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Year 2023, Volume: 8 Issue: 2, 104 - 111, 31.08.2023

Musa Tatar Kiymet Kubra Tüfekci

https://doi.org/10.24880/maeuvfd.1240829
Cited By: 1

Abstract

Supporting Institution

Proje herhangi bir kurum veya kuruluştan finansal destek almamıştır.

References

  • 1. Alarcon de la Lastra, C., Barranco M.D., Motilva V., & Herrerias J.M. (2001). Mediterranean diet and health: biological importance of olive oil. Current Pharmaceutical Design, 7, 933-950. https://doi.org/10.2174/1381612013397654
  • 2. Bakir, M., Geyikoglu F., Koc K., & Cerig S. (2018). Therapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats. Journal of Cancer Research and Therapeutics, 14, 671-678. https://doi.org/10.4103/jcrt.JCRT_1040_16
  • 3. Bin-Jumah, M.N., Al-Huqail A.A., Abdelnaeim N., Kamel M., Fouda M.M.A., Abulmeaty M.M.A., Saadeldin I.M., & Abdel-Daim M.M. (2021). Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats. Environmental Science and Pollution Research, 28, 26653-26663. https://doi.org/10.1007/s11356-021-12422-x
  • 4. Dewerchin, M., & Carmeliet P. (2012). PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harbor Perspectives in Medicine, 2. https://doi.org/10.1101/cshperspect.a011056
  • 5. Domitrovic, R., Jakovac H., Marchesi V.V., Sain I., Romic Z., & Rahelic D. (2012). Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. Pharmacology Research, 65, 451-464. https://doi.org/10.1016/j.phrs.2011.12.005
  • 6. El-Beltagi, H.S., & Ahmed, M.M. (2016). Assessment the protective role of quercetin on acrylamide-induced oxidative stress in rats Journal of Food Biochemistry 40, 715–723. https://doi.org/10.1111/jfbc.12262
  • 7. Esposito, F., Nolasco A., Caracciolo F., Velotto S., Montuori P., Romano R., Stasi T., & Cirillo T. (2021). Acrylamide in Baby Foods: A Probabilistic Exposure Assessment. Foods, 10. https://doi.org/10.3390/foods10122900
  • 8. Gao, H., Xue Y., Wu L., Huo J., Pang Y., Chen J., & Gao Q. (2022). Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats. Molecules, 27. https://doi.org/10.3390/molecules27134100
  • 9. Gedik, S., Erdemli M.E., Gul M., Yigitcan B., Gozukara Bag H., Aksungur Z., & Altinoz E. (2017). Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats. Biomedicine Pharmacotherapy, 95, 764-770. https://doi.org/10.1016/j.biopha.2017.08.139
  • 10. Ghorbel, I., Maktouf S., Kallel C., Ellouze Chaabouni S., Boudawara T., & Zeghal N. (2015). Disruption of erythrocyte antioxidant defense system, hematological parameters, induction of pro-inflammatory cytokines and DNA damage in liver of co-exposed rats to aluminium and acrylamide. Chemico-biological interactions, 236, 31-40. https://doi.org/10.1016/j.cbi.2015.04.020
  • 11. Hassen, I., Casabianca, H., & Hosni, K. (2015). Biological activities of the natural antioxidant oleuropein: Exceeding the expectation–A mini-review. Journal of Functional Foods, 18, 926-940. https://doi.org/10.1016/j.jff.2014.09.001
  • 12. Heindryckx, F., Coulon S., Terrie E., Casteleyn C., Stassen J.M., Geerts A., Libbrecht L., Allemeersch J., Carmeliet P., Colle I., & Van Vlierberghe H. (2013). The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model. Journal of Hepatology, 58, 319-328. https://doi.org/10.1016/j.jhep.2012.09.032
  • 13. Jemai, H., Mahmoudi A., Feryeni A., Fki I., Bouallagui Z., Choura S., Chamkha M., & Sayadi S. (2020). Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice. BioMed Research International, 2020, 4398924. https://doi.org/10.1155/2020/4398924
  • 14. Khalatbary, A.R., & Ahmadvand H. (2012). Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurological research, 34, 44-51. https://doi.org/10.1179/1743132811Y.0000000058
  • 15. Khalatbary, A.R., Ghaffari E., & Mohammadnegad B. (2015). Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain. Iranian Biomedical Journal, 19, 247-253. https://doi.org/10.7508/ibj.2015.04.009
  • 16. Kim, S.W., Hur W., Li T.Z., Lee Y.K., Choi J.E., Hong S.W., Lyoo K.S., You C.R., Jung E.S., Jung C.K., Park T., Um S.J., & Yoon S.K. (2014). Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. Experimental & Molecular Medicine, 46, e92. https://doi.org/10.1038/emm.2014.10
  • 17. Koc, K., Cerig S., Ozek N.S., Aysin F., Yildirim S., & Cakmak O., Hosseinigouzdagani M. and Geyikoglu F. (2019). The efficacy of oleuropein against non-steroidal anti-inflammatory drug induced toxicity in rat kidney. Environmental Toxicology, 34, 67-72. https://doi.org/10.1002/tox.22658
  • 18. Li, S.X., Cui N., Zhang C.L., Zhao X.L., Yu S.F., & Xie K.Q. (2006). Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system. Toxicology, 217, 46-53. https://doi.org/10.1016/j.tox.2005.08.018
