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Pathological features of fetal anasarca in Pekingese puppies

Year 2020, Volume: 91 Issue: 2, 164 - 168, 15.06.2020
https://doi.org/10.33188/vetheder.687446

Abstract

Fetal anasarca is a congenital condition defined by excessive fluid accumulation throughout the body and subcutaneous edema. A 9-month-old Pekingese bitch with dystocia was presented to the Obstetrics and Gynecology Department of Ankara University, Faculty of Veterinary Medicine. Three stillborn puppies were removed by caesarian section and sent to the Pathology Department of Ankara University, Faculty of Veterinary Medicine for necropsy. Grossly, two of the puppies were larger than normal, had diffuse subcutaneous swelling with visceral effusion and were diagnosed with fetal anasarca. As for the third one, pulmonary hypoplasia was reported. All the fetuses additionally showed palatoschisis, bird tongue and lissencephaly. For histopathological examination, samples from the organs were collected and routinely processed. Severe edematous and degenerative changes were noted in the skin, liver, heart and kidneys of the anasarcous fetuses. Extramedullary hematopoiesis was also observed to different degrees in the livers and the spleens of all fetuses. The current case represents the first histopathologically described case of canine fetal anasarca in Turkey and it highlights the predisposition of brachycephalic dogs to fetal anasarca which is referred to be heritable as a recessive trait.

References

  • Cunto M, Zambelli D, Castagnetti C, Linta N, Bini C (2015): Diagnosis and treatment of foetal anasarca in two English Bull dog puppies. Pak Vet J, 35(2), 251-253.
  • Farrell LL, Schoenebeck JJ, Wiener P, Clements DN, Summers KM (2015): The challenges of pedigree dog health: approaches to combating inherited disease. Canine Genet Epidemiol, 2(1), 3.
  • Hailat N, Lafi Sq, Al‐Darraji A, El‐Maghraby Hm, Al‐Ani F, Fathalla M (1997): Foetal anasarca in Awassi sheep. Aust Vet J, 75(4), 257-259.
  • Hopper BJ, Richardson JL, Lester NV (2004): Spontaneous antenatal resolution of canine hydrops fetalis diagnosed by ultrasound. J Small Anim Pract, 45(1), 2-8.
  • Monteagudo L, Lujan L, Tejedor T, Climent S, Acı́n C, Navarro A, Arrug MV (2002): Fetal anasarca (Hydrops foetalis) associated with lymphoid tissue agenesis possibly due to an autosomal recessive gene defect in sheep. Theriogenology, 58(6), 1219-1228.
  • Prabaharan V, Sivakumar A, Jayaganthan P, Raja S, Vijayarajan A, Kumar S (2016): Dystocia due to fetal anasarca and ascities with live fetus in a doe. Int J Sci Environ Tech, 5(4), 2586-2589.
  • Rothuizen J, Bunch S, Charles J. (2006): WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases. Philadelphia, USA: Elsevier Health 373 Sciences.
  • Sousa CGA, Gonçalves IFL, Souza ALM, Fernandes DA, Hyppolito RRC, Rodrigues ABF (2018): Morphological Analysis of the Cleft Palate in Dogs (Canis lupus familiaris). J Health Sci, 6, 427-431.
  • Smith OF (2011): Prenatal Care of the Bitch and Queen. 735-737. In: Peterson ME, Kutzler M (Ed), Small Animal Pediatrics-E-Book: The First 12 Months of Life, Elsevier, St Louis.
  • Sridevi P, Reena D, Safiuzamma M (2016): Diagnosis of fetal anasarca by real time ultrasonograpy in a pug bitch and its surgical management. IJAR, 37(2), 65-66.

Pekingese yavrularda fetal anasarka’nın patolojik bulguları

Year 2020, Volume: 91 Issue: 2, 164 - 168, 15.06.2020
https://doi.org/10.33188/vetheder.687446

