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Pnömonili Sığırlarda Miyeloid Hücrelerde Eksprese Edilen Mid-regional Pro-adrenomedullin ve Soluble Tetikleyici Reseptörün Serum Düzeyleri

Year 2023, Volume: 16 Issue: 1, 109 - 117, 31.03.2023
https://doi.org/10.30607/kvj.1215383

Abstract

Bu çalışma, pnömoni tanısı konulan sığırlarda mid-regional pro-adrenomedullin (MR-Pro ADM) ve miyeloid hücrelerde eksprese soluble tetikleyici reseptör olmak üzere iki enflamatuvar biyobelirteç ile bazı biyokimyasal ve hematolojik parametrelerin serum düzeylerinin belirlenmesini amaçladı. Bu amaçla 2-7 yaş arası öksürük, nefes darlığı, burun akıntısı, iştahsızlık ve abdominal solunumu gösteren 40 hasta dişi sığır ve aynı yaş aralığında 15 sağlıklı dişi sığır değerlendirildi. Hasta sığırlar tedavi edilmeden önce klinik ve radyolojik muayenelere tabi tutuldu ve kan örnekleri alındı. Sağlıklı sığırlar ayrıca klinik muayeneye tabi tutuldu ve bir kez kan örnekleri alındı. Kan örnekleri biyokimyasal ve hematolojik ölçümler için kullanıldı. Hasta grupta MR-Pro ADM serum düzeyleri (86,38±6,33) kontrol grubuna (61,81±4,96) göre daha yüksek bulundu. Hasta sığırların sTREM-1 seviyeleri (75,93±1,86) sağlıklı gruba kıyasla (96,55±9,13) karşılaştırıldığında istatistiksel olarak anlamlı düşük bulundu.
Sonuç olarak: MR-Pro ADM ve sTREM-1 seviyeleri pnömonili sığırlarda diagnostik açıdan oldukça önemlidir.

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References

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Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

Year 2023, Volume: 16 Issue: 1, 109 - 117, 31.03.2023
https://doi.org/10.30607/kvj.1215383

Abstract

This study aimed to determine the serum levels of two inflammatory biomarkers, named, mid-regional pro-adrenomedullin (MR-Pro ADM) and soluble triggering receptor expressed on myeloid cells (sTREM-1), in cattle diagnosed with pneumonia. For this purpose, 40 patient female cattle, which were aged 2-7 years and displayed coughing, dyspnea, nasal discharge, anorexia and abdominal respiration, and 15 healthy female cattle within the same age range, were evaluated. The diseased cattle underwent clinical and radiological examinations and were sampled for blood prior to receiving treatment. The healthy subjects also underwent clinical examination and were sampled for blood once. Blood samples were used for biochemical and hematological measurements. While the diseased group had higher serum levels of MR-Pro ADM (86.38±6.33), compared to the healthy control group (61.81±4.96); the pneumonic cattle had lower levels of sTREM-1 (75.93±1.86), in comparison to the healthy group (96.55±9.13).
In conclusion: MR-Pro ADM and sTREM-1 levels are very important diagnostically in cattle with pneumonia

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References

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  • Akpınar S, Rollas K, Alagöz A, Seğmen F, Sipit T. Performance evaluation of MR-proadrenomedullin and other scoring systems in severe sepsis with pneumonia. J Thorac Dis. 2014; 6(7): 921-929.
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  • Akyüz E, Merhan O, Aydın U, Sezer M, Kuru M, Karakurt E, Yıldız U, Bozukluhan K, Batı YU, Yıldız A, Gökce G. Neopterin, procalcitonin, total sialic acid, paraoxonase-1 and selected haematological indices in calves with aspiration pneumonia. Acta Vet Brno. 2022; 91: 115-124.
  • Altuğ, N, Özdemir R, Cantekin Z. Ruminantlarda koruyucu hekimlik: I. Aşı uygulamaları. Erciyes Üniv Vet Fak Derg. 2013; 10(1): 33-44.
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  • Aydoğdu U, Yıldız R, Güzelbekteş H, Coşkun A, İsmail Ş. Yenidoğan ishalli buzağılarda mortalite indikatörü olarak kan laktat, glikoz, total protein ve gama glutamil transferaz seviyeleri. F Ü Sağ Bil Vet Derg, 2019; 33(3): 201-206.
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  • Batmaz H. Sığırların İç Hastalıkları, Semptomdan Tanıya, Tanıdan Sağaltıma. Genişletilmiş 2. Baskı, F Özsan Mat San ve Tic Ltd Şti, Bursa, 2010.
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  • Coşkun A, Şen İ. Haematological, biochemical and coagulation changes in calves with endotoxemia. Agric J. 2012; 7: 37-41.
  • Derek M. Review of BRD pathogenesis: the old and the new. Anim Health Res Rev. 2014; 15(2):166-8.
  • Dörtkardeş AB. Klinik olarak pneumoni tespit edilen buzağılarda haptoglobin, serum amiloid A ve hepsidin değerlerinin araştırılması. Yüksek Lisans Tez, Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü, Burdur, 2018.
  • Durgut R, Köse Sİ. Sığırlarda Akut İntersitisyel Pnömoni Turkiye Klinikleri. J Vet Sci Intern Med-Special Topics. 2017; 3(2): 143-7.
  • Elitok B, Elitok OM. Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. J Vet Pharmacol Ther. 2004; 27(5):317-20.
  • Eroğlu MS, Kırbaş A. Sistemik inflamatuar yanıt sendromu ve sepsis. F Ü Sağ Bil Vet Derg. 2020; 34(1): 61-67.
  • Fahmey SS, Mostafa H, Abd Elhafeez N, Hussain H. Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis. Korean J Pediatr. 2018; 61(5):156-159.
  • Gamez-Diaz LY, Enriquez LE, Matute JD, Velásquez S, Iván DG, Toro F, Ospina S, Bedoya V, Arango CM, Valencia ML, De La Rosa G, Gómez CI, García A, Patiño PJ, Jaimes FA. Diagnostic accuracy of HMGB-1, s-TREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department. Acad Emerg Med. 2011; 18: 807-815.
  • Garayoa M, Martinez A, Lee S, Pio R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M, Cuttitta F. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis. Mol Endocrinol. 2000; 14(6): 848-862.
  • Garazzino S, Altieri E, Denina M. The role of Pro-adrenomedullin as a marker of severe bacterial infection in children: A Review. Reports. 2019; 2:17.
  • Geven C, Kox M, Pickkers P. Adrenomedullin and Adrenomedullin- targeted therapy as treatment strategies relevant for sepsis. Front Immunol. 2018; 9:292.
  • Ghobrial EE, Khorshied MM, Adly SB, Aziz MM. Proadrenomedullin as a prognostic biomarker for critically-ill septic children. Res Square. 2020; 1:15.
  • Griffin D, Chengappa MM, Kuszak J, McVey DS. Bacterial pathogens of the bovine respiratory disease complex. Vet Clin North Am Food Anim Pract. 2010; 26(2): 381-94.
  • Guterbock WM. The impact of BRD: the current dairy experiance. Anim Health Res Rev. 2014; 15(2);130-4.
  • Gülersoy E, Şen İ. Turkiye Klinikleri J Vet Sci Intern Med-Special Topics. 2017; 3(2): 114-21.
  • Henry B, Charmley E, Eckard R, Gaughan JB, Hegarty R. Livestock production in a changing climate: adaptation and mitigation research in Australia. Crop Pasture Sci. 2012; 63: 191-202.
  • Hilton WM. BRD in 2014: where have we been, where are we now, and where do we want to go? Anim Health Res Rev. 2014; 15(2): 120-2.
  • Hodgins DC, Conlon JA, Shewen PE. Respiratory viruses and bacteria in cattle, Ed; Brogden KA, Guthmiller JM, Polymicrobial Diseases. Washington DC, ASM Press. 2002; p. 213-230.
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There are 66 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences
Journal Section RESEARCH ARTICLE
Authors

