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“Paraquat Brain”: Have We Researched Enough?

Yıl 2023, Cilt: 5 Sayı: 3, 25 - 28, 31.12.2023

Ananth Rupesh Kattamreddy Mohit Kumar Moses Thathapudi Victor Ghosh Jacinth Karunya Midde Pravin Kalyankar

https://doi.org/10.51262/ejtox.1344451

Öz

This letter examines the potential relationship between the highly toxic herbicide paraquat (PQ) and Parkinson's disease (PD). Despite animal studies implicating PQ as a causative factor for PD, the evidence is insufficient due to limited human research on this topic. There is a pressing need for human autopsy-based studies in PQ poisoning fatalities to comprehend paraquat's neuropathology. Further studies are crucial to assess the morbidity in paraquat poisoning survivors, potentially shedding light on clinical links with PD. Although current research hasn't definitively established a causal connection, the absence of evidence shouldn't discourage ongoing investigation. The pursuit of understanding the PQ-PD connection necessitates unwavering commitment from the scientific community.

Anahtar Kelimeler

Paraquat parkinson's disease toxicology neurotoxicants

Destekleyen Kurum

Not Applicable

Proje Numarası

Not Applicable

Teşekkür

Nil

Kaynakça

  • Gao L, Yuan H, Xu E, Liu J. Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics. Sci Rep 2020;10. https://doi.org/10.1038/s41598-020-58599-y
  • Shanbhag V, Sukumar CA, Shastry AB. Paraquat: The poison potion. Indian J Crit Care Med 2019;23:0–0. https://doi.org/10.5005/jp-journals-10071-23306.
  • Suntres Z. Role of antioxidants in paraquat toxicity. Toxicology 2002;180:65–77. https://doi.org/10.1016/s0300-483x(02)00382-7.
  • Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F. Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 2008;38:13–71. https://doi.org/10.1080/10408440701669959.
  • Delirrad M, Majidi M, Boushehri B. Clinical features, and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med 2015;8:8122–8.
  • Delirrad M, Majidi M, Boushehri B. Clinical features and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med. 2015;8(5):8122–8.
  • Wang X, Wang X, Zhu Y, Chen X. ADME/T-based strategies for paraquat detoxification: Transporters and enzymes. Environ Pollut 2021;291:118137. https://doi.org/10.1016/j.envpol.2021.118137.
  • Vaccari C, El Dib R, Gomaa H, Lopes LC, de Camargo JL. Paraquat and Parkinson’s disease: a systematic review and meta-analysis of observational studies. J Toxicol Environ Health B Crit Rev 2019;22:172–202. https://doi.org/10.1080/10937404.2019.1659197.
  • Tangamornsuksan W, Lohitnavy O, Sruamsiri R, Chaiyakunapruk N, Norman Scholfield C, Reisfeld B, et al. Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis. Arch Environ Occup Health 2019;74:225–38. https://doi.org/10.1080/19338244.2018.1492894.
  • Briñez-Gallego P, da Costa Silva DG, Cordeiro MF, Horn AP, Hort MA. Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review. J Toxicol Environ Health B Crit Rev 2023;26:201–37. https://doi.org/10.1080/10937404.2023.2182390.
  • Lama J, Buhidma Y, Fletcher EJR, Duty S. Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research. Neuronal Signal 2021;5. https://doi.org/10.1042/ns20210026.
  • Uversky VN. Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res 2004;318:225–41. https://doi.org/10.1007/s00441-004-0937-z.
  • Cicchetti F, Lapointe N, Roberge-Tremblay A, Saint-Pierre M, Jimenez L, Ficke BW, et al. Systemic exposure to paraquat and maneb models early Parkinson’s disease in young adult rats. Neurobiol Dis 2005;20:360–71.
  • Soontornniyomkij V, Bunyaratvej S. Fatal paraquat poisoning: a light microscopic study in eight autopsy cases. J Med Assoc Thai 1992;75 Suppl 1:98–105.
  • Mukada T, Sasano N, Sato K. Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura. Tohoku J Exp Med 1978;125:253–63. https://doi.org/10.1620/tjem.125.253.
  • Hughes JT. Brain damage due to Paraquat poisoning: a fatal case with neuropathological examination of the brain. Neurotoxicology Park For South. 1988;9(2):243–8.
  • Jovic-Stosic J, Babic G, Todorovic V. Fatal diquat intoxication. Vojnosanit Pregl 2009;66:477–81. https://doi.org/10.2298/vsp0906477j.
  • Demonstrated at the Division of Medicine (Clinical) Royal Infirmary, Edinburgh., Matthew H. Paraquat poisoning: clinicopathological conference. Scott Med J 1971;16:407–21. https://doi.org/10.1177/003693307101600905.
  • von der Hardt, H., Cardesa, A. Early histopathological changes after paraquat intoxication. Klin Wochenschr 49, 544–550 (1971). https://doi.org/10.1007/BF01487992
  • Paraquat. Safety - Humans: Paraquat and Parkinson's Disease [Internet]. Paraquat; [cited 2023 Aug 15]. Available from: https://www.paraquat.com/en/safety/safety-humans/paraquat-and-parkinsons-disease

Yıl 2023, Cilt: 5 Sayı: 3, 25 - 28, 31.12.2023

Ananth Rupesh Kattamreddy Mohit Kumar Moses Thathapudi Victor Ghosh Jacinth Karunya Midde Pravin Kalyankar

https://doi.org/10.51262/ejtox.1344451

Öz

Proje Numarası

Not Applicable

Kaynakça

  • Gao L, Yuan H, Xu E, Liu J. Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics. Sci Rep 2020;10. https://doi.org/10.1038/s41598-020-58599-y
  • Shanbhag V, Sukumar CA, Shastry AB. Paraquat: The poison potion. Indian J Crit Care Med 2019;23:0–0. https://doi.org/10.5005/jp-journals-10071-23306.
  • Suntres Z. Role of antioxidants in paraquat toxicity. Toxicology 2002;180:65–77. https://doi.org/10.1016/s0300-483x(02)00382-7.
  • Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F. Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 2008;38:13–71. https://doi.org/10.1080/10408440701669959.
  • Delirrad M, Majidi M, Boushehri B. Clinical features, and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med 2015;8:8122–8.
  • Delirrad M, Majidi M, Boushehri B. Clinical features and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med. 2015;8(5):8122–8.
  • Wang X, Wang X, Zhu Y, Chen X. ADME/T-based strategies for paraquat detoxification: Transporters and enzymes. Environ Pollut 2021;291:118137. https://doi.org/10.1016/j.envpol.2021.118137.
  • Vaccari C, El Dib R, Gomaa H, Lopes LC, de Camargo JL. Paraquat and Parkinson’s disease: a systematic review and meta-analysis of observational studies. J Toxicol Environ Health B Crit Rev 2019;22:172–202. https://doi.org/10.1080/10937404.2019.1659197.
  • Tangamornsuksan W, Lohitnavy O, Sruamsiri R, Chaiyakunapruk N, Norman Scholfield C, Reisfeld B, et al. Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis. Arch Environ Occup Health 2019;74:225–38. https://doi.org/10.1080/19338244.2018.1492894.
  • Briñez-Gallego P, da Costa Silva DG, Cordeiro MF, Horn AP, Hort MA. Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review. J Toxicol Environ Health B Crit Rev 2023;26:201–37. https://doi.org/10.1080/10937404.2023.2182390.
  • Lama J, Buhidma Y, Fletcher EJR, Duty S. Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research. Neuronal Signal 2021;5. https://doi.org/10.1042/ns20210026.
  • Uversky VN. Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res 2004;318:225–41. https://doi.org/10.1007/s00441-004-0937-z.
  • Cicchetti F, Lapointe N, Roberge-Tremblay A, Saint-Pierre M, Jimenez L, Ficke BW, et al. Systemic exposure to paraquat and maneb models early Parkinson’s disease in young adult rats. Neurobiol Dis 2005;20:360–71.
  • Soontornniyomkij V, Bunyaratvej S. Fatal paraquat poisoning: a light microscopic study in eight autopsy cases. J Med Assoc Thai 1992;75 Suppl 1:98–105.
  • Mukada T, Sasano N, Sato K. Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura. Tohoku J Exp Med 1978;125:253–63. https://doi.org/10.1620/tjem.125.253.
  • Hughes JT. Brain damage due to Paraquat poisoning: a fatal case with neuropathological examination of the brain. Neurotoxicology Park For South. 1988;9(2):243–8.
  • Jovic-Stosic J, Babic G, Todorovic V. Fatal diquat intoxication. Vojnosanit Pregl 2009;66:477–81. https://doi.org/10.2298/vsp0906477j.
  • Demonstrated at the Division of Medicine (Clinical) Royal Infirmary, Edinburgh., Matthew H. Paraquat poisoning: clinicopathological conference. Scott Med J 1971;16:407–21. https://doi.org/10.1177/003693307101600905.
  • von der Hardt, H., Cardesa, A. Early histopathological changes after paraquat intoxication. Klin Wochenschr 49, 544–550 (1971). https://doi.org/10.1007/BF01487992
  • Paraquat. Safety - Humans: Paraquat and Parkinson's Disease [Internet]. Paraquat; [cited 2023 Aug 15]. Available from: https://www.paraquat.com/en/safety/safety-humans/paraquat-and-parkinsons-disease
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Toksikoloji
Bölüm Review Article
Yazarlar

Ananth Rupesh Kattamreddy 0000-0003-1525-3740

Mohit Kumar Moses Thathapudi Bu kişi benim 0000-0003-4524-8387

Victor Ghosh Bu kişi benim 0000-0003-0914-1056

Jacinth Karunya Midde 0009-0003-3224-3533

Pravin Kalyankar Bu kişi benim 0000-0002-6187-8138

Proje Numarası Not Applicable
Yayımlanma Tarihi 31 Aralık 2023
Gönderilme Tarihi 17 Ağustos 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 3

Kaynak Göster

APA Kattamreddy, A. R., Thathapudi, M. K. M., Ghosh, V., Midde, J. K., vd. (2023). “Paraquat Brain”: Have We Researched Enough?. Eurasian Journal of Toxicology, 5(3), 25-28. https://doi.org/10.51262/ejtox.1344451
AMA Kattamreddy AR, Thathapudi MKM, Ghosh V, Midde JK, Kalyankar P. “Paraquat Brain”: Have We Researched Enough?. Eurasian J Tox. Aralık 2023;5(3):25-28. doi:10.51262/ejtox.1344451
Chicago Kattamreddy, Ananth Rupesh, Mohit Kumar Moses Thathapudi, Victor Ghosh, Jacinth Karunya Midde, ve Pravin Kalyankar. “‘Paraquat Brain’: Have We Researched Enough?”. Eurasian Journal of Toxicology 5, sy. 3 (Aralık 2023): 25-28. https://doi.org/10.51262/ejtox.1344451.
EndNote Kattamreddy AR, Thathapudi MKM, Ghosh V, Midde JK, Kalyankar P (01 Aralık 2023) “Paraquat Brain”: Have We Researched Enough?. Eurasian Journal of Toxicology 5 3 25–28.
IEEE A. R. Kattamreddy, M. K. M. Thathapudi, V. Ghosh, J. K. Midde, ve P. Kalyankar, “‘Paraquat Brain’: Have We Researched Enough?”, Eurasian J Tox, c. 5, sy. 3, ss. 25–28, 2023, doi: 10.51262/ejtox.1344451.
ISNAD Kattamreddy, Ananth Rupesh vd. “‘Paraquat Brain’: Have We Researched Enough?”. Eurasian Journal of Toxicology 5/3 (Aralık 2023), 25-28. https://doi.org/10.51262/ejtox.1344451.
JAMA Kattamreddy AR, Thathapudi MKM, Ghosh V, Midde JK, Kalyankar P. “Paraquat Brain”: Have We Researched Enough?. Eurasian J Tox. 2023;5:25–28.
MLA Kattamreddy, Ananth Rupesh vd. “‘Paraquat Brain’: Have We Researched Enough?”. Eurasian Journal of Toxicology, c. 5, sy. 3, 2023, ss. 25-28, doi:10.51262/ejtox.1344451.
Vancouver Kattamreddy AR, Thathapudi MKM, Ghosh V, Midde JK, Kalyankar P. “Paraquat Brain”: Have We Researched Enough?. Eurasian J Tox. 2023;5(3):25-8.
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