Abstract

Fötal anasarka, vücutta aşırı sıvı birikimi ve subkutan ödem ile tanımlanan konjenital bir bozukluktur. Dokuz aylık bir Pekinez dişi köpek Ankara Üniversitesi, Veteriner Fakültesi, Doğum ve Jinekoloji Anabilim Dalı’na, güç doğum şikâyeti ile getirildi. Sezaryen operasyonuyla üç adet ölü doğmuş yavru çıkarıldı ve Ankara Üniversitesi Veteriner Fakültesi Patoloji Anabilim Dalı’na nekropsi amacıyla gönderildi. Makroskobik olarak iki yavru normalden daha büyüktü. Bu yavrularda visseral efüzyon ve subkutan ödeme rastlandığı için fötal anasarka tanısı konuldu. Üçüncü yavruda ise pulmoner hiperplazi ile karşılaşıldı. Tüm yavrularda ayrıca, palatoşizis, kuş dili ve lissensefali anomalilerine rastlandı. Histopatolojik yönden incelenmesi için organlardan örnekler alınarak rutin doku takibine koyuldu. Anasarka’lı fötusların deri, karaciğer, kalp ve böbreklerinde şiddetli ödem ve dejeneratif değişikliklere rastlandı. Tüm fötusların karaciğer ve dalaklarında farklı derecelerde ekstramedüller hematopoez gözlendi. Bu çalışma Türkiye’de histopatolojik olarak köpeklerde tanımlanan ilk fötal anasarka olgusunu oluşturmuştur. Ayrıca, brakisefallik köpeklerin resesif kalıtsal bir bozukluğu olan fötal anasarkaya yatkınlık gösterdikleri vurgulamıştır.

References

  • Cunto M, Zambelli D, Castagnetti C, Linta N, Bini C (2015): Diagnosis and treatment of foetal anasarca in two English Bull dog puppies. Pak Vet J, 35(2), 251-253.
  • Farrell LL, Schoenebeck JJ, Wiener P, Clements DN, Summers KM (2015): The challenges of pedigree dog health: approaches to combating inherited disease. Canine Genet Epidemiol, 2(1), 3.
  • Hailat N, Lafi Sq, Al‐Darraji A, El‐Maghraby Hm, Al‐Ani F, Fathalla M (1997): Foetal anasarca in Awassi sheep. Aust Vet J, 75(4), 257-259.
  • Hopper BJ, Richardson JL, Lester NV (2004): Spontaneous antenatal resolution of canine hydrops fetalis diagnosed by ultrasound. J Small Anim Pract, 45(1), 2-8.
  • Monteagudo L, Lujan L, Tejedor T, Climent S, Acı́n C, Navarro A, Arrug MV (2002): Fetal anasarca (Hydrops foetalis) associated with lymphoid tissue agenesis possibly due to an autosomal recessive gene defect in sheep. Theriogenology, 58(6), 1219-1228.
  • Prabaharan V, Sivakumar A, Jayaganthan P, Raja S, Vijayarajan A, Kumar S (2016): Dystocia due to fetal anasarca and ascities with live fetus in a doe. Int J Sci Environ Tech, 5(4), 2586-2589.
  • Rothuizen J, Bunch S, Charles J. (2006): WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases. Philadelphia, USA: Elsevier Health 373 Sciences.
  • Sousa CGA, Gonçalves IFL, Souza ALM, Fernandes DA, Hyppolito RRC, Rodrigues ABF (2018): Morphological Analysis of the Cleft Palate in Dogs (Canis lupus familiaris). J Health Sci, 6, 427-431.
  • Smith OF (2011): Prenatal Care of the Bitch and Queen. 735-737. In: Peterson ME, Kutzler M (Ed), Small Animal Pediatrics-E-Book: The First 12 Months of Life, Elsevier, St Louis.
  • Sridevi P, Reena D, Safiuzamma M (2016): Diagnosis of fetal anasarca by real time ultrasonograpy in a pug bitch and its surgical management. IJAR, 37(2), 65-66.
There are 10 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Case Report
Authors

Yanad Monsef 0000-0002-4929-9395

Kübra Karakaş Alkan 0000-0001-9177-9299

Gözde Yücel 0000-0002-2586-8346

Rıfkı Hazıroğlu 0000-0002-1134-3581

Publication Date June 15, 2020
Submission Date February 10, 2020
Acceptance Date February 18, 2020
Published in Issue Year 2020 Volume: 91 Issue: 2

Cite

Vancouver Monsef Y, Karakaş Alkan K, Yücel G, Hazıroğlu R. Pathological features of fetal anasarca in Pekingese puppies. Vet Hekim Der Derg. 2020;91(2):164-8.

Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society) is an open access publication, and the journal’s publication model is based on Budapest Access Initiative (BOAI) declaration. All published content is licensed under a Creative Commons CC BY-NC 4.0 license, available online and free of charge. Authors retain the copyright of their published work in Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society). 

Veteriner Hekimler Derneği / Turkish Veterinary Medical Society