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İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi

Yıl 2022, Cilt: 5 Sayı: 3, 585 - 590, 01.09.2022
https://doi.org/10.19127/bshealthscience.1092589

Öz

Tıp ve biyoteknolojide birçok uygulamaya sahip olan elektroporasyon (EP), hücre membranını harici, kısa ve yüksek voltajlı elektrik pulsları ile geçirgen hale getirmek için kullanılan bir yöntemdir. EP sonrasında hücre membranı boyunca artan molekül akışı gözlenir. Elektrokemoterapi (EKT), kemoterapi ile EP tekniğini birleştirerek tümörlerin palyatif tedavisi için kullanılmaktadır. Birçok anti-kanser uygulaması, kalsiyum (Ca+2) sinyallerini etkileyerek kanser tedavisinde hedef olarak Ca+2 yolaklarını desteklemektedir. EKT uygulamasının yanı sıra Ca+2 elektroporasyonun (CaEP) kullanılması ATP miktarının azalmasına bağlı olarak tümör hücrelerinin ölümüne neden olur. Bu derlemede, CaEP’nin mevcut in vitro, in vivo ve klinik çalışmaların deney sonuçlarının gözden geçirilmesi ve yeni bir anti-kanser tedavi yöntemi olarak değerlendirilmesi amaçlanmıştır.

