Research Article
BibTex RIS Cite

B12 VİTAMİN EKSİKLİĞİ OLAN ÇOCUKLARDA HEMATOLOJİK BULGULAR

Year 2022, Volume: 29 Issue: 1, 47 - 51, 01.03.2022
https://doi.org/10.17343/sdutfd.960640

Abstract

Amaç
Vitamin B12 eksikliği çocukluk çağında sık görülen bir
durumdur ve eksikliğine bağlı olarak çeşitli nörolojik,
hematolojik ve dermatolojik bulgular görülebilmektedir.
Çalışmanın amacı B12 vitamini eksikliği tanısı
alan çocuklarda hematolojik bulguları değerlendirmektir.
Gereç ve Yöntem
Çocuk Hematoloji Bölümü'nde B12 eksikliği tanısı ile
izlenen hastaların hematolojik verileri geriye dönük
olarak incelendi.
Bulgular
Çalışmamızda yüz yirmi dört hastanın hematolojik verileri
değerlendirildi. Kırksekiz hastada anemi, 8 hastada
trombositopeni ve 6 hastada lökopeni tespit edildi.
İki süt çocuğu uzamış sarılık ve hemolitik anemi ile
başvurdu. Hastaların ortalama vitamin B12 düzeyleri
97.3±30.6 (5-140) pg/ml idi.
Sonuç
Vitamin B12 eksikliği gelişmekte olan ülkelerde sık
görülen bir hastalıktır ve çoğunlukla annedeki eksiklikten
kaynaklanır. Çalışmamızda 52 bebekten 42'sinin
(%80) annesinde B12 vitamini eksikliği saptandı.
Buda gebelerde B12 vitamini düzeyinin belirlenmesinin
ve eksiklik durumunda tedavisinin önemini açıkça
göstermektedir. B12 vitamini eksikliği olan hastalar
çeşitli nedenlerle hastaneye başvurabilirler. Bu nedenle
özellikle uzamış sarılık ve hemolitik anemi ile
başvuran hastalarda B12 vitamini eksikliğinin neden
olabileceği akılda tutulmalıdır.

References

  • 1- Tucker K.L, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PW, et al. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Off spring study. Am J Clin Nutr. 2000;71(2):514-522.
  • 2- Monsen ALB, Refsum H, Markestad T, Ueland PM. Cobalamin status and its biochemical markers methyl malonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem. 2003;49(12):2067-2075.
  • 3- Fokkema MR, Woltil HA, van Beusekom CM, Schaafsma A, Dijck Brouwer DAJ, Muskiet FAJ. Plasma total homocysteine increases from day 20 to 40 in breast fed but not formula-fed low-birth weigh tinfants. ActaPaediatr. 2002;91(5):507-511.
  • 4- Greibe E, Lildballe DL, Streym S, Vestergaard P, Rejnmark L, Mosekilde , et al.Cobalamin and haptocorrin in human milk and cobalamin-related variables in mother and child: a 9-mo longitudinal study. Am J Clin Nutr. 2013;98(2):389-395.
  • 5- Roumeliotis N, Dix D, Lipson A. Vitamin B(12) deficiency in infants secondary to maternal causes. CMAJ. 2012;184(14):1593-8.
  • 6- Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, et al. High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr. 2006;45(5):291-7.
  • 7- Çoban S, Yılmaz Keskin E, İğde M. Association between Maternal and Infantile Markers of Cobalamin Status During the First Month Post-Delivery. Indian J Pediatr. 2018;85(7):517-522.
  • 8- Işık Balcı Y, Karabulut A, Gürses D, Ethem Çövüt I. Prevalence and risk factors of anemia among adolescents in Denizli, Turkey. Iran J Pediatr.2012;22(1):77-81.
  • 9- Yenicesu I. Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. Pediatr Hematol Oncol. 2008;25(4):365-367.
  • 10- Erdeve O, Arsan S, Atasay B, Ileri T, Uysal Z. A breast-fed newborn with megaloblastic anemia-treated with the vitamin B12 supplementation of the mother. J Pediatr Hematol Oncol. 2009;31(10):763-765.
  • 11- Andrès E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol. 2006;28(1):50–6.
  • 12- Eroglu N, Kandur Y, Kalay S, Kalay Z, Guney O. Neonatal hyperbilirubinemia in a Turkish cohort: association of vitamin B12. J Clin Med Res. 2015;7(7):556-559.
  • 13- Bigg E. Spleen size in pernicious anemia. Ann Int Med. 1940;14(2):277–80.
  • 14- Pruthi RK, Tefferi AI, Petitt RM. Reversible marked splenomegaly in pernicious anemia. Ann Intern Med.1953;119(10):1053.

