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Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu

Year 2015, Volume: 3 Issue: 1, 1 - 9, 10.03.2015

Duygu Mutluay Hakan Öner

Abstract

Farede fertilizasyon ile başlayan preimplantasyon dönemi sıvı dolu kaviteye sahip blastosistin zona pellusida’dan kurtularak annenin uterus dokusuna implante olması ile son bulur. Erken blastosist, iç hücre kütlesi (ICM) ve trofoektoderm (TE) olarak adlandırılan iki farklı hücre kökeninden meydana gelir. Pluripotent özellik gösteren ICM, farklılaşmamış hücrelerden oluşarak embr yoyu meydana getirir. Trofoblastın progenitörü olan trofoektoderm hücreleri ise ICM’i ve blastosist kavitesini sararak, uterus duvarına implantasyona aracılık eder ve plasentasyona katkıda bulunur. Bu derlemede preimplantasyon döneminde meydana gelen moleküler ve hücresel olaylar açıklanmış, implantasyonun gerçekleşmesi ve gebeliğin sürdürülebilmesi için esansiyel olan, TE, ICM, blastosist kavitesinin oluşumu, bu süreçte anahtar rol oynayan transkripsiyon faktörleri ve hücre polaritesi hakkında bilgi verilmiştir. Bu dönemde yer alan mekanizmaların anlaşılması hem memeli gelişimi hem de klinik açıdan özellikle yapay üreme yöntemlerinin geliştirilmesi bakımından önem taşımaktadır.

Keywords

Embriyo gelişimi preimplantasyon TE ICM

References

  • allocation
  • embryogenesis. Semin Cell Dev Biol. 15: 583–597. polarity and cell during mouse 13.
  • foundation of two distinct cell lineages within the mouse morula. Cell. 24: 71–80. 14.
  • Hatano SY, Suemori H, Nakatsuji N, Tada T. 2005. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol. 25: 2475–2485. 15.
  • Rho-associated kinase Activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol. Reprod. 89:122.
  • Larue L, Ohsugi M, Hirchenhain J, Kemler R. 1994. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci USA. 91: 8263–8267 17.
  • P, Maro B. 1996. Ezrin becomes restricted to outer cells
  • preimplantation mouse embryo. Dev Biol. 177: 568– 579. division in
  • the Louvet-Vallee S, Dard N, Santa-Maria A, Aghion J, Maro B. 2001. A majör posttranslational modification of ezrin takes place during epithelial differentiation in the early mouse embryo. Dev Biol. 231: 190–200. 19.
  • Establishment of trophectoderm and inner cell mass lineages in the mouse embryo. Mol Reprod Dev., 76, 1019-32. Alarcon VB. 2009. 20.
  • Trophectoderm, the First epithelium, in Mouse Preimplantation Development. Results Probl Cell Differ. 55: 165-84.
  • Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. 2003. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 113: 631–642 22.
  • Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. Dev Biol. 312: 509–522. 23.
  • H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 95: 379–391. 24.
  • components of the adherens junction. Biochim Biophys Acta. 1778: 562–571 25.
  • Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin. Dev Biol. 185: 261–271 26.
  • Muramatsu M, Hamada H. 1990. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 60: 461–472 27.
  • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol. 166: 259–267. 28.
  • expression and stage-specific localization of protein kinase C isotypes during Mouse preimplantation development. Dev Biol. 223: 411–421. 29.
  • Binns K, Kulkarni S, Pawson T. 2003. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol., 5, 301–308. 30.
  • Hadjantonakis AK, Moore CA, Papalopulu N, Papaioannou VE, Glover DM, Zernicka-Goetz M (2005): Down regulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo. J Cell Sci., 118, 505–515. 31.
  • PM, Poirier F, Rigby PW, Staudt LM. 1990. A POU- domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 345: 686–692. 32.
  • polar asymmetries in the peri-implantation mouse blastocysts. Seminars in Cell & Developmental Biology. 15: 573-581. 33.
  • Chowdhury K, Gruss P. 1990. New type of POU domain in germ line-specific protein Oct-4. Nature. 344: 435–439. 34.
  • WY, Papenbrock T, Fleming TP. 2008. Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation. Exp Cell Res. 314: 3356–3368. 35.
  • The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early mouse development. Cell. 35: 631–638. 36.
  • A, Chawengsaksophak K, Beck F, Rossant J. 2005. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 132: 2093–2102. 37.
  • defined media and the culture of mammalian preimplantation embryos: Historical perspective and current issues. Hum Reprod Update. 9: 557–582. 38.
  • Tarkowski AK. 2008. Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental
  • blastomeres of 16- and 32-cell embryos. Dev Biol. 322: 133–144 of inner and
  • outer Thomas FC, Sheth B, Eckert JJ, Bazzoni G, Dejana E, Fleming TP. 2004. Contribution of JAM-1 to
  • biogenesis in the mouse preimplantation embryo. J Cell Sci. 117: 5599–5608. and tight-junction 40.
  • A, Tsukita S. 2008. Tight junction-based epithelial microenvironment and cell proliferation. Oncogene, 27: 6930–6938.
  • Verlhac M-H, Lefebvre C, Guillaud P, Rassinier P, Maro B. 2000. Asymmetric division in mouse oocytes: with or without Mos. Curr Biol. 10: 1303–1306. 42.
  • Louvet-Vallee S. 2005. Asymmetric distribution of PAR proteins in the Mouse embryo begins at the 8- cell stage during compaction. Dev Biol. 282: 307– 319. 43.
  • Prince LS, Reese J, Paria BC (2008): Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 318: 112–125.
  • Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S. 2003. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol. 13: 734–743. 45.
  • Rossant J. 2006. Cell and Molecular Regulation of the Mouse Blastocyst. Dev Dyn. 235: 2301-2314.

