Öz
Visceral leishmaniasis (VL), also known as dumdum fever or kala-azar, is characterized by intermittent fever, substantial weight loss, hepatosplenomegaly and pancytopenia. If left untreated, the disease can have a fatality rate as high as 100% within two years. This study was aimed to investigate the presence of Leishmania sp. in VL suspected patients who applied to Erciyes University Medical Faculty Department of Parasitology between January 1995 and August 2012. Bone marrow samples obtained from 37 (54.4%) males and 31 (45.6%) females making a total of 68 VL suspected patients between January 1995 and January 2004 were examined by Giemsa stain technique. Microscopic examination showed Leishmania amastigotes in 4 (5.9%) patients. Bone marrow and sera samples obtained from 42 (55.3%) males and 34 (44.7%) females making a total of 76 VL suspected patients between January 2004 and August 2012 were examined by Giemsa stain technique and Indirect Fluorescent Antibody Test (IFAT). Three (3.9%) patients were found to be positive with both IFAT and Giemsa stain technique. Four (5.3%) patients were found to be positive with only IFAT. As a result, VL is a health problem in Kayseri and the fight against VL must be supported by special programs. Therefore, we believe that it should be safer to use both Giemsa stain technique and IFAT together for diagnosis of VL
Anahtar Kelimeler
Kaynakça
- Arik Yilmaz E, Tanir G, Tuygun N, Taylan Ozkan A (2009): Visceral leishmaniasis in 13 pediatric patients in Turkey: treatment experience. Turkiye Parazitol Derg, 33, 259-262.
- Balcı YI, Türk M, Özgür A, Küçüktaşçı K (2011): Dört Çocuk Hastada İndirekt Floresan Antikor Test Kullanımı ile Visceral Leishmaniasis Tanısının Değerlendirilmesi. 35(2), 114-116.
- Belazzoug S (1992): Leishmaniasis in Mediterranean countries. Vet Parasitol, 44, 15-19.
- Berman JD (1997): Human Leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis, 24, 684-703.
- Blackwell JM, Fakiola M, Ibrahim ME, Jamieson SE, Jeronimo SB, Miller EN, Mishra A, Mohamed HS, Peacock CS, Raju M, Sundar S, Wilson ME (2009): Genetics and visceral leishmaniasis: of mice and man. Parasite Immunol, 31, 254-266.
- Desjeux P, (1998): UNAIDS. Leishmania and HIV in Gridlock. In PF Beales, World Health Organization and United Nations Programme on HIV/AIDS, WHO/CTD/ LEISH/98.9 Add 1.
- Dursun O, Erişir S, Yeşilipek A (2009): Visceral childhood leishmaniasis in southern Turkey: experience of twenty years. Turk J Pediatr, 51, 1-5.
- Maltezou HC, Siafas C, Mavrikou M, Spyridis P, Stavrinadis C, Karpathios T, Kafetzis DA (2000): Visceral leishmaniasis during childhood in southern Greece. Clin Infect Dis, 31, 1139-1143.
- Ok UZ, Balcioglu IC, Taylan Ozkan A, Ozensoy S, Ozbel Y (2002): Leishmaniasis in Turkey. Acta Trop, 84, 43-48.
- Ozensoy S, Ozbel Y, Turgay N, Alkan MZ, Gul K, Gilman-Sachs A, Chang KP, Reed SG, Ozcel MA (1998): Serodiagnosis and epidemiology of visceral leishmaniasis in Turkey. Am J Trop Med Hyg, 59, 363- 369.
- Ozensoy Töz S, Sakru N, Ertabaklar H, Demir S, Sengul M, Ozbel Y (2009): Serological and entomological survey of zoonotic visceral leishmaniasis in Denizli Province, Aegean Region, Turkey. New Microbiol, 32, 93- 100.
- Srivastava P, Dayama A, Mehrotra S, Sundar S (2011): Diagnosis of visceral leishmaniasis. Trans R Soc Trop Med Hyg, 105(1), 1-6.
- Tanir G, Taylan Ozkan A, Dağlar E (2006). Pediatric visceral Leishmaniasis in Turkey. Pediatr Int, 48, 66-69.
Öz
Dumdum ateşi veya kala-azar olarak bilinen, aralıklı ateş, kilo kaybı, hepatosplenomegali ve pansitopeni ile karakterize visseral leishmaniasis (VL), tedavi edilmezse iki yılda %100 ölüm oranına sahip olabilmektedir. Bu çalışmada, Ocak 1995 ve Ağustos 2012 arasında Erciyes Üniversitesi Tıp Fakültesi Parazitoloji Anabilim Dalı'na VL şüphesi ile başvuran hastalarda Leishmania sp. araştırılması amaçlanmıştır. Ocak 1995 ile Ocak 2004 tarihleri arasında 37 (%54.4)’si erkek ve 31 (%45.6)’i kadın olmak üzere toplam 68 VL şüpheli hastadan alınan kemik iliği örneği Giemsa boyama tekniği ile incelenmiştir. Mikroskobik inceleme sonucunda 4 (%5.9) hastada Leishmania amastigotları tespit edilmiştir. Ocak 2004 ve Ağustos 2012 tarihleri arasında 42 (%55.3)'si erkek ve 34 (%44.7)'ü kadın olmak üzere toplam 76 VL şüpheli hastadan alınan kemik iliği ve serum örnekleri Giemsa boyama ve İndirekt Fluoresan Antikor (IFA) teknikleri ile incelenmiştir. İncelenen hastalardan 3 (%3.9)'ü hem IFA hem de Giemsa boyama tekniği ile pozitif bulunmuştur. Dört (%5.3) hasta ise yalnızca IFAT ile pozitif bulunmuştur. Sonuç olarak VL Kayseri’de bir sağlık sorunudur ve VL'ye karşı mücadele özel programlar ile desteklenmelidir. Bununla birlikte, VL tanısında IFA ve Giemsa boyamanın birlikte kullanılması daha güvenli olacaktır
Anahtar Kelimeler
Kaynakça
- Arik Yilmaz E, Tanir G, Tuygun N, Taylan Ozkan A (2009): Visceral leishmaniasis in 13 pediatric patients in Turkey: treatment experience. Turkiye Parazitol Derg, 33, 259-262.
- Balcı YI, Türk M, Özgür A, Küçüktaşçı K (2011): Dört Çocuk Hastada İndirekt Floresan Antikor Test Kullanımı ile Visceral Leishmaniasis Tanısının Değerlendirilmesi. 35(2), 114-116.
- Belazzoug S (1992): Leishmaniasis in Mediterranean countries. Vet Parasitol, 44, 15-19.
- Berman JD (1997): Human Leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis, 24, 684-703.
- Blackwell JM, Fakiola M, Ibrahim ME, Jamieson SE, Jeronimo SB, Miller EN, Mishra A, Mohamed HS, Peacock CS, Raju M, Sundar S, Wilson ME (2009): Genetics and visceral leishmaniasis: of mice and man. Parasite Immunol, 31, 254-266.
- Desjeux P, (1998): UNAIDS. Leishmania and HIV in Gridlock. In PF Beales, World Health Organization and United Nations Programme on HIV/AIDS, WHO/CTD/ LEISH/98.9 Add 1.
- Dursun O, Erişir S, Yeşilipek A (2009): Visceral childhood leishmaniasis in southern Turkey: experience of twenty years. Turk J Pediatr, 51, 1-5.
- Maltezou HC, Siafas C, Mavrikou M, Spyridis P, Stavrinadis C, Karpathios T, Kafetzis DA (2000): Visceral leishmaniasis during childhood in southern Greece. Clin Infect Dis, 31, 1139-1143.
- Ok UZ, Balcioglu IC, Taylan Ozkan A, Ozensoy S, Ozbel Y (2002): Leishmaniasis in Turkey. Acta Trop, 84, 43-48.
- Ozensoy S, Ozbel Y, Turgay N, Alkan MZ, Gul K, Gilman-Sachs A, Chang KP, Reed SG, Ozcel MA (1998): Serodiagnosis and epidemiology of visceral leishmaniasis in Turkey. Am J Trop Med Hyg, 59, 363- 369.
- Ozensoy Töz S, Sakru N, Ertabaklar H, Demir S, Sengul M, Ozbel Y (2009): Serological and entomological survey of zoonotic visceral leishmaniasis in Denizli Province, Aegean Region, Turkey. New Microbiol, 32, 93- 100.
- Srivastava P, Dayama A, Mehrotra S, Sundar S (2011): Diagnosis of visceral leishmaniasis. Trans R Soc Trop Med Hyg, 105(1), 1-6.
- Tanir G, Taylan Ozkan A, Dağlar E (2006). Pediatric visceral Leishmaniasis in Turkey. Pediatr Int, 48, 66-69.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA79SG32NC |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Eylül 2013 |
| Yayımlandığı Sayı | Yıl 2013 |