Kaynakça

  • Armstrong JS. 2006. The role of the mitochondrial permeability transition in cell death. Mitochondrion, 6(5): 225-234.
  • Aung CS, Kruger WA, Poronnik P, Roberts-Thomson SJ, Monteith GR. 2007. Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. Biochem Biophys Res Commun, 355(4): 932-936.
  • Aung CS, Ye W, Plowman G, Peters AA, Monteith GR, Roberts-Thomson SJ. 2009. Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells. Carcinogenesis, 30(11): 1962-1969.
  • Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek JJr, Mir LM. 1993. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer, 72(12): 3694-3700.
  • Bergner A, Kellner J, Tufman A, Huber RM. 2009. Endoplasmic reticulum Ca2+-homeostasis is altered in small and non-small cell lung cancer cell lines. J Exp Clin Cancer Res, 28(1): 25.
  • Bergner A, Huber RM. 2008. Regulation of the endoplasmic reticulum Ca2 + store in cancer. Anti Cancer Agents Med. Chem. 8(7): 705-709.
  • Berridge MJ, Bootman MD, Roderick HL. 2003. Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol, 4(7): 517-529.
  • Berridge MJ, Lipp P, Bootman MD. 2000. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol, 1: 11-21.
  • Bianchi G, Campanacci L, Ronchetti M, Donati D. 2016. Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial. World J Surg, 40(12): 3088-3094.
  • Bimonte S, Leongito M, Granata V, Barbieri A, Del Vecchio V, Falco M, Nasto A, Albino V, Piccirillo M, Palaia R. 2016. Electrochemotherapy in pancreatic adenocarcinoma treatment: Pre-clinical and clinical studies. Radiol Oncol, 50(1): 14-20.
  • Brini M, Carafoli E. 2000. Calcium signalling: A historical account, recent developments and future perspectives. Cell Mol Life Sci, 57(3): 354-370.
  • Campana LG, Edhemovic I, Soden D, Perrone AM, Scarpa M, Campanacci L, Cemazar M, Valpione S, Miklavcic D, Mocellin S, Sieni E, Serša G. 2019. Electrochemotherapy - emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol, 45(2): 92-102.
  • Cerella C, Diederich M, Ghibelli L. 2010. The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol, 2010: 546163. DOI: 10.1155/2010/546163.
  • Chang DC, Chassy BM, Saunders JA, Sowers AE. 1992. Overview of Electroporation and Electrofusion, in Guide to Electroporation and Electrofusion, Academic Press: San Diego, US, pp: 1-6.
  • Chen C, Smye SW, Robinson MP, Evans JA. 2006. Membrane electroporation theories: a review. Med Biol Eng Comput, 44(1-2): 5-14.
  • Clapham DE. 2007. Calcium signaling. Cell, 131(6): 1047-1058.
  • Coster HG, Simmermann U. 1975. The mechanism of electrical breakdown in the membranes of Valonai utricularis. J Membrane Biol, 22(1): 73-90.
  • Curatolo P, Quaglino P, Marenco F, Mancini M, Nardo T, Mortera C, Rotunno R, Calvieri S, Bernengo MG. 2012. Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: A two-center prospective phase II trial. Ann Surg Oncol, 19(1): 192-198.
  • Decuypere JP, Monaco G, Bultynck G, Missiaen L, De Smedt H, Parys JB. 2011. The IP(3) receptor-mitochondria connection in apoptosis and autophagy. Biochim Biophys Acta, 1813(5): 1003-1013.
  • Dev SB, Widera DP, Hofmann GA. 2000. Medical applications of electroporation. IEEE Trans Plasm Sci, 28(1): 206-223.
  • Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, Mali B, Jarm T, Pavliha D, Marcan M. 2011. Electrochemotherapy: A new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat, 10(5): 475-485.
  • Egeland C, Baeksgaard L, Johannesen HH, Lofgren J, Plaschke CC, Svendsen LB, Gehl J, Achiam MP. 2018. Endoscopic electrochemotherapy for esophageal cancer: A phase I clinical study. Endosc Int Open, 6(6): E727-E734.
  • Endo Y, Uzawa K, Mochida Y, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. 2004. Sarcoendoplasmic reticulum Ca2+ATPase type 2 downregulated in human oral squamous cell carcinoma. Int J Cancer, 110(2): 225-231.
  • Falk H, Matthiessen LW, Wooler G, Gehl J. 2018. Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy. Acta Oncol, 57(3): 311-319.
  • Florea AM, Busselberg D. 2009. Anti-cancer drugs interfere with intracellular calcium signaling. Neurotoxicology, 30: 803-810.
  • Frandsen SK, Gehl J. 2017. Effect of calcium electroporation in combination with metformin in vivo and correlation between viability and intracellular ATP level after calcium electroporation in vitro. Plos One, 12(7): e018183948.
  • Frandsen SK, Gibot L, Madi M, Gehl J, and Rols MP. 2015. Calcium electroporation: Evidence for differential effects in normal and malignant cell lines, evaluated in a 3D spheroid model. Plos One, 10(12): e0144028.
  • Frandsen SK, Gissel H, Hojman P, Eriksen J, Gehl J. 2014. Calcium electroporation in three cell lines: A comparison of bleomycin and calcium, calcium compounds, and pulsing conditions. Biochim Biophys Acta, 1840(3): 1204-1208.
  • Frandsen SK, Gissel H, Hojman P, Tramm T, Eriksen J, Gehl J. 2012. Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis. Cancer Res, 72(6): 1336-1341.
  • Frandsen SK, McNeil AK, Novak I, McNeil PL, Gehl J. 2016. Difference in membrane repair capacity between cancer cell lines and a normal cell line. J Membr Biol, 249: 569-576.
  • Geboers B, Scheffer HJ, Graybill PM, Ruarus AH, Nieuwenhuizen S, Puijk RS, Van den Tol PM, Davalos RV, Rubinsky B, De Gruijl TD, Miklavcic D, Meijerink MR. 2020. High-voltage electrical pulses in oncology: irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy. Radiology, 295(2): 254-272.
  • Gehl J, Sersa G, Matthiessen LW, Muir T, Soden D, Occhini A, Quaglino P, Curatolo P, Campana LG, Kunte C. 2018. Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol, 57(7): 874-882.
