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Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Yıl 2024, , 487 - 496, 23.09.2024

Nazmiye Semiz , Mehmet Zeki Yılmaz Deveci

https://doi.org/10.33988/auvfd.1085562

Öz

The aim of this study was to investigate the effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil in a full-thickness excisional skin wound model in rats. In the present study, 18 adult male Wistar rats were divided into three groups (n=6) the control (CO) group, the common centaury oil (CCO) group, and the laurel seed oil (LSO) group. Under general anesthesia, a full-thickness excisional wound (2.25 cm²) was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO disturbed the healing process (P≤0.001). In the histopathological results, blood vessel formation, fiber synthesis, granulation, and mononuclear cells in the wounds were higher in the CCO group than the other groups and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU, and UREA values (P<0.05). As a result, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

Anahtar Kelimeler

Alternative centaurium dermatology experimental herbal oil in vivo

Etik Beyan

The ethical approval of this study was obtained from the Local Ethics Board of Animal Experiments of Hatay Mustafa Kemal University (Decision No: 2020/04-34).

Teşekkür

This study was derived from the MSc thesis of the first author. The authors would like to thank Assist. Prof. Dr. Ömer KIRGIZ for his help in the experimental work and the images of the study.

Kaynakça

  • Afifi FU, Khalil E, Tamimi SO, et al (1997): Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats. J Ethnopharmacol, 58, 9-14.
  • Altan A, Aras MH, Damlar İ, et al (2018): The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats. Eur Oral Res, 52, 143-149.
  • Altıparmak M, Eskitaşçıoğlu T (2018): Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. J Invest Surg, 31, 29-37.
  • Altuğ ME, Deveci MZY (2016): Dokularına Göre Tümöral Oluşumlara Cerrahi Yaklaşımlar. Turkiye Klinikleri J Vet Sci Surg-Special Topics, 2, 70-79.
  • Armutak Eİ, Yiğit F (2014): Laboratuvar hayvanları rehberi. 1st ed. İstanbul, Türkiye: Nobel Tıp Kitapevleri; 2014.
  • Atalan G, Demirkan İ, Yaman H, et al (2003): Effect of topical kefir application on open wound healing an in vivo study. Kafkas Univ Vet Fak Derg, 9, 43-47.
  • Augustine R, Augustine A, Kalarikkal N, et al (2016): Fabrication and characterization of biosilver nanoparticles loaded calcium pectinate nano-micro dual-porous antibacterial wound dressings. Prog Biomater, 5, 223-235.
  • Bahramsoltani R, Farzaei MH, Rahimi R (2014): Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res, 306, 601-617.
  • Barla A, Topçu G, Öksüz S, et al (2007): Kingston DGI. Identification of cytotoxic sesquiterpenes from Laurus nobilis L. Food Chem, 104, 1478-1484.
  • Biswas TK, Pandit S, Chakrabarti S, et al (2017): Evaluation of Cynodon dactylon for wound healing activity. J Ethnopharmacol, 197, 128-137.
  • Bouyahya A, Belmehdi O, El Jemli M, et al (2019): Chemical variability of Centaurium erythraea essential oils at three developmental stages and investigation of their in vitro antioxidant, antidiabetic, dermatoprotective and antibacterial activities. Ind Crops Prod, 132, 111-117.
  • Canpolat I, Eroksuz Y, Rızaoğlu T (2021): Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. Turkish J Vet Res, 5, 25-33.
  • Cemboluk Ö (2015): Rat tam kalınlıklı deri defektlerinde dermal analogların kontraksiyon üzerine etkileri. Tıpta uzmanlık tezi. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Plastik Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Eskişehir.
  • Dadalioǧlu I, Evrendilek GA (2004): Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens. J Agric Food Chem, 52, 8255-8260.
  • Deveci MZY, Gönenci R, Canpolat İ, et al (2020): In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride-chitosan-collagen biocomposite coating in rats. Turk J Vet Anim Sci, 44, 76-88.
  • Ekizce E (2019): Deneysel olarak tip II diyabet oluşturulmuş ratlardaki yara modelinde kudret narı (momordica charantia) meyvesi yağının yara iyileşmesi üzerine etkileri. MSc, Kırıkkale Üniversitesi, Kırıkkale.
  • Elmastaş M, Gülçin İ, Işildak Ö, et al (2006): Radical Scavenging Activity and Antioxidant Capacity of Bay Leaf Extracts. J Iran Chem Soc, 3, 258-266.
  • Fang F, Sang S, Chen KY, et al (2005): Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis). Food Chem, 93, 497-501.
  • Gawronska-Kozak B (2011): Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression. Matrix Biology, 30, 290-300.
  • Ham A, Shin J, Oh K, et al (2011): Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease. Biomol Ther, 19, 118-125.
  • Han MC, Durmuş AS, Sağlıyan A, et al (2017): Effects of Nigella sativa and Hypericum perforatum on wound healing. Turk J Vet Anim Sci, 41, 99-105.
