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COVID-19 FARMAKOTERAPİSİ

Year 2020, Volume: 11 Issue: 2, 80 - 114, 28.08.2020
https://doi.org/10.38137/vetfarmatoksbulten.769889

Abstract

SARS-CoV-2'nin neden olduğu yeni koronavirüs hastalığı (COVID-19) global bir pandemi olarak tanımlanmıştır. Tüm dünyada yoğun araştırmalara karşın halen etkili bir tedavisi veya aşısı bulunmamaktadır. Bu nedenle korunma, erken virüs tespiti ve tanımlanma yöntemleri hastalığın kontrolü için önem taşımaktadır. Kontrollü randomize klinik araştırmaların sonuçları ile sürekli olarak tedavi protokolleri güncellenmektedir; ancak çok sayıda hasta ile yapılan araştırmaların çoğunluğu halen devam etmektedir. Bireysel farklılıklara (değişen fenotip, diğer kronik hastalıklar gibi) bağlı ilaç etkinliği ve güvenirliğine ilişkin değişiklikler nedeniyle tedavide tek tip ilaç uygulaması bulunmamaktadır. Tedavi protokolleri sürekli güncellenmektedir ve yapay zeka/in siliko araştırmalarla yeni ilaçların geliştirilmesi ve ilaç yeniden konumlandırma araştırmaları hızla devam etmektedir. Bu derleme, COVID-19 tedavisinde kullanılan bazı ajanlar hakkında güncel bilgi sunmaktadır.

Thanks

Değerli bilimsel katkı ve yönlendirici önerilerinden dolayı Prof.Dr. Ş.Şefik Alkan'a teşekkürlerimizi sunarız.

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PHARMACOTHERAPY of COVID-19

Year 2020, Volume: 11 Issue: 2, 80 - 114, 28.08.2020
https://doi.org/10.38137/vetfarmatoksbulten.769889

Abstract

The novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been described as a global pandemic. Regardless the efforts all over the world, there is still no effective treatment or vaccine. Therefore, prevention, early virus detection and identification methods are crutially important for disease control. Treatment protocols are constantly updated with the results of controlled randomized clinical trials; however, the majority of research with a large number of patients are still not concluded. Individualized medicine is forefront since there is no uniform drug application in treatment as the drug efficacy and safety changes with respect to individual differences (such as changing phenotype, other chronic diseases). Treatment protocols are constantly being updated and drug research using artificial intelligence/in silico methods for new compounds and drug repurposing gained prominence. This review provides updated information on some of the agents used in the treatment of COVID-19.

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There are 134 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Review
Authors

Begüm Yurdakök Dikmen 0000-0002-0385-3602

Yağız Pat This is me 0000-0003-4268-4933

Ergin Dilekoz This is me 0000-0001-5868-364X

Gökçe Yağmur Summak This is me 0000-0001-6274-3385

Oguz Kul This is me 0000-0002-1282-650X

Ayhan Filazi 0000-0002-2800-6215

Publication Date August 28, 2020
Acceptance Date August 26, 2020
Published in Issue Year 2020 Volume: 11 Issue: 2

Cite

APA Yurdakök Dikmen, B., Pat, Y., Dilekoz, E., Summak, G. Y., et al. (2020). COVID-19 FARMAKOTERAPİSİ. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 11(2), 80-114. https://doi.org/10.38137/vetfarmatoksbulten.769889