  • Gehl J, Skovsgaard T, Mir LM. 1998. Enhancement of cytotoxicity by Electropermeabilization: An improved method for screening drugs. Anti Cancer Drugs, 9(4): 319-325.
  • Gehl J. 2003. Electroporation: Theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand, 177(4): 437-447.
  • Gelebart P, Kovacs T, Brouland JP, van Gorp R, Grossmann J, Rivard N, Panis Y, Martin V, Bredoux R, Enouf J. 2002. Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. J Biol Chem, 277(29): 26310-26320.
  • Golberg AL, Rubinsky B, Rubinsky B. 2010. A statistical model for multidimensional irreversible electroporation cell death in tissue. Biomed Eng Online, 26(9): 13.
  • Hansen EL, Sozer EB, Romeo S, Frandsen SK, Vernier PT, Gehl J. 2015. Dose-dependent ATP depletion and cancer cell death following calcium electroporation, relative effect of calcium concentration and electric field strength. Plos One, 10(4): e0122973.
  • Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, Glass LF. 1998. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer, 83(1): 148-157.
  • Hojman P, Gissel H, Andre FM. 2008. Physiological effects of high- and low-voltage pulse combinations for gene electrotransfer in muscle. Hum Gene Ther, 19(11): 1249-1260.
  • Jaroszeski MJ, Dang V, Pottinger C. 2000. Toxicity of anticancer agents mediated by electroporation in vitro. Anticancer Drugs, 11(3): 201-208.
  • Lambricht L, Lopes A, Kos Š, Serša G, Préat V, Vandermeulen G. 2016. Clinical potential of electroporation for gene therapy and DNA vaccine delivery, Expert Opinion Drug Deliv,13(2): 295-310.
  • Lytton J, Westlin M, Burk SE, Shull GE, MacLennan DH. 1992. Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem, 267(20): 14483-14489.
  • Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, Billard V, Geertsen PF, Larkin, JO, Miklavcic D. 2006. Electrochemotherapy An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC Suppl, 4: 3-13.
  • Matthiessen LW, Johannesen HH, Hendel HW, Moss T, Kamby C, Gehl J. 2012. Electrochemotherapy for large cutaneous recurrence of breast cancer: A phase II clinical trial. Acta Oncol, 51(6): 713-721.
  • McNeil PL, Steinhardt RA. 2003. Plasma membrane disruption: Repair, prevention, adaptation. Annu Rev Cell Dev Biol, 19: 697-731.
  • Miklavcic D, Kotnik T. 2004. Electroporation for electrochemotherapy and gene therapy. In: Markov MS (ed) Bioelectromagnetic medicine. Marcel Dekker, New York, US, pp: 637-656.
  • Mozzillo N, Simeone E, Benedetto L, Curvietto M, Giannarelli D, Gentilcore G, Camerlingo R, Capone M, Madonna G, Festino L. 2015. Assessing a novel immuno-oncology-based combination therapy: Ipilimumab plus electrochemotherapy. Oncoimmunology, 4(6): e1008842.
  • Orlowski S, Mir LM. 1993. Cell electropermeabilization: A new tool for biochemical and pharmacological studies. Biochim Biophys Acta, 1154(1): 51-63.
  • Papp B, Brouland JP, Arbabian A, Gélébart P, Kovács T, Bobe R, Enouf J,7 Blank NV, Apáti A. 2012. Endoplasmic reticulum calcium pumps and cancer cell differentiation. Biomolecules, 2: 165-186.
  • Pavlin M, Kanduser M, Rebersek M, Pucihar G, Hart FX, Magjarevic R, Miklavcic D. 2005. Effect of cell electroporation on the conductivity of a cell suspension. Biophys J, 88: 4378-4390.
  • Plaschke CC, Bertino G, McCaul JA, Grau JJ, de Bree R, Sersa G, Occhini A, Groselj A, Langdon C, Heuveling DA. 2017. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers. Eur J Cancer, 87: 172-181.
  • Plaschke CC, Gehl J, Johannesen HH, Fischer BM, Kjaer A, Lomholt AF. 2019. Calcium electroporation for recurrent head and neck cancer: A clinical phase I study. Laryn-goscope Investig Otolaryngol, 4(1): 49-56.
  • Puc M, Kotnik T, Mir LM, Miklavčič D. 2003. Quantitative model of small molecules uptake after in vitro cell electropermeabilization. Bioelectrochemistry, 60(1-2): 1-10.
  • Ramos A, Suzuki DO, Marques JL. 2004. Numerical simulation of electroporation in spherical cells. J Artif Organs, 28: 357-561.
  • Reberšek M. and Miklavčič D. 2014. Cell Membrane Electroporation-Part 1: The equipment. IEEE Electrical Insul Magaz, 28(5): 14-23.
  • Ribiczey P, Tordai A, Andrikovics H, Filoteo AG, Penniston JT, Enouf J, Enyedi A, Papp B, Kovacs T. 2007. Isoform-specific up-regulation of plasma membrane Ca2+ATPase expression during colon and gastric cancer cell differentiation. Cell Calcium, 42(6): 590-605.
  • Roderick HL, Cook SJ. 2008. Ca2+ signalling checkpoints in cancer: Remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer, 8(5): 361-375.
  • Ruscho JH, Brandenburger T, Strehler EE, Filoteo AG, Heinmoller E, Aumuller G, Wilhelm B. 2012. Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis. Cancer Invest, 30(4): 251-257.
  • Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M. 2012. Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev, 38(5): 379-386.
  • Staresinic B, Jesenko T, Kamensek U, Frandsen SK, Sersa G, Gehl J. 2018. Effect of calcium electroporation on tumour vasculature, Scientific Rep, 8: 9412.
  • Tsong TY. 1991. Electroporation of cell membranes. Biophys J, 60(2): 297-306.
  • Vissing M, Ploen J, Pervan M, Vestergaard K, Schnefeldt M, Frandsen SK, Rafaelsen SR, Lindhardt CL, Jensen LJ, Rody A, Gehl J. 2021. Study protocol designed to investigate tumour response to calcium electroporation in cancers affecting the skin: a non-randomised phase II clinical trial. Bmj Open, 11: e046779. DOI: 10.1136/bmjopen-2020-046779.
  • Zielichowska A, Daczewska M, Saczko J, Michel O, Kulbacka J. 2016. Applications of calcium electroporation to effective apoptosis induction in fibrosarcoma cells and stimulation of normal muscle cells. Bioelectrochemistry, 109: 70-78.

