Araştırma Makalesi
Yıl 2021,
Cilt: 11 Sayı: 1, 74 - 80, 31.03.2021
Öz
Kaynakça
- Bahmani M, Zargaran A, Rafieian Kopaei M, Saki K. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran. Asian Pac J Trop Med. 2014;7(S1):348–354.
- Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ern LY, Ashraf NA, Kit SW, Yee TS, Pichika MR, Gorain B, Kesharwani P. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 2018;3:361–376.
- Tripathi V, Verma J. Different Models Used to Induced Diabetes: A Comprehensive Review. Int J Pharm Pharm Sci. 2014;6(6):29–32.
- American Diabetes Association. Classification and Diagnosis of Diabetes Diabetes. Diabetes Care. 2015;35(Suppl. 1):S8-16.
- Arumugam G, Manjula P, Paari N. A review : Anti diabetic medicinal plants used for diabetes mellitus. J Acute Dis. 2013;2(3):196–200.
- Coşkunçelebi K, Makbul S, Gültepe M, Okur S, Güzel ME. A conspectus of Scorzonera s.l. in Turkey. Turk J Botany. 2015;39:76–87.
- Baytop T. Turkiye’de Bitkiler ile Tedavi (Phytotherapy in Turkey, Past and Present). Istanbul: Nobel Publishers; 1999.
- Granica S, Lohwasser U, Jöhrer K, Zidorn C. Qualitative and quantitative analyses of secondary metabolites in aerial and subaerial of Scorzonera hispanica L. (black salsify). Food Chem. 2015;173:321–31.
- Wang Y, Wray V, Tsevegsuren N, Lin W, Proksch P. Phenolic compounds from the Mongolian medicinal plant Scorzonera radiata. Zeitschrift fur Naturforsch - Sect C J Biosci. 2012;67:135–43.
- Zidorn C, Ellmerer-Müller E, Stuppner H. Sesquiterpenoids from Scorzonera hispanica L. Pharmazie. 2000;55(7):550–1.
- Dolota A, Dabrowska B, Radzanowska J. Chemical and Sensory Characteristics of Some Scorzonera (Scorzonera hispanica L.) Cultiars. Acta Hortic. 2005;682:527–34.
- Ajebli M, Amssayef A, Eddouks M. Assessment of Antihyperglycemic Effect and Acute Toxicity of the Aqueous Scorzonera undulata Extract in Rats. Endocr Metab Immune Disord Drug Targets. 2020;20:1.
- Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazig-Turkey). J Ethnopharmacol. 2010;132:165–175.
- Polat R, Cakilcioglu U, Satil F. Traditional uses of medicinal plants in Solhan (Bingöl - Turkey). J Ethnopharmacol. 2013;148(3):951–963.
- Dalar A. Plant Taxa Used in the Treatment of Diabetes in Van Province, Turkey. Int J Second Metab. 2018;5(3):170–184.
- Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305–312.
- Stanley Mainzen Prince P, Kamalakkannan N. Rutin Improves Glucose Homeostasis in Streptozotocin Diabetic Tissues by Altering Glycolytic and Gluconeogenic Enzymes. J Biochem Mol Toxicol. 2006;20(2):96–102.
- Kumar S, Kumar D, Deshmukh RR, Lokhande PD, More SN, Rangari VD. Antidiabetic potential of Phyllanthus reticulatus in alloxan-induced diabetic mice. Fitoterapia. 2008;79:21–23.
- Ozbek H, Acikara OB, Keskin I, Kirmizi NI, Ozbilgin S, Oz BE, Kurtul E, Ozrenk BC, Tekin M, Saltan G. Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis. Biomed Pharmacother. 2017;86:172–176.
- Sun C, Li X, Liu L, Canet MJ, Guan Y, Fan Y, Zhou Y. Effect of fasting time on measuring mouse blood glucose level. Int J Clin Exp Med. 2016;9(2):4186–4189.
- Özbek H, Yılmaz BS. Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharm Sci. 2017;55(4):7–14.
- Küpeli Akkol E, Acikara OB, Süntar I, Citolu GS, Kele H, Ergene B. Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method. J Ethnopharmacol. 2011;137:1018–1027.
- Özbek H, Bahadır Acıkara Ö, Keskİn İ, Kirmizi Nİ, Yiğitbaşi T, Şakul AA, Iscan Saltan G. Preclinical Evaluation of Scorzonera sp . Root Extracts and Major Compounds against Acute Hepatotoxicity Induced by Carbon Tetrachloride. Indian J Pharm Sci. 2017;79(5):715–723.
- Temiz MA. Antioxidant and antihyperglycemic activities of Scorzonera cinerea radical leaves in streptozocin-induced diabetic rats. Acta Pharm. 2021;71:Article in Press.
