FONKSİYONEL GIDA BİLEŞENLERİNİN BİLİŞSEL FONKSİYONLAR ÜZERİNE MOLEKÜLER ETKİ MEKANİZMALARI

Zeynep Seydim; Sinem Keles; Gülçin Şatır

doi:10.34084/bshr.1413281

Derleme

EFFECT OF FUNCTIONAL FOOD COMPONENTS ON COGNITIVE FUNCTIONS

Yıl 2024, Cilt: 8 Sayı: 1, 1 - 15, 30.04.2024

Zeynep Seydim Sinem Keles Gülçin Şatır

https://doi.org/10.34084/bshr.1413281

Öz

60% of the brain consists of fat and is a structure vulnerable to damage from free radicals formed as a result of oxidative stress at cellular level. Accumulation of free radicals can cause oxidation, disruption of DNA repair mechanisms; such cellular changes can cause neuronal dysfunction and damages in functional neuroplasticity. Nutrition is one of the primary factors affecting brain development, and continues to affect cell renewal throughout life. In this review, it is aimed to explain the effects of oxidative stress at molecular level and some nutritional components, bioactive substances in foods on brain cells and therefore cognitive functions. It has been determined in various studies that omega 3 fatty acids, vitamins, minerals, bioactive components such as choline, polyphenols and psychobiotics positively affect cognitive function by supporting cell repair against oxidative damage. In this review, prominent nutritional components, bioactive substances and their mechanisms are explained as much as possible.

Anahtar Kelimeler

Brain health, oxidative stress, omega-3 fatty acids, vitamins, bioactive food components, psychobiotics

Etik Beyan

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Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

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FONKSİYONEL GIDA BİLEŞENLERİNİN BİLİŞSEL FONKSİYONLAR ÜZERİNE MOLEKÜLER ETKİ MEKANİZMALARI

Yıl 2024, Cilt: 8 Sayı: 1, 1 - 15, 30.04.2024

Zeynep Seydim Sinem Keles Gülçin Şatır

https://doi.org/10.34084/bshr.1413281

Öz

Beynin %60’ı yağdan oluşur ve hücre düzeyinde oksidatif stres sonucunda oluşan serbest radikallerin vereceği hasara açık bir yapıdır. Nöronlarda üretilen başlıca serbest radikaller, süperoksit ve nitrik oksittir. Serbest radikallerin birikimi DNA oksidasyonuna ve DNA onarım mekanizmalarının bozulmasına neden olabilir; bu gibi hücresel değişiklikler nöronal işlev bozukluğuna, işlevsel ve yapısal nöroplastisiteye zarar verebilmektedir. Erken beyin gelişimini etkileyen faktörlerin başında beslenme gelmekte ve beslenme şekli hayat boyu hücre yenileme ve onarımını etkilemeyi sürdürmektedir. Bu derlemede oksidatif stresin moleküler düzeyde hücreye etkilerinin açıklanması ve gıdalardaki bazı besin bileşenleriyle, biyoaktif maddelerin beyin hücrelerine ve dolayısıyla bilişsel fonksiyonlara etkilerinin açıklanması hedeflenmiştir. Omega 3 yağ asitlerinin, vitaminlerin ve minerallerin, kolin, polifenoller gibi biyoaktif bileşenlerle psikobiyotiklerin, oksidatif hasara karşı hücre onarımına destek vererek, bilişsel fonksiyonu olumlu etkilediği çeşitli araştırmalarda belirlenmiştir. Bu derlemede öne çıkan besin bileşenleriyle, biyoaktif maddeler ve etki mekanizmaları mümkün olabildiğince açıklanmıştır.

Anahtar Kelimeler

Beyin sağlığı, oksidatif stres, omega-3 yağ asitleri, vitamin, biyoaktif gıda bileşeni, psikobiyotikler

Proje Numarası

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Kaynakça

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147. Benton D, Williams C, Brown A. Impact of consuming a milk drink containing a probiotic on mood and cognition. European Journal of Clinical Nutrition. 2007;61(3):355-361. doi: 10.1038/sj.ejcn.1602546.
148. Nishida K, Sawada D, Kawai T, Kuwano Y, Fujiwara S, Rokutan K. Para‐psychobiotic Lactobacillus gasseri CP2305 ameliorates stress‐related symptoms and sleep quality. Journal of Applied Microbiology. 2017;123(6): 1561-1570. doi: 10.1111/jam.13594.
149. Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, Cazaubiel JM. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition. 2011;105(5): 755-764. doi: 10.1017/S0007114510004319.
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158. Liu YW, Liu WH, Wu CC, Juan YC, Wu YC, Tsai HP, Tsai YC. Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research. 2016;1631: 1-12. doi: 10.1016/j.brainres.2015.11.018.
159. Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PW. Psychobiotics and the manipulation of bacteria-gut-brain signals. Trends in Neurosciences. 2016;39(11): 763-781. doi: 10.1016/j.tins.2016.09.002.
160. McVey Neufeld KA, Kay S, Bienenstock J. Mouse strain affects behavioral and neuroendocrine stress responses following administration of probiotic Lactobacillus rhamnosus JB-1 or traditional antidepressant fluoxetine. Frontiers in Neuroscience. 2018;12: 294. doi: 10.3389/fnins.2018.00294.
161. Cheng LH, Chou PY, Hou AT, Huang CL, Shiu WL, Wang S. (. Lactobacillus paracasei PS23 improves cognitive deficits via modulating the hippocampal gene expression and the gut microbiota in D-galactose-induced aging mice. Food & Function. 2022;13(9): 5240-5251. doi: 10.1039/D2FO00165A.
162. Deepika Shukla, AK, Kumari A, Kumar A. Gut brain regulation using psychobiotics for improved neuropsychological illness. Developmental Psychobiology. 2023; 65(5): e22404 doi: 10.1002/dev.22404.

Toplam 162 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Gıda ve Beslenme Dengesi
Bölüm	Derleme
Yazarlar	Zeynep Seydim 0000-0002-1536-6545 Sinem Keles 0000-0003-1861-7116 Gülçin Şatır 0000-0003-1862-6434
Proje Numarası	----
Erken Görünüm Tarihi	19 Mayıs 2024
Yayımlanma Tarihi	30 Nisan 2024
Gönderilme Tarihi	3 Ocak 2024
Kabul Tarihi	9 Mart 2024
Yayımlandığı Sayı	Yıl 2024 Cilt: 8 Sayı: 1

Kaynak Göster

AMA	Seydim Z, Keles S, Şatır G. FONKSİYONEL GIDA BİLEŞENLERİNİN BİLİŞSEL FONKSİYONLAR ÜZERİNE MOLEKÜLER ETKİ MEKANİZMALARI. J Biotechnol and Strategic Health Res. Nisan 2024;8(1):1-15. doi:10.34084/bshr.1413281

Makale Dosyaları

Tam Metin

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