HEMATOLOGICAL FINDINGS IN CHILDREN WITH VITAMIN B12 DEFICIENCY

Year 2022, Volume: 29 Issue: 1, 47 - 51, 01.03.2022
https://doi.org/10.17343/sdutfd.960640

Abstract

Objective
Vitamin B12 deficiency is a common condition in
childhood and various neurological, hematological,
and dermatological findings could be seen due to its
deficiency. The aim of the study is to evaluate the
hematological findings in children diagnosed with
vitamin B12 deficiency.
Materials and Methods
Hematological data of children with B12 deficiency
who were examined in Pediatric Hematology
Department were retrospectively reviewed.
Results
Hematological data of one hundred twenty-four
patients were assessed in our study. Anemia,
thrombocytopenia and leucopenia were detected in
48 patients, 8 patients and 6 patients, respectively.
Two infants presented with prolonged jaundice and
hemolytic anemia. The mean vitamin B12 levels of the
patients were 97.3±30.6 (5-140) pg/ml.
Conclusion
Vitamin B12 deficiency is a common disease in
developing countries and it is mostly of maternal
origin. In our study, vitamin B12 deficiency in mothers
of 42 out of 52 infants (80%) were discovered. This
percentage clearly shows the importance of the vitamin
B12 level determination in pregnant women and its
treatment in case of deficiency. Patients with vitamin
B12 deficiency might be admitted to the hospital for
various reasons. Therefore, it is recommended to
keep in mind that vitamin B12 deficiency might be
the base of various diseases, especially for patients
presenting prolonged jaundice and hemolytic anemia.

References

  • 1- Tucker K.L, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PW, et al. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Off spring study. Am J Clin Nutr. 2000;71(2):514-522.
  • 2- Monsen ALB, Refsum H, Markestad T, Ueland PM. Cobalamin status and its biochemical markers methyl malonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem. 2003;49(12):2067-2075.
  • 3- Fokkema MR, Woltil HA, van Beusekom CM, Schaafsma A, Dijck Brouwer DAJ, Muskiet FAJ. Plasma total homocysteine increases from day 20 to 40 in breast fed but not formula-fed low-birth weigh tinfants. ActaPaediatr. 2002;91(5):507-511.
  • 4- Greibe E, Lildballe DL, Streym S, Vestergaard P, Rejnmark L, Mosekilde , et al.Cobalamin and haptocorrin in human milk and cobalamin-related variables in mother and child: a 9-mo longitudinal study. Am J Clin Nutr. 2013;98(2):389-395.
  • 5- Roumeliotis N, Dix D, Lipson A. Vitamin B(12) deficiency in infants secondary to maternal causes. CMAJ. 2012;184(14):1593-8.
  • 6- Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, et al. High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr. 2006;45(5):291-7.
  • 7- Çoban S, Yılmaz Keskin E, İğde M. Association between Maternal and Infantile Markers of Cobalamin Status During the First Month Post-Delivery. Indian J Pediatr. 2018;85(7):517-522.
  • 8- Işık Balcı Y, Karabulut A, Gürses D, Ethem Çövüt I. Prevalence and risk factors of anemia among adolescents in Denizli, Turkey. Iran J Pediatr.2012;22(1):77-81.
  • 9- Yenicesu I. Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. Pediatr Hematol Oncol. 2008;25(4):365-367.
  • 10- Erdeve O, Arsan S, Atasay B, Ileri T, Uysal Z. A breast-fed newborn with megaloblastic anemia-treated with the vitamin B12 supplementation of the mother. J Pediatr Hematol Oncol. 2009;31(10):763-765.
  • 11- Andrès E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol. 2006;28(1):50–6.
  • 12- Eroglu N, Kandur Y, Kalay S, Kalay Z, Guney O. Neonatal hyperbilirubinemia in a Turkish cohort: association of vitamin B12. J Clin Med Res. 2015;7(7):556-559.
  • 13- Bigg E. Spleen size in pernicious anemia. Ann Int Med. 1940;14(2):277–80.
  • 14- Pruthi RK, Tefferi AI, Petitt RM. Reversible marked splenomegaly in pernicious anemia. Ann Intern Med.1953;119(10):1053.
There are 14 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Nergiz Öner 0000-0002-8569-3971

Gülcihan Özek This is me 0000-0001-7111-4214

Publication Date March 1, 2022
Submission Date July 2, 2021
Acceptance Date August 18, 2021
Published in Issue Year 2022 Volume: 29 Issue: 1

Cite

Vancouver Öner N, Özek G. HEMATOLOGICAL FINDINGS IN CHILDREN WITH VITAMIN B12 DEFICIENCY. Med J SDU. 2022;29(1):47-51.

                                                                                               14791 


Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.