; 194(1): 252-260.
  • Zamiri MJ, Qotbi A, Izadifard J. Effect of daily oxytocin injection on milk yield and lactation length in sheep. Small Rum Res. 2001; 40(2): 179-185.

Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri

Year 2020, Volume: 13 Issue: 3, 313 - 318, 30.09.2020
https://doi.org/10.30607/kvj.748613

Abstract

Doğum sonrası uterus involüsyonunu hızlandırmak ve sütün indirilmesini sağlamak amacıyla sıklıkla uygulanan oksitosin hormonu vasküler tonusun düzenlenmesinde de etkilidir. Doppler ultrasonografi, doku ve organlara ait kan akımı özelliklerinin değerlendirilebilmesine olanak sağlayan oldukça pratik bir tekniktir. Bu çalışmada postpartum dönemdeki koyunlara uygulanan oksitosin hormonunun meme kan akımında oluşturduğu hemodinamik değişikliklerin incelenmesi amaçlandı. Çalışma tekiz kuzulamış olan 20 adet primipar Kıvırcık ırkı koyun ile gerçekleştirildi. Koyunlar randomize şekilde oksitosin ve kontrol gruplarına ayrıldı (her grup için n=10). Oksitosin ve kontrol gruplarına sırasıyla 10 IU/koyun dozda oksitosin ve 1 ml/koyun dozda serum fizyolojik doğum sonrası ilk üç gün boyunca günde 2 kez kas içi yoldan uygulandı. Puls Doppler ultrasonografi tekniği kullanılarak eksternal pudendal artere ait pulsatilite ve rezistans indeksleri (sırasıyla PI ve RI) ölçüldü. Oksitosin grubu daha yüksek PI ve RI değerlerine sahip olma eğiliminde olmasına karşın gruplar arasında anlamlı farklılık sadece birinci ve ikinci postpartum günlerin PI değerlerinde saptandı (sırasıyla p<0,001 ve p<0,05). Postpartum erken dönemdeki koyunlara uygulanan oksitosin hormonunun, meme arterinin direncini arttırdığı sonucuna ulaşıldı.

Thanks

Yazar, istatistiksel analizlerin gerçekleştirilmesinde emeği geçen Prof. Dr. Ömür Koçak’a; hayvanların muayenesi esnasındaki desteklerinden ötürü Doç. Dr. Ahmet Sabuncu, Doç. Dr. Sinem Özlem Enginler, Araş. Gör. Ali Can Çetin ve Veteriner Hekim Kerem Baykal’a teşekkürlerini sunar.