Mert Sezer 0000-0003-1691-7764

Enes Akyüz 0000-0002-3288-2058

Oğuz Merhan 0000-0002-3399-0667

Uğur Aydın 0000-0001-5756-4841

Umut Batı 0000-0001-7528-4376

Uğur Yıldız 0000-0002-4782-1012

Tahir Gezer 0000-0001-7838-2553

Ekin Emre Erkılıç 0000-0003-2461-5598

Ali Haydar Kırmızıgül 0000-0002-9283-1391

Gürbüz Gökçe 0000-0002-2492-5193

Project Number destekleyen kurum yok
Early Pub Date March 31, 2023
Publication Date March 31, 2023
Acceptance Date March 14, 2023
Published in Issue Year 2023 Volume: 16 Issue: 1

Cite

APA Sezer, M., Akyüz, E., Merhan, O., Aydın, U., et al. (2023). Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia. Kocatepe Veterinary Journal, 16(1), 109-117. https://doi.org/10.30607/kvj.1215383
AMA Sezer M, Akyüz E, Merhan O, Aydın U, Batı U, Yıldız U, Gezer T, Erkılıç EE, Kırmızıgül AH, Gökçe G. Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia. kvj. March 2023;16(1):109-117. doi:10.30607/kvj.1215383
Chicago Sezer, Mert, Enes Akyüz, Oğuz Merhan, Uğur Aydın, Umut Batı, Uğur Yıldız, Tahir Gezer, Ekin Emre Erkılıç, Ali Haydar Kırmızıgül, and Gürbüz Gökçe. “Serum Levels of Mid-Regional Pro-Adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle With Pneumonia”. Kocatepe Veterinary Journal 16, no. 1 (March 2023): 109-17. https://doi.org/10.30607/kvj.1215383.
EndNote Sezer M, Akyüz E, Merhan O, Aydın U, Batı U, Yıldız U, Gezer T, Erkılıç EE, Kırmızıgül AH, Gökçe G (March 1, 2023) Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia. Kocatepe Veterinary Journal 16 1 109–117.
IEEE M. Sezer, “Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia”, kvj, vol. 16, no. 1, pp. 109–117, 2023, doi: 10.30607/kvj.1215383.
ISNAD Sezer, Mert et al. “Serum Levels of Mid-Regional Pro-Adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle With Pneumonia”. Kocatepe Veterinary Journal 16/1 (March 2023), 109-117. https://doi.org/10.30607/kvj.1215383.
JAMA Sezer M, Akyüz E, Merhan O, Aydın U, Batı U, Yıldız U, Gezer T, Erkılıç EE, Kırmızıgül AH, Gökçe G. Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia. kvj. 2023;16:109–117.
MLA Sezer, Mert et al. “Serum Levels of Mid-Regional Pro-Adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle With Pneumonia”. Kocatepe Veterinary Journal, vol. 16, no. 1, 2023, pp. 109-17, doi:10.30607/kvj.1215383.
Vancouver Sezer M, Akyüz E, Merhan O, Aydın U, Batı U, Yıldız U, Gezer T, Erkılıç EE, Kırmızıgül AH, Gökçe G. Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia. kvj. 2023;16(1):109-17.

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