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Yıl 2023, Cilt: 13 Sayı: 1, 129 - 136, 28.03.2023

Mehmet Ali Temiz

https://doi.org/10.33808/clinexphealthsci.1061083
Cited By: 1

Öz

Kaynakça

  • World Health Organization. Global report on diabetes. Geneva: WHO press; 2016.
  • Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. Biochim Biophys Acta. 2014;1840(9):2709–2729.
  • Temiz MA. Antioxidant and antihyperglycemic activities of Scorzonera cinerea radical leaves in streptozocin-induced diabetic rats. Acta Pharm. 2021;71:603–617.
  • Zhang P, Li T, Wu X, Nice EC, Huang C, Zhang Y. Oxidative stress and diabetes: Antioxidative strategies. Front Med. 2020;14(5):583–600.
  • Jafar N, Edriss H, Nugent K. The effect of short-term hyperglycemia on the innate immune system. Am J Med Sci. 2016;351(2):201–211.
  • Reichert KP, Schetinger MRC, Gutierres JM, Pelinson LP, Stefanello P, Dalenogare DP, Baldissarelli J, Lopes TF, Morsch VM. Lingonberry extract provides neuroprotection by regulating the purinergic system and reducing oxidative stress in diabetic rats. Mol Nutr Food Res. 2018;62(1800050):1–7.
  • Kumar R, Chhatwal S, Arora S, Sharma S, Singh J, Singh N, Bhandari V, Khurana A. Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase–lowering effects of garlic in patients with type 2 diabetes mellitus with obesity. Diabetes Metab Syndr Obes: Targets Ther. 2013;6:49–56.
  • Ahmad AA, Merkhan MM, Abdulrazzaq GM. Effect of xanthine oxidase inhibition on immunity modulation in human. Eur J Mol Clin Med. 2020;7(10):1037–1316.
  • Ojha S, Alkaabi J, Amir N, Sheikh A, Agil A, Fahim MA, Adem A. Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats. Oxid Med Cell Longev. 2014;201436:1–9.
  • Hamza RZ, Al-Baqami NM, Khojah E, Mansour AMA, Al-Motaani SE, Al-Salmi FA, El-Megharbel SM. Possible antioxidant and antidiabetic effects of Combretum molle extract in a diabetes mellitus experimental model in male rats. Nat Prod Commun. 2021;16(10):1–10.
  • Belviranli M, Gökbel H, Okudan N, Büyükbaş S. Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats. Turk J Med Sci. 2015;45:489–495.
  • Jhang, JJ, Ong JW, Lu CC, Hsu CL, Lin JH, Liao JW, Yen GC. Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo. Food & Function. 2016;7(10):4239–4246.
  • Minh TN, Van TM, Andriana Y, Vinh LT, Hau DV, Duyen DH, Guzman-Gelani C. Antioxidant, Xanthine Oxidase, α-Amylase and α-Glucosidase inhibitory activities of bioactive compounds from Rumex crispus L. root. Molecules. 2019;24(3899):1–12.
  • Lee HS, Coates GA. Vitamin C in frozen, fresh squeezed, unpasteurized, polyethylene-bottled orange juice: A storage study. Food Chem. 1999;65(2):165–168.
  • Lowry H, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-275.
  • Giusti G. Adenosine deaminase. Bergmeyer HU, editors. Methods of Enzymatic Analysis. New York: Academic Press; 1974.p.1092–1099.
  • Prajda N, Weber G. Malignant transformation-linked imbalance: Decreased xanthine oxidase activity in hepatomas. FEBS Lett. 1975;59(2):245–249.
  • Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol. 1982;78:206–209.
  • Nizami NS, Uddin CSM. Strong Immunity – A major weapon to fight against Covid-19. IOSR J Pharm Biol Sci. 2020;15(3):22–29.
  • Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev. 2020;16:442–449.
  • Badescu M, Badulescu O, Badescu L, Ciocoiu M. Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol. 2015;53(4):533–539.
  • Ding S, Jiang H, Fang J. Regulation of immune function by polyphenols. J Immunol Res. 2018;(1264074):1–8.
  • Holzwarth M, Korhummel S, Carle R, Kammerer DR. Evaluation of the effects of different freezing and thawing methods on color, polyphenol and ascorbic acid retention in strawberries (Fragaria×ananassa Duch.). Food Res Int. 2012;48:241–248.