- Chua LS. A review on plant-based rutin extraction methods and its pharmacological activities. J Ethnopharmacol. 2013;150:805–817.
- Kamalakkannan N, Prince PS. Antihyperglycaemic and Antioxidant Effect of Rutin , a Polyphenolic Flavonoid , in Streptozotocin-Induced Diabetic Wistar Rats. Basic Clin Pharmacol Toxicol. 2006;98:97–103.
- Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids : a cellular mechanism review. Nutr Metab (Lond). 2015;12(60):1–20.
- Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR. Diabetes and Cardiovascular Disease A Statement for Healthcare Professionals From the American Heart Association. Circulation. 1999;100:1134–1146.
- Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats : An effect mediated through cytokines , antioxidants and lipid biomarkers. Indian J Exp Biol. 2014;52:720–727.
- Prince PSM, Kannan NK. Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. J Pharm Pharmacol. 2006;58(10):1373–1383.
- Leon BM, Maddox TM. Diabetes and cardiovascular disease : Epidemiology , biological mechanisms , treatment recommendations and future research. World J Diabetes 2015. 2015;6(13):1246–1258.
- Akkol EK, Šmejkal K, Kurtul E, Ilhan M, Güragac FT, İşcan GS, Acıkara ÖB, Cvačka J, Buděšínský M. Inhibitory activity of Scorzonera latifolia and its components on enzymes connected with healing process. J Ethnopharmacol. 2019;245:112168.
- Bahadır Acıkara Ö, Ilhan M, Kurtul E, Šmejkal K, Küpeli Akkol E. Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes. Bioorg Chem. 2019;93:103330.
Yıl 2021,
Cilt: 11 Sayı: 1, 74 - 80, 31.03.2021
Öz
Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin is the primary component responsible of this activity.
Methods: The extracts of aerial parts of Scorzonera tomentosa, S. mollis ssp. szowitsii, S. suberosa ssp. suberosa, S. eriophora, S. acuminata, S. sublanata and S. cana var. jacquiniana were used in the experiment. Additionally, rutin, which has been analysed and detected by using HPLC qualitatively and quantitatively in some Scorzonera species, was also tested for its antidiabetic activity in the same conditions. An alloxaninduced diabetic mice test model was used in order to verify antidiabetic activity. Antidiabetic activities of the 9 groups (n=5; each) were measured at four different times: before Scorzonera extracts and rutin treatment and after 1, 2 and 4 hours of treatments.
Results: S. sublanata extract exhibited the highest antidiabetic activity and at 100 mg/kg dose, it significantly reduced blood glucose levels
measured after 1, 2 and 4 hours of treatments when compared to isotonic saline solution group (diabetic control group). S. cana var. jacquiniana extract also displayed notable decrease after 4 hours of treatment. Significant lowering effect on blood glucose level was also observed by treatment with rutin in all tested times at 100 mg/kg i.p. injection. According to the HPLC analyses the highest rutin content was determined in the S. acuminata aerial parts.
Conclusion: Rutin content and the antidiabetic activity of the plant extracts were not correlated as displayed in this present study. Further
studies should be performed to reveal responsible compunds for antidiabetic activity.
Anahtar Kelimeler
Kaynakça
- Bahmani M, Zargaran A, Rafieian Kopaei M, Saki K. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran. Asian Pac J Trop Med. 2014;7(S1):348–354.
- Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ern LY, Ashraf NA, Kit SW, Yee TS, Pichika MR, Gorain B, Kesharwani P. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 2018;3:361–376.
- Tripathi V, Verma J. Different Models Used to Induced Diabetes: A Comprehensive Review. Int J Pharm Pharm Sci. 2014;6(6):29–32.
- American Diabetes Association. Classification and Diagnosis of Diabetes Diabetes. Diabetes Care. 2015;35(Suppl. 1):S8-16.
- Arumugam G, Manjula P, Paari N. A review : Anti diabetic medicinal plants used for diabetes mellitus. J Acute Dis. 2013;2(3):196–200.
- Coşkunçelebi K, Makbul S, Gültepe M, Okur S, Güzel ME. A conspectus of Scorzonera s.l. in Turkey. Turk J Botany. 2015;39:76–87.
- Baytop T. Turkiye’de Bitkiler ile Tedavi (Phytotherapy in Turkey, Past and Present). Istanbul: Nobel Publishers; 1999.
- Granica S, Lohwasser U, Jöhrer K, Zidorn C. Qualitative and quantitative analyses of secondary metabolites in aerial and subaerial of Scorzonera hispanica L. (black salsify). Food Chem. 2015;173:321–31.
- Wang Y, Wray V, Tsevegsuren N, Lin W, Proksch P. Phenolic compounds from the Mongolian medicinal plant Scorzonera radiata. Zeitschrift fur Naturforsch - Sect C J Biosci. 2012;67:135–43.
