Ankilozan Spondilit ve Romatoid Artrit Hastalarının Sosyodemografik ve Klinik Değişkenlere Göre İlaç Uyumları: Betimsel bir çalışma
Abstract
Amaç: Romatoid Artrit (RA) ve Ankilozan Spondilit (AS) hastalıkları uzun süreli medikal tedavi gerektirdiği için ilaç uyumu kritik bir önem gösterir. Bu hastaların ilaç uyumlarının incelenmesi ve uyuma etki eden faktörlerin ortaya konması çalışmanın amacını oluşturmaktadır. Gereç ve Yöntem: 222 hastaya (RA: N=112; %50,45; AS: N=110; %49,55) İlaç Uyumunu Bildirim Ölçeği, Sosydemografik Bilgi Formu ve Klinik Bilgi Formu uygulanmıştır. Bulgular: Tanı durumunun diğer değişkenlerle ortak etkisinin uyum davranışı üzerindeki rolünün sınandığı iki yönlü varyans analizi sonuçlarına göre öncelikle tanının ilaç uyumu üzerindeki ana etkisinin anlamlı olmadığı tespit edilmiştir. Yanı sıra, sosyodemografik (yaş, cinsiyet, eğitim düzeyi ve çalışma durumu) ve klinik (ilaç kodu ve türü) değişkenlerin hiçbirinin de ilaç uyumu üzerinde anlamlı ana etkisi görülmemiştir. Öte yandan, tanı durumu ile hiçbir sosyodemografik özelliklerin ilaç uyumu üzerinde ortak etkisi gözlenmemiştir. Sadece tanı ile ilaç kodunun uyum üzerindeki ortak etkisi anlamlı bulunmuştur (p<.05). Sonuç: Bu bulgular, RA ve AS hastalarının ilaç uyum davranışlarının ilaç kodu dışında pek çok klinik ve sosyodemografik değişken açısından benzer olduğunu ve bu iki tanı grubunun bir arada ele alınabileceğini düşündürmüştür. Ayrıca, RA ve AS hastaları ile gerçekleştirilen yeni ilaç uyumu araştırmalarının ve uygulamalarının hastaların ilaç kodunun dikkate alınarak tasarlanması gerektiğini ortaya koymuştur.
Keywords
romatoid artrit ankilozan spondilit ilaç uyumu sosyodemografik özellikler klinik değişkenler
References
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- 25. López-González R, León L, Loza E, Redondo M, Garcia de Yébenes M, Carmona L. Adherence to biologic therapies and associated factors in rheumatoid arthritis, spondyloarthritis and psoriatic arthritis: a systematic literature review. Clin Exp Rheumatol. 2015;33(4):559-69.
- 26. Küçük E, Yapar K. Health perception, health-related behaviors, and medication adherence of patients with type II diabetes: A study in the Black Sea region of Turkey. TAF Preventive Medicine Bulletin. 2016;15(4):285-92.
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Medication Adherence of Patients with Ankylosing Spondylitis and Rheumatoid Arthritis by Sociodemographic Variables and Clinical Properties: A Descriptive Study
Abstract
Objective: Medication adherence is critical to Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) patients since they need long-term medical treatment. Therefore, the purpose of the study is to examine medication adherence and reveal the factors influencing adherence. Materials and Methods: Medication Adherence Report Scale, Sociodemographic Information Form, and Clinical Information Form were conducted on 222 patients (RA: N=112; 50.45%; AS: N=110; 49.55%). Results: The Two-way ANOVA results tested the combined effect on diagnosis and sociodemographic and clinical factors on medication adherence that was not significant. Besides, neither sociodemographic (age, gender, education level, and employment status) nor clinical (drug code and type) variables had a significant main effect on medication adherence. On the other hand, no common effect of diagnosis and any sociodemographic characteristics on adherence. Also, only the combined effect of diagnosis and drug code on medication adherence was significant (p<.05). Conclusion: These results showed that RA and AS patients' medication adherence was similar in terms of many clinical and sociodemographic variables, except for the drug code. Consequently, both clinical groups could be carried out together, but these studies should be designed to consider the patients' drug code.
Keywords
Rheumatoid arthritis ankylosing spondylitis medication adherence sociodemographic characteristics clinical properties
References
- 1. Akhondi H, Varacallo M. Rheumatoid Arthritis And Ankylosing Spondylitis. [Updated 2021 Sep 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.
- 2. Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet 2016;388(10055):2023-38.
- 3. O’Dell JR, Imboden JB, Miller LD. Rheumatoid Arthritis In: Imboden JB, Hellmann DB, Stone JB eds. Current Diagnosis and Treatment Rheumatology 3rd ed. The McGraw-Hill Education; 2013. p.139-156.
- 4. Tuncer T, Gilgil E, Kaçar C, Kurtaiş Y, Kutlay Ş, Bütün B, et al. Prevalence of rheumatoid arthritis and spondyloarthritis in Turkey: A nationwide study. Arch Rheumatol 2018;33(2);128.