  • 19. Li, X., Jin Q., Yao Q., Zhou Y., Zou Y., Li Z., Zhang S., & Tu C. (2017). Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation. Frontiers in immunology, 8, 801. https://doi.org/10.3389/fimmu.2017.00801
  • 20. Li, X., Yao Q.Y., Liu H.C., Jin Q.W., Xu B.L., Zhang S.C., & Tu C.T. (2017). Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. Journal of Cellular and Molecular Medicine, 21, 2370-2385. https://doi.org/10.1111/jcmm.13158
  • 21. Manna, C., Migliardi V., Golino P., Scognamiglio A., Galletti P., Chiariello M., & Zappia V. (2004). Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. The Journal of Nutritional Biochemistry, 15, 461-466. https://doi.org/10.1016/j.jnutbio.2003.12.010
  • 22. Numata, M., Morinaga S., Watanabe T., Tamagawa H., Yamamoto N., Shiozawa M., Nakamura Y., Kameda Y., Okawa S., Rino Y., Akaike M., Masuda M., & Miyagi Y. (2013). The clinical significance of SWI/SNF complex in pancreatic cancer. International Journal of Oncology 42, 403-410. https://doi.org/10.3892/ijo.2012.1723
  • 23. Omar, M.M., Elbashir A.A., & Schmitz O.J. (2015). Determination of acrylamide in Sudanese food by high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometry. Food chemistry, 176, 342-349. https://doi.org/10.1016/j.foodchem.2014.12.091
  • 24. Pietropaoli, F., Pantalone S., Cichelli A., & d'Alessandro N. (2022). Acrylamide in widely consumed foods - a review. Food additives and contaminants Part A, chemistry, analysis, control, exposure and risk assessment, 39, 853-887. https://doi.org/10.1080/19440049.2022.2046292
  • 25. Rifai, L., & Saleh FA. (2020). A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies. International Journal of Toxicology, 39, 93-102. https://doi.org/10.1177/1091581820902405
  • 26. Santhanasabapathy, R., Vasudevan S., Anupriya K., Pabitha R., & Sudhandiran G. (2015). Farnesol quells oxidative stress, reactive gliosis and inflammation during acrylamide-induced neurotoxicity: Behavioral and biochemical evidence. Neuroscience, 308, 212-227. https://doi.org/10.1016/j.neuroscience.2015.08.067
  • 27. Sengul, E., Gelen V., Yildirim S., Tekin S., & Dag Y. (2021). The Effects of Selenium in Acrylamide-Induced Nephrotoxicity in Rats: Roles of Oxidative Stress, Inflammation, Apoptosis, and DNA Damage. Biological trace element research, 199, 173-184. https://doi.org/10.1007/s12011-020-02111-0
  • 28. Seydi, E., Rajabi, M., Salimi, A., & Pourahmad, J. (2015). Involvement of mitochondrial-mediated caspase-3 activation and lysosomal labilization in acrylamide-induced liver toxicity. Toxicological & Environmental Chemistry, 97, 563-575. https://doi.org/10.1080/02772248.2015.1047671
  • 29. Sharif, K.O.M., Tufekci E.F., Ustaoglu B., Altunoglu Y.C., Zengin G., Llorent-Martínez E.J., Guney K. & Baloglu M.C. (2021). Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench. Food Bioscience, 41, 101005. https://doi.org/10.1016/j.fbio.2021.101005
  • 30. Topuz, S., & Bayram, M. . (2022). Oleuropein extraction from leaves of three olive varieties (Olea europaea L.): Antioxidant and antimicrobial properties of purified oleuropein and oleuropein extracts. Journal of food processing and preservation, 46, e15697. https://doi.org/10.1111/jfpp.15697
  • 31. Uthra, C., Reshi M.S., Jaswal A., Yadav D., Shrivastava S., Sinha N., & Shukla S. (2022). Protective efficacy of rutin against acrylamide-induced oxidative stress, biochemical alterations and histopathological lesions in rats. Toxicology Research, 11, 215-225. https://doi.org/10.1093/toxres/tfab125
  • 32. Valavanidis, A., Vlachogianni T., & Fiotakis C. (2009). 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 27, 120-139. https://doi.org/10.1080/10590500902885684
  • 33. Yano, K., Liaw P.C., Mullington J.M., Shih S.C., Okada H., Bodyak N., Kang P.M., Toltl L., Belikoff B., Buras J., Simms B.T., Mizgerd J.P., Carmeliet P., Karumanchi S.A., & Aird W.C. (2006). Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Journal of Experimental Medicine, 203, 1447-1458. https://doi.org/10.1084/jem.20060375
  • 34. Yano, K., Okada Y., Beldi G., Shih S.C., Bodyak N., Okada H., Kang P.M., Luscinskas W., Robson S.C., Carmeliet P., Karumanchi S.A., & Aird W.C. (2008). Elevated levels of placental growth factor represent an adaptive host response in sepsis. Journal of Experimental Medicine, 205, 2623-2631. https://doi.org/10.1084/jem.20080398 35. Yoon, S.K. (2018). Oleuropein as an Antioxidant and Liver Protect. Oxidative Stress and Dietary Antioxidants. Amsterdam, The Netherlands: Elsevier Inc, 323-335.

