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VETERİNER HEKİMLİKTE ETİKET DIŞI İLAÇ KULLANIMI: ANTİMİKROBİYAL İLAÇLAR

Year 2020, Volume: 11 Issue: 3, 134 - 150, 30.12.2020
https://doi.org/10.38137/vetfarmatoksbulten.803682

Abstract

Etiket dışı ya da endikasyon dışı ilaç kullanımı kavramı, bir ürünün, prospektüsünde veya etiketinde belirtildiğinden farklı şekilde uygulanması olarak tanımlanabilir. Bu tanımdan hareketle hekim; ilacın prospektüs bilgileri dışında olacak şekilde, farklı bir türde, farklı bir doz aralığında, dozaj rejiminde ve süreyle ilaç uygulaması yapabilir. Bu durum gerek ülkemizde gerekse uluslararası alanda kabul gören bir yaklaşımdır. Veteriner hekimliği ve beşeri hekimlikte yasal mevzuat ile çerçevesi çizilmiştir. Ancak bu uygulama ile sorumluluk tümüyle hekime yüklenmektedir. Dolayısıyla hekim bu türden bir uygulama yapacaksa mutlaka bir onam formu/belgesi almalı, hasta sahibine konuyla ilgili bilgi vermelidir. Antimikrobiyal ilaçlar bu uygulamanın önemli bir parçasını oluşturur. Olası bir hata ya da yanlış kullanım, hasta yönüyle olduğu kadar halk sağlığı yönüyle de “antimikrobiyal direnç” ve “kalıntı” gibi olumsuzluklara neden olabilir. Bu makale kapsamında etiket dışı ilaç kullanımı konusunda temel bilgiler sunuldu ve konu özellikle antimikrobiyal ilaçlar yönüyle tür bazında değerlendirildi.

References

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  • Bailey, J., Line E. (2001). In ovo gentamicin and mucosal starter culture to control Salmonella in broiler production. The Journal of Applied Poultry Research, 10 (4), 376-379.
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  • Burch, D.G.S., Harding C., Alvarez R., Valks M. (2006). Treatment of a field case of avian intestinal spirochaetosis caused by Brachyspira pilosicoli with tiamulin. Avian Pathology, 35 (3), 211-216.
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  • Dallap Schaer, B.L., Linton, J.K., Aceto, H. (2012). Antimicrobial use in horses undergoing colic surgery. J Vet Intern Med, 26 (6), 1449-1456.
  • Davis, G., Cooles, S., Vasan, N. (2015). Suspected adverse events, 2013. The Veterinary record, 176(1), 11-14.
  • Diesel, G. (2011). Review of adverse events following off-label use of medicines. Veterinary Record, 168(8), 205-207.
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OFF-LABEL DRUG USE IN VETERINARY MEDICINE: ANTIMICROBIAL DRUGS

Year 2020, Volume: 11 Issue: 3, 134 - 150, 30.12.2020
https://doi.org/10.38137/vetfarmatoksbulten.803682

Abstract

The concept of off-label or off-indication drug use can be defined as the administration of a product used in a different way than it is prescribed in its prospectus or label. Based on this definition, physicians can administrate drugs in; different species, a different dosage range, dosage regime and periods. This is an approach which is accepted by both our country and globally. The framework of this practice is drawn by the legal legislation in human medicine and veterinary medicine. However, with this approach, the responsibility belongs to the physician entirely. Therefore, the physician must inform the animal owner and obtain a consent form if such an application is to be administered Antimicrobial drugs are major part of this application. A possible mistake or misuse may cause undesirable effects in terms of public health as well as the patient such as antimicrobial resistance and residue. In this article, basic information about the use of off-label drug was given and the subject was evaluated according to species, especially in terms of antimicrobial drugs.

References

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  • Dallap Schaer, B.L., Linton, J.K., Aceto, H. (2012). Antimicrobial use in horses undergoing colic surgery. J Vet Intern Med, 26 (6), 1449-1456.
  • Davis, G., Cooles, S., Vasan, N. (2015). Suspected adverse events, 2013. The Veterinary record, 176(1), 11-14.
  • Diesel, G. (2011). Review of adverse events following off-label use of medicines. Veterinary Record, 168(8), 205-207.
  • Dobiasova, H., Kutilova, I., Piackova, V., Vesely, T., Cizek, A., Dolejska, M. (2014). Ornamental fish as a source of plasmid-mediated quinolone resistance genes and antibiotic resistance plasmids. Veterinary microbiology, 171 (3), 413-421.
  • Dutil, L., Irwin, R., Finley, R., Ng, L.K., Avery, B., Boerlin, P., Bourgault, A.M., Cole, L., Daignault, D., Desruisseau, A., Demczuk, W., Hoang, L., Horsman, G.B., Ismail, J., Jamieson, F., Maki, A., Pacagnella, A., Pillai, D.R. (2010). Ceftiofur resistance in Salmonella enterica serovar Heidelberg from chicken meat and humans. Canada, Emerg Infect Dis, 16 (1), 48-54.
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  • Holso, K., Rantala, M., Lillas, A., Eerikainen, S., Huovinen, P., Kaartinen, L. (2005). Prescribing Antimicrobial Agents for Dogs and Cats via University Pharmacies in Finland-Patterns and Quality of Information. Acta Veterinaria Scandinavica, 46 (1-2), 87-94.
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There are 62 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Review
Authors

Ender Yarsan 0000-0002-3008-9240

Sinem Pehlivan This is me 0000-0001-5493-0447

Publication Date December 30, 2020
Acceptance Date November 16, 2020
Published in Issue Year 2020 Volume: 11 Issue: 3

Cite

APA Yarsan, E., & Pehlivan, S. (2020). VETERİNER HEKİMLİKTE ETİKET DIŞI İLAÇ KULLANIMI: ANTİMİKROBİYAL İLAÇLAR. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 11(3), 134-150. https://doi.org/10.38137/vetfarmatoksbulten.803682