Formation of Trophectoderm and Inner Cell Mass in Mouse Preimplantation Development

Year 2015, Volume: 3 Issue: 1, 1 - 9, 10.03.2015

Duygu Mutluay Hakan Öner

Abstract

Preimplantation development in mouse initiates with fertilization and results in the formation of blastocysts, a fluid filled cavity that is released from zona pellucida and implanted into the mother’s uterine wall. The early blastocysts consists of two distinct cell lineages, called trophectoderm (TE) and inner cell mass (ICM). The pluripotent ICM is an undifferentiated mass of cells that will give rise to the embryo proper. TE is the progenitor of trophoblasts, which surrounds the ICM and blastocyst cavity, mediates blastocyst implantation to the uterine wall, and contributes to placentation. In this review, molecular and cellular events that occur during preimplantation development are described. Additionally, some information was given about formation of TE, ICM, blastocyst cavity and cell polarity and transcription factors playing a key role in this process that are essential for implantation and maintaining the pregnancy. Understanding of such mechanisms is important for mammalian evolution and clinical aspects, particularly for developing the human artificial reproductive technology. 

Keywords

Embryo development preimplantation TE ICM

References

  • allocation
  • embryogenesis. Semin Cell Dev Biol. 15: 583–597. polarity and cell during mouse 13.
  • foundation of two distinct cell lineages within the mouse morula. Cell. 24: 71–80. 14.
  • Hatano SY, Suemori H, Nakatsuji N, Tada T. 2005. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol. 25: 2475–2485. 15.
  • Rho-associated kinase Activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol. Reprod. 89:122.
  • Larue L, Ohsugi M, Hirchenhain J, Kemler R. 1994. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci USA. 91: 8263–8267 17.
  • P, Maro B. 1996. Ezrin becomes restricted to outer cells
  • preimplantation mouse embryo. Dev Biol. 177: 568– 579. division in
  • the Louvet-Vallee S, Dard N, Santa-Maria A, Aghion J, Maro B. 2001. A majör posttranslational modification of ezrin takes place during epithelial differentiation in the early mouse embryo. Dev Biol. 231: 190–200. 19.
  • Establishment of trophectoderm and inner cell mass lineages in the mouse embryo. Mol Reprod Dev., 76, 1019-32. Alarcon VB. 2009. 20.
  • Trophectoderm, the First epithelium, in Mouse Preimplantation Development. Results Probl Cell Differ. 55: 165-84.
  • Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. 2003. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 113: 631–642 22.
  • Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. Dev Biol. 312: 509–522. 23.
  • H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 95: 379–391. 24.
  • components of the adherens junction. Biochim Biophys Acta. 1778: 562–571 25.
  • Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin. Dev Biol. 185: 261–271 26.
  • Muramatsu M, Hamada H. 1990. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 60: 461–472 27.
  • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol. 166: 259–267. 28.
  • expression and stage-specific localization of protein kinase C isotypes during Mouse preimplantation development. Dev Biol. 223: 411–421. 29.
  • Binns K, Kulkarni S, Pawson T. 2003. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol., 5, 301–308. 30.
  • Hadjantonakis AK, Moore CA, Papalopulu N, Papaioannou VE, Glover DM, Zernicka-Goetz M (2005): Down regulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo. J Cell Sci., 118, 505–515. 31.
  • PM, Poirier F, Rigby PW, Staudt LM. 1990. A POU- domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 345: 686–692. 32.
