Öz
1 yaşından küçük köpeklerde kanin parvovirus (CPV) önemli bir morbidite ve mortalite sebebidir. Kanin parvoviral enteritis (CPE), sepsis gelişimi için predispoze edici bir faktördür. Hastalığa verilen yangısal cevap, sepsis varlığında gözlenen değişimler için prediktif bir değere sahip olabilir. Bu sebeple, CPE’li septik bir köpeğe diagnostik yaklaşım klinik muayeneleri takiben hemogram gibi rutin laboravutar muayenelerini içermelidir. Bu çalışmanın hayvan materyalini 4-6 aylık, sağlıklı 7 adet (Kontrol Grubu), anoreksi, kusma ve hemorajik enteritis gibi CPE’nin klinik bulgularına sahip 54 adet hasta (CPE Grubu), toplam 61 adet köpek oluşturdu. 2001 SIRS kriterleri doğrultusunda CPE grubu köpekleri Septik CPE (n: 25) ve Non Septik CPE (n: 29) alt gruplarına ayrıldı. Tüm köpeklerin klinik muayeneleri ve venöz kan örneklerinden hemogram analizleri yapıldı. Kontrol grubu ile karşılaştırıldığında CPE grubu köpeklerinin RR, HR ve vücut sıcaklığı değerleri daha yüksek (p<0.000), CRT değeri ise daha kısaydı (p<0.014). Septik CPE ve Non Septik CPE gruplarının karşılaştırılmasında ise RR değeri Septik CPE grubunda daha düşüktü (p<0.001). Kontrol grubu ile karşılaştırıldığında CPE grubunun WBC, granülosit, MCH, MCHC ve Hb değerleri daha düşük (p<0.031), RDW değeri ise daha yüksekti (p<0.001). Septik CPE ve Non Septik CPE gruplarının karşılaştırmasında ise Septik CPE grubunun WBC, lenfosit, monosit, granülosit değerleri daha düşük (p<0.006), MCH değeri ise daha yüksekti (p<0.004). Sonuç olarak, ROC temelli diagnostic performans analizi doğrultusunda RR, WBC, lenfosit, MCH, monosit ve granülosit değerlerinin ise septik ve non septik CPE’li köpeklerin ayırt edilmesinde faydalı diagnostik bilgi sağlayıp, triajda hastalık şiddetini daha erken tanımlayıp erken müdahale ile hayatta kalma oranını arttırabileceği kanısına varıldı.
Anahtar Kelimeler
Kaynakça
- Gülersoy E, Ok M, Yıldız R, Koral E, İder M, Sevinç M, Zhunushova A. (2020). Assessment of Intestinal and Cardiac-related Biomarkers in Dogs with Parvoviral Enteritis. Pol J Vet Sci. 23(2): 211-219.
- Alves F, Prata S, Nunes T, Gomes J, Aguiar S, Aires da Silva F, Tavares L, Almeida V, Gil S. (2020). Canine Parvovirus: A Predicting Canine Model for Sepsis. BMC Vet Res. 16(1): 199.
- Mylonakis ME, Kalli I, Rallis TS. (2016). Canine Parvoviral Enteritis: An Update on the Clinical Diagnosis, Treatment, and Prevention. Vet Med (Auckl).7: 91-100.
- Krentz T, Allen S. (2017). Bacterial Translocation in Critical Illness. J Small Anim Pract. 58(4): 191-198.
- Drobatz KJ, Hopper K, Rozanski EA, Silverstein DC. (2019). Gastroenteritis. In: Textbook of Small Animal Emergency Medicine. Drobatz KJ, Hopper K, Rozanski EA, Silverstein DC (eds). 1st ed. pp. 485-486. Wiley-Blackwell, New Jersey, USA.
- Yilmaz Z, Senturk S. (2007). Characterisation of Lipid Profiles in Dogs with Parvoviral Enteritis. J Small Anim Pract. 48(11): 643–50.
- Goddard A, Leisewitz A. (2010). Canine Parvovirus. Vet Clin NA Small Anim Pract. 40(6):1041–1053.
- Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (sepsis-3). JAMA. 315: 801–810.
- Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA (1992). Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest. 101(6): 1644–1655.
- Sykes JE. (2014). Canine Parvovirus Infections and Other Viral Enteritides. Canine and Feline Infectious Diseases. PMC7152455: 141-151.
- Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D. (2003). 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 29(4): 530–538.
- Goddard A, Leisewitz AL, Christopher MM, Duncan NM, Becker PJ. (2008). Prognostic Usefulness of Blood Leukocyte Changes in Canine Parvoviral Enteritis. J Vet Intern Med. 22(2): 309-316.
- Sharp CL. (2018). Systemic Inflammatory Response Syndrome, Sepsis, and Multiple Organ Dysfunction Syndrome. In: Textbook Of Small Animal Emergency Medicine. Drobatz KJ, Hopper K, Rozanski E, Silverstein DC (eds). pp. 1030-1037. Wiley Blackwell, New Jersey, USA.
- Girardot T, Rimmelé T, Venet F, Monneret G. (2016). Apoptosis-induced Lymphopenia in Sepsis and Other Severe Injuries. Apoptosis. 22(2): 295-305.
- Prittie J. (2004). Canine Parvoviral Enteritis: A Review of Diagnosis, Management, and Prevention. Vet Emerg Crit Care. 14(3): 167-176.
- Gülersoy E, Balıkçı C, Günal İ, Şahan A. (2022). Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis. Revista Cientifica, FCV-LUZ. 32(rcfcv-e32091): 1-8.
- Loughlin PC, Sebat F, Kellett JG. (2018). Respiratory Rate: The Forgotten Vital Sign—Make It Count! Jt Comm J Qual Patient Saf. 44(8): 494-499.
- Sharma R, Kumar A, Goel P, Kumar R. (2008). Clinical Haematology in Canine Haemorrhagic Gastroenteritis. Haryana Vet. 47(8): 35-38.
- Wysoke JM, Van Heerden J. (1990). Polycythemia Vera in a Dog. J S Afr Vet Assoc. 61(4):182–183.
- Biswas S, Chakravorty D, Pradhan NR. (2005). Clinical and Haemato-biochemical Changes in Parvovirus Infection in Dogs. Indian J Vet Med. 25(1): 16-18.
- Alves FS, Barbosa BC, Coelho NGD, Pinto PCO, Campos MTG, Horta RS, Freitas PMC, Beier SL, Paes PRO. (2019). Clinical and Hematological Prognostic Factors in Dogs with Parvoviral Enteritis and Sepsis. Braz J Dev. 40(3): 1477-1488.
- Gülersoy E, Kapar MM, Durgut MK, Naseri A, Ok M. (2022). Evaluation of Clinical, Hematochemical and Cerebrospinal Fluid Analysis Findings in Dogs Naturally Affected by the Neurological Form of Canine Distemper. Magy Allatorvosok Lapja. 144(1): 13-29.
- Pierini A, Gori E, Lippi I, Lubas G, Marchetti V. (2020). Are Leukocyte and Platelet Abnormalities and Complete Blood Count Ratios Potential Prognostic Markers in Canine Sepsis? Front Vet Sci. 7:578846.
- Lee SH, Kim JW, Lee BC, Oh HJ. (2020). Age-specific Variations in Hematological and Biochemical Parameters in Middle- and Large-sized of Dogs. J Vet Sci. 21(1): e7.
Öz
Canine parvovirus (CPV) is an important cause of morbidity and mortality for dogs younger than 1 year-old. Canine parvoviral enteritis (CPE) is a predisposing factor for the development of sepsis. The inflammatory response to the disease may have predictive value for the alterations in the presence of sepsis. Therefore, the diagnostic approach to a septic dog with CPE should include clinical examinations followed by routine laboratory examinations such as hemogram. In this study, a total of 61 dogs, aged 4-6 months, 7 healthy (Control Group) and 54 diseased dogs with clinical signs of CPE such as anorexia, vomiting and hemorrhagic enteritis (CPE Group) were used. CPE group was divided into Septic CPE (n: 25) and Non Septic CPE (n: 29) subgroups in accordance with 2001 systemic inflammatory response syndrome (SIRS) criterias. Clinical examinations and hemogram analysis from venous blood samples were performed. When compared to the Control group, the respiratory rate (RR), heart rate (HR) and body temperature of the dogs in the CPE group were higher (p<0.000) and the capillary refill time (CRT) was shorter (p<0.014). In the comparison of Septic CPE and Non Septic CPE groups, the RR was higher in the Septic CPE group (p<0.001). When compared to the Control group, the leukocytes (WBC), granulocyte, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and hemoglobin (Hb) values of the CPE group were lower (p<0.031) and the reticulocyte distribution width (RDW) value was higher (p<0.001). In the comparison of Septic CPE and Non Septic CPE groups, WBC, lymphocyte, monocytes and granulocyte values of the Septic CPE group were lower (p<0.006) and MCH values were higher (p<0.004). As a result, it was concluded that in accordance with the receiver operating characteristic (ROC) based diagnostic performance analysis, RR, WBC, lymphocyte, MCH, monocytes and granulocyte values can provide useful diagnostic information in differentiating dogs with septic and non septic CPE and may help identifying the disease severity earlier in triage and increase survival rate with early intervention.
Anahtar Kelimeler
Kaynakça
- Gülersoy E, Ok M, Yıldız R, Koral E, İder M, Sevinç M, Zhunushova A. (2020). Assessment of Intestinal and Cardiac-related Biomarkers in Dogs with Parvoviral Enteritis. Pol J Vet Sci. 23(2): 211-219.
- Alves F, Prata S, Nunes T, Gomes J, Aguiar S, Aires da Silva F, Tavares L, Almeida V, Gil S. (2020). Canine Parvovirus: A Predicting Canine Model for Sepsis. BMC Vet Res. 16(1): 199.
- Mylonakis ME, Kalli I, Rallis TS. (2016). Canine Parvoviral Enteritis: An Update on the Clinical Diagnosis, Treatment, and Prevention. Vet Med (Auckl).7: 91-100.
- Krentz T, Allen S. (2017). Bacterial Translocation in Critical Illness. J Small Anim Pract. 58(4): 191-198.
- Drobatz KJ, Hopper K, Rozanski EA, Silverstein DC. (2019). Gastroenteritis. In: Textbook of Small Animal Emergency Medicine. Drobatz KJ, Hopper K, Rozanski EA, Silverstein DC (eds). 1st ed. pp. 485-486. Wiley-Blackwell, New Jersey, USA.
- Yilmaz Z, Senturk S. (2007). Characterisation of Lipid Profiles in Dogs with Parvoviral Enteritis. J Small Anim Pract. 48(11): 643–50.
- Goddard A, Leisewitz A. (2010). Canine Parvovirus. Vet Clin NA Small Anim Pract. 40(6):1041–1053.
- Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (sepsis-3). JAMA. 315: 801–810.
- Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA (1992). Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest. 101(6): 1644–1655.
- Sykes JE. (2014). Canine Parvovirus Infections and Other Viral Enteritides. Canine and Feline Infectious Diseases. PMC7152455: 141-151.
- Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D. (2003). 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 29(4): 530–538.
- Goddard A, Leisewitz AL, Christopher MM, Duncan NM, Becker PJ. (2008). Prognostic Usefulness of Blood Leukocyte Changes in Canine Parvoviral Enteritis. J Vet Intern Med. 22(2): 309-316.
- Sharp CL. (2018). Systemic Inflammatory Response Syndrome, Sepsis, and Multiple Organ Dysfunction Syndrome. In: Textbook Of Small Animal Emergency Medicine. Drobatz KJ, Hopper K, Rozanski E, Silverstein DC (eds). pp. 1030-1037. Wiley Blackwell, New Jersey, USA.
- Girardot T, Rimmelé T, Venet F, Monneret G. (2016). Apoptosis-induced Lymphopenia in Sepsis and Other Severe Injuries. Apoptosis. 22(2): 295-305.
- Prittie J. (2004). Canine Parvoviral Enteritis: A Review of Diagnosis, Management, and Prevention. Vet Emerg Crit Care. 14(3): 167-176.
- Gülersoy E, Balıkçı C, Günal İ, Şahan A. (2022). Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis. Revista Cientifica, FCV-LUZ. 32(rcfcv-e32091): 1-8.
- Loughlin PC, Sebat F, Kellett JG. (2018). Respiratory Rate: The Forgotten Vital Sign—Make It Count! Jt Comm J Qual Patient Saf. 44(8): 494-499.
- Sharma R, Kumar A, Goel P, Kumar R. (2008). Clinical Haematology in Canine Haemorrhagic Gastroenteritis. Haryana Vet. 47(8): 35-38.
- Wysoke JM, Van Heerden J. (1990). Polycythemia Vera in a Dog. J S Afr Vet Assoc. 61(4):182–183.
- Biswas S, Chakravorty D, Pradhan NR. (2005). Clinical and Haemato-biochemical Changes in Parvovirus Infection in Dogs. Indian J Vet Med. 25(1): 16-18.
- Alves FS, Barbosa BC, Coelho NGD, Pinto PCO, Campos MTG, Horta RS, Freitas PMC, Beier SL, Paes PRO. (2019). Clinical and Hematological Prognostic Factors in Dogs with Parvoviral Enteritis and Sepsis. Braz J Dev. 40(3): 1477-1488.
- Gülersoy E, Kapar MM, Durgut MK, Naseri A, Ok M. (2022). Evaluation of Clinical, Hematochemical and Cerebrospinal Fluid Analysis Findings in Dogs Naturally Affected by the Neurological Form of Canine Distemper. Magy Allatorvosok Lapja. 144(1): 13-29.
- Pierini A, Gori E, Lippi I, Lubas G, Marchetti V. (2020). Are Leukocyte and Platelet Abnormalities and Complete Blood Count Ratios Potential Prognostic Markers in Canine Sepsis? Front Vet Sci. 7:578846.
- Lee SH, Kim JW, Lee BC, Oh HJ. (2020). Age-specific Variations in Hematological and Biochemical Parameters in Middle- and Large-sized of Dogs. J Vet Sci. 21(1): e7.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Araştıma |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2022 |
| Kabul Tarihi | 21 Haziran 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 15 Sayı: 1 |
Kaynak Göster
DANIŞMA KURULU
Prof. Dr. Abit AKTAŞ, İstanbul Üniversitesi-Cerrahpaşa
Prof. Dr. Yılmaz ARAL, Ankara Üniversitesi
Prof. Dr. Ali ARSLAN, Fırat Üniversitesi, Elazığ
Prof. Dr. M. Sedat BARAN, Dicle Üniversitesi, Diyarbakır
Prof. Dr. Cengiz CEYLAN, Balıkesir Üniversitesi
Prof. Dr. Ahmet ÇAKIR, Ankara Üniversitesi
Prof. Dr. Burhan ÇETİNKAYA, Fırat Üniversitesi, Elazığ
Prof. Dr. Ülker EREN, Adnan Menderes Üniversitesi, Aydın
Prof. Dr. Abdurrahman GÜL, Bingöl Üniversitesi
Prof. Dr. Hakki KARA, Cumhuriyet Üniversitesi, Sivas
Prof. Dr. Narin LİMAN, Erciyes Üniversitesi, Kayseri
Prof. Dr. Abdullah ÖZEN, Fırat Üniversitesi, Elazığ
Prof. Dr. Ayşe SERBEST, Uludağ Üniversitesi, Bursa
Prof. Dr. Kazım ŞAHİN, Fırat Üniversitesi, Elazığ
Prof. Dr. Tekin ŞAHİN, Siirt Üniversitesi
Prof. Dr. Nihat ŞINDAK, Siirt Üniversitesi
Prof. Dr. Muzaffer TAŞ, Namık Kemal Üniversitesi, Tekirdağ
Prof. Dr. Necati TİMURKAN Fırat Üniversitesi, Elazığ
Prof. Dr. Emine ÜNSALDI, Fırat Üniversitesi, Elazığ
Prof. Dr. Murat YILDIRIM, Kırıkkale Üniversitesi
Doç. Dr. M. Osman ATLI, Harran Üniversitesi, Şanlıurfa
Doç. Dr. Bülent ELİTOK, Afyon Kocatepe Üniversitesi
Doç. Dr. Serkan ERDOĞAN, Namık Kemal Üniversitesi, Tekirdağ
Dr. Öğr. Üyesi Zelal KARAKOÇ, Dicle Üniversitesi, Diyarbakır
Dr. Öğr. Üyesi Ersin UYSAL, Dicle Üniversitesi, Diyarbakır
*Not: Yayın ve Danışma Kurulu Üyeleri alfabetik sıraya göre dizilmiştir.