- Zidorn C, Ellmerer-Müller E, Stuppner H. Sesquiterpenoids from Scorzonera hispanica L. Pharmazie. 2000;55(7):550–1.
- Dolota A, Dabrowska B, Radzanowska J. Chemical and Sensory Characteristics of Some Scorzonera (Scorzonera hispanica L.) Cultiars. Acta Hortic. 2005;682:527–34.
- Ajebli M, Amssayef A, Eddouks M. Assessment of Antihyperglycemic Effect and Acute Toxicity of the Aqueous Scorzonera undulata Extract in Rats. Endocr Metab Immune Disord Drug Targets. 2020;20:1.
- Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazig-Turkey). J Ethnopharmacol. 2010;132:165–175.
- Polat R, Cakilcioglu U, Satil F. Traditional uses of medicinal plants in Solhan (Bingöl - Turkey). J Ethnopharmacol. 2013;148(3):951–963.
- Dalar A. Plant Taxa Used in the Treatment of Diabetes in Van Province, Turkey. Int J Second Metab. 2018;5(3):170–184.
- Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305–312.
- Stanley Mainzen Prince P, Kamalakkannan N. Rutin Improves Glucose Homeostasis in Streptozotocin Diabetic Tissues by Altering Glycolytic and Gluconeogenic Enzymes. J Biochem Mol Toxicol. 2006;20(2):96–102.
- Kumar S, Kumar D, Deshmukh RR, Lokhande PD, More SN, Rangari VD. Antidiabetic potential of Phyllanthus reticulatus in alloxan-induced diabetic mice. Fitoterapia. 2008;79:21–23.
- Ozbek H, Acikara OB, Keskin I, Kirmizi NI, Ozbilgin S, Oz BE, Kurtul E, Ozrenk BC, Tekin M, Saltan G. Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis. Biomed Pharmacother. 2017;86:172–176.
- Sun C, Li X, Liu L, Canet MJ, Guan Y, Fan Y, Zhou Y. Effect of fasting time on measuring mouse blood glucose level. Int J Clin Exp Med. 2016;9(2):4186–4189.
- Özbek H, Yılmaz BS. Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharm Sci. 2017;55(4):7–14.
- Küpeli Akkol E, Acikara OB, Süntar I, Citolu GS, Kele H, Ergene B. Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method. J Ethnopharmacol. 2011;137:1018–1027.
- Özbek H, Bahadır Acıkara Ö, Keskİn İ, Kirmizi Nİ, Yiğitbaşi T, Şakul AA, Iscan Saltan G. Preclinical Evaluation of Scorzonera sp . Root Extracts and Major Compounds against Acute Hepatotoxicity Induced by Carbon Tetrachloride. Indian J Pharm Sci. 2017;79(5):715–723.
- Temiz MA. Antioxidant and antihyperglycemic activities of Scorzonera cinerea radical leaves in streptozocin-induced diabetic rats. Acta Pharm. 2021;71:Article in Press.
- Chua LS. A review on plant-based rutin extraction methods and its pharmacological activities. J Ethnopharmacol. 2013;150:805–817.
- Kamalakkannan N, Prince PS. Antihyperglycaemic and Antioxidant Effect of Rutin , a Polyphenolic Flavonoid , in Streptozotocin-Induced Diabetic Wistar Rats. Basic Clin Pharmacol Toxicol. 2006;98:97–103.
- Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids : a cellular mechanism review. Nutr Metab (Lond). 2015;12(60):1–20.
- Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR. Diabetes and Cardiovascular Disease A Statement for Healthcare Professionals From the American Heart Association. Circulation. 1999;100:1134–1146.
- Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats : An effect mediated through cytokines , antioxidants and lipid biomarkers. Indian J Exp Biol. 2014;52:720–727.
- Prince PSM, Kannan NK. Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. J Pharm Pharmacol. 2006;58(10):1373–1383.
- Leon BM, Maddox TM. Diabetes and cardiovascular disease : Epidemiology , biological mechanisms , treatment recommendations and future research. World J Diabetes 2015. 2015;6(13):1246–1258.
- Akkol EK, Šmejkal K, Kurtul E, Ilhan M, Güragac FT, İşcan GS, Acıkara ÖB, Cvačka J, Buděšínský M. Inhibitory activity of Scorzonera latifolia and its components on enzymes connected with healing process. J Ethnopharmacol. 2019;245:112168.
- Bahadır Acıkara Ö, Ilhan M, Kurtul E, Šmejkal K, Küpeli Akkol E. Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes. Bioorg Chem. 2019;93:103330.
Toplam 33 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Mart 2021 |
| Gönderilme Tarihi | 21 Eylül 2020 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 11 Sayı: 1 |
Kaynak Göster
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