Case Report
Year 2023,
Volume: 16 Issue: 3, 459 - 463, 30.09.2023
Abstract
Beş yaşında, kısırlaştırılmamış, dişi kobay sağ meme lobunda bir kitle şikayeti ile kliniğimize getirildi. Ultrasonografik muayeneye göre kitle; kapsüllü, 8,1 cm çapında, polikistik yapıda, miks ekojenite ve miks vaskülarizasyona sahipti. Hastaya mastektomi uygulandı. Kitlenin histopatolojisi sonucunda solid karsinom teşhisi konuldu (Grade-III). Mastektomiden ortalama 2,5 ay sonra kobayda karın şişliği meydana geldi. Laparotomi sonrasında her iki overde de kist ve korpus uteri üzerinde leiomyosarkom içeren kitle saptandı. Sonuç olarak, meme tümörü öyküsü olan gine piglerde metastas ihtimaline karşı genital organ patolojileri klinik açıdan mümkün olan en kısa süre içerisinde değerlendirilmelidir.
Project Number
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References
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- Oliveira, R.E.M., Oliveira, R.K.M., Dalmagro, M.J., Silva, D.N., Gurgel, J.V.O., Sousa, A.C.F.C., Attademo, F.L.N., Soares, M.K.F., Arcoverde, K.N., Olinda, R.G., Santos, P.R.S., Torres, D.C.B., Rego, R.O., Diniz, J.A.R., Moura, C.E.B., Batista, J.S., Oliveira, M.F. (2023). Mammary tubular carcinoma in a guinea pig (Cavia porcellus): case report. Brazilian Journal of Case Reports, 3(4), 18-23. https://doi.org/10.52600/2763-583X.bjcr.2023.3.4.18-23. Pilny, A. (2014). Ovarian cystic disease in guinea pigs. Veterinary Clinics: Exotic Animal Practice, 17(1), 69-75. https://doi.org/10.1016/j.cvex.2013.09.003.
- Rivas, G., Bonilla, C., Rubiano, J., & Arango, N. (2014). Primary leiomyosarcoma of the ovary: A case report. Case Reports in Clinical Medicine, 3, 192-196. https://doi.org/10.4236/crcm.2014.34045. Suárez-Bonnet, A., Martín de Las Mulas, J., Millan, M. Y., Herráez, P., Rodríguez, F., & Espinosa de los Monteros, A. (2010). Morphological and immunohistochemical characterization of spontaneous mammary gland tumors in the guinea pig (Cavia porcellus). Veterinary pathology, 47(2), 298-305. https://doi.org/10.1177/0300985809358426.
- Uyguner, K., Enginler, S. Ö., Yıldar, E., Öztürk, G. Y., & Gülçubuk, A. (2021). Serous multicystic papillary adenoma of the ovaries and glandular cystic hyperplasia of uterus in a Guinea Pig (Cavia porcellus). Journal of Istanbul Veterinary Sciences, 5(3), 144-148. https://doi.org/10.30704/http-www-jivs-net.999648.
- Veiga-Parga, T., La Perle, K. M., & Newman, S. J. (2016). Spontaneous reproductive pathology in female guinea pigs. Journal of Veterinary Diagnostic Investigation, 28(6),656-661.https://doi.org/10.1177/1040638716665429.
Uterine Leiomyosarcoma and Bilateral Ovarian Cysts Subsequent to Mammary Tumor in a Guinea Pig (cavia porcellus)
Abstract
A 5-year-old, intact female guinea pig was brought to our clinic with a complaint of a large mass in the right mammary lobe. According to ultrasonographic examination, the mass was encapsulated, had a diameter of 8.1 cm, exhibited a polycystic structure, mixed echogenicity, and mixed vascularization. The patient underwent mastectomy. Histopathological analysis of the mass revealed a diagnosis of solid carcinoma (Grade-III). Approximately 2.5 months after mastectomy, the guinea pig developed abdominal swelling. Upon laparotomy, cysts were identified in both ovaries, and a mass containing leiomyosarcoma on the corpus uteri was detected. In conclusion, guinea pigs with a history of mammary tumors should be evaluated for genital organ pathologies as a precaution against the possibility of metastasis at the earliest opportunity.
Supporting Institution
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Project Number
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Thanks
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References
- Abma, E., Stock, E., De Spiegelaere, W., Van Brantegem, L., Vanderperren, K., Ni, Y., Vynck, M., Daminet, S., De Clercq, S.,& De Rooster, H. (2019). Power Doppler ultrasound and contrast-enhanced ultrasound demonstrate non-invasive tumour vascular response to anti-vascular therapy in canine cancer patients. Scientific Reports, 9(1), 1-12. https://doi.org/10.1038/s41598-019-45682-2.