  • polar asymmetries in the peri-implantation mouse blastocysts. Seminars in Cell & Developmental Biology. 15: 573-581. 33.
  • Chowdhury K, Gruss P. 1990. New type of POU domain in germ line-specific protein Oct-4. Nature. 344: 435–439. 34.
  • WY, Papenbrock T, Fleming TP. 2008. Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation. Exp Cell Res. 314: 3356–3368. 35.
  • The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early mouse development. Cell. 35: 631–638. 36.
  • A, Chawengsaksophak K, Beck F, Rossant J. 2005. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 132: 2093–2102. 37.
  • defined media and the culture of mammalian preimplantation embryos: Historical perspective and current issues. Hum Reprod Update. 9: 557–582. 38.
  • Tarkowski AK. 2008. Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental
  • blastomeres of 16- and 32-cell embryos. Dev Biol. 322: 133–144 of inner and
  • outer Thomas FC, Sheth B, Eckert JJ, Bazzoni G, Dejana E, Fleming TP. 2004. Contribution of JAM-1 to
  • biogenesis in the mouse preimplantation embryo. J Cell Sci. 117: 5599–5608. and tight-junction 40.
  • A, Tsukita S. 2008. Tight junction-based epithelial microenvironment and cell proliferation. Oncogene, 27: 6930–6938.
  • Verlhac M-H, Lefebvre C, Guillaud P, Rassinier P, Maro B. 2000. Asymmetric division in mouse oocytes: with or without Mos. Curr Biol. 10: 1303–1306. 42.
  • Louvet-Vallee S. 2005. Asymmetric distribution of PAR proteins in the Mouse embryo begins at the 8- cell stage during compaction. Dev Biol. 282: 307– 319. 43.
  • Prince LS, Reese J, Paria BC (2008): Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 318: 112–125.
  • Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S. 2003. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol. 13: 734–743. 45.
  • Rossant J. 2006. Cell and Molecular Regulation of the Mouse Blastocyst. Dev Dyn. 235: 2301-2314.
There are 38 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Makaleler
Authors

Duygu Mutluay

Hakan Öner This is me

Publication Date March 10, 2015
Submission Date February 13, 2015
Published in Issue Year 2015 Volume: 3 Issue: 1

Cite

APA Mutluay, D., & Öner, H. (2015). Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 3(1), 1-9.
AMA Mutluay D, Öner H. Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu. Mehmet Akif Ersoy University Journal of Health Sciences Institute. November 2015;3(1):1-9.
Chicago Mutluay, Duygu, and Hakan Öner. “Farelerde Preimplantasyon Döneminde Trofoektoderm Ve İç Hücre Kütlesinin Oluşumu”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 3, no. 1 (November 2015): 1-9.
EndNote Mutluay D, Öner H (November 1, 2015) Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu. Mehmet Akif Ersoy University Journal of Health Sciences Institute 3 1 1–9.
IEEE D. Mutluay and H. Öner, “Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 3, no. 1, pp. 1–9, 2015.
ISNAD Mutluay, Duygu - Öner, Hakan. “Farelerde Preimplantasyon Döneminde Trofoektoderm Ve İç Hücre Kütlesinin Oluşumu”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 3/1 (November 2015), 1-9.
JAMA Mutluay D, Öner H. Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2015;3:1–9.
MLA Mutluay, Duygu and Hakan Öner. “Farelerde Preimplantasyon Döneminde Trofoektoderm Ve İç Hücre Kütlesinin Oluşumu”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 3, no. 1, 2015, pp. 1-9.
Vancouver Mutluay D, Öner H. Farelerde Preimplantasyon Döneminde Trofoektoderm ve İç Hücre Kütlesinin Oluşumu. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2015;3(1):1-9.
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