  • Rickman JC, Barrett DM, Bruhn CM. Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. C and B and phenolic compounds. J Sci Food. Agric 2007;87:930–944.
  • Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington DC: The National Academies Press; 2006.p.286–402.
  • Sapkota LB, Thapa S, Subedi N. Correlation study of adenosine deaminase and its isoenzymes in type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2017;5(e000357):1–6.
  • Niraula N, Thapa S, Kunwar S, Lamsal M, Baral N, Maskey R. Adenosine deaminase activity in type 2 diabetes mellitus: Does it have any role? BMC Endocr Disord. 2018;18(58):1–5.
  • Gezginci-Oktayoglu S, Saçan O, Bolkent S, İpci Y, Kabasakal L, Şener G, Yanardağ R. Chard (Beta vulgaris L.var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats. Acta Histochem. 2014;116:32–39.
  • Bitencourt PER, De Bona KS, Cargnelutti LO, Bonfanti G, Pigatto A, Boligon A, Athayde ML, Pierezan F, Zanette RA, Moretto MB. Syzygium cumini seed extract ameliorates adenosine deaminase activity and biochemical parameters but does not alter insulin sensitivity and pancreas architecture in a short-term model of diabetes. J Complem Integr Med. 2015;12(3):187–193.
  • Saçan O, Türkyılmaz IB, Bayrak BB, Mutlu O, Akev N, Yanardağ R. Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters. J Biochem Mol Toxicol. 2020;35(e22617):1–6.
  • Chielle EO, Bonfanti G, De Bona KS, Cargnelutti LO, Bitencourt PER, Da Silva PS, Campos, MMA, Moretto MB. Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats. Rev Bras de Plantas Medicinais. 2016;18(1):273– 278.
  • Liu J, Wang C, Liu F, Lu Y, Cheng J. Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy. Anal Bioanal Chem. 2015;407:2569–2579.
  • Nessa F, Khan SA. Evaluation of antioxidant and xanthine oxidase inhibitory activity of different solvent extracts of leaves of Citrullus colocynthis. Pharmacog Res. 2014;6(3):218– 226.
  • Tüzün BS, Hajdú Z, Orbán-Gyapai O, Zomborszki ZP, Jedlinszki N, Forgo P, Kıvçak B, Hohmann J. Isolation of chemical constituents of Centaurea virgata Lam. and xanthine oxidase inhibitory activity of the plant extract and compounds. Med Chem. 2017;13:498–502.
  • Davies MJ, Hawkins CL. The role of myeloperoxidase in biomolecule modification, chronic inflammation, and disease. Antioxid Redox Signal. 2020;32(13):957–982.
  • Tong PC, Lee KF, So WY, Ng MH, Chan WB, Lo MK, Chan NN, Chan JC. White blood cell count is associated with macro – and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care. 2004;27:216–222.
  • Tsai JC, Sheu SH, Chiu HC, Chung FM, Chang DM, Chen MP, Shin SJ, Lee YJ. Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2007;23:111–118.
  • Manzoni AG, Passos DF, da Silva JLG, Bernardes VM, Bremm JM, Jantsch MH, de Oliveir JS, Mann TR, de Andrade JM, Leal DBR. Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia. Blood Cells Mol Dis. 2019;76:13–21.
  • Chen X, Fang L, Lin H, Shen P, Zhang T, Li H, Li X, Yu M, Xu C, Zhang J, Lu F, Du X, Hu R, Zhong J. The relationship between type 2 diabetes and platelet indicators. Iran J Public Health. 2017;46(9):1211–1216.
  • Otton R, Soriano FG, Verlengia R, Curi R. Diabetes induces apoptosis in lymphocytes. J Endocrinol. 2004;182(1):145–156.
  • Mahmoud AM. Hematological alterations in diabetic rats – role of adipocytokines and effect of citrus flavonoids. EXCLI J. 2013;12:647–657.
  • Dowey R, Iqbal A, Heller SR, Sabroe I, Prince LR. A Bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity. Front Immunol. 2021;12:1–21.
  • Bahadır Açıkara Ö, Hošek J, Babula P, Cvačka J, Budešínský M, Dračinský M, Saltan-İşcan G, Kadlecová D, Ballová L, Šmejkal K. Turkish Scorzonera species extracts attenuate cytokine secretion via inhibition of NF-κB activation, showing antiinflammatory effect in vitro. Molecules. 2016;21(1):E43.

Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia

Yıl 2023, Cilt: 13 Sayı: 1, 129 - 136, 28.03.2023

Mehmet Ali Temiz

https://doi.org/10.33808/clinexphealthsci.1061083
Cited By: 1

Öz

Objective: Objective: Medicinal herbs offer natural remedies for various ailments because of their comprehensive effects. Scorzonera cinerea L. (Sc) is an edible wild plant and is used in traditional medicine against various diseases. The purpose of this study was to investigate the immune system effects of S. cinerea radical leaf extract in diabetic rats.
Methods: The 5 groups were formed — Control, Diabetic, Sc-Dried, Sc-Frozen, and Acarbose. Adenosine deaminase (ADA), xanthine oxidase (XO), and myeloperoxidase (MPO) activities in liver and kidney tissues were analyzed. Hematological parameters were also evaluated.
Results: ADA, XO, and MPO activities in both tissues significantly increased in diabetic conditions. However, Sc treatments significantly decreased liver ADA, liver and kidney XO, and liver and kidney MPO activities. There was no significant change in red blood cell (RBC) parameters. Although platelet (PLT) count and MPV were raised in the diabetic group, these parameters were reduced with Sc-Dried and Sc-Frozen treatment. While lymphocyte (LYM%) significantly decreased in defense cells in the diabetic group, neutrophil (NEU%), monocyte (MO%), and eosinophil (EOS%) elevated. However, a significant decrease was observed in NEU% and EOS% with Sc treatment.
Conclusion: S. cinerea treatment can exert a potential immunoregulatory effect in diabetes. Thus, S. cinerea can be considered as an adjuvant to augment immune system on diabetes.

Anahtar Kelimeler

Adenosine deaminase Hematology Immunity myeloperoxidase Scorzonera cinerea xanthine oxidase