Oleuropein attenuates placental growth factor expression by regulating oxidative stress and apoptosis in acrylamide hepatotoxicity

Year 2023, Volume: 8 Issue: 2, 104 - 111, 31.08.2023

Musa Tatar Kiymet Kubra Tüfekci

https://doi.org/10.24880/maeuvfd.1240829
Cited By: 1

Abstract

The liver is susceptible to toxic effects, as it is the main site of acrylamide biotransformation and detoxification. Researchers have claimed that placental growth factor (PlGF) and its pathway are potentially involved in numerous diseases, including liver fibrosis and angiogenesis. Oleuropein is a natural phenolic compound with potent antioxidant effects. The purpose of this study was to examine the role of PlGF and the potential protection provided by oleuropein in acrylamide hepatotoxicity. Wistar albino rats were assigned into control, acrylamide (ACR) (5 mg/kg), oleuropein (OLE) (4.2 mg/kg), and ACR+OLE groups. Acrylamide and oleuropein were administered for 21 days. The control group received only physiological saline. Liver tissues were evaluated histologically and immunohistochemically. Histological examinations revealed significant enlargement of the sinusoidal vessels and abundant hepatocytes with pyknotic nuclei in the ACR group. Acrylamide toxicity resulted in elevated PlGF, accumulation of 8-hydroxydeoxyguanosine (8-OHdG), and increased Caspase-3 immunoreactivity in the liver. Oleuropein treatment reduced the increased expression of PlGF, 8-OHdG, and Caspase-3 against these deleterious effects observed in the ACR group. A positive correlation was observed between PlGF levels as well as oxidative stress and apoptosis markers in acrylamide toxicity. Oleuropein probably counteracted this mechanism by exhibiting antioxidant activity.