Evaluation of Calcium Electroporation in Cancer Treatment with In Vitro, In Vivo and Clinical Studies

Yıl 2022, Cilt: 5 Sayı: 3, 585 - 590, 01.09.2022
https://doi.org/10.19127/bshealthscience.1092589

Öz

Electroporation (EP), which has many applications in medicine and biotechnology, is a method used to make the cell membrane permeable with external, short and high voltage electrical pulses. After EP, an increased flow of molecules across the cell membrane is observed. Electrochemotherapy (ECT) is used for palliative treatment of tumors by combining chemotherapy and EP technique. Many anti-cancer applications support Ca2+ pathways as a target in cancer treatment by affecting calcium (Ca2+) signals. The use of Ca2+ electroporation (CaEP) instead of ECT application causes the death of tumor cells due to the decrease in the amount of ATP. In this review, it is aimed to review the experimental results of existing in vitro, in vivo and clinical studies of CaEP and to evaluate it as a new anti-cancer treatment method.

Kaynakça

  • Armstrong JS. 2006. The role of the mitochondrial permeability transition in cell death. Mitochondrion, 6(5): 225-234.
  • Aung CS, Kruger WA, Poronnik P, Roberts-Thomson SJ, Monteith GR. 2007. Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. Biochem Biophys Res Commun, 355(4): 932-936.
  • Aung CS, Ye W, Plowman G, Peters AA, Monteith GR, Roberts-Thomson SJ. 2009. Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells. Carcinogenesis, 30(11): 1962-1969.
  • Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek JJr, Mir LM. 1993. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer, 72(12): 3694-3700.
  • Bergner A, Kellner J, Tufman A, Huber RM. 2009. Endoplasmic reticulum Ca2+-homeostasis is altered in small and non-small cell lung cancer cell lines. J Exp Clin Cancer Res, 28(1): 25.
  • Bergner A, Huber RM. 2008. Regulation of the endoplasmic reticulum Ca2 + store in cancer. Anti Cancer Agents Med. Chem. 8(7): 705-709.
  • Berridge MJ, Bootman MD, Roderick HL. 2003. Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol, 4(7): 517-529.
  • Berridge MJ, Lipp P, Bootman MD. 2000. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol, 1: 11-21.
  • Bianchi G, Campanacci L, Ronchetti M, Donati D. 2016. Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial. World J Surg, 40(12): 3088-3094.
  • Bimonte S, Leongito M, Granata V, Barbieri A, Del Vecchio V, Falco M, Nasto A, Albino V, Piccirillo M, Palaia R. 2016. Electrochemotherapy in pancreatic adenocarcinoma treatment: Pre-clinical and clinical studies. Radiol Oncol, 50(1): 14-20.
  • Brini M, Carafoli E. 2000. Calcium signalling: A historical account, recent developments and future perspectives. Cell Mol Life Sci, 57(3): 354-370.
  • Campana LG, Edhemovic I, Soden D, Perrone AM, Scarpa M, Campanacci L, Cemazar M, Valpione S, Miklavcic D, Mocellin S, Sieni E, Serša G. 2019. Electrochemotherapy - emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol, 45(2): 92-102.
  • Cerella C, Diederich M, Ghibelli L. 2010. The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol, 2010: 546163. DOI: 10.1155/2010/546163.
  • Chang DC, Chassy BM, Saunders JA, Sowers AE. 1992. Overview of Electroporation and Electrofusion, in Guide to Electroporation and Electrofusion, Academic Press: San Diego, US, pp: 1-6.
  • Chen C, Smye SW, Robinson MP, Evans JA. 2006. Membrane electroporation theories: a review. Med Biol Eng Comput, 44(1-2): 5-14.
  • Clapham DE. 2007. Calcium signaling. Cell, 131(6): 1047-1058.
  • Coster HG, Simmermann U. 1975. The mechanism of electrical breakdown in the membranes of Valonai utricularis. J Membrane Biol, 22(1): 73-90.
  • Curatolo P, Quaglino P, Marenco F, Mancini M, Nardo T, Mortera C, Rotunno R, Calvieri S, Bernengo MG. 2012. Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: A two-center prospective phase II trial. Ann Surg Oncol, 19(1): 192-198.
  • Decuypere JP, Monaco G, Bultynck G, Missiaen L, De Smedt H, Parys JB. 2011. The IP(3) receptor-mitochondria connection in apoptosis and autophagy. Biochim Biophys Acta, 1813(5): 1003-1013.