- Amorim, I., Faria, F., Rema, A., & Gärtner, F. (2009). Immunohistochemical Characterization of a Mammary Carcinoma in a Male Guinea Pig (Cavia porcellus). Journal of Comparative Pathology, 141(4), 279. https://doi.org/10.1016/j.jcpa.2009.08.008.
- Chittenden, B. G., Fullerton, G., Maheshwari, A., & Bhattacharya, S. (2009). Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reproductive Biomedicine Online, 19(3), 398-405. https://doi.org/10.1016/S1472-6483(10)60175-7.
- Donnelly, T.M. (2021). Guinea pigs. Available at https://www.merckvetmanual.com/all-other-pets/guinea-pigs/disorders-and-diseases-of-guinea-pigs#v3227529 (Accessed Jan 06, 2021).
- Greenacre, C. B. (2004). Spontaneous tumors of small mammals. Veterinary Clinics: Exotic Animal Practice, 7(3),627-651. https://doi.org/10.1016/j.cvex.2004.04.009. Fish, R.E., Brown, M.J., Danneman, P.J. & Karas, A.Z. (2008) Anesthesia and Analgesia in Laboratory Animals (2nd ed) Elsevier, San Diego, CA, U.S.A.
- Keller, L. S. F., Griffith, J. W., & Lang, C. M. (1987). Reproductive failure associated with cystic rete ovarii in guinea pigs. Veterinary pathology, 24(4), 335-339. https://doi.org/10.1177/030098588702400408. Kohutova, S., Paninarova, M., Škorič, M., Jekl, V., Knotek, Z., & Hauptman, K. (2018). Cystic endometrial hyperplasia and bacterial endometritis associated with an intrauterine foreign body in a guinea pig with ovarian cystic disease. Journal of Exotic Pet Medicine, 27(1), 41-45. https://doi.org/10.1053/j.jepm.2017.10.001.
- Mantziaras, G., & Luvoni, G. C. (2020). Advanced ultrasound techniques in small animal reproduction imaging. Reproduction in Domestic Animals, 55, 17-25. https://doi.org/10.1111/rda.13587.
- Oliveira, R.E.M., Oliveira, R.K.M., Dalmagro, M.J., Silva, D.N., Gurgel, J.V.O., Sousa, A.C.F.C., Attademo, F.L.N., Soares, M.K.F., Arcoverde, K.N., Olinda, R.G., Santos, P.R.S., Torres, D.C.B., Rego, R.O., Diniz, J.A.R., Moura, C.E.B., Batista, J.S., Oliveira, M.F. (2023). Mammary tubular carcinoma in a guinea pig (Cavia porcellus): case report. Brazilian Journal of Case Reports, 3(4), 18-23. https://doi.org/10.52600/2763-583X.bjcr.2023.3.4.18-23. Pilny, A. (2014). Ovarian cystic disease in guinea pigs. Veterinary Clinics: Exotic Animal Practice, 17(1), 69-75. https://doi.org/10.1016/j.cvex.2013.09.003.
- Rivas, G., Bonilla, C., Rubiano, J., & Arango, N. (2014). Primary leiomyosarcoma of the ovary: A case report. Case Reports in Clinical Medicine, 3, 192-196. https://doi.org/10.4236/crcm.2014.34045. Suárez-Bonnet, A., Martín de Las Mulas, J., Millan, M. Y., Herráez, P., Rodríguez, F., & Espinosa de los Monteros, A. (2010). Morphological and immunohistochemical characterization of spontaneous mammary gland tumors in the guinea pig (Cavia porcellus). Veterinary pathology, 47(2), 298-305. https://doi.org/10.1177/0300985809358426.
- Uyguner, K., Enginler, S. Ö., Yıldar, E., Öztürk, G. Y., & Gülçubuk, A. (2021). Serous multicystic papillary adenoma of the ovaries and glandular cystic hyperplasia of uterus in a Guinea Pig (Cavia porcellus). Journal of Istanbul Veterinary Sciences, 5(3), 144-148. https://doi.org/10.30704/http-www-jivs-net.999648.
- Veiga-Parga, T., La Perle, K. M., & Newman, S. J. (2016). Spontaneous reproductive pathology in female guinea pigs. Journal of Veterinary Diagnostic Investigation, 28(6),656-661.https://doi.org/10.1177/1040638716665429.
There are 11 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Obstetrics and Gynecology |
| Journal Section | CASE REPORT |
| Authors | |
| Project Number | - |
| Publication Date | September 30, 2023 |
| Acceptance Date | September 4, 2023 |
| Published in Issue | Year 2023 Volume: 16 Issue: 3 |
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