Öz
Bu çalışmada octreotide tedavisinin başarıyla sonuçlandığı, sirozlu bir köpekteki Nekrolitik Migratuar Eritem (NME) olgusu sunulmaktadır. Derinin histopatolojik incelemesi NME’i göstermiştir. Kan parametreleri, karaciğer biyopsi sonucu, karaciğer ve pankreasın ultrasonografik ve bilgisayarlı tomografik incelemeleri şiddetli siroz varlığına işaret etmiş, bununla beraber pankreasta herhangi bir kitle ya da tümör bulunamamıştır. Hastada görülen deri hastalığının, sekonder hipergliseminin eşlik ettiği kronik hepatopati (siroz) sonucu oluştuğu düşünülmüştür. Octreotide, yüksek protein diyeti, yağ asitleri ve çinko kullanılmış ve böylelikle semptomlarda geçici bir düzelme sağlanmıştır. Sonunda karaciğer yetmezliğine bağlı nörolojik semptomlar, tekrarlanan kusma, kilo kaybı ve belirgin ağrı görülmüş ve hasta ötanazi edilmiştir. Deri, pankreas ve karaciğer dokularının makroskobik ve mikroskobik değerlendirmelerini kapsayan postmortem muayene sonuçları tanımızı doğrulamıştır
Anahtar Kelimeler
Kaynakça
- Allenspach K, Arnold P, Glaus T, Hauser B, Wolff C, Eberle C, Komminoth P (2000): Glucagon-producing neuroendocrine tumour associated with hypoaminoacidemia and skin lesions. J Small Anim Pract, 41, 402-406.
- Bond R, McNeil PE, Evans H, Srebernik N (1995): Metabolic epidermal necrosis in two dogs with different underlying diseases. Vet Rec, 136, 466-71.
- Byrne KP (1999): Metabolic epidermal necrosis- hepatocutaneous syndrome. Vet Clin N Am-Small 29, 1337-55.
- Godfrey DR, Rest JR (2000): Suspected necrolytic migratory ervthema associated with chronic hepatopathy in a cat. J Small Anim Pract, 41, 324-28.
- Griffing GT (2013): Hyperglucagonemia treatment & management. Erişim tarihi: 18.06.2014. Erişim adresi: http://www.emedicine.medscape.com/article/121575- treatment.
- Gross TL, O'Brien TD, Davies AP, Long RE (1990): Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis. J Am Vet Med Assoc, 197, 1619-22.
- Gross TL, Song MD, Havel PJ, Ihrke PJ (1993): Superficial Necrolytic Dermatitis (Necrolytic Migratory Erythema) in Dogs. Vet Pathol, 30, 75-81.
- Henricks PM (1987): Dermatitis associated with the use of primidone in a dog. J Am Vet Med Assoc, 191, 237-8.
- Hill PB, Auxilia ST, Munro E, Genovese, L, Silkstone MA, Kirby B (2000): Resolution of skin lesions and long- term survival in a dog with superficial necrolytic dermatitis and liver cirrhosis. J Small Anim Pract, 41, 519-523.
- March PA, Hillier A, Weisbrode SE, Mattoon JS, Johnson SE, DiBartola SP, Brofman PJ (2004): Superficial Necrolytic Dermatitis in 11 Dogs with a History of Phenobarbital Administration (1995-2002). J Vet Intern Med, 18, 65-74.
- Marsh KA, RuedisueliFL, Coe SL, Watson TGD (2000): Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs receiving a complete and balanced diet. Vet Dermatol, 11, 277-284.
- Miller WH, Scott DW, Buerger RG, Shanley KJ, Paradis M, McMurdy MA, Angarano DW (1990): Necrolytic Migratory Erythema in Dogs: A Hepatocutaneous Syndrome. J Am Anim Hosp Assoc, 26, 573-580.
- Oberkirchner U, Linder KE, Zadrozny L, Olivry T (2010): Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide. Vet Dermatol, 21, 510-516.
- Outerbridge CA (2010): Hepatocutaneous Syndrome. 112. In: SJ Ettinger, EC Feldman. (Eds), Textbook of Veterinary Internal medicine, 7th ed, Elsevier Saunders, St. Louis, Missiouri, USA.
- Outerbridge CA, Marks SL, Rogers QR (2002): Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis. Vet Dermatol, 13, 177-186.
- Torres S, Johnson K, McKeever P, Hardy R (1997): Superficial necrolytic dermatitis and a pancreatic endocrine tumour in a dog. J Small Anim Pract, 38, 246- 50.
- Torres SMF, Caywood DD, O’Brien TD, O’Leary TP, McKeever PJ (1997) : Resolution of Superficial Necrolytic Dermatitis Following Excision of a Glucagon-Secreting Pancreatic Neoplasm in a Dog. J Am Anim Hosp Assoc, 33, 313-319.