  • Dev SB, Widera DP, Hofmann GA. 2000. Medical applications of electroporation. IEEE Trans Plasm Sci, 28(1): 206-223.
  • Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, Mali B, Jarm T, Pavliha D, Marcan M. 2011. Electrochemotherapy: A new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat, 10(5): 475-485.
  • Egeland C, Baeksgaard L, Johannesen HH, Lofgren J, Plaschke CC, Svendsen LB, Gehl J, Achiam MP. 2018. Endoscopic electrochemotherapy for esophageal cancer: A phase I clinical study. Endosc Int Open, 6(6): E727-E734.
  • Endo Y, Uzawa K, Mochida Y, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. 2004. Sarcoendoplasmic reticulum Ca2+ATPase type 2 downregulated in human oral squamous cell carcinoma. Int J Cancer, 110(2): 225-231.
  • Falk H, Matthiessen LW, Wooler G, Gehl J. 2018. Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy. Acta Oncol, 57(3): 311-319.
  • Florea AM, Busselberg D. 2009. Anti-cancer drugs interfere with intracellular calcium signaling. Neurotoxicology, 30: 803-810.
  • Frandsen SK, Gehl J. 2017. Effect of calcium electroporation in combination with metformin in vivo and correlation between viability and intracellular ATP level after calcium electroporation in vitro. Plos One, 12(7): e018183948.
  • Frandsen SK, Gibot L, Madi M, Gehl J, and Rols MP. 2015. Calcium electroporation: Evidence for differential effects in normal and malignant cell lines, evaluated in a 3D spheroid model. Plos One, 10(12): e0144028.
  • Frandsen SK, Gissel H, Hojman P, Eriksen J, Gehl J. 2014. Calcium electroporation in three cell lines: A comparison of bleomycin and calcium, calcium compounds, and pulsing conditions. Biochim Biophys Acta, 1840(3): 1204-1208.
  • Frandsen SK, Gissel H, Hojman P, Tramm T, Eriksen J, Gehl J. 2012. Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis. Cancer Res, 72(6): 1336-1341.
  • Frandsen SK, McNeil AK, Novak I, McNeil PL, Gehl J. 2016. Difference in membrane repair capacity between cancer cell lines and a normal cell line. J Membr Biol, 249: 569-576.
  • Geboers B, Scheffer HJ, Graybill PM, Ruarus AH, Nieuwenhuizen S, Puijk RS, Van den Tol PM, Davalos RV, Rubinsky B, De Gruijl TD, Miklavcic D, Meijerink MR. 2020. High-voltage electrical pulses in oncology: irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy. Radiology, 295(2): 254-272.
  • Gehl J, Sersa G, Matthiessen LW, Muir T, Soden D, Occhini A, Quaglino P, Curatolo P, Campana LG, Kunte C. 2018. Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol, 57(7): 874-882.
  • Gehl J, Skovsgaard T, Mir LM. 1998. Enhancement of cytotoxicity by Electropermeabilization: An improved method for screening drugs. Anti Cancer Drugs, 9(4): 319-325.
  • Gehl J. 2003. Electroporation: Theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand, 177(4): 437-447.
  • Gelebart P, Kovacs T, Brouland JP, van Gorp R, Grossmann J, Rivard N, Panis Y, Martin V, Bredoux R, Enouf J. 2002. Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. J Biol Chem, 277(29): 26310-26320.
  • Golberg AL, Rubinsky B, Rubinsky B. 2010. A statistical model for multidimensional irreversible electroporation cell death in tissue. Biomed Eng Online, 26(9): 13.
  • Hansen EL, Sozer EB, Romeo S, Frandsen SK, Vernier PT, Gehl J. 2015. Dose-dependent ATP depletion and cancer cell death following calcium electroporation, relative effect of calcium concentration and electric field strength. Plos One, 10(4): e0122973.
  • Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, Glass LF. 1998. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer, 83(1): 148-157.
  • Hojman P, Gissel H, Andre FM. 2008. Physiological effects of high- and low-voltage pulse combinations for gene electrotransfer in muscle. Hum Gene Ther, 19(11): 1249-1260.
  • Jaroszeski MJ, Dang V, Pottinger C. 2000. Toxicity of anticancer agents mediated by electroporation in vitro. Anticancer Drugs, 11(3): 201-208.
  • Lambricht L, Lopes A, Kos Š, Serša G, Préat V, Vandermeulen G. 2016. Clinical potential of electroporation for gene therapy and DNA vaccine delivery, Expert Opinion Drug Deliv,13(2): 295-310.