Kaynakça

  • World Health Organization. Global report on diabetes. Geneva: WHO press; 2016.
  • Rochette L, Zeller M, Cottin Y, Vergely C. Diabetes, oxidative stress and therapeutic strategies. Biochim Biophys Acta. 2014;1840(9):2709–2729.
  • Temiz MA. Antioxidant and antihyperglycemic activities of Scorzonera cinerea radical leaves in streptozocin-induced diabetic rats. Acta Pharm. 2021;71:603–617.
  • Zhang P, Li T, Wu X, Nice EC, Huang C, Zhang Y. Oxidative stress and diabetes: Antioxidative strategies. Front Med. 2020;14(5):583–600.
  • Jafar N, Edriss H, Nugent K. The effect of short-term hyperglycemia on the innate immune system. Am J Med Sci. 2016;351(2):201–211.
  • Reichert KP, Schetinger MRC, Gutierres JM, Pelinson LP, Stefanello P, Dalenogare DP, Baldissarelli J, Lopes TF, Morsch VM. Lingonberry extract provides neuroprotection by regulating the purinergic system and reducing oxidative stress in diabetic rats. Mol Nutr Food Res. 2018;62(1800050):1–7.
  • Kumar R, Chhatwal S, Arora S, Sharma S, Singh J, Singh N, Bhandari V, Khurana A. Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase–lowering effects of garlic in patients with type 2 diabetes mellitus with obesity. Diabetes Metab Syndr Obes: Targets Ther. 2013;6:49–56.
  • Ahmad AA, Merkhan MM, Abdulrazzaq GM. Effect of xanthine oxidase inhibition on immunity modulation in human. Eur J Mol Clin Med. 2020;7(10):1037–1316.
  • Ojha S, Alkaabi J, Amir N, Sheikh A, Agil A, Fahim MA, Adem A. Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats. Oxid Med Cell Longev. 2014;201436:1–9.
  • Hamza RZ, Al-Baqami NM, Khojah E, Mansour AMA, Al-Motaani SE, Al-Salmi FA, El-Megharbel SM. Possible antioxidant and antidiabetic effects of Combretum molle extract in a diabetes mellitus experimental model in male rats. Nat Prod Commun. 2021;16(10):1–10.
  • Belviranli M, Gökbel H, Okudan N, Büyükbaş S. Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats. Turk J Med Sci. 2015;45:489–495.
  • Jhang, JJ, Ong JW, Lu CC, Hsu CL, Lin JH, Liao JW, Yen GC. Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo. Food & Function. 2016;7(10):4239–4246.
  • Minh TN, Van TM, Andriana Y, Vinh LT, Hau DV, Duyen DH, Guzman-Gelani C. Antioxidant, Xanthine Oxidase, α-Amylase and α-Glucosidase inhibitory activities of bioactive compounds from Rumex crispus L. root. Molecules. 2019;24(3899):1–12.
  • Lee HS, Coates GA. Vitamin C in frozen, fresh squeezed, unpasteurized, polyethylene-bottled orange juice: A storage study. Food Chem. 1999;65(2):165–168.
  • Lowry H, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-275.
  • Giusti G. Adenosine deaminase. Bergmeyer HU, editors. Methods of Enzymatic Analysis. New York: Academic Press; 1974.p.1092–1099.
  • Prajda N, Weber G. Malignant transformation-linked imbalance: Decreased xanthine oxidase activity in hepatomas. FEBS Lett. 1975;59(2):245–249.
  • Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol. 1982;78:206–209.
  • Nizami NS, Uddin CSM. Strong Immunity – A major weapon to fight against Covid-19. IOSR J Pharm Biol Sci. 2020;15(3):22–29.
  • Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev. 2020;16:442–449.
  • Badescu M, Badulescu O, Badescu L, Ciocoiu M. Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol. 2015;53(4):533–539.
  • Ding S, Jiang H, Fang J. Regulation of immune function by polyphenols. J Immunol Res. 2018;(1264074):1–8.
  • Holzwarth M, Korhummel S, Carle R, Kammerer DR. Evaluation of the effects of different freezing and thawing methods on color, polyphenol and ascorbic acid retention in strawberries (Fragaria×ananassa Duch.). Food Res Int. 2012;48:241–248.
  • Rickman JC, Barrett DM, Bruhn CM. Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. C and B and phenolic compounds. J Sci Food. Agric 2007;87:930–944.
  • Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington DC: The National Academies Press; 2006.p.286–402.
  • Sapkota LB, Thapa S, Subedi N. Correlation study of adenosine deaminase and its isoenzymes in type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2017;5(e000357):1–6.
  • Niraula N, Thapa S, Kunwar S, Lamsal M, Baral N, Maskey R. Adenosine deaminase activity in type 2 diabetes mellitus: Does it have any role? BMC Endocr Disord. 2018;18(58):1–5.
  • Gezginci-Oktayoglu S, Saçan O, Bolkent S, İpci Y, Kabasakal L, Şener G, Yanardağ R. Chard (Beta vulgaris L.var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats. Acta Histochem. 2014;116:32–39.
  • Bitencourt PER, De Bona KS, Cargnelutti LO, Bonfanti G, Pigatto A, Boligon A, Athayde ML, Pierezan F, Zanette RA, Moretto MB. Syzygium cumini seed extract ameliorates adenosine deaminase activity and biochemical parameters but does not alter insulin sensitivity and pancreas architecture in a short-term model of diabetes. J Complem Integr Med. 2015;12(3):187–193.
  • Saçan O, Türkyılmaz IB, Bayrak BB, Mutlu O, Akev N, Yanardağ R. Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters. J Biochem Mol Toxicol. 2020;35(e22617):1–6.
  • Chielle EO, Bonfanti G, De Bona KS, Cargnelutti LO, Bitencourt PER, Da Silva PS, Campos, MMA, Moretto MB. Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats. Rev Bras de Plantas Medicinais. 2016;18(1):273– 278.
  • Liu J, Wang C, Liu F, Lu Y, Cheng J. Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy. Anal Bioanal Chem. 2015;407:2569–2579.
  • Nessa F, Khan SA. Evaluation of antioxidant and xanthine oxidase inhibitory activity of different solvent extracts of leaves of Citrullus colocynthis. Pharmacog Res. 2014;6(3):218– 226.
  • Tüzün BS, Hajdú Z, Orbán-Gyapai O, Zomborszki ZP, Jedlinszki N, Forgo P, Kıvçak B, Hohmann J. Isolation of chemical constituents of Centaurea virgata Lam. and xanthine oxidase inhibitory activity of the plant extract and compounds. Med Chem. 2017;13:498–502.
  • Davies MJ, Hawkins CL. The role of myeloperoxidase in biomolecule modification, chronic inflammation, and disease. Antioxid Redox Signal. 2020;32(13):957–982.
  • Tong PC, Lee KF, So WY, Ng MH, Chan WB, Lo MK, Chan NN, Chan JC. White blood cell count is associated with macro – and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care. 2004;27:216–222.
  • Tsai JC, Sheu SH, Chiu HC, Chung FM, Chang DM, Chen MP, Shin SJ, Lee YJ. Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2007;23:111–118.
  • Manzoni AG, Passos DF, da Silva JLG, Bernardes VM, Bremm JM, Jantsch MH, de Oliveir JS, Mann TR, de Andrade JM, Leal DBR. Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia. Blood Cells Mol Dis. 2019;76:13–21.
  • Chen X, Fang L, Lin H, Shen P, Zhang T, Li H, Li X, Yu M, Xu C, Zhang J, Lu F, Du X, Hu R, Zhong J. The relationship between type 2 diabetes and platelet indicators. Iran J Public Health. 2017;46(9):1211–1216.
  • Otton R, Soriano FG, Verlengia R, Curi R. Diabetes induces apoptosis in lymphocytes. J Endocrinol. 2004;182(1):145–156.
  • Mahmoud AM. Hematological alterations in diabetic rats – role of adipocytokines and effect of citrus flavonoids. EXCLI J. 2013;12:647–657.
  • Dowey R, Iqbal A, Heller SR, Sabroe I, Prince LR. A Bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity. Front Immunol. 2021;12:1–21.
  • Bahadır Açıkara Ö, Hošek J, Babula P, Cvačka J, Budešínský M, Dračinský M, Saltan-İşcan G, Kadlecová D, Ballová L, Šmejkal K. Turkish Scorzonera species extracts attenuate cytokine secretion via inhibition of NF-κB activation, showing antiinflammatory effect in vitro. Molecules. 2016;21(1):E43.
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Articles
Yazarlar