Keywords

Placental growth factor toxicity liver immunohistochemistry antioxidant

References

  • 1. Alarcon de la Lastra, C., Barranco M.D., Motilva V., & Herrerias J.M. (2001). Mediterranean diet and health: biological importance of olive oil. Current Pharmaceutical Design, 7, 933-950. https://doi.org/10.2174/1381612013397654
  • 2. Bakir, M., Geyikoglu F., Koc K., & Cerig S. (2018). Therapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats. Journal of Cancer Research and Therapeutics, 14, 671-678. https://doi.org/10.4103/jcrt.JCRT_1040_16
  • 3. Bin-Jumah, M.N., Al-Huqail A.A., Abdelnaeim N., Kamel M., Fouda M.M.A., Abulmeaty M.M.A., Saadeldin I.M., & Abdel-Daim M.M. (2021). Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats. Environmental Science and Pollution Research, 28, 26653-26663. https://doi.org/10.1007/s11356-021-12422-x
  • 4. Dewerchin, M., & Carmeliet P. (2012). PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harbor Perspectives in Medicine, 2. https://doi.org/10.1101/cshperspect.a011056
  • 5. Domitrovic, R., Jakovac H., Marchesi V.V., Sain I., Romic Z., & Rahelic D. (2012). Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. Pharmacology Research, 65, 451-464. https://doi.org/10.1016/j.phrs.2011.12.005
  • 6. El-Beltagi, H.S., & Ahmed, M.M. (2016). Assessment the protective role of quercetin on acrylamide-induced oxidative stress in rats Journal of Food Biochemistry 40, 715–723. https://doi.org/10.1111/jfbc.12262
  • 7. Esposito, F., Nolasco A., Caracciolo F., Velotto S., Montuori P., Romano R., Stasi T., & Cirillo T. (2021). Acrylamide in Baby Foods: A Probabilistic Exposure Assessment. Foods, 10. https://doi.org/10.3390/foods10122900
  • 8. Gao, H., Xue Y., Wu L., Huo J., Pang Y., Chen J., & Gao Q. (2022). Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats. Molecules, 27. https://doi.org/10.3390/molecules27134100
  • 9. Gedik, S., Erdemli M.E., Gul M., Yigitcan B., Gozukara Bag H., Aksungur Z., & Altinoz E. (2017). Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats. Biomedicine Pharmacotherapy, 95, 764-770. https://doi.org/10.1016/j.biopha.2017.08.139
  • 10. Ghorbel, I., Maktouf S., Kallel C., Ellouze Chaabouni S., Boudawara T., & Zeghal N. (2015). Disruption of erythrocyte antioxidant defense system, hematological parameters, induction of pro-inflammatory cytokines and DNA damage in liver of co-exposed rats to aluminium and acrylamide. Chemico-biological interactions, 236, 31-40. https://doi.org/10.1016/j.cbi.2015.04.020
  • 11. Hassen, I., Casabianca, H., & Hosni, K. (2015). Biological activities of the natural antioxidant oleuropein: Exceeding the expectation–A mini-review. Journal of Functional Foods, 18, 926-940. https://doi.org/10.1016/j.jff.2014.09.001
  • 12. Heindryckx, F., Coulon S., Terrie E., Casteleyn C., Stassen J.M., Geerts A., Libbrecht L., Allemeersch J., Carmeliet P., Colle I., & Van Vlierberghe H. (2013). The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model. Journal of Hepatology, 58, 319-328. https://doi.org/10.1016/j.jhep.2012.09.032
  • 13. Jemai, H., Mahmoudi A., Feryeni A., Fki I., Bouallagui Z., Choura S., Chamkha M., & Sayadi S. (2020). Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice. BioMed Research International, 2020, 4398924. https://doi.org/10.1155/2020/4398924