  • Lytton J, Westlin M, Burk SE, Shull GE, MacLennan DH. 1992. Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem, 267(20): 14483-14489.
  • Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, Billard V, Geertsen PF, Larkin, JO, Miklavcic D. 2006. Electrochemotherapy An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC Suppl, 4: 3-13.
  • Matthiessen LW, Johannesen HH, Hendel HW, Moss T, Kamby C, Gehl J. 2012. Electrochemotherapy for large cutaneous recurrence of breast cancer: A phase II clinical trial. Acta Oncol, 51(6): 713-721.
  • McNeil PL, Steinhardt RA. 2003. Plasma membrane disruption: Repair, prevention, adaptation. Annu Rev Cell Dev Biol, 19: 697-731.
  • Miklavcic D, Kotnik T. 2004. Electroporation for electrochemotherapy and gene therapy. In: Markov MS (ed) Bioelectromagnetic medicine. Marcel Dekker, New York, US, pp: 637-656.
  • Mozzillo N, Simeone E, Benedetto L, Curvietto M, Giannarelli D, Gentilcore G, Camerlingo R, Capone M, Madonna G, Festino L. 2015. Assessing a novel immuno-oncology-based combination therapy: Ipilimumab plus electrochemotherapy. Oncoimmunology, 4(6): e1008842.
  • Orlowski S, Mir LM. 1993. Cell electropermeabilization: A new tool for biochemical and pharmacological studies. Biochim Biophys Acta, 1154(1): 51-63.
  • Papp B, Brouland JP, Arbabian A, Gélébart P, Kovács T, Bobe R, Enouf J,7 Blank NV, Apáti A. 2012. Endoplasmic reticulum calcium pumps and cancer cell differentiation. Biomolecules, 2: 165-186.
  • Pavlin M, Kanduser M, Rebersek M, Pucihar G, Hart FX, Magjarevic R, Miklavcic D. 2005. Effect of cell electroporation on the conductivity of a cell suspension. Biophys J, 88: 4378-4390.
  • Plaschke CC, Bertino G, McCaul JA, Grau JJ, de Bree R, Sersa G, Occhini A, Groselj A, Langdon C, Heuveling DA. 2017. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers. Eur J Cancer, 87: 172-181.
  • Plaschke CC, Gehl J, Johannesen HH, Fischer BM, Kjaer A, Lomholt AF. 2019. Calcium electroporation for recurrent head and neck cancer: A clinical phase I study. Laryn-goscope Investig Otolaryngol, 4(1): 49-56.
  • Puc M, Kotnik T, Mir LM, Miklavčič D. 2003. Quantitative model of small molecules uptake after in vitro cell electropermeabilization. Bioelectrochemistry, 60(1-2): 1-10.
  • Ramos A, Suzuki DO, Marques JL. 2004. Numerical simulation of electroporation in spherical cells. J Artif Organs, 28: 357-561.
  • Reberšek M. and Miklavčič D. 2014. Cell Membrane Electroporation-Part 1: The equipment. IEEE Electrical Insul Magaz, 28(5): 14-23.
  • Ribiczey P, Tordai A, Andrikovics H, Filoteo AG, Penniston JT, Enouf J, Enyedi A, Papp B, Kovacs T. 2007. Isoform-specific up-regulation of plasma membrane Ca2+ATPase expression during colon and gastric cancer cell differentiation. Cell Calcium, 42(6): 590-605.
  • Roderick HL, Cook SJ. 2008. Ca2+ signalling checkpoints in cancer: Remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer, 8(5): 361-375.
  • Ruscho JH, Brandenburger T, Strehler EE, Filoteo AG, Heinmoller E, Aumuller G, Wilhelm B. 2012. Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis. Cancer Invest, 30(4): 251-257.
  • Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M. 2012. Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev, 38(5): 379-386.
  • Staresinic B, Jesenko T, Kamensek U, Frandsen SK, Sersa G, Gehl J. 2018. Effect of calcium electroporation on tumour vasculature, Scientific Rep, 8: 9412.
  • Tsong TY. 1991. Electroporation of cell membranes. Biophys J, 60(2): 297-306.
  • Vissing M, Ploen J, Pervan M, Vestergaard K, Schnefeldt M, Frandsen SK, Rafaelsen SR, Lindhardt CL, Jensen LJ, Rody A, Gehl J. 2021. Study protocol designed to investigate tumour response to calcium electroporation in cancers affecting the skin: a non-randomised phase II clinical trial. Bmj Open, 11: e046779. DOI: 10.1136/bmjopen-2020-046779.
  • Zielichowska A, Daczewska M, Saczko J, Michel O, Kulbacka J. 2016. Applications of calcium electroporation to effective apoptosis induction in fibrosarcoma cells and stimulation of normal muscle cells. Bioelectrochemistry, 109: 70-78.
Toplam 63 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