Mehmet Ali Temiz 0000-0002-4680-3023

Yayımlanma Tarihi 28 Mart 2023
Gönderilme Tarihi 21 Ocak 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 13 Sayı: 1

Kaynak Göster

APA Temiz, M. A. (2023). Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia. Clinical and Experimental Health Sciences, 13(1), 129-136. https://doi.org/10.33808/clinexphealthsci.1061083
AMA Temiz MA. Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia. Clinical and Experimental Health Sciences. Mart 2023;13(1):129-136. doi:10.33808/clinexphealthsci.1061083
Chicago Temiz, Mehmet Ali. “Effects of Scorzonera Cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia”. Clinical and Experimental Health Sciences 13, sy. 1 (Mart 2023): 129-36. https://doi.org/10.33808/clinexphealthsci.1061083.
EndNote Temiz MA (01 Mart 2023) Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia. Clinical and Experimental Health Sciences 13 1 129–136.
IEEE M. A. Temiz, “Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia”, Clinical and Experimental Health Sciences, c. 13, sy. 1, ss. 129–136, 2023, doi: 10.33808/clinexphealthsci.1061083.
ISNAD Temiz, Mehmet Ali. “Effects of Scorzonera Cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia”. Clinical and Experimental Health Sciences 13/1 (Mart 2023), 129-136. https://doi.org/10.33808/clinexphealthsci.1061083.
JAMA Temiz MA. Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia. Clinical and Experimental Health Sciences. 2023;13:129–136.
MLA Temiz, Mehmet Ali. “Effects of Scorzonera Cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia”. Clinical and Experimental Health Sciences, c. 13, sy. 1, 2023, ss. 129-36, doi:10.33808/clinexphealthsci.1061083.
Vancouver Temiz MA. Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia. Clinical and Experimental Health Sciences. 2023;13(1):129-36.

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