- Walton DK, Center SA, Scott DW, Collins K (1986): Ulcerative Dermatosis Associated with Diabetes Mellitus in the Dog: A Report of Four Cases. J Am Anim Hosp Assoc, 22, 79-88.
Öz
We report here a case of Necrolytic Migratory Erythema (NME) seen in a dog with cirrhosis in which octreotide therapy succeeded. Histopathologic examination of skin revealed NME. Blood parameters and liver cytology result, USG and CT examination of liver and pancreas indicated a severe cirrhosis, however any mass or tumor couldn’t be found on pancreas at the time. In this case, the skin disease was believed to be due to a chronic hepatopathy (cirrhosis) associated with secondary hyperglucagonemia. Octreotide, high level of protein diet, fatty acids and zinc supplement were used, and this provided temporary relief of signs. Neurologic symptoms related to liver failure, profuse vomiting, weight loss and apparent pain were eventually observed and the patient was euthanized. Postmortem examination including gross necropsy and microscobic evaluation of skin, liver and pancreas tissues confirmed our diagnosis
Anahtar Kelimeler
Kaynakça
- Allenspach K, Arnold P, Glaus T, Hauser B, Wolff C, Eberle C, Komminoth P (2000): Glucagon-producing neuroendocrine tumour associated with hypoaminoacidemia and skin lesions. J Small Anim Pract, 41, 402-406.
- Bond R, McNeil PE, Evans H, Srebernik N (1995): Metabolic epidermal necrosis in two dogs with different underlying diseases. Vet Rec, 136, 466-71.
- Byrne KP (1999): Metabolic epidermal necrosis- hepatocutaneous syndrome. Vet Clin N Am-Small 29, 1337-55.
- Godfrey DR, Rest JR (2000): Suspected necrolytic migratory ervthema associated with chronic hepatopathy in a cat. J Small Anim Pract, 41, 324-28.
- Griffing GT (2013): Hyperglucagonemia treatment & management. Erişim tarihi: 18.06.2014. Erişim adresi: http://www.emedicine.medscape.com/article/121575- treatment.
- Gross TL, O'Brien TD, Davies AP, Long RE (1990): Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis. J Am Vet Med Assoc, 197, 1619-22.
- Gross TL, Song MD, Havel PJ, Ihrke PJ (1993): Superficial Necrolytic Dermatitis (Necrolytic Migratory Erythema) in Dogs. Vet Pathol, 30, 75-81.
- Henricks PM (1987): Dermatitis associated with the use of primidone in a dog. J Am Vet Med Assoc, 191, 237-8.
- Hill PB, Auxilia ST, Munro E, Genovese, L, Silkstone MA, Kirby B (2000): Resolution of skin lesions and long- term survival in a dog with superficial necrolytic dermatitis and liver cirrhosis. J Small Anim Pract, 41, 519-523.
- March PA, Hillier A, Weisbrode SE, Mattoon JS, Johnson SE, DiBartola SP, Brofman PJ (2004): Superficial Necrolytic Dermatitis in 11 Dogs with a History of Phenobarbital Administration (1995-2002). J Vet Intern Med, 18, 65-74.
- Marsh KA, RuedisueliFL, Coe SL, Watson TGD (2000): Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs receiving a complete and balanced diet. Vet Dermatol, 11, 277-284.
- Miller WH, Scott DW, Buerger RG, Shanley KJ, Paradis M, McMurdy MA, Angarano DW (1990): Necrolytic Migratory Erythema in Dogs: A Hepatocutaneous Syndrome. J Am Anim Hosp Assoc, 26, 573-580.
- Oberkirchner U, Linder KE, Zadrozny L, Olivry T (2010): Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide. Vet Dermatol, 21, 510-516.
- Outerbridge CA (2010): Hepatocutaneous Syndrome. 112. In: SJ Ettinger, EC Feldman. (Eds), Textbook of Veterinary Internal medicine, 7th ed, Elsevier Saunders, St. Louis, Missiouri, USA.
- Outerbridge CA, Marks SL, Rogers QR (2002): Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis. Vet Dermatol, 13, 177-186.
- Torres S, Johnson K, McKeever P, Hardy R (1997): Superficial necrolytic dermatitis and a pancreatic endocrine tumour in a dog. J Small Anim Pract, 38, 246- 50.
- Torres SMF, Caywood DD, O’Brien TD, O’Leary TP, McKeever PJ (1997) : Resolution of Superficial Necrolytic Dermatitis Following Excision of a Glucagon-Secreting Pancreatic Neoplasm in a Dog. J Am Anim Hosp Assoc, 33, 313-319.
- Walton DK, Center SA, Scott DW, Collins K (1986): Ulcerative Dermatosis Associated with Diabetes Mellitus in the Dog: A Report of Four Cases. J Am Anim Hosp Assoc, 22, 79-88.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA85BY39BB |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2016 |
| Yayımlandığı Sayı | Yıl 2016 |