  • 14. Khalatbary, A.R., & Ahmadvand H. (2012). Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurological research, 34, 44-51. https://doi.org/10.1179/1743132811Y.0000000058
  • 15. Khalatbary, A.R., Ghaffari E., & Mohammadnegad B. (2015). Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain. Iranian Biomedical Journal, 19, 247-253. https://doi.org/10.7508/ibj.2015.04.009
  • 16. Kim, S.W., Hur W., Li T.Z., Lee Y.K., Choi J.E., Hong S.W., Lyoo K.S., You C.R., Jung E.S., Jung C.K., Park T., Um S.J., & Yoon S.K. (2014). Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. Experimental & Molecular Medicine, 46, e92. https://doi.org/10.1038/emm.2014.10
  • 17. Koc, K., Cerig S., Ozek N.S., Aysin F., Yildirim S., & Cakmak O., Hosseinigouzdagani M. and Geyikoglu F. (2019). The efficacy of oleuropein against non-steroidal anti-inflammatory drug induced toxicity in rat kidney. Environmental Toxicology, 34, 67-72. https://doi.org/10.1002/tox.22658
  • 18. Li, S.X., Cui N., Zhang C.L., Zhao X.L., Yu S.F., & Xie K.Q. (2006). Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system. Toxicology, 217, 46-53. https://doi.org/10.1016/j.tox.2005.08.018
  • 19. Li, X., Jin Q., Yao Q., Zhou Y., Zou Y., Li Z., Zhang S., & Tu C. (2017). Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation. Frontiers in immunology, 8, 801. https://doi.org/10.3389/fimmu.2017.00801
  • 20. Li, X., Yao Q.Y., Liu H.C., Jin Q.W., Xu B.L., Zhang S.C., & Tu C.T. (2017). Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. Journal of Cellular and Molecular Medicine, 21, 2370-2385. https://doi.org/10.1111/jcmm.13158
  • 21. Manna, C., Migliardi V., Golino P., Scognamiglio A., Galletti P., Chiariello M., & Zappia V. (2004). Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. The Journal of Nutritional Biochemistry, 15, 461-466. https://doi.org/10.1016/j.jnutbio.2003.12.010
  • 22. Numata, M., Morinaga S., Watanabe T., Tamagawa H., Yamamoto N., Shiozawa M., Nakamura Y., Kameda Y., Okawa S., Rino Y., Akaike M., Masuda M., & Miyagi Y. (2013). The clinical significance of SWI/SNF complex in pancreatic cancer. International Journal of Oncology 42, 403-410. https://doi.org/10.3892/ijo.2012.1723
  • 23. Omar, M.M., Elbashir A.A., & Schmitz O.J. (2015). Determination of acrylamide in Sudanese food by high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometry. Food chemistry, 176, 342-349. https://doi.org/10.1016/j.foodchem.2014.12.091
  • 24. Pietropaoli, F., Pantalone S., Cichelli A., & d'Alessandro N. (2022). Acrylamide in widely consumed foods - a review. Food additives and contaminants Part A, chemistry, analysis, control, exposure and risk assessment, 39, 853-887. https://doi.org/10.1080/19440049.2022.2046292
  • 25. Rifai, L., & Saleh FA. (2020). A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies. International Journal of Toxicology, 39, 93-102. https://doi.org/10.1177/1091581820902405
  • 26. Santhanasabapathy, R., Vasudevan S., Anupriya K., Pabitha R., & Sudhandiran G. (2015). Farnesol quells oxidative stress, reactive gliosis and inflammation during acrylamide-induced neurotoxicity: Behavioral and biochemical evidence. Neuroscience, 308, 212-227. https://doi.org/10.1016/j.neuroscience.2015.08.067
