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ROLE OF TENASCIN-C IN THE DIFFERENTIAL DIAGNOSIS OF SMALL ROUND BLUE CELL TUMORS

Year 2015, Volume: 22 Issue: 3, 0 - 0, 30.09.2015

Abstract

Objective: The aim of this study was to evaluate the significance of serum tenascin-C levels in the diagnosis, treatment, and monitoring of small round blue cell tumors.
Materials and methods: Forty patients and 30 healthy children (control group) were included in this prospective study. Serum tenascin-C levels were measured from blood drawn at the time of diagnosis, at the 3rd and 6th months of treatment, and at 3 months following the completion of treatment. While serum tenascin-C levels were measured a total of 4 times in the patient group, they were measured just once in the control group.
Results: Each of the four measured serum tenascin-C levels in the patient group was significantly higher than that of the control group (p=0,013, p=0,009, p=0,011 and p=0,015, respectively). However, when the patient group was categorized into subgroups, only those with Wilms tumor had a significantly higher serum tenascin-C level at the time of diagnosis than did the control group (p=0,026).
Conclusion: While larger, more thorough studies are needed, our data suggest that tenascin-C may be useful in the differential diagnosis of certain specific tumors, such as the Wilms tumor.

Year 2015, Volume: 22 Issue: 3, 0 - 0, 30.09.2015

Abstract

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Details

Journal Section Research Articles
Authors

Doğan Köse

Publication Date September 30, 2015
Submission Date July 27, 2015
Published in Issue Year 2015 Volume: 22 Issue: 3

Cite

Vancouver Köse D. ROLE OF TENASCIN-C IN THE DIFFERENTIAL DIAGNOSIS OF SMALL ROUND BLUE CELL TUMORS. Med J SDU. 2015;22(3).

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