ankara univ vet fak dergAnkara Üniversitesi Veteriner Fakültesi Dergisi1300-08611308-2817Ankara ÜniversitesiHistopathological and immunohistochemical evaluation of congenital cutaneous melanomas in calves (3 cases)BeytutEnverKılıçEnginYaylaSadık10.1501/Vetfak_0000002877Veterinary SurgeryVeteriner Cerrahi110920186544254320811201701152018Three male calves with a dark mass, hanging down on the skin at various parts of the body, were presented forclinical examination. All masses were present at the birth of the calves and their size increased with time. The masses were extirpatedby a routine surgical operation and presented for histopathological examination. Tumour cells having cytoplasmic melanin granulesshowed a round or spindle-shaped nuclei. The mean mitotic rate was 5-7 at a high power field. Neoplastic melanocytes displayed anevident cytoplasmic immunolabeling to Melan A, HMB-45, S-100, NSE, and Vimentin. Tumour cells showed a nuclear positivity forKi-67. Nuclear pleomorphism and a high mitotic rate along with the positive reaction of neoplastic cells to the melanocytic markerswere indicative of melanoma. Nevertheless, neoplasms originating from melanocytes always need advanced imaging techniques alongwith histopathological and immunohistochemical examination while assessing biological behavior of the tumour. Calves congenital cutaneous melanoma histopathology immunohistochemistry.1. Aydoğan A, Haligür M, Özmen O (2013): Hepatic
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