  • 27. Sengul, E., Gelen V., Yildirim S., Tekin S., & Dag Y. (2021). The Effects of Selenium in Acrylamide-Induced Nephrotoxicity in Rats: Roles of Oxidative Stress, Inflammation, Apoptosis, and DNA Damage. Biological trace element research, 199, 173-184. https://doi.org/10.1007/s12011-020-02111-0
  • 28. Seydi, E., Rajabi, M., Salimi, A., & Pourahmad, J. (2015). Involvement of mitochondrial-mediated caspase-3 activation and lysosomal labilization in acrylamide-induced liver toxicity. Toxicological & Environmental Chemistry, 97, 563-575. https://doi.org/10.1080/02772248.2015.1047671
  • 29. Sharif, K.O.M., Tufekci E.F., Ustaoglu B., Altunoglu Y.C., Zengin G., Llorent-Martínez E.J., Guney K. & Baloglu M.C. (2021). Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench. Food Bioscience, 41, 101005. https://doi.org/10.1016/j.fbio.2021.101005
  • 30. Topuz, S., & Bayram, M. . (2022). Oleuropein extraction from leaves of three olive varieties (Olea europaea L.): Antioxidant and antimicrobial properties of purified oleuropein and oleuropein extracts. Journal of food processing and preservation, 46, e15697. https://doi.org/10.1111/jfpp.15697
  • 31. Uthra, C., Reshi M.S., Jaswal A., Yadav D., Shrivastava S., Sinha N., & Shukla S. (2022). Protective efficacy of rutin against acrylamide-induced oxidative stress, biochemical alterations and histopathological lesions in rats. Toxicology Research, 11, 215-225. https://doi.org/10.1093/toxres/tfab125
  • 32. Valavanidis, A., Vlachogianni T., & Fiotakis C. (2009). 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 27, 120-139. https://doi.org/10.1080/10590500902885684
  • 33. Yano, K., Liaw P.C., Mullington J.M., Shih S.C., Okada H., Bodyak N., Kang P.M., Toltl L., Belikoff B., Buras J., Simms B.T., Mizgerd J.P., Carmeliet P., Karumanchi S.A., & Aird W.C. (2006). Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Journal of Experimental Medicine, 203, 1447-1458. https://doi.org/10.1084/jem.20060375
  • 34. Yano, K., Okada Y., Beldi G., Shih S.C., Bodyak N., Okada H., Kang P.M., Luscinskas W., Robson S.C., Carmeliet P., Karumanchi S.A., & Aird W.C. (2008). Elevated levels of placental growth factor represent an adaptive host response in sepsis. Journal of Experimental Medicine, 205, 2623-2631. https://doi.org/10.1084/jem.20080398 35. Yoon, S.K. (2018). Oleuropein as an Antioxidant and Liver Protect. Oxidative Stress and Dietary Antioxidants. Amsterdam, The Netherlands: Elsevier Inc, 323-335.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Musa Tatar 0000-0002-5707-8832

Kiymet Kubra Tüfekci 0000-0002-4722-3813

Publication Date August 31, 2023
Submission Date January 23, 2023
Published in Issue Year 2023 Volume: 8 Issue: 2

Cite

APA Tatar, M., & Tüfekci, K. K. (2023). Oleuropein attenuates placental growth factor expression by regulating oxidative stress and apoptosis in acrylamide hepatotoxicity. Veterinary Journal of Mehmet Akif Ersoy University, 8(2), 104-111. https://doi.org/10.24880/maeuvfd.1240829

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