  • Hierner R, Degreef H, Vranckx JJ, et al (2005): Skin grafting and wound healing the “dermato-plastic team approach”. Clin Dermatol, 23, 343-352.
  • Ilango K, Chitra V (2010): Wound healing and anti-oxidant activities of the fruit pulp of Limonia acidissima Linn (Rutaceae) in rats. Trop J Pharm Res, 9, 223-230.
  • Jerković I, Gašo-Sokač D, Pavlović H, et al (2012): Volatile organic compounds from Centaurium erythraea Rafn (Croatia) and the antimicrobial potential of its essential oil. Molecules, 17, 2058-2072.
  • Jovanović O, Radulović N, Stojanović G, et al (2009): Chemical composition of the essential oil of Centaurium erythraea Rafn (Gentianaceae) from Serbia. J Essent Oil Res, 21, 317-322.
  • Kaurinovic B, Popovic M, Vlaisavljevic S (2010): In vitro and in vivo effects of laurus nobilis L. leaf extracts. Molecules, 15, 3378-3390.
  • Kesbiç OS (2019): Effects of juniper berry oil on growth performance and blood parameters in common carp (Cyprinus carpio). Aquac Res, 50, 342-349.
  • Kordjazi M, Shabanpour B, Zabihi E, et al (2017): Investigation of effects of fucoidan polysaccharides extracted from two species of Padina on the wound-healing process in the rat. Turk J Vet Anim Sci, 41, 106-117.
  • Kumandaş A, Karslı B, Kürüm A, et al (2020): Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Univ Vet Fak Derg, 67, 33-40.
  • Kupeli E, Orhan I, Yesilada E (2007): Evaluation of Some Plants Used in Turkish Folk Medicine for Their Anti-inflammatory and Antinociceptive Activities. Pharm Biol, 45, 547-555.
  • Kurt B, Bilge N, Sözmen M, et al (2018): Effects of Plantago lanceolata L. extract on full-thickness excisional wound healing in a mouse model. Biotech Histochem, 93, 249-257.
  • Lenhardt R, Akca O (2014): Hyperglycemia in the Intensive Care Unit. J Turk Soc Intens Care, 12, 67-71.
  • Loizzo MR, Saab AM, Tundis R, et al (2008): Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers, 5, 461-470.
  • Nayak S, Nalabothu P, Sandiford S, et al (2006): Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats. BMC Complement Altern Med, 6, 1-6.
  • Nevin KG, Rajamohan T (2010): Effect of Topical Application of Virgin Coconut oil on Skin Components and Antioxidant Status During Dermal Wound Healing in Young Rats. Skin Pharmacol Physiol, 23, 290-297.
  • Nguyen KT, Akhil KS, Seok JH, et al (2013): Deficient cytokine expression and neutrophil oxidative burst contribute to impaired cutaneous wound healing in diabetic, biofilm‐containing chronic wounds. Wound Repair and Regen, 21, 833-841.
  • Ozcan B, Esen M, Sangun MK, et al (2010): Effective antibacterial and antioxidant properties of methanolic extract of Laurus nobilis seed oil. J Environ Biol, 31, 637-641.
  • Poljšak N, Kreft S, Glavač NK (2020): Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. Phytotherapy Research, 34, 254-269.
  • Robbins SL, Kumar B, Cotran R (2000) Tissue repair: Cellular growth, fibrosis and wound healing. 46-59. In: Robbins SL (Ed), Pathologic Basic of Disease, Philadelphia.
  • Samejima K, Kanazawa K, Ashida H, et al (1998): Bay Laurel Contains Antimutagenic Kaempferyl Coumarate Acting against the Dietary Carcinogen 3-Amino-1-methyl-5H-pyrido [4, 3- b]indole. J Agric Food Chem, 46, 4864-4868.
  • Sangun MK, Aydin E, Timur M, et al (2007): Comparison of chemical composition of the essential oil of Laurus nobilis L. leaves and fruits from different regions of Hatay, Turkey. J Environ Biol, 28, 731-733.
  • Saporito F, Sandri G, Bonferoni MC, et al (2018): Essential oil-loaded lipid nanoparticles for wound healing. Int J Nanomedicine, 13, 175-186.
  • Sayyah M, Valizadeh J, Kamalinejad M (2002): Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Phytomedicine, 9, 212-216.
  • Srıvastava N, Jaın GK, Raghubir R (2011): Poly antioxidant mixture accelerates healing of experimental wounds in albino rats. Asian J Pharm Clin Res, 4, 46-50.
  • Stejskalova A, Almquist BD (2017): Using biomaterials to rewire the process of wound repair. Biomater Sci, 5, 1421-1434.
  • Sudsai T, Wattanapiromsakul C, Tewtrakul S (2016): Wound healing property of isolated compounds from Boesenbergia kingii rhizomes. J Ethnopharmacol, 184, 42-48.
  • Süntar IP, Akkol EK, Yılmazer D, et al (2010): Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol, 127, 468-477.
  • Şındak N, Akgül MB, Gülaydın A, et al (2017): Japon Bıldırcınlarında (Coturnix Coturnix Japonica) Topikal Olarak Uygulanan Menengiç Yağı ve Farklı Deneysel Karışımlarının Yara İyileşmesi Üzerine Etkileri. Van Vet J, 28, 69-74.
  • Wölfle U, Seelinger G, Schempp CM (2014): Topical application of St. Johnʼs wort (Hypericum perforatum). Planta Med, 80, 109-120.
  • Yilmaz ES, Timur M, Aslim B (2013): Antimicrobial, antioxidant activity of the essential oil of Bay Laurel from Hatay, Turkey. J Essent Oil-Bear Plants, 16, 108-116.
  • Yipel M, İlhan A, Tekeli İO, et al (2020): İlaçlarla Etkileşim Potansiyeline Sahip Hayvan Sağlığında Da Kullanılan Tıbbi Bitkiler. Vet Farm Toks Dern Bült, 11, 13-26.

Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Yıl 2024, , 487 - 496, 23.09.2024

Nazmiye Semiz , Mehmet Zeki Yılmaz Deveci

https://doi.org/10.33988/auvfd.1085562

Öz

Çalışmanın amacı, kırmızı kantaron (Centaurium erythraea) yağı ve defne (Laurus nobilis) tohumu yağının ratlarda tam kalınlıklı eksizyonel deri yara modelinde etkilerinin araştırılmasıdır. Çalışmada kullanılan 18 adet erişkin, erkek Wistar rat; kontrol (CO), kırmızı kantarın yağı (CCO) ve defne tohumu yağı (LSO) olmak üzere üç gruba (n=6) ayırıldı. Genel anestezi altında her bir ratın sırtında interskapular bölgenin kaudalinde tam kalınlıklı eksizyonel yara (2.25 cm2) oluşturuldu. Tedaviler tüm gruplarda günde bir kez topikal olarak uygulandı. Yara alanı ölçümleri CCO’nun yara iyileşmesini hızlandırdığını, LSO’nun ise yara iyileşmesini geciktirdiğini gösterdi. Histopatolojik sonuçlarda kan damarları oluşumu, fiber sentezi, granülasyon ve mononükleer hücreler CCO grubundaki yara dokularında diğer gruplardan daha yüksek, LSO’da ise CO grubundan daha yüksek bulundu. Biyokimyasal sonuçlar gruplar arasında TP, GLU ve UREA değerlerinde anlamlı farklılıklar gösterdi (p < 0.05). Sonuç olarak, bu çalışma, ratlarda deneysel tam kalınlıklı eksizyonel deri yara modelinde kırmızı kantaron yağının topikal kullanımının yara iyileşmesini hızlandırdığını, defne tohumu yağının ise yara iyileşmesini olumsuz etkilediğini ortaya koymaktadır.