References

  • Adam ZA, Ragab GA, Awaad AS, Tawfiek MG, Abdel Maksoud MKM. Anatomical and radiographical studies on the arterial supply of the udder in goat and their surgical importance. BJBAS. 2016; 5(3): 291-298.
  • Barbagianni MS, Gouletsou PG, Valasi I, Petridis IG, Giannenas I, Fthenakis GC. Ultrasonographic findings in the ovine udder during lactogenesis in healthy ewes or ewes with pregnancy toxaemia. J Dairy Res. 2015; 82(3): 293-303.
  • Cumbers MR, Chung ST, Wakerley JB. A neuromodulatory role for oxytocin within the supramammillary nucleus. Neuropeptides. 2007; 41(4): 217-226.
  • Dantas A, Siqueira ER, Fernandes S, Oba E, Machado VMV, Castilho AM, Sartori MMP, Santos RV. Mammary artery Doppler ultrasonography of Brazilian Bergamasca dairy ewe lambs under the influence of two different feding plans. Pesq Vet Bras. 2017; 37(2): 179-182.
  • Erdogan G. Veteriner jinekolojide Doppler ultrasonografi kullanım alanları. Turkiye Klinikleri J Vet Sci Obstet Gynecol-Special Topics. 2018; 4(1): 43-49.
  • Ginther OJ. Producing Spectral Graphs, In: Ultrasonic Imaging and Animal Reproduction: Color-Doppler Ultrasonography Book 4, Ed; Ginther OJ, Equiservices Publishing, Wisconsin, USA. 2007; pp. 61-86.
  • Gorewit RC, Aromando MC, Bristol DG. Measuring bovine mammary gland blood flow using a transit time ultrasonic flow probe. J Dairy Sci. 1989; 72(7): 1918-1928.
  • Gutkowska J, Jankowski M, Mukaddam-Daher S, McCann SM. Oxytocin is a cardiovascular hormone. Braz J Med Biol Res. 2000; 33(6): 625-633.
  • Haanwickel MA, Elias LK, Favaretto ALV, Gutkowska J, McCann SM. Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat. Proc Natl Acad Sci USA. 1995; 92(17): 7902-7906.
  • Kensinger MH, Collier RJ, Wilcox CJ, Caton D. Variability of resting mammary blood flow in nonlactating Holstein cows. J Dairy Sci. 1983; 66(8): 1742-1746.
  • Kuru M, Mülazımoglu SB, Kaya D. Koyun ve keçilerde güç doğum. Turkiye Klinikleri J Vet Sci Obstet Gynecol-Special Topics. 2016; 2(1): 74-77.
  • Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrin. 2004; 25(3-4): 150-176.
  • Macuhova J, Tancin V, Bruckmaler RM. Effects of oxytocin administration on oxytocin release and milk ejection. J Dairy Sci. 2004; 87(5): 1236-1244.
  • Meinecke-Tillmann S. Basics of ultrasonographic examination in sheep. Small Rumin Res. 2017; 152: 10-21.
  • Nakano J, Fisher RD. Studies on the cardiovascular effects of synthetic oxytocin. J Pharmacol Exp Ther. 1963; 142(2): 206-214.
  • Petersson M. Cardiovascular effects of oxytocin. Prog Brain Res. 2002; 139: 281-288.
  • Petersson M, Alster P, Lundeberg T, Uvnas-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiol Behav. 1996; 60(5): 1311-1315.
  • Petridis IG, Barbagianni MS, Ioannidi KS, Samaras E, Fthenakis GC, Vloumidi EI. Doppler ultraonographic examination in sheep. Small Rumin Res. 2017; 152: 22-32.
  • Petridis IG, Gouletsou PG, Barbagianni MS, Amiridis GS, Brozos C, Valasi I, Fthenakis GC. Ultrasonographic findings in the ovine udder during involution. J Dairy Res. 2014; 81(3): 288-296.
  • Piccione G, Arcigli A, Assenza A, Percipalle M, Coala G. Pulsed wave-Doppler ultrasonographic evaluation of the mammary blood flow in the ewe. Acta Vet Brno. 2004; 73(1): 23-27.
  • Prosser CG, Davis SR, Farr VC, Lacasse P. Regulation of blood flow in the mammary microvasculature. J Dairy Sci. 1996; 79(7): 1184-1197.
  • Reynolds M, Linzell JL, Rasmussen F. Comparison of four methods for measuring mammary blood flow in conscious goats. Am J Physiol. 1968; 214(6): 1415-1424.
  • Risvanli A, Dogan H, Saat N, Seker I. Relationship between pulsed wave Doppler ultrasonographic features of milk veins and CMT scores in Simmental cows. Ankara Üniv Vet Fak Derg. 2018; 65(1): 69-72.
  • Rizzo A, Mutinati M, Minoia G, Spedicato M, Pantaleo M, Sciorsci RL. The impact of oxytocin on the hemodynamic features of the milk vein in dairy cows: a color Doppler investigation. Res Vet Sci. 2012; 93(2): 983-988.
  • Russel AJ, Doney FJM, Gunn RG. Subjective assessment of fat in live sheep. J Agric Sci. 1969; 72(3): 451-454.
  • Santos VJC, Simplicio K, Sanchez D, Coutinho I, Teixeira P, Barros F, Almeida V, Rodrigues I, Bartlewski P, Oliveira M, Feliciano M, Vicente W. B-mode and Doppler sonography of the mammary glands in dairy goats for mastitis diagnosis. Reprod Dom Anim. 2015; 50(2): 251-255.
  • Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC. Human vascular endothelial cells Express oxytocin receptors. Endocrinology. 1999; 140(3): 1301-1309.
  • Vedernikov YP, Betancourt A, Wentz MJ, Saade GR, Garfield RE. Adaption to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin. Am J Obstet Gynecol. 2006; 194(1): 252-260.
  • Zamiri MJ, Qotbi A, Izadifard J. Effect of daily oxytocin injection on milk yield and lactation length in sheep. Small Rum Res. 2001; 40(2): 179-185.
There are 29 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section RESEARCH ARTICLE
Authors

Gamze Evkuran Dal 0000-0002-9996-3290

Publication Date September 30, 2020
Acceptance Date September 1, 2020
Published in Issue Year 2020 Volume: 13 Issue: 3

Cite

APA Evkuran Dal, G. (2020). Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri. Kocatepe Veterinary Journal, 13(3), 313-318. https://doi.org/10.30607/kvj.748613
AMA Evkuran Dal G. Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri. kvj. September 2020;13(3):313-318. doi:10.30607/kvj.748613
Chicago Evkuran Dal, Gamze. “Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri”. Kocatepe Veterinary Journal 13, no. 3 (September 2020): 313-18. https://doi.org/10.30607/kvj.748613.
EndNote Evkuran Dal G (September 1, 2020) Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri. Kocatepe Veterinary Journal 13 3 313–318.
IEEE G. Evkuran Dal, “Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri”, kvj, vol. 13, no. 3, pp. 313–318, 2020, doi: 10.30607/kvj.748613.
ISNAD Evkuran Dal, Gamze. “Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri”. Kocatepe Veterinary Journal 13/3 (September 2020), 313-318. https://doi.org/10.30607/kvj.748613.
JAMA Evkuran Dal G. Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri. kvj. 2020;13:313–318.
MLA Evkuran Dal, Gamze. “Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri”. Kocatepe Veterinary Journal, vol. 13, no. 3, 2020, pp. 313-8, doi:10.30607/kvj.748613.
Vancouver Evkuran Dal G. Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri. kvj. 2020;13(3):313-8.

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