Öz
In this case, a female boxer dog, 6-year-old, with tonic-clonic convulsions and hind-limb paresis was evaluated. The serum insulin and serum glucose levels were 58 µU/ml and 5 mg/dl, respectively. In spite of all care, the comatose dog died. At necropsy, one well-circumscribed white-grayish mass, 4x3x2 cm, was found at the caudal edge of right lobe of the pancreas. Subcortical malacic areas in reddish color was seen in the brain. Microscopically, the tumoral mass consisted of neoplastic cells with round shape, basophilic nucleous and granular eosinophilic cytoplasm. In addition to these findings, metastasis to the regional lymph node of the pancreas was observed. Immunohistochemically, the tumor cells from both primary and metastatic tissues showed immunoreactivity to monoclonal mouse anti-insulin antibody. Clinically, histologically and immunohistochemically, functional insulinoma with lymph node metastasis was diagnosed in the present case
Anahtar Kelimeler
Kaynakça
- Katsuo M, Hiroyuki N, Nobuhiko O, Ken-ichiro O, Kazuo Y, Kunuhiko S, Reiji T, Kosaku F (1987): Two cases of canine insulinoma. Jpn J Vet Sci, 49, 1151-1153.
- Lamb CR, Simpson KW, Boswood A, Matthewman LA (1995): Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec, 137, 65- 68.
- Leifer, CE, Peterson ME, Matus RE (1986): Insulin- secreting tumor: Diagnosis and medical and surgical management in 55 dogs. J Am Vet Med Assoc, 188, 60-64.
- Petar D, Vesna M, Zoran S, Sven S, Branka A, Zeljko G (2000): Insulinoma in a dog; case report. Veterinarski Arhiv, 70, 13-20.
- Shimada A, Morita T, Ikeda N, Torii S, Haruna A (2000): Hypoglycaemic brain lesions in a dog with insulinoma. J Comp Path, 122, 67-71.
- Steiner JM, Bruyette DS (1996): Canine insulinoma. Compend Contin Educ Pract Vet, 18, 13-22.
- Vallee KI (2003): Insulin-secreting beta cell neoplasia in a 10-year-old dog. Can Vet J, 44, 592-59.
Öz
Bu olguda tonik-klonik konvulsiyonlar ve arka bacaklarda parezisi olan 6 yaşlı boxer ırkı dişi bir köpek değerlendirildi. Serum insülin ve serum glukoz seviyeleri sırasıyla 58 µU/ml ve 5 mg/dl olarak bulundu. Yapılan tüm müdahalelere rağmen koma halindeki köpek öldü. Nekropside pankreasın sağ lobunun arka ucunda 4x3x2 cm ebadında beyazımsı-gri renkte iyi sınırlı bir kitle görüldü. Beyinde kırmızımsı renkte subkortikal malasik alanlar dikkati çekti. Mikroskobik olarak tümör hücreleri yuvarlak şekilli, bazofilik çekirdekli ve granüler yapıda eozinofilik sitoplazmadan oluşmaktaydı. Bu bulgulara ek olarak pankreasın bölgesel lenf nodunda metastaza rastlandı. İmmunohistokimyasal olarak hem primer hem de metastatik tümör dokusu hücreleri monoklonal fare insüline karşı elde edilen antikor ile pozitif reaksiyon verdi. Sunulan olgu klinik, histolojik ve immunohistokimyasal olarak lenf yumrusu metastazlı fonksiyonel bir insülinoma olarak tanımlandı
Anahtar Kelimeler
Kaynakça
- Katsuo M, Hiroyuki N, Nobuhiko O, Ken-ichiro O, Kazuo Y, Kunuhiko S, Reiji T, Kosaku F (1987): Two cases of canine insulinoma. Jpn J Vet Sci, 49, 1151-1153.
- Lamb CR, Simpson KW, Boswood A, Matthewman LA (1995): Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec, 137, 65- 68.
- Leifer, CE, Peterson ME, Matus RE (1986): Insulin- secreting tumor: Diagnosis and medical and surgical management in 55 dogs. J Am Vet Med Assoc, 188, 60-64.
- Petar D, Vesna M, Zoran S, Sven S, Branka A, Zeljko G (2000): Insulinoma in a dog; case report. Veterinarski Arhiv, 70, 13-20.
- Shimada A, Morita T, Ikeda N, Torii S, Haruna A (2000): Hypoglycaemic brain lesions in a dog with insulinoma. J Comp Path, 122, 67-71.
- Steiner JM, Bruyette DS (1996): Canine insulinoma. Compend Contin Educ Pract Vet, 18, 13-22.
- Vallee KI (2003): Insulin-secreting beta cell neoplasia in a 10-year-old dog. Can Vet J, 44, 592-59.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA63YJ38AY |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2012 |
| Yayımlandığı Sayı | Yıl 2012 |