Güney Gürsoy 0000-0003-1849-9068

Meric Esmekaya 0000-0003-0469-4954

Zehra Çiçek 0000-0003-3205-5463

Yayımlanma Tarihi 1 Eylül 2022
Gönderilme Tarihi 24 Mart 2022
Kabul Tarihi 9 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 5 Sayı: 3

Kaynak Göster

APA Gürsoy, G., Esmekaya, M., & Çiçek, Z. (2022). İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi. Black Sea Journal of Health Science, 5(3), 585-590. https://doi.org/10.19127/bshealthscience.1092589
AMA Gürsoy G, Esmekaya M, Çiçek Z. İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi. BSJ Health Sci. Eylül 2022;5(3):585-590. doi:10.19127/bshealthscience.1092589
Chicago Gürsoy, Güney, Meric Esmekaya, ve Zehra Çiçek. “İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi”. Black Sea Journal of Health Science 5, sy. 3 (Eylül 2022): 585-90. https://doi.org/10.19127/bshealthscience.1092589.
EndNote Gürsoy G, Esmekaya M, Çiçek Z (01 Eylül 2022) İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi. Black Sea Journal of Health Science 5 3 585–590.
IEEE G. Gürsoy, M. Esmekaya, ve Z. Çiçek, “İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi”, BSJ Health Sci., c. 5, sy. 3, ss. 585–590, 2022, doi: 10.19127/bshealthscience.1092589.
ISNAD Gürsoy, Güney vd. “İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi”. Black Sea Journal of Health Science 5/3 (Eylül 2022), 585-590. https://doi.org/10.19127/bshealthscience.1092589.
JAMA Gürsoy G, Esmekaya M, Çiçek Z. İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi. BSJ Health Sci. 2022;5:585–590.
MLA Gürsoy, Güney vd. “İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi”. Black Sea Journal of Health Science, c. 5, sy. 3, 2022, ss. 585-90, doi:10.19127/bshealthscience.1092589.
Vancouver Gürsoy G, Esmekaya M, Çiçek Z. İn Vitro, İn Vivo Ve Klinik Çalışmalarla Kanser Tedavisinde Kalsiyum Elektroporasyonun Değerlendirilmesi. BSJ Health Sci. 2022;5(3):585-90.