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Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies

Yıl 2015, Cilt: 20 Sayı: 2, 101 - 105, 15.01.2015

Neşe Çölçimen Hanım Güler Şahin

Öz

The aim of this study is to compare the uric acid and leptin levels in preeclamtic and normal pregnants and to investigate the relationship between these levels and the severity of the disease. This study was performed on 40 (20 severe, 20 mild) patients who had received a diagnosis of preecclampsia and on 30 normal healthy pregnant women, a total of 70 singleton pregnancies, at 34-42 nd gestational weeks who had recourse to obstetric and gynecology clinic from February to September. Plasma leptin levels were determined by using ELISA method. Levels of those parameters were compared in preeclamptic and normal pregnant woman. Leptin levels were found as 9.6±7.2 ng/ml in severely preeclamptic group, 5.4±3.0 ng/ml in mildly preeclamptic group and 3.1±3.1 ng/ml in control group. In severe preeclampsia group, leptin levels were statistically significantly higher (p=0.001). Uric acid levels were found as 6.3±1.8 mg/ml in severe preeclamptic group, 5.0±1.4 mg/ml in mildly preeclamptic group and 4.02±0.73 mg/ml in control group. When uric acid levels of preeclamptic groups were compared with the control, statistically significant difference was determined among the groups (p=0.001). The highest uric acid level was found in severely preeclamptic group. A weak, positive correlation was determined between serum uric acid and leptin levels (r=0.039). Increased uric acid values were found with increasing serum leptin levels. In preeclamptic patients it was found that uric acid levels were increased with increasing serum leptin levels. We consider that leptin hormone which has various functions may have some role in etiopathogenesis of preeclampsia and may be a useful marker of preeclampsia.

Keywords: Leptin, Preeclampsia, uric acid.    

Anahtar Kelimeler

Leptin preeclampsia uric acid

Kaynakça

  • Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci 1997; 94: 11073-11078.
  • Acien P, Lıoret G, Lıoret M. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings. Int J Gynecol Obstet 1990; 32: 229-235.
  • Sagen N, Kjell H, Nilsen S. Serum urate as a predictor of fetal outcome in severe preeclampsia. Acta Obstet Gynecol Scand 1984; 63: 71-75.
  • Hayashi T. Uric acid and endogenous clearance stuides in normal pregnancy and toxemias of pregnancy. Am J Obstet Gynecol 1956; 70.
  • Redman CVG, Beilin LJ, Bonnar J, Wilkinson RH. Plasma urate measurements in predicting fetal death in hypertensive pregnancy. Lancet 1976; 2: 1370- 1373.
  • Roberts J. Pregnancy related hypertension. In: Creasy R, Resnik R, eds. Maternal Fetal Medicine: principles and practice 3rd ed. Philadelphia: WB Saunders; 1994. p. 804-843.
  • McCarthy JF, Misra DN, Roberts JM. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999; 180: 731-736.
  • Odegard RA, Vattten LJ, Nilsen ST, Salvesen KA, Austgulen R. Umblikal cord plasma leptin is increased in preeclampsia. Am J Obstet Gynecol 2002; 186: 427-432.
  • Bartha JL, Romero-Carmonad R, Escobar-Llompart M, Comino-Delgado R. The relationships between leptin and inflammatory cytokines in women with pre- eclampsia. Br J Obstet Gynaecol 2001; 108: 1272- 1276.
  • Kokot F, Wiecek A, Adamczak M. Pathophysiological role of leptin in patients with chronic renal failure, in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. Artif Organs 1999; 23: 70-74.
  • Schubring C, Englaro P, Siebler T. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six steroids and umblical cord blood leptin levels Horm Res 1998; 50: 76-83.
  • ACOG practice bulletin. Dagnosisi and management of preeclampsia and eclampsia. Number 33, januray 2002. American Collage of Obsteticians and Gynecologists. Int J Gynaecol Obstet 2002; 77: 67-75.
  • Çelik Ö, Hasçalık Ş, Bay A. Serum ß2-Mikroglobulin: Preeklampsinin Erken Tahminindeki Önemi. İnönü Üniversitesi Tıp Fakültesi Dergisi 2002; 9: 49-52.
  • Hallak M. Hypertension in pregnancy. In: James DK, Steer PS, Weiner CP, Gonik B(eds.) High Risk Pregnancy Management Options. (2 nd Ed). Vol 37. China, W.B. Saunders 1999: 639-663.
  • Herrasti SM, Ruiz RA, Teran VL. Variations in the uric acid levels in pregnancy hypertension. Ginecol Obstet Max 1997; 65: 59-63.
  • Hoff C, Peevy K, Giattina K, Spinnato JA, Peterson RDA. Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. Obstet Gynecol 1992; 80: 1007-1012.
  • Boyle JA, Campbell S, Duncan AM, Greig WR, Buchanan WW. Serum uric acid leveles in normal pregnanc with observation on the renal excretion of urate in pregnancy. J Clin Pathol 1996; 19: 501-503.
  • Chesley L, Williams L. Renal glomerular and tubular function is relation to the hyperuricemia of preeclampsia and eclampsia. Am J Obstet Gynecol 1945; 50: 367-375.
  • Chesley LC. The movement of radioactive sodium in normal pregnant, nonpregnant, and preeclamptic weomen. Am J Obstet Gynecol 1970; 106: 530-533.
  • Ğallery ED, Ross M, Grigg R, Bean C. Are the renal functional changes of human pregnancy caused by prostacyclin? Prostaglandins 1985; 30: 1019-1029.
  • D’Anna R, Bavıera G, Scilipoti A, Leonardi I, Leo R. The clinical utility of serum uric acid measurement in preeclampsia and transient hypertension in pregnancy. Panminerva Med 2000; 42: 101-103.
  • Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclmapsia, revisited. Am J Obstet Gynecol 1996; 174: 288-291.
  • Faggioni R, Gatti S, Demitri MT, et al. Role of xanthine oxidase and reactive oxygen intermediates in LPS and TNF induced pulmonary edema. J Lab Clin MED 1994; 123: 394-399.
  • Falciani F, Ghezzi P, Tetao M, Cazzaniga G, Garaniti E. Interferons induce xanthine dehydrogenase gene expression in 11929 cele. Biochem J 1992; 285: 1001- 1008.
  • Dupont GP, Huecksteadt TP, Marshall BC, et al. Reegulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest 1992; 89: 197-202.
  • Mise H, Sagawa N, Matsumoto T, et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab 1998; 83: 3225-3229.
  • Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human plasenta. J Clin Endocrinol Metab 1997; 82: 1582-1588.
  • Bouloumie A, Marumo T, Lafontan M, et al. Leptin induces oxidative stres in human endothelial cells. FASEB J 1999; 13: 1231-1238.
  • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (London) 1993; 362: 801-809.
  • Ren J. Leptin and hyperleptinemia-form friend to foe for cardiovascular function. J Endoc 2004; 181: 1-10.

Yıl 2015, Cilt: 20 Sayı: 2, 101 - 105, 15.01.2015

Neşe Çölçimen Hanım Güler Şahin

Öz

Kaynakça

  • Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci 1997; 94: 11073-11078.
  • Acien P, Lıoret G, Lıoret M. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings. Int J Gynecol Obstet 1990; 32: 229-235.
  • Sagen N, Kjell H, Nilsen S. Serum urate as a predictor of fetal outcome in severe preeclampsia. Acta Obstet Gynecol Scand 1984; 63: 71-75.
  • Hayashi T. Uric acid and endogenous clearance stuides in normal pregnancy and toxemias of pregnancy. Am J Obstet Gynecol 1956; 70.
  • Redman CVG, Beilin LJ, Bonnar J, Wilkinson RH. Plasma urate measurements in predicting fetal death in hypertensive pregnancy. Lancet 1976; 2: 1370- 1373.
  • Roberts J. Pregnancy related hypertension. In: Creasy R, Resnik R, eds. Maternal Fetal Medicine: principles and practice 3rd ed. Philadelphia: WB Saunders; 1994. p. 804-843.
  • McCarthy JF, Misra DN, Roberts JM. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999; 180: 731-736.
  • Odegard RA, Vattten LJ, Nilsen ST, Salvesen KA, Austgulen R. Umblikal cord plasma leptin is increased in preeclampsia. Am J Obstet Gynecol 2002; 186: 427-432.
  • Bartha JL, Romero-Carmonad R, Escobar-Llompart M, Comino-Delgado R. The relationships between leptin and inflammatory cytokines in women with pre- eclampsia. Br J Obstet Gynaecol 2001; 108: 1272- 1276.
  • Kokot F, Wiecek A, Adamczak M. Pathophysiological role of leptin in patients with chronic renal failure, in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. Artif Organs 1999; 23: 70-74.
  • Schubring C, Englaro P, Siebler T. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six steroids and umblical cord blood leptin levels Horm Res 1998; 50: 76-83.
  • ACOG practice bulletin. Dagnosisi and management of preeclampsia and eclampsia. Number 33, januray 2002. American Collage of Obsteticians and Gynecologists. Int J Gynaecol Obstet 2002; 77: 67-75.
  • Çelik Ö, Hasçalık Ş, Bay A. Serum ß2-Mikroglobulin: Preeklampsinin Erken Tahminindeki Önemi. İnönü Üniversitesi Tıp Fakültesi Dergisi 2002; 9: 49-52.
  • Hallak M. Hypertension in pregnancy. In: James DK, Steer PS, Weiner CP, Gonik B(eds.) High Risk Pregnancy Management Options. (2 nd Ed). Vol 37. China, W.B. Saunders 1999: 639-663.
  • Herrasti SM, Ruiz RA, Teran VL. Variations in the uric acid levels in pregnancy hypertension. Ginecol Obstet Max 1997; 65: 59-63.
  • Hoff C, Peevy K, Giattina K, Spinnato JA, Peterson RDA. Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. Obstet Gynecol 1992; 80: 1007-1012.
  • Boyle JA, Campbell S, Duncan AM, Greig WR, Buchanan WW. Serum uric acid leveles in normal pregnanc with observation on the renal excretion of urate in pregnancy. J Clin Pathol 1996; 19: 501-503.
  • Chesley L, Williams L. Renal glomerular and tubular function is relation to the hyperuricemia of preeclampsia and eclampsia. Am J Obstet Gynecol 1945; 50: 367-375.
  • Chesley LC. The movement of radioactive sodium in normal pregnant, nonpregnant, and preeclamptic weomen. Am J Obstet Gynecol 1970; 106: 530-533.
  • Ğallery ED, Ross M, Grigg R, Bean C. Are the renal functional changes of human pregnancy caused by prostacyclin? Prostaglandins 1985; 30: 1019-1029.
  • D’Anna R, Bavıera G, Scilipoti A, Leonardi I, Leo R. The clinical utility of serum uric acid measurement in preeclampsia and transient hypertension in pregnancy. Panminerva Med 2000; 42: 101-103.
  • Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclmapsia, revisited. Am J Obstet Gynecol 1996; 174: 288-291.
  • Faggioni R, Gatti S, Demitri MT, et al. Role of xanthine oxidase and reactive oxygen intermediates in LPS and TNF induced pulmonary edema. J Lab Clin MED 1994; 123: 394-399.
  • Falciani F, Ghezzi P, Tetao M, Cazzaniga G, Garaniti E. Interferons induce xanthine dehydrogenase gene expression in 11929 cele. Biochem J 1992; 285: 1001- 1008.
  • Dupont GP, Huecksteadt TP, Marshall BC, et al. Reegulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest 1992; 89: 197-202.
  • Mise H, Sagawa N, Matsumoto T, et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab 1998; 83: 3225-3229.
  • Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human plasenta. J Clin Endocrinol Metab 1997; 82: 1582-1588.
  • Bouloumie A, Marumo T, Lafontan M, et al. Leptin induces oxidative stres in human endothelial cells. FASEB J 1999; 13: 1231-1238.
  • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (London) 1993; 362: 801-809.
  • Ren J. Leptin and hyperleptinemia-form friend to foe for cardiovascular function. J Endoc 2004; 181: 1-10.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Neşe Çölçimen

Hanım Güler Şahin Bu kişi benim

Yayımlanma Tarihi 15 Ocak 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 20 Sayı: 2

Kaynak Göster

APA Çölçimen, N., & Şahin, H. G. (2015). Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies. EASTERN JOURNAL OF MEDICINE, 20(2), 101-105.
AMA Çölçimen N, Şahin HG. Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies. EASTERN JOURNAL OF MEDICINE. Temmuz 2015;20(2):101-105.
Chicago Çölçimen, Neşe, ve Hanım Güler Şahin. “Plasma Levels of Uric Acid and Leptin in Preeclampsia and Normal Pregnancies”. EASTERN JOURNAL OF MEDICINE 20, sy. 2 (Temmuz 2015): 101-5.
EndNote Çölçimen N, Şahin HG (01 Temmuz 2015) Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies. EASTERN JOURNAL OF MEDICINE 20 2 101–105.
IEEE N. Çölçimen ve H. G. Şahin, “Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies”, EASTERN JOURNAL OF MEDICINE, c. 20, sy. 2, ss. 101–105, 2015.
ISNAD Çölçimen, Neşe - Şahin, Hanım Güler. “Plasma Levels of Uric Acid and Leptin in Preeclampsia and Normal Pregnancies”. EASTERN JOURNAL OF MEDICINE 20/2 (Temmuz 2015), 101-105.
JAMA Çölçimen N, Şahin HG. Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies. EASTERN JOURNAL OF MEDICINE. 2015;20:101–105.
MLA Çölçimen, Neşe ve Hanım Güler Şahin. “Plasma Levels of Uric Acid and Leptin in Preeclampsia and Normal Pregnancies”. EASTERN JOURNAL OF MEDICINE, c. 20, sy. 2, 2015, ss. 101-5.
Vancouver Çölçimen N, Şahin HG. Plasma levels of uric acid and leptin in preeclampsia and normal pregnancies. EASTERN JOURNAL OF MEDICINE. 2015;20(2):101-5.