Anahtar Kelimeler

Alternatif bitkisel yağ deneysel dermatoloji in vivo kantaron

Kaynakça

  • Afifi FU, Khalil E, Tamimi SO, et al (1997): Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats. J Ethnopharmacol, 58, 9-14.
  • Altan A, Aras MH, Damlar İ, et al (2018): The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats. Eur Oral Res, 52, 143-149.
  • Altıparmak M, Eskitaşçıoğlu T (2018): Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. J Invest Surg, 31, 29-37.
  • Altuğ ME, Deveci MZY (2016): Dokularına Göre Tümöral Oluşumlara Cerrahi Yaklaşımlar. Turkiye Klinikleri J Vet Sci Surg-Special Topics, 2, 70-79.
  • Armutak Eİ, Yiğit F (2014): Laboratuvar hayvanları rehberi. 1st ed. İstanbul, Türkiye: Nobel Tıp Kitapevleri; 2014.
  • Atalan G, Demirkan İ, Yaman H, et al (2003): Effect of topical kefir application on open wound healing an in vivo study. Kafkas Univ Vet Fak Derg, 9, 43-47.
  • Augustine R, Augustine A, Kalarikkal N, et al (2016): Fabrication and characterization of biosilver nanoparticles loaded calcium pectinate nano-micro dual-porous antibacterial wound dressings. Prog Biomater, 5, 223-235.
  • Bahramsoltani R, Farzaei MH, Rahimi R (2014): Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res, 306, 601-617.
  • Barla A, Topçu G, Öksüz S, et al (2007): Kingston DGI. Identification of cytotoxic sesquiterpenes from Laurus nobilis L. Food Chem, 104, 1478-1484.
  • Biswas TK, Pandit S, Chakrabarti S, et al (2017): Evaluation of Cynodon dactylon for wound healing activity. J Ethnopharmacol, 197, 128-137.
  • Bouyahya A, Belmehdi O, El Jemli M, et al (2019): Chemical variability of Centaurium erythraea essential oils at three developmental stages and investigation of their in vitro antioxidant, antidiabetic, dermatoprotective and antibacterial activities. Ind Crops Prod, 132, 111-117.
  • Canpolat I, Eroksuz Y, Rızaoğlu T (2021): Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. Turkish J Vet Res, 5, 25-33.
  • Cemboluk Ö (2015): Rat tam kalınlıklı deri defektlerinde dermal analogların kontraksiyon üzerine etkileri. Tıpta uzmanlık tezi. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Plastik Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Eskişehir.
  • Dadalioǧlu I, Evrendilek GA (2004): Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens. J Agric Food Chem, 52, 8255-8260.
  • Deveci MZY, Gönenci R, Canpolat İ, et al (2020): In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride-chitosan-collagen biocomposite coating in rats. Turk J Vet Anim Sci, 44, 76-88.
  • Ekizce E (2019): Deneysel olarak tip II diyabet oluşturulmuş ratlardaki yara modelinde kudret narı (momordica charantia) meyvesi yağının yara iyileşmesi üzerine etkileri. MSc, Kırıkkale Üniversitesi, Kırıkkale.
  • Elmastaş M, Gülçin İ, Işildak Ö, et al (2006): Radical Scavenging Activity and Antioxidant Capacity of Bay Leaf Extracts. J Iran Chem Soc, 3, 258-266.
  • Fang F, Sang S, Chen KY, et al (2005): Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis). Food Chem, 93, 497-501.
  • Gawronska-Kozak B (2011): Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression. Matrix Biology, 30, 290-300.
  • Ham A, Shin J, Oh K, et al (2011): Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease. Biomol Ther, 19, 118-125.
  • Han MC, Durmuş AS, Sağlıyan A, et al (2017): Effects of Nigella sativa and Hypericum perforatum on wound healing. Turk J Vet Anim Sci, 41, 99-105.
  • Hierner R, Degreef H, Vranckx JJ, et al (2005): Skin grafting and wound healing the “dermato-plastic team approach”. Clin Dermatol, 23, 343-352.
  • Ilango K, Chitra V (2010): Wound healing and anti-oxidant activities of the fruit pulp of Limonia acidissima Linn (Rutaceae) in rats. Trop J Pharm Res, 9, 223-230.
  • Jerković I, Gašo-Sokač D, Pavlović H, et al (2012): Volatile organic compounds from Centaurium erythraea Rafn (Croatia) and the antimicrobial potential of its essential oil. Molecules, 17, 2058-2072.
  • Jovanović O, Radulović N, Stojanović G, et al (2009): Chemical composition of the essential oil of Centaurium erythraea Rafn (Gentianaceae) from Serbia. J Essent Oil Res, 21, 317-322.
  • Kaurinovic B, Popovic M, Vlaisavljevic S (2010): In vitro and in vivo effects of laurus nobilis L. leaf extracts. Molecules, 15, 3378-3390.
  • Kesbiç OS (2019): Effects of juniper berry oil on growth performance and blood parameters in common carp (Cyprinus carpio). Aquac Res, 50, 342-349.
  • Kordjazi M, Shabanpour B, Zabihi E, et al (2017): Investigation of effects of fucoidan polysaccharides extracted from two species of Padina on the wound-healing process in the rat. Turk J Vet Anim Sci, 41, 106-117.
  • Kumandaş A, Karslı B, Kürüm A, et al (2020): Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Univ Vet Fak Derg, 67, 33-40.
  • Kupeli E, Orhan I, Yesilada E (2007): Evaluation of Some Plants Used in Turkish Folk Medicine for Their Anti-inflammatory and Antinociceptive Activities. Pharm Biol, 45, 547-555.
  • Kurt B, Bilge N, Sözmen M, et al (2018): Effects of Plantago lanceolata L. extract on full-thickness excisional wound healing in a mouse model. Biotech Histochem, 93, 249-257.
  • Lenhardt R, Akca O (2014): Hyperglycemia in the Intensive Care Unit. J Turk Soc Intens Care, 12, 67-71.
  • Loizzo MR, Saab AM, Tundis R, et al (2008): Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers, 5, 461-470.
  • Nayak S, Nalabothu P, Sandiford S, et al (2006): Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats. BMC Complement Altern Med, 6, 1-6.
  • Nevin KG, Rajamohan T (2010): Effect of Topical Application of Virgin Coconut oil on Skin Components and Antioxidant Status During Dermal Wound Healing in Young Rats. Skin Pharmacol Physiol, 23, 290-297.
  • Nguyen KT, Akhil KS, Seok JH, et al (2013): Deficient cytokine expression and neutrophil oxidative burst contribute to impaired cutaneous wound healing in diabetic, biofilm‐containing chronic wounds. Wound Repair and Regen, 21, 833-841.
  • Ozcan B, Esen M, Sangun MK, et al (2010): Effective antibacterial and antioxidant properties of methanolic extract of Laurus nobilis seed oil. J Environ Biol, 31, 637-641.
  • Poljšak N, Kreft S, Glavač NK (2020): Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. Phytotherapy Research, 34, 254-269.
  • Robbins SL, Kumar B, Cotran R (2000) Tissue repair: Cellular growth, fibrosis and wound healing. 46-59. In: Robbins SL (Ed), Pathologic Basic of Disease, Philadelphia.
  • Samejima K, Kanazawa K, Ashida H, et al (1998): Bay Laurel Contains Antimutagenic Kaempferyl Coumarate Acting against the Dietary Carcinogen 3-Amino-1-methyl-5H-pyrido [4, 3- b]indole. J Agric Food Chem, 46, 4864-4868.
  • Sangun MK, Aydin E, Timur M, et al (2007): Comparison of chemical composition of the essential oil of Laurus nobilis L. leaves and fruits from different regions of Hatay, Turkey. J Environ Biol, 28, 731-733.
  • Saporito F, Sandri G, Bonferoni MC, et al (2018): Essential oil-loaded lipid nanoparticles for wound healing. Int J Nanomedicine, 13, 175-186.
  • Sayyah M, Valizadeh J, Kamalinejad M (2002): Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Phytomedicine, 9, 212-216.
  • Srıvastava N, Jaın GK, Raghubir R (2011): Poly antioxidant mixture accelerates healing of experimental wounds in albino rats. Asian J Pharm Clin Res, 4, 46-50.
  • Stejskalova A, Almquist BD (2017): Using biomaterials to rewire the process of wound repair. Biomater Sci, 5, 1421-1434.
  • Sudsai T, Wattanapiromsakul C, Tewtrakul S (2016): Wound healing property of isolated compounds from Boesenbergia kingii rhizomes. J Ethnopharmacol, 184, 42-48.
  • Süntar IP, Akkol EK, Yılmazer D, et al (2010): Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol, 127, 468-477.
  • Şındak N, Akgül MB, Gülaydın A, et al (2017): Japon Bıldırcınlarında (Coturnix Coturnix Japonica) Topikal Olarak Uygulanan Menengiç Yağı ve Farklı Deneysel Karışımlarının Yara İyileşmesi Üzerine Etkileri. Van Vet J, 28, 69-74.
  • Wölfle U, Seelinger G, Schempp CM (2014): Topical application of St. Johnʼs wort (Hypericum perforatum). Planta Med, 80, 109-120.
  • Yilmaz ES, Timur M, Aslim B (2013): Antimicrobial, antioxidant activity of the essential oil of Bay Laurel from Hatay, Turkey. J Essent Oil-Bear Plants, 16, 108-116.
  • Yipel M, İlhan A, Tekeli İO, et al (2020): İlaçlarla Etkileşim Potansiyeline Sahip Hayvan Sağlığında Da Kullanılan Tıbbi Bitkiler. Vet Farm Toks Dern Bült, 11, 13-26.
Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Nazmiye Semiz 0000-0002-1417-8948

Mehmet Zeki Yılmaz Deveci 0000-0002-9532-247X

Erken Görünüm Tarihi 27 Ekim 2023
Yayımlanma Tarihi 23 Eylül 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Semiz, N., & Deveci, M. Z. Y. (2024). Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 71(4), 487-496. https://doi.org/10.33988/auvfd.1085562
AMA Semiz N, Deveci MZY. Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Univ Vet Fak Derg. Eylül 2024;71(4):487-496. doi:10.33988/auvfd.1085562
Chicago Semiz, Nazmiye, ve Mehmet Zeki Yılmaz Deveci. “Effects of Common Centaury (Centaurium Erythraea) Oil and Laurel (Laurus Nobilis) Seed Oil on Full-Thickness Excisional Skin Wound Healing in Rats”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71, sy. 4 (Eylül 2024): 487-96. https://doi.org/10.33988/auvfd.1085562.
EndNote Semiz N, Deveci MZY (01 Eylül 2024) Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71 4 487–496.
IEEE N. Semiz ve M. Z. Y. Deveci, “Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats”, Ankara Univ Vet Fak Derg, c. 71, sy. 4, ss. 487–496, 2024, doi: 10.33988/auvfd.1085562.
ISNAD Semiz, Nazmiye - Deveci, Mehmet Zeki Yılmaz. “Effects of Common Centaury (Centaurium Erythraea) Oil and Laurel (Laurus Nobilis) Seed Oil on Full-Thickness Excisional Skin Wound Healing in Rats”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71/4 (Eylül 2024), 487-496. https://doi.org/10.33988/auvfd.1085562.
JAMA Semiz N, Deveci MZY. Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Univ Vet Fak Derg. 2024;71:487–496.
MLA Semiz, Nazmiye ve Mehmet Zeki Yılmaz Deveci. “Effects of Common Centaury (Centaurium Erythraea) Oil and Laurel (Laurus Nobilis) Seed Oil on Full-Thickness Excisional Skin Wound Healing in Rats”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 71, sy. 4, 2024, ss. 487-96, doi:10.33988/auvfd.1085562.
Vancouver Semiz N, Deveci MZY. Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Univ Vet Fak Derg. 2024;71(4):487-96.