Editöre Mektup
Yıl 2011,
, 61 - 64, 01.03.2011
Öz
Ghrelin is a novel 28-amino-acid-peptide isolated from the rat and human stomach. This peptide is predominantly produced by the stomach, in addition lower amounts derive from small and large intestines, pancreas, pituitary gland, kidney, placenta, immun system organs and cells, testis, ovary and arcuate nucleus of hypothalamus. In this study, distrubition of ghrelin immunoreactive cells in the abomasum of sheep was investigated. Tissue samples were taken from cardia, fundus , the proximal region of pylorus, main/distal pylorus regions of abomasum. The results have revealed that ghrelin immunopositive cells distrubuted throughout the mucosal layer of abomasum of sheep, in other mammalian species
Anahtar Kelimeler
Kaynakça
- Ahmed S., Harvey S (2002): Ghrelin a Hypotalamic GH- releasing factor in Domestic fowl (Gallus Domesticus). J. Endocrinol. 172:117-25.
- Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000): Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 141:4255–4261.
- Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N (2001): Ghrelin in domestic animals: distribution in stomach and its possible role. Domest Anim Endocrinol. 21:17–24
- Hsu S. M., Raiıne L.,Fanger H (1981): Use of Avidin- Biotin-Peroxidase Complex (ABC) in immunperoxidase techniques. The Journal of Histochemistry and Cytochemistry, 29: 577-580,.
- Huang Z.G., Xiong L., Liu Z. S., Qiao Y., Dai R., Xie Z., Liu s.R.,Shi G.Q., Liu G.Q (2006): The tissue distribution and developmental changes of ghrelin mRNA expression in sheep.Yi Chuan Xue Bao. Sep; 33(9):808-13.
- Kojima M.,Hosoda H., Date Y, Nakazato M, Matsuo H, Kangawa K (1999): Ghrelin is a Growth- Hormone- releasing acylated peptide from stomach, Nature. 402:656- 60.
- Kojima M., Kangawa K (2001): Ghrelin: a novel growth hormone releasing peptide (in japanese). Nippon Rinsho 59:1400-7.
- Leaflet A. S (2004): Effect of Feed Intake on Plasma Ghrelin Concentration in Beef Cattle. Iowa state University Animal Industry Report, 1881,.
- Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. (2001): A role for ghrelin in the central regulation feeding. Nature. 409:194-8
- Rindi G., Necchi V., Savio A., Torsello A., Zoli M., Locatelli V., Raimondo F., Cocchi D., Solcia E (2002): Characterisation of Gastric Ghrelin Cells in Man and Other Mammals: Studies in Adult and Fetal Tissues, Histochem Cell Bio. 117:511-519.
- Sakata I., Nakamura K., Yamazaki M., Matsubara M., Hayashi Y., Kangawa K., Sakai T (2002): Ghrelin- Producing cells exist as two types of cells, closed and opened type cells, in the rat gastrointestinal tract. Peptides. 23:531-6.
- Smith A., Bruton J (1978): A Colour Atlas of Histological Staining Techniques. 2nd Publications Ltd., London 181-184,
- Tanaka M., Watanabe M (2005): Distrubition of Ghrelin-İmmunreactive Cells in Human Gastric Mucosa: Comparision with that of Parietal Cells, J. Gastroenterol. 40: 345-349
- Tschöp M, Smiley DL, Heiman ML (2000): Ghrelin induces adiposity in rodents, Nature. 407:908-13.
- Wada R., Sakata I., Kaiya H., Nakamura K., Hayashi Y., Kangawa K., Sakai T (2003): Existence of ghrelin- immunpositive and expressing cells in the proventriculus of the hatching and adult chicken, Peptides. 111;123-128.
- Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, et al. (2000): The novel hypotalamic peptide ghrelin stimulates food intake and growth hormone secretion, Endocrinology. 141: 4325-8.
Yıl 2011,
, 61 - 64, 01.03.2011
Öz
Ghrelin rat ve insan midesinden izole edilen 28 amino asitli bir peptiddir. Bu peptid öncelikle mide tarafından üretilmektedir, ayrıca ince ve kalın barsaklardan, pankreas, hipofiz, böbrek, plasenta, immun sistem, testis, ovaryum ve hipotalamusun arkuat nukleusundan küçük miktarlarda elde edilmiştir. Çalışmamızda, koyun abomasumunda Ghrelin immun pozitif hücrelerin dağılımı incelendi. Abomasum cardia, fundus, proksimal ve distal pilorus olmak üzere 4 bölüme ayrılarak incelendi. Sonuç olarak, Ghrelin immunpozitif hücrelerin diğer memeli hayvanlarda olduğu gibi abomasumun mukozal katmanına dağıldığı görüldü
Anahtar Kelimeler
Kaynakça
- Ahmed S., Harvey S (2002): Ghrelin a Hypotalamic GH- releasing factor in Domestic fowl (Gallus Domesticus). J. Endocrinol. 172:117-25.
- Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000): Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 141:4255–4261.
- Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N (2001): Ghrelin in domestic animals: distribution in stomach and its possible role. Domest Anim Endocrinol. 21:17–24
- Hsu S. M., Raiıne L.,Fanger H (1981): Use of Avidin- Biotin-Peroxidase Complex (ABC) in immunperoxidase techniques. The Journal of Histochemistry and Cytochemistry, 29: 577-580,.
- Huang Z.G., Xiong L., Liu Z. S., Qiao Y., Dai R., Xie Z., Liu s.R.,Shi G.Q., Liu G.Q (2006): The tissue distribution and developmental changes of ghrelin mRNA expression in sheep.Yi Chuan Xue Bao. Sep; 33(9):808-13.
- Kojima M.,Hosoda H., Date Y, Nakazato M, Matsuo H, Kangawa K (1999): Ghrelin is a Growth- Hormone- releasing acylated peptide from stomach, Nature. 402:656- 60.
- Kojima M., Kangawa K (2001): Ghrelin: a novel growth hormone releasing peptide (in japanese). Nippon Rinsho 59:1400-7.
- Leaflet A. S (2004): Effect of Feed Intake on Plasma Ghrelin Concentration in Beef Cattle. Iowa state University Animal Industry Report, 1881,.
- Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. (2001): A role for ghrelin in the central regulation feeding. Nature. 409:194-8
- Rindi G., Necchi V., Savio A., Torsello A., Zoli M., Locatelli V., Raimondo F., Cocchi D., Solcia E (2002): Characterisation of Gastric Ghrelin Cells in Man and Other Mammals: Studies in Adult and Fetal Tissues, Histochem Cell Bio. 117:511-519.
- Sakata I., Nakamura K., Yamazaki M., Matsubara M., Hayashi Y., Kangawa K., Sakai T (2002): Ghrelin- Producing cells exist as two types of cells, closed and opened type cells, in the rat gastrointestinal tract. Peptides. 23:531-6.
- Smith A., Bruton J (1978): A Colour Atlas of Histological Staining Techniques. 2nd Publications Ltd., London 181-184,
- Tanaka M., Watanabe M (2005): Distrubition of Ghrelin-İmmunreactive Cells in Human Gastric Mucosa: Comparision with that of Parietal Cells, J. Gastroenterol. 40: 345-349
- Tschöp M, Smiley DL, Heiman ML (2000): Ghrelin induces adiposity in rodents, Nature. 407:908-13.
- Wada R., Sakata I., Kaiya H., Nakamura K., Hayashi Y., Kangawa K., Sakai T (2003): Existence of ghrelin- immunpositive and expressing cells in the proventriculus of the hatching and adult chicken, Peptides. 111;123-128.
- Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, et al. (2000): The novel hypotalamic peptide ghrelin stimulates food intake and growth hormone secretion, Endocrinology. 141: 4325-8.
Toplam 16 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA63RR66EA |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2011 |
| Yayımlandığı Sayı | Yıl 2011 |