- 5. Scherer, Hans Ulrich, Thomas Häupl, and Gerd R. Burmester. "The etiology of rheumatoid arthritis." Journal of autoimmunity 110 (2020): 102400.
- 6. Nerurkar L, Siebert S, McInnes IB, Cavanagh J. Rheumatoid arthritis and depression: an inflammatory perspective. Lancet Psychiatry 2019 1;6(2):164-73.
- 7. Zhu W, He X, Cheng K, Zhang L, Chen D, Wang X, et al.. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Research 2019;7. doi:10.1038/s41413-019-0057-8.
- 8. Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR. Firestein & Kelley’s Textbook of Rheumatology-E-Book: Elsevier Health Sciences; 2020.
- 9. Hatemi G, Akar S, Akdoğan A, Atagündüz P, Ersözlü ED, Esatoğlu SN, et al. Türkiye Romatoloji Derneği aksiyel spondilartrit ulusal tedavi önerileri. Ulus Romatol Derg 2018;10(2):88-98.
- 10. Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021;73(7):924-939. doi:10.1002/acr.24596
- 11. Singh JA, Saag KG, Bridges SL Jr, et al. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 2016;68(1):1-26. doi:10.1002/art.39480
- 12. Ward MM, Deodhar A, Gensler LS, et al. 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2019;71(10):1599-1613. doi:10.1002/art.41042
- 13. Farisoğulları B, Karadağ Ö. Ankilozan spondilit tedavisi. Ulus Romatol Derg 2020;12.
- 14. van den Bemt, B. J., Gettings, L., Domańska, B., Bruggraber, R., Mountian, I., & Kristensen, L. E. (2019). A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience. Drug Delivery, 26(1), 384-392.
- 15. Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 2012, 73(5):691-705.
- 16. Brown M, Bussell J. Medication adherence: WHO cares?. Mayo Clin. Proc. 2011 Apr 1; 86(4): 304–314.
- 17. Van Den Bemt BJ, Zwikker HE, Van Den Ende CH. Medication adherence in patients with rheumatoid arthritis: a critical appraisal of the existing literature. Expert review of clinical immunology. 2012;8(4):337-51.
- 18. Arturi P, Schneeberger EE, Sommerfleck F, Buschiazzo E, Ledesma C, Cocco JAM, et al. Adherence to treatment in patients with ankylosing spondylitis. Clinical rheumatology. 2013;32(7):1007-15.
- 19. Hyphantis T, Kotsis K, Tsifetaki N, Creed F, Drosos AA, Carvalho AF, et al. The relationship between depressive symptoms, illness perceptions and quality of life in ankylosing spondylitis in comparison to rheumatoid arthritis. Clinical Rheumatology. 2013;32(5):635-44.
- 20. Horne R, Weinman J. Self-regulation and self-management in asthma: exploring the role of illness perceptions and treatment beliefs in explaining non-adherence to preventer medication. Psychology and Health. 2002;17(1):17-32.
- 21. Temeloğlu-Şen, E., Sertel-Berk, Ö. ve Sindel D. İlaç Uyumunu Bildirim Ölçeği’nin Türkçe Uyarlamasinin Geçerlik ve Güvenirlik Çalişmasi. Journal of Istanbul Faculty of Medicine. 2019;82(1):52-61.
- 22. Onur B. Gelişim psikolojisi. İmge Kitabevi, Ankara. 1995;152.
- 23. Kotsis K, Voulgari PV, Tsifetaki N, Drosos AA, Carvalho AF, Hyphantis T. Illness perceptions and psychological distress associated with physical health-related quality of life in primary Sjögren’s syndrome compared to systemic lupus erythematosus and rheumatoid arthritis. Rheumatology international. 2014;34(12):1671-81.
- 24. Henriksson K, From J, Stratelis G. Patient-reported adherence to coprescribed proton pump inhibitor gastroprotection in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs. Patient preference and adherence. 2014;8:1611.
- 25. López-González R, León L, Loza E, Redondo M, Garcia de Yébenes M, Carmona L. Adherence to biologic therapies and associated factors in rheumatoid arthritis, spondyloarthritis and psoriatic arthritis: a systematic literature review. Clin Exp Rheumatol. 2015;33(4):559-69.
- 26. Küçük E, Yapar K. Health perception, health-related behaviors, and medication adherence of patients with type II diabetes: A study in the Black Sea region of Turkey. TAF Preventive Medicine Bulletin. 2016;15(4):285-92.
- 27. Gürçay E, Ekşioğlu E, Yüzer S, BAL HASTÜRK A, ÇAKCI A. Ankilozan spondilitli hastalarda ilaç uyumunu ve uyumsuzluğunu etkileyen faktörle. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2006;52(4):163-7.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2022 |
| Acceptance Date | August 19, 2022 |
| Published in Issue | Year 2022 Volume: 9 Issue: 4 |
Cited By
TÜRKİYE’DE AKILCI İLAÇ KULLANIMINA YÖNELİK ÖLÇEKLER
Sağlık Bilimleri Dergisi
https://doi.org/10.34108/eujhs.1323068
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