Olgu Sunumu
BibTex RIS Kaynak Göster

First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye

Yıl 2024, , 105 - 107, 02.01.2024
https://doi.org/10.33988/auvfd.1153036

Öz

Lethal acrodermatitis (LAD) is a rare disease affecting bull terriers and miniature bull terriers characterized by poor growth, progressive skin lesions, and immunodeficiency. A mutation in the Muskelin 1 (MKLN1) gene was determined as the causative mutation for LAD, and a genetic testing method for affected dogs has been established. A bull terrier representing symptoms similar to those of LAD was submitted to clinics, and a blood sample was taken for genetic testing. DNA was extracted, and direct mutation screening confirmed the causative mutation MKLN1:c.400+3A>C. Due to the severe progression of the disease and lack of available treatment, we have been informed that the patient was euthanised. This is the first reported case of LAD from Turkiye, and based on our findings, we strongly suggest that owners and breeders implement genetic testing before breeding to reduce and eventually eradicate this mutation from the population.

Etik Beyan

This study does not present any ethical concerns.

Teşekkür

The authors would like to thank the owners of the patient.

Kaynakça

  • Bauer A, Jagannathan V, Högler S, et al (2018): MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS genetics4, e1007264.
  • Bell J, Cavanagh K, Tilley L, et al (2012): Veterinary medical guide to dog and cat breeds. CRC press.
  • Flaim D (2020): Bull Terrier History, Behind the Breed. Available at: https://www.akc.org/expert-advice/dog-breeds/bull-terrier-history-behind-the-breed/. (Accessed July 12, 2022).
  • Hall TA (1999): BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In: Nucleic acids symposium series. Vol. 41, pp. 95-98.
  • Jezyk PF, Haskins ME, Mackay-Smith WE, et al (1986): Lethal acrodermatitis in Bull Terriers. J Am Vet Med A, 188, 833-839.
  • Mauldin EA, Peters-Kennedy J (2016): Chapter 6 - Integumentary System. 509-736. In: Jubb, Kennedy, and Palmer's pathology of Domestic Animals. Elsevier, St. Louis.
  • McEwan NA, Huang HP, Mellor DJ (2003): Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol, 96, 235–238.
  • McEwan NA, McNeil PE, Thompson H, et al (2000): Diagnostic features, confirmation and dis- ease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract, 41, 501–507.
  • McEwan NA (2001): Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract, 42, 291-297.
  • Mena VP, Cardenas RH, Contreras LM, et al (2021): Clinical management of lethal acrodermatitis syndrome in a bull terrier. Res J Vet Pract, 9, 9-11.
  • Patterson DF, Aguirre GA, Fyfe JC, et al (1989): Is this a genetic disease? J Small Anim Pract, 30, 127-139.
  • Salgirli Y, Emre B, Besgul K, et al (2012): A pilot study on assessment of dog owners’ attitude towards their dogs. Ankara Univ Vet Fak Derg, 59, 11-15.
  • Smits B, Croft DL, Abrams-Ogg AC (1991): Lethal acrodermatitis in bull terriers: a problem of defective zinc metabolism. Vet Dermatol, 2, 91-95.
Yıl 2024, , 105 - 107, 02.01.2024
https://doi.org/10.33988/auvfd.1153036

Öz

Kaynakça

  • Bauer A, Jagannathan V, Högler S, et al (2018): MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS genetics4, e1007264.
  • Bell J, Cavanagh K, Tilley L, et al (2012): Veterinary medical guide to dog and cat breeds. CRC press.
  • Flaim D (2020): Bull Terrier History, Behind the Breed. Available at: https://www.akc.org/expert-advice/dog-breeds/bull-terrier-history-behind-the-breed/. (Accessed July 12, 2022).
  • Hall TA (1999): BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In: Nucleic acids symposium series. Vol. 41, pp. 95-98.
  • Jezyk PF, Haskins ME, Mackay-Smith WE, et al (1986): Lethal acrodermatitis in Bull Terriers. J Am Vet Med A, 188, 833-839.
  • Mauldin EA, Peters-Kennedy J (2016): Chapter 6 - Integumentary System. 509-736. In: Jubb, Kennedy, and Palmer's pathology of Domestic Animals. Elsevier, St. Louis.
  • McEwan NA, Huang HP, Mellor DJ (2003): Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol, 96, 235–238.
  • McEwan NA, McNeil PE, Thompson H, et al (2000): Diagnostic features, confirmation and dis- ease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract, 41, 501–507.
  • McEwan NA (2001): Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract, 42, 291-297.
  • Mena VP, Cardenas RH, Contreras LM, et al (2021): Clinical management of lethal acrodermatitis syndrome in a bull terrier. Res J Vet Pract, 9, 9-11.
  • Patterson DF, Aguirre GA, Fyfe JC, et al (1989): Is this a genetic disease? J Small Anim Pract, 30, 127-139.
  • Salgirli Y, Emre B, Besgul K, et al (2012): A pilot study on assessment of dog owners’ attitude towards their dogs. Ankara Univ Vet Fak Derg, 59, 11-15.
  • Smits B, Croft DL, Abrams-Ogg AC (1991): Lethal acrodermatitis in bull terriers: a problem of defective zinc metabolism. Vet Dermatol, 2, 91-95.
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Zootekni, Genetik ve Biyoistatistik
Bölüm Olgu Sunumu
Yazarlar

Furkan Kutlu 0000-0003-0310-2590

Nüket Bilgen 0000-0003-2324-7965

Yayımlanma Tarihi 2 Ocak 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Kutlu, F., & Bilgen, N. (2024). First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 71(1), 105-107. https://doi.org/10.33988/auvfd.1153036
AMA Kutlu F, Bilgen N. First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye. Ankara Univ Vet Fak Derg. Ocak 2024;71(1):105-107. doi:10.33988/auvfd.1153036
Chicago Kutlu, Furkan, ve Nüket Bilgen. “First Genetically Confirmed Case of Lethal Acrodermatitis in a Bull Terrier in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71, sy. 1 (Ocak 2024): 105-7. https://doi.org/10.33988/auvfd.1153036.
EndNote Kutlu F, Bilgen N (01 Ocak 2024) First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71 1 105–107.
IEEE F. Kutlu ve N. Bilgen, “First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye”, Ankara Univ Vet Fak Derg, c. 71, sy. 1, ss. 105–107, 2024, doi: 10.33988/auvfd.1153036.
ISNAD Kutlu, Furkan - Bilgen, Nüket. “First Genetically Confirmed Case of Lethal Acrodermatitis in a Bull Terrier in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 71/1 (Ocak 2024), 105-107. https://doi.org/10.33988/auvfd.1153036.
JAMA Kutlu F, Bilgen N. First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye. Ankara Univ Vet Fak Derg. 2024;71:105–107.
MLA Kutlu, Furkan ve Nüket Bilgen. “First Genetically Confirmed Case of Lethal Acrodermatitis in a Bull Terrier in Türkiye”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 71, sy. 1, 2024, ss. 105-7, doi:10.33988/auvfd.1153036.
Vancouver Kutlu F, Bilgen N. First genetically confirmed case of Lethal Acrodermatitis in a Bull Terrier in Türkiye. Ankara Univ Vet Fak Derg. 2024;71(1):105-7.