In this study, the antioxidant, anti-inflammatory, and neuroprotective effects of kefir were investigated in spinal cord injury that was experimentally created on rats with a compression trauma model. A total of 56 Wistar-Albino male rats were used in the study. Daily freshly prepared 18 ml/kg/day of kefir was given by oral gavage to animals 7 days before and during the trauma and during the trauma. Spinal cord injury was created according to the weight drop method. On the 1st and 7th days before euthanasia, intracardiac blood was collected for analysis, and then they were sacrificed. The damaged spinal cord segments were examined biochemically, immunohistochemically, and histopathologically. When compared to the sham groups, kefir had a positive effect in the preconditioning and treatment groups by decreasing spinal cord bleeding, edema, myelin sheath damage, liquefactive necrosis, neuronal necrosis, selectivity of canalis centralis, and gitter cell levels significantly. When compared to the sham groups, kefir was found to have a positive effect in the treatment groups by decreasing the neuron specific enolase (NSE), ionized calcium binding adapter molecule 1 (IBA-1), inducible nitric oxide synthase (INOS), cyclooxygenase 2 (COX-2) and myelin basic protein (MBP) levels significantly on the 1st and 7th days, and by increasing the glial fibrillary acidic protein (GFAP) level significantly. As a result, it was demonstrated that kefir had a protective and therapeutic effect on spinal cord injury.
The Coordinatorship of Scientific Research Projects of Hatay Mustafa Kemal University
18.M.021
The authors would like to thank Assoc. Prof. Dr. Pınar PEKER AKALIN for their contribution in the evaluation phase of biochemistry parameters. X. National and I. International Veterinary Pathology Congress (online) is presented as an oral presentation (27-37 October 2020, Burdur-Türkiye).
18.M.021
Birincil Dil | İngilizce |
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Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Proje Numarası | 18.M.021 |
Yayımlanma Tarihi | 30 Aralık 2022 |
Yayımlandığı